Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen.

Abstract:

:Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. Humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. A presumptive diagnosis is often made based on clinical features, a history of mollusc consumption, eosinophilic pleocytosis in cerebral spinal fluid, and advanced imaging such as computed tomography. Serological tests are available for angiostrongyliasis, though many tests are still under development. While there is no treatment consensus, therapy often includes a combination of anthelmintics and corticosteroids. Angiostrongyliasis is relatively rare, but is often associated with morbidity and sometimes mortality. Recent reports suggest the parasites' range is increasing, leading to fatalities in regions previously considered Angiostrongylus-free, and sometimes, delayed diagnosis in newly invaded regions. Increased awareness of angiostrongyliasis would facilitate rapid diagnosis and improved clinical outcomes. This paper summarizes knowledge on the parasites' life cycle, clinical aspects and epidemiology. The molecular biology of Angiostrongylus spp. is also discussed. Attention is paid to the significance of angiostrongyliasis in Australia, given the recent severe cases reported from the Sydney region.

journal_name

Parasitology

journal_title

Parasitology

authors

Barratt J,Chan D,Sandaradura I,Malik R,Spielman D,Lee R,Marriott D,Harkness J,Ellis J,Stark D

doi

10.1017/S0031182016000652

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1087-118

issue

9

eissn

0031-1820

issn

1469-8161

pii

S0031182016000652

journal_volume

143

pub_type

杂志文章,评审
  • Antiparasitic effects of ethanolic extracts of Piper arboreum and Jatropha gossypiifolia leaves on cercariae and adult worms of Schistosoma mansoni.

    abstract::New treatment strategies for schistosomiasis should be evaluated, since resistant strains to the only available drug, Praziquantel, have already been described. Thus, we demonstrated antiparasitic effects of ethanolic extracts of Jatropha gossypiifolia and Piper arboreum on cercariae and adult worms of Schistosoma man...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118202000181X

    authors: da Silva Alves RR,Mendes Rodrigues JG,Teles-Reis A,Araújo Nogueira R,Correia Lima Licá I,Sampaio Lira MG,da Silva Alves R,Silva-Souza N,Aguiar Dos Santos Andrade TJ,Silva Miranda G

    更新日期:2020-12-01 00:00:00

  • Characterization of surface proteins and glycoproteins on red blood cells from mice infected with haemosporidia: Plasmodium berghei infections of BALB/c mice.

    abstract::The surface proteins and glycoproteins of red cells from Plasmodium berghei-infected blood have been radio-isotope labelled and compared with those of normal mouse erythrocytes using the following protein labelling probes: lactoperoxidase-catalysed radio-iodination of tyrosyl residues, periodate oxidation and NaB3H4 r...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000056031

    authors: Howard RJ,Smith PM,Mitchell GF

    更新日期:1980-10-01 00:00:00

  • Comparison of cysteine peptidase activities in Trichobilharzia regenti and Schistosoma mansoni cercariae.

    abstract::Cercariae of the bird schistosome Trichobilharzia regenti and of the human schistosome Schistosoma mansoni employ proteases to invade the skin of their definitive hosts. To investigate whether a similar proteolytic mechanism is used by both species, cercarial extracts of T. regenti and S. mansoni were biochemically ch...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007002910

    authors: Kasný M,Mikes L,Dalton JP,Mountford AP,Horák P

    更新日期:2007-10-01 00:00:00

  • Lethality of intestinal tissue extracts from Eimeria-infected chickens.

    abstract::Evidence exists that lethal activity is associated with extracts from Eimeria tenella-infected caecal tissues. We examined tissues of the small intestine infected with other species of Eimeria for a similar lethal activity. Extracts were prepared from intestinal tissues of chickens infected with either E. acervulina, ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000055554

    authors: McKenzie ME,Johnson J,Long PL

    更新日期:1985-06-01 00:00:00

  • Overlapping antigenic repertoires of variant antigens expressed on the surface of erythrocytes infected by Plasmodium falciparum.

    abstract::Antibodies against variable antigens expressed on the surface of Plasmodium falciparum-infected erythrocytes are believed to be important for protection against malaria. A target for these antibodies is the P. falciparum erythrocyte membrane protein 1, PfEMP1, which is encoded by around 50 var genes and undergoes clon...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099004485

    authors: Giha HA,Staalsoe T,Dodoo D,Elhassan IM,Roper C,Satti GM,Arnot DE,Hviid L,Theander TG

