Abstract:
:We present observational and experimental evidence that cycles of the Lyme disease spirochaete, Borrelia burgdorferi s.l., can be maintained by sheep in the virtual absence of alternative hosts. A 2-year field study in upland moorland habitats of northwest UK established that sheep feed up to 80% of larval, > 99% of nymphal and all of the adult female tick (Ixodes ricinus) population. Infection prevalence of B. burgdorferi in questing ticks reaches over 20%, but amplification of infection occurs principally as nymphs (20- to 30-fold), rather than larvae (4- to 7-fold), feed on sheep, and transmission from sheep to ticks occurred only during peak tick abundance in May and September. Experimental transmission studies confirmed that sheep, previously exposed to infected ticks on the moorland site, do not support systemic infections of B. burgdorferi, but they can transmit localized infections from infected to uninfected ticks co-feeding at the same site on the sheep's body.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Ogden NH,Nuttall PA,Randolph SEdoi
10.1017/s0031182097001868subject
Has Abstractpub_date
1997-12-01 00:00:00pages
591-9eissn
0031-1820issn
1469-8161journal_volume
115 ( Pt 6)pub_type
杂志文章相关文献
PARASITOLOGY文献大全abstract::We examined the effects of Haemoproteus infection on the survival and pathology caused in the biting midges. Forty-six females of Culicoides impunctatus were exposed experimentally by allowing them to feed on a naturally infected red-backed shrike infected with Haemoproteus lanii (lineage hRB1, gametocytaemia 5·2%). S...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182016001426
更新日期:2016-11-01 00:00:00
abstract::A key issue relating to developing multi-component anti-malarial vaccines, lies in studying Plasmodium vivax surface proteins' genetic variation. The present work was aimed at amplifying, cloning and sequencing the gene encoding P. vivax merozoite surface protein 5 (PvMSP5) in samples obtained from infected patients f...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182006001168
更新日期:2006-12-01 00:00:00
abstract::Biochemical characterization of 137 Leishmania braziliensis isolates from South and Central America, and from selected endemic foci in Bolivia, Brazil and Colombia, performed by isoenzymatic electrophoresis using 10 enzymatic systems, showed a high enzymatic polymorphism (44 zymodemes obtained) based on the variation ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182097001376
更新日期:1997-10-01 00:00:00
abstract::Conventional mice and congenitally athymic, nude mice were infected with 20 metacercariae of the intestinal trematode Echinostoma revolutum. The sequential events in the pathological changes in the intestine were studied at different intervals post-infection. By day 11 onwards the conventional mice displayed dilatatio...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000054706
更新日期:1984-06-01 00:00:00
abstract::The capacity of Acanthocheilonema viteae to metabolize fructose was investigated in vitro. In common with other filarial species A. viteae oxidized fructose to lactate but its rate of consumption was only 40% of the glucose-containing control value. Fructose was not incorporated into glycogen. Release of 14CO2 from [U...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000060649
更新日期:1990-12-01 00:00:00
abstract::American trypanosamiasis occurs in nature as a sylvatic cycle, where Trypanosoma cruzi interacts with wild triatomines and mammalian reservoirs, such as marsupials, rodents, armadillos and other animals. Due to difficulties in trying to isolate T. cruzi stocks from the sylvatic cycle, very few studies have been perfor...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098003709
更新日期:1999-02-01 00:00:00
abstract::Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs....
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182016000652
更新日期:2016-08-01 00:00:00
abstract::The effects of dietary urea supplementation and of a 10-week trickle infection regime, simulating chronic exposure to Haemonchus contortus, on the zymogenic population of the abomasa of Hampshire Down lambs was examined. At necropsy a variety of parameters including plasma pepsinogen concentration, the wet weights of ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098002704
更新日期:1998-06-01 00:00:00
abstract::BALB/c mice were characterized as more resistant to infection with Heligmosomoides polygyrus (Nematoda) than C57BL/6 mice based on lower establishment and survival during a primary infection and stronger protection induced by an immunizing regime. It was hypothesized, therefore, that C57BL/6 mice would be more heavily...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059953
更新日期:1991-12-01 00:00:00
abstract::We have determined the molar content of guanine + cytosine (GC content) of DNA of the filarial nematode (Brugia malayi, Brugia pahangi and Dirofilaria imitis) and of the free-living soil nematodes Caenorhabditis elegans and have analysed the DNA for the presence of methylcytosine. Two independent methods, thermal dena...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000066750
更新日期:1988-08-01 00:00:00
abstract::Sexual size dimorphism (SSD) in mammals reveals the extent of sexual selection, which may in turn explain why males are often more infected by parasites than females and that parasites may contribute to the association between SSD and male-biased mortality. Here, we investigated the relationship between SSD in small m...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004005840
更新日期:2004-10-01 00:00:00
abstract::To test the homogeneity of 18S sequences within Trypanosoma cruzi, riboprint profiles were separated by temperature gradient gel electrophoresis (TGGE). Upon interpretation of melting curves of fragments within a riboprint profile, there appeared to be two 18S sequence types within each stock examined. Two similar typ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098002972
更新日期:1998-09-01 00:00:00
abstract::Endotoxaemia has been described in cases of Human African trypanosomiasis (HAT), but it is unclear if this phenomenon influences inflammatory pathology either in the periphery or central nervous system (CNS). We studied endotoxin concentrations in the plasma and cerebrospinal fluid (CSF) of Trypanosoma brucei rhodesie...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182016002158
更新日期:2017-04-01 00:00:00
abstract::Currently available methods for the diagnosis of human schistosomiasis often lack enough sensitivity and specificity. Recently, several authors have developed more specific and sensitive diagnostic methods, mainly based on the polymerase chain reaction (PCR) technique. Nevertheless, these have been only applied for th...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182006000898
