Phagocyte-specific S100 proteins in the local response to the Echinococcus granulosus larva.

Abstract:

:Infection by larval Echinococcus granulosus is usually characterized by tight inflammatory control. However, various degrees of chronic granulomatous inflammation are also observed, reaching a high point in infection of cattle by the most prevalent parasite strain worldwide, which is not well adapted to this host species. In this context, epithelioid and multinucleated giant macrophages surround the parasite, and the secreted products of these cells often associate with the larval wall. The phagocyte-specific S100 proteins, S100A8, S100A9 and S100A12, are important non-conventionally secreted amplifiers of inflammatory responses. We have analysed by proteomics and immunohistochemistry the presence of these proteins at the E. granulosus larva-host interface. We found that, in the context of inflammatory control as observed in human infections, the S100 proteins are not abundant, but S100A9 and S100A8 can be expressed by eosinophils distal to the parasite. In the granulomatous inflammation context as observed in cattle infections, we found that S100A12 is one of the most abundant host-derived, parasite-associated proteins, while S100A9 and S100A8 are not present at similarly high levels. As expected, S100A12 derives mostly from the epithelioid and multinucleated giant cells. S100A12, as well as cathepsin K and matrix metalloproteinase-9, also expressed by E. granulosus-elicited epithelioid cells, are connected to the Th17 arm of immunity, which may therefore be involved in this granulomatous response.

journal_name

Parasitology

journal_title

Parasitology

authors

Basika T,Muñoz N,Casaravilla C,Irigoín F,Batthyány C,Bonilla M,Salinas G,Pacheco JP,Roth J,Durán R,Díaz A

doi

10.1017/S003118201100179X

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

271-83

issue

2

eissn

0031-1820

issn

1469-8161

pii

S003118201100179X

journal_volume

139

pub_type

杂志文章
  • Temperature gradient gel electrophoresis (TGGE) analysis of riboprints from Trypanosoma cruzi.

    abstract::To test the homogeneity of 18S sequences within Trypanosoma cruzi, riboprint profiles were separated by temperature gradient gel electrophoresis (TGGE). Upon interpretation of melting curves of fragments within a riboprint profile, there appeared to be two 18S sequence types within each stock examined. Two similar typ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098002972

    authors: Stothard JR,Frame IA,Carrasco HJ,Miles MA

    更新日期:1998-09-01 00:00:00

  • Cryptostatin, a chagasin-family cysteine protease inhibitor of Cryptosporidium parvum.

    abstract::Cysteine proteases of pathogenic protozoan parasites play pivotal roles in the life cycle of parasites, but strict regulation of their activities is also essential for maintenance of parasite physiology and interaction with hosts. In this study, we identified and characterized cryptostatin, a novel inhibitor of cystei...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012000297

    authors: Kang JM,Ju HL,Yu JR,Sohn WM,Na BK

    更新日期:2012-07-01 00:00:00

  • Protease inhibitors and haemagglutinins associated with resistance to the protozoan parasite, Perkinsus marinus, in the Pacific oyster, Crassostrea gigas.

    abstract::Perkinsus marinus is a protozoan responsible for dramatic mortality in the Eastern oyster, Crassostrea virginica, but not in the Pacific oyster, C. gigas. To understand the host-parasite relationship, we inoculated P. marinus trophozoites into the shell cavity of C. gigas and measured, over 2 months, (i) intensity of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182002002135

    authors: Romestand B,Corbier F,Roch P

    更新日期:2002-10-01 00:00:00

  • Epidemiology and optimal foraging: modelling the ideal free distribution of insect vectors.

    abstract::Existing models of the basic case reproduction number (R0) for vector-borne diseases assume (i) that the distribution of vectors over the susceptible host species is homogeneous and (ii) that the biting preference for the susceptible host species rather than other potential hosts is a constant. Empirical evidence cont...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099005442

    authors: Kelly DW,Thompson CE

    更新日期:2000-03-01 00:00:00

  • Insights on adaptive and innate immunity in canine leishmaniosis.

    abstract::Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neg...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118201600055X

    authors: Hosein S,Blake DP,Solano-Gallego L

    更新日期:2017-01-01 00:00:00

  • Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony.

    abstract::The current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL). Although contributory mechanisms studied in laboratory-raised Sb-R parasites include an up-regulation of drug efflux pumps and increased thiols, their role in c...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003150

    authors: Mandal G,Wyllie S,Singh N,Sundar S,Fairlamb AH,Chatterjee M

    更新日期:2007-11-01 00:00:00

  • Use of clomipramine as chemotherapy of the chronic phase of Chagas disease.

    abstract::Chagas infection is a major endemic disease affecting Latin American countries. The persistence of Trypanosoma cruzi generates a chronic inflammatory reactivity that induces an immune response directed to the host's tissues. The effectiveness of the treatment in the chronic phase is still unsatisfactory due, amongst o...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000103

    authors: Fauro R,Lo Presti S,Bazan C,Baez A,Strauss M,Triquell F,Cremonezzi D,Negrete OS,Willhuber GC,Paglini-Oliva P,Rivarola HW

    更新日期:2013-06-01 00:00:00

  • A phylogenetic analysis of filarial nematodes: comparison with the phylogeny of Wolbachia endosymbionts.

    abstract::Infection with the endosymbiotic bacteria Wolbachia is widespread in filarial nematodes. Previous studies have suggested concordance between the phylogeny of Wolbachia with that of their nematode hosts. However, there is only one published molecular phylogenetic study of filarial species, based on the 5S rRNA gene spa...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000007149

    authors: Casiraghi M,Anderson TJ,Bandi C,Bazzocchi C,Genchi C

    更新日期:2001-01-01 00:00:00

  • Factors generating aggregation of Heligmosomoides polygyrus (Nematoda) in laboratory mice.