    更新日期:1999-07-01 00:00:00

  • The mannitol cycle in Eimeria.

    abstract::A metabolic pathway known as the mannitol cycle has been identified in Eimerian parasites. The pathway is a shunt off of the glycolytic pathway at fructose-6-phosphate (F6P). Two enzymes convert F6P to mannitol and two other enzymes are responsible for converting mannitol back to F6P when it is utilized. Although the ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:

    authors: Schmatz DM

    更新日期:1997-01-01 00:00:00

  • Five types of nuclei present in the capsule of Trichinella spiralis.

    abstract::This study describes morphological changes during capsule formation of Trichinella spiralis with emphasis on nuclei within the capsule. The nuclei of the pre-existing muscle cell may become hypertrophied or degrade soon after the entrance of newborn larvae. Cytoplasm associated with these hypertrophied nuclei was baso...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099006198

    authors: Matsuo A,Wu Z,Nagano I,Takahashi Y

    更新日期:2000-08-01 00:00:00

  • Malaria, quinine and red cell lysis.

    abstract::An hypothesis is presented to explain the red cell lysis which accompanies an acute malarial infection, as well as the mode of action of certain schizonticidal drugs in the quinoline and acridine series. Quinine and a number of other antimalarial drugs have been found to counteract the inhibition by protein of fatty a...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200004662x

    authors: Laser H,Kemp P,Miller N,Lander D,Klein R

    更新日期:1975-10-01 00:00:00

  • Cystic echinococcosis in a wild population of the brush-tailed rock-wallaby (Petrogale penicillata), a threatened macropodid.

    abstract::Infection of small macropodids with the larval stage of Echinococcus granulosus can cause fatalities as well as significant pulmonary impairment and other adverse sequelae. The brush-tailed rock-wallaby (Petrogale penicillata) is a small macropodid listed as vulnerable on the IUCN's Red List of Threatened Species. Thi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004423

    authors: Barnes TS,Goldizen AW,Morton JM,Coleman GT

    更新日期:2008-05-01 00:00:00

  • Impact of chemical structure of flavanol monomers and condensed tannins on in vitro anthelmintic activity against bovine nematodes.

    abstract::Plants containing condensed tannins (CT) may have potential to control gastrointestinal nematodes (GIN) of cattle. The aim was to investigate the anthelmintic activities of four flavan-3-ols, two galloyl derivatives and 14 purified CT fractions, and to define which structural features of CT determine the anti-parasiti...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015001912

    authors: Desrues O,Fryganas C,Ropiak HM,Mueller-Harvey I,Enemark HL,Thamsborg SM

    更新日期:2016-04-01 00:00:00

  • Microgametogony of Sarcocystis hirsuta in the intestine of the cat.

    abstract::The development of microgamonts was studied in the small intestine of a 2-day-old cat after oral inoculation with 10(7) bradyzoites of Sarcocystis hirsuta. The cat was given bradyzoites in 2 doses at 2 h apart and killed 4 h later. Gamonts were seen in parasitophorous vacuoles of goblet cells in the epithelium of the ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000057115

    authors: Dubey JP

    更新日期:1983-02-01 00:00:00

  • Serial passage of Eimeria tenella and E. necatrix in turkey embryos.

    abstract::The serial passage of 3 strains of Eimeria from the chicken in embryonating turkey embryos is reported here. All 3 strains increased their reproduction in turkey embryos; reproduction being equal to or better than the same lines maintained in chicken embryos. Pathogenicity and immunogenicity trials conducted in chicke...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200005037x

    authors: Kogut MH,Gore TC,Long PL

    更新日期:1983-04-01 00:00:00

  • Development of a strategy for the identification of surface proteins in the pathogenic microsporidian Nosema bombycis.

    abstract::Parasite-host interactions mediated by cell surface proteins have been implicated as a critical step in infections caused by the microsporidian Nosema bombycis. Such cell surface proteins are considered as promising diagnostic markers and targets for drug development. However, little research has specifically addresse...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015000190

    authors: Zhao W,Hao Y,Wang L,Zhou Z,Li Z

    更新日期:2015-06-01 00:00:00

  • Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen.