更新日期:2006-11-01 00:00:00
abstract::Hybridization events between Schistosoma species (Digenea, Platyhelminthes) are reported with increasing frequency, largely due to improved access to molecular tools. Nevertheless, little is known about the distribution and frequency of hybrid schistosomes in nature. Screening for hybrids on a large scale is complicat...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182018000525
更新日期:2018-04-01 00:00:00
abstract::The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus in Poland, Eire and the UK are identified as Aspiculuris tianjinensis, previously known only from China, while worms from Mus musculus from a range of loc...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182015000864
更新日期:2015-10-01 00:00:00
abstract::A serine protease was purified 942-fold from culture supernatant of L. amazonensis promastigotes using (NH4)2SO4 precipitation followed by affinity chromatography on aprotinin-agarose and continuous elution electrophoresis by Prep Cell, yielding a total recovery of 61%. The molecular mass of the active enzyme estimate...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004006675
更新日期:2005-07-01 00:00:00
abstract::In Strongyloides ratti-infected rats, 2 peaks of egg excretion were observed; a large one with maximum egg production on days 7-8 of infection and a small more inconspicuous one around day 25. The second peak, which had been ignored in most studies, was produced by adults in the caecum and the colon. The adults were l...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182099004631
更新日期:1999-08-01 00:00:00
abstract::The flatworm nervous system employs a wide repertoire of neuroactive substances, including small chemical messengers, the so called classical transmitters, and several types of neuropeptides. A large body of research accumulated over four decades has provided a wealth of information on the tissue localization and effe...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182005008565
更新日期:2005-01-01 00:00:00
abstract::The complete nucleotide sequence of the mitochondrial genome was determined for the fish tapeworm Diphyllobothrium latum. This genome is 13,608 bp in length and encodes 12 protein-coding genes (but lacks the atp8), 22 transfer RNA (tRNA) and 2 ribosomal RNA (rRNA) genes, corresponding to the gene complement found thus...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S003118200600206X
更新日期:2007-05-01 00:00:00
abstract::Planning of the control of Plasmodium falciparum malaria leads to a need for models of malaria epidemiology that provide realistic quantitative prediction of likely epidemiological outcomes of a wide range of control strategies. Predictions of the effects of control often ignore medium- and long-term dynamics. The com...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182008000371
更新日期:2008-11-01 00:00:00
abstract::The transmission-blocking monoclonal antibody 13.1, which recognizes the ookinete surface antigen Pbs21 of Plasmodium berghei, and an IgG2a isotype control antibody 26.37 were purified by caprylic acid and ammonium sulphate precipitation. Fab fragments were prepared by papain digestion. IgG but not Fab from antibody 1...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000077702
更新日期:1994-07-01 00:00:00
abstract::In this study, we describe the molecular analysis of zinc-metalloproteases from the abomasal nematode Ostertagia ostertagi which were exclusively recognized by local antibodies of immune cattle. Full-length or partial coding sequences of 4 different zinc-metalloprotease cDNAs of Ostertagia (met-1, -2, -3 and -4) were ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004006274
更新日期:2005-01-01 00:00:00
abstract::The present study was undertaken to investigate the antiparasitic activity of extracellular products of Streptomyces albus. Bioactivity-guided isolation of chloroform extracts affording a compound showing potent activity. The structure of the compound was elucidated as salinomycin (SAL) by EI-MS, 1H NMR and 13C NMR. I...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182018001919
更新日期:2019-04-01 00:00:00
abstract::A specific enzyme-linked immunosorbent assay, based on a 48 kDa metallo-proteinase isolated from the frontal glands of a porocephalid pentastomid (Porocephalus crotali) in rat intermediate hosts, is described. SDS-PAGE analysis of whole nymphal homogenate, followed by Western blotting and probing with immune rat serum...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059849
更新日期:1991-12-01 00:00:00
abstract::The evolution of host specificity and the potential trade-off between being a generalist and a specialist are central issues in the evolutionary ecology of parasites. Different species of parasites or even different populations of the same species often show different degrees of host specificity. However, less is know...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009991107
更新日期:2010-02-01 00:00:00
abstract::Several approaches were adopted for the disruption and removal of the tegumental surface from protoscoleces of the horse strain of the hydatid organism, Echinococcus granulosus. The effectiveness of each method and the purity of subsequent microthrix-enriched fractions obtained by differential centrifugation were eval...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000049064
更新日期:1985-02-01 00:00:00
abstract::Oligosaccharides are broadly present on Leishmania cell surfaces. They can be useful for the leishmaniases diagnosis and also helpful in identifying new cell markers for the disease. The disaccharide Galα1-3Galβ is the immunodominant saccharide in Leishmania cell surface and is the unique non-reducing terminal glycosp...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182018000720
更新日期:2018-12-01 00:00:00
abstract::The numbers, distribution in the small intestine, sexual development and growth (dry weight) of 5-week-old Moniliformis dubius (Acanthocephala) were investigated experimentally in adult, female CFHB rats fed on theoretically isoenergetic diets containing known amounts of fructose in combination with either maize-oil f...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000057176
更新日期:1983-02-01 00:00:00
abstract::The amitochondriate parasitic protist Trichomonas vaginalis can utilize either glucose or maltose as carbon and energy source. The mechanisms of maltose utilization were explored with uptake experiments using radio-isotope labelled maltose in combination with the silicone-oil centrifugation technique and enzymatic ass...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000081026
更新日期:1995-01-01 00:00:00