    abstract::Serology is an important tool for the diagnosis of alveolar echinococcosis (AE) in humans. In order to improve serodiagnostic performance, we have developed an in vitro-produced Echinococcus mulilocularis metacestode vesicle fluid (EmVF) antigen for application in an immunoblot assay. Immunoblot analysis of EmVF revea...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006002083

    authors: Müller N,Frei E,Nuñez S,Gottstein B

    更新日期:2007-06-01 00:00:00

  • The effect of drugs on the cell cycle of Giardia intestinalis.

    abstract::Flow cytometric analysis of the binucleated protozoan parasite Giardia intestinalis gave DNA histograms with a broad G1 peak and a definable G2 + M peak with twice the DNA content of G1. Twenty-four hour treatment with metronidazole arrested cell cycle progression of susceptible trophozoites in the G2 + M phase, but h...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000059047

    authors: Hoyne GF,Boreham PF,Parsons PG,Ward C,Biggs B

    更新日期:1989-12-01 00:00:00

  • Schistosoma mansoni: changes in elemental composition in relation to the age and sexual status of the worms.

    abstract::Changes during development in the elemental contents (Ca, P, K, Mg and S) of male and female Schistosoma mansoni from both mixed and single sex infections have been measured for the first time. In mixed infections, there is a significant difference between the calcium content of male and female worms; female worms hav...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000050630

    authors: Shaw MK,Erasmus DA

    更新日期:1983-06-01 00:00:00

  • Phagocyte-specific S100 proteins in the local response to the Echinococcus granulosus larva.

    abstract::Infection by larval Echinococcus granulosus is usually characterized by tight inflammatory control. However, various degrees of chronic granulomatous inflammation are also observed, reaching a high point in infection of cattle by the most prevalent parasite strain worldwide, which is not well adapted to this host spec...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118201100179X

    authors: Basika T,Muñoz N,Casaravilla C,Irigoín F,Batthyány C,Bonilla M,Salinas G,Pacheco JP,Roth J,Durán R,Díaz A

    更新日期:2012-02-01 00:00:00

  • Functional characterization of X-prolyl aminopeptidase from Toxoplasma gondii.

    abstract::In the present study, a recombinant aminopeptidase P (rTgAPP) from Toxoplasma gondii was expressed in Escherichia coli to evaluate its enzyme parameters. The rTgAPP showed strong activity against a synthetic substrate for aminopeptidase P at pH 8·0 with a K m value of 0·255 µ m and a k cat value of 35·6 s-1. The overa...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016000986

    authors: Yang M,Zheng J,Jia H,Song M

    更新日期:2016-09-01 00:00:00

  • Immunologically mediated, non-specific interactions between the intestinal phases of Trichinella spiralis and Nippostrongylus brasiliensis in the mouse.

    abstract::Interactions between infections of Trichinella spiralis and Nippostrongylus brasiliensis were studied in the NIH strain of mouse which is known to react strongly to T. spiralis. The course of N. brasiliensis infection in this strain of mouse is described and expulsion is shown to be accelerated in immunized mice and i...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000000512

    authors: Kennedy MW

    更新日期:1980-02-01 00:00:00

  • Rat-dietary fructose and the intestinal distribution and growth of Moniliformis (Acanthocephala).

    abstract::The numbers, distribution in the small intestine, sexual development and growth (dry weight) of 5-week-old Moniliformis dubius (Acanthocephala) were investigated experimentally in adult, female CFHB rats fed on theoretically isoenergetic diets containing known amounts of fructose in combination with either maize-oil f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000057176

    authors: Crompton DW,Keymer A,Singhvi A,Nesheim MC

    更新日期:1983-02-01 00:00:00

  • Interspecific characterization of several taeniid cestodes by isoenzyme analysis using isoelectric focusing in agarose.

    abstract::Taenia cestodes were obtained from 5 different definitive host species in Kenya and 175 different samples were examined by classical morphological methods and by isoenzyme analysis using isoelectric focusing in agarose. Gels were stained for 17 different enzymes and 3 of these were used in the construction of isoenzym...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000058017

    authors: Allsopp BA,Jones A,Allsopp MT,Newton SD,Macpherson CN

    更新日期:1987-12-01 00:00:00

  • Cross-reactions between Eimeria falciformis and Eimeria pragensis in mice induced by trickle infections.

    abstract::We describe a laboratory model using Eimeria falciformis and E. pragensis to investigate some of the interactions in double-species infections of Eimeria. Mice were given trickle infections by oral inoculation of 100 sporulated oocysts of one species at 3 or 4 day intervals throughout the experiments and, once immunit...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098003308

    authors: Shehu K,Nowell F

    更新日期:1998-11-01 00:00:00

  • Proteomics at the schistosome-mammalian host interface: any prospects for diagnostics or vaccines?

    abstract::Since 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The p...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182012000339

    authors: Wilson RA

    更新日期:2012-08-01 00:00:00

  • The three-spined stickleback-Schistocephalus solidus system: an experimental model for investigating host-parasite interactions in fish.

    abstract::Plerocercoids of the pseudophyllidean cestode Schistocephalus solidus infect the three-spined stickleback Gasterosteus aculeatus, with important consequences for the biology of host fish. Techniques for culturing the parasite in vitro and generating infective stages that can be used to infect sticklebacks experimental...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009991466

    authors: Barber I,Scharsack JP

    更新日期:2010-03-01 00:00:00

  • Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta.

    abstract::The host-parasite relationship is exquisitely specific. In exploiting the host niche, a variety of helminth parasites have been shown to directly manipulate their hosts' immune responses. We assessed the ability of a whole-worm extract of Hymenolepis diminuta to modulate immune cell activation. Immune cells isolated f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004006985

    authors: Wang A,McKay DM

    更新日期:2005-05-01 00:00:00

  • Chemotherapy for patients with multiple parasitic infections.

    abstract::Multiple parasitic infections have become increasingly recognized as a result of improvements in laboratory diagnosis and a growing population of immunocompromised individuals. This review examines the principles of chemotherapy in groupings of multiple infections which are of particular clinical significance. ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000017674

    authors: Chiodini PL

    更新日期:2001-01-01 00:00:00

  • Characterization of the effector mechanisms of a transmission-blocking antibody upon differentiation of Plasmodium berghei gametocytes into ookinetes in vitro.

    abstract::The transmission-blocking monoclonal antibody 13.1, which recognizes the ookinete surface antigen Pbs21 of Plasmodium berghei, and an IgG2a isotype control antibody 26.37 were purified by caprylic acid and ammonium sulphate precipitation. Fab fragments were prepared by papain digestion. IgG but not Fab from antibody 1...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000077702

    authors: Ranawaka GR,Alejo-Blanco AR,Sinden RE

    更新日期:1994-07-01 00:00:00

  • Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony.

    abstract::The current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL). Although contributory mechanisms studied in laboratory-raised Sb-R parasites include an up-regulation of drug efflux pumps and increased thiols, their role in c...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003150

    authors: Mandal G,Wyllie S,Singh N,Sundar S,Fairlamb AH,Chatterjee M

    更新日期:2007-11-01 00:00:00

  • Host and ecology both play a role in shaping distribution of digenean parasites of New Zealand whelks (Gastropoda: Buccinidae: Cominella).

    abstract::Digenean parasites infecting four Cominella whelk species (C. glandiformis, C. adspersa, C. maculosa and C. virgata), which inhabit New Zealand's intertidal zone, were analysed using molecular techniques. Mitochondrial 16S and cytochrome oxidase 1 (COI) and nuclear rDNA ITS1 sequences were used to infer phylogenetic r...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016000494

    authors: Donald KM,Spencer HG

    更新日期:2016-08-01 00:00:00

  • Cytogenetic and sequence comparison of adult Phyllodistomum (Digenea: Gorgoderidae) from the three-spined stickleback with larvae from two bivalves.

    abstract::Due to the low informative value of available morphological characters, cytogenetic and molecular methods, based on rDNA sequencing, were used to characterize adult and larval stages of Phyllodistomum spp. Species studied have 18 chromosomes with comparable absolute and relative lengths. Conventional Giemsa staining a...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004006109

    authors: Petkeviciŭte R,Stunzenas V,Staneviciŭte G

    更新日期:2004-12-01 00:00:00