    abstract::The importance of host heterogeneity in generating aggregation was investigated using Heligmosomoides polygyrus (Nematoda) in laboratory mice. Parameters of infection were compared between inbred and outbred mice, between primary and challenge infection protocols, and between gavage and natural exposure protocols, to ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000063782

    authors: Tanguay GV,Scott ME

    更新日期:1992-06-01 00:00:00

  • Myxozoans as biological tags for stock identification of the Argentine hake, Merluccius hubbsi (Gadiformes: Merlucciidae).

    abstract::Myxozoans have been successfully used as tags for fish stock identification around the world. However, few studies using myxozoan tags have been carried out in the Southern Atlantic, a region with complex oceanography that constitutes a potentially suitable scenario for testing the utility of myxozoans as indicators. ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016000226

    authors: Cantatore DM,Irigoitia MM,Holzer AS,Timi JT

    更新日期:2016-05-01 00:00:00

  • Re-evaluation of the life cycle of Eimeria maxima Tyzzer, 1929 in chickens (Gallus domesticus).

    abstract::A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the Eimeria maxima life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million E. maxima oocysts (APU1), and were necropsied...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017002153

    authors: Dubey JP,Jenkins MC

    更新日期:2018-07-01 00:00:00

  • A novel member of the ligand-gated chloride channel gene family from Haemonchus contortus.

    abstract::Ligand-gated chloride channels (LGCCs) are key components of the nervous system of parasitic nematodes and important targets for anthelmintics. Here, we describe the isolation and characterization of a novel member of the LGCC gene family (HcLGCC1) from the parasitic nematode Haemonchus contortus. Sequence analysis re...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007004088

    authors: Forrester SG,Siddiqui SZ

    更新日期:2008-04-01 00:00:00

  • An introduced pentastomid parasite (Raillietiella frenata) infects native cane toads (Rhinella marina) in Panama.

    abstract::The pentastomid parasite, Raillietiella frenata, is native to Asia where it infects the Asian House gecko, Hemidactylus frenatus. This gecko has been widely introduced and recently R. frenata was found in introduced populations of cane toads (Rhinella marina) in Australia, indicating a host-switch from introduced geck...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182014001759

    authors: Kelehear C,Saltonstall K,Torchin ME

    更新日期:2015-04-01 00:00:00

  • Sialic acid analysis and tritium-labelling of sialoglycoproteins of mouse erythrocytes infected with Plasmodium berghei.

    abstract::Schizont-infected red blood cells (SI-RBC) from Plasmodium berghei-infected mice contain between 2 and 10 times as much sialic acid as uninfected RBC from the same blood (99-550 micrograms/10(10) RBC versus 33-65 micrograms/10(10) RBC). Total RBC samples from infected animals containing up to 63% ring- and trophozoite...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000065434

    authors: Howard RJ,Seeley DC Jr,Kao V,Wember M,Schauer R

    更新日期:1986-06-01 00:00:00

  • Integrating the landscape epidemiology and genetics of RNA viruses: rabies in domestic dogs as a model.

    abstract::Landscape epidemiology and landscape genetics combine advances in molecular techniques, spatial analyses and epidemiological models to generate a more real-world understanding of infectious disease dynamics and provide powerful new tools for the study of RNA viruses. Using dog rabies as a model we have identified how ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S003118201200090X

    authors: Brunker K,Hampson K,Horton DL,Biek R

    更新日期:2012-12-01 00:00:00

  • Conventional PCR for molecular diagnosis of human strongyloidiasis.

    abstract::Strongyloidiasis is frequently asymptomatic and diagnosis of latent infection is difficult due to limitations of current parasitological and serological methods. This study aimed to verify the use of conventional polymerase chain reaction (PCR) assay for molecular diagnosis of Strongyloides stercoralis infection. Fres...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013002035

    authors: Sitta RB,Malta FM,Pinho JR,Chieffi PP,Gryschek RC,Paula FM

    更新日期:2014-04-01 00:00:00

  • Identification and characterization of cross-reactive antigens from Neospora caninum and Toxoplasma gondii.

    abstract::Murine monoclonal antibodies (mAbs) against Neospora caninum tachyzoites were produced to identify the cross-reactive antigens between N. caninum and Toxoplasma gondii. Ten mAbs recognizing cross-reactive antigens of both parasites were obtained and tentatively classified into 6 different groups based on their reactiv...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004006948

    authors: Liao M,Xuan X,Huang X,Shirafuji H,Fukumoto S,Hirata H,Suzuki H,Fujisaki K

    更新日期:2005-05-01 00:00:00

  • Modulation of immune responses to parasitoids by polydnaviruses.

    abstract::Parasitoids are parasites that invariably kill their host. Polydnaviruses are injected by parasitoid wasps into the body cavity of their insect host and cause immunosuppression, allowing the parasitoid to develop in the absence of encapsulation. One of the targets of the polydnaviruses are the haemocytes of the host, ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000084948

    authors: Beckage NE

    更新日期:1998-01-01 00:00:00

  • Bank voles (Myodes glareolus) and house mice (Mus musculus musculus; M. m. domesticus) in Europe are each parasitized by their own distinct species of Aspiculuris (Nematoda, Oxyurida).

    abstract::The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus in Poland, Eire and the UK are identified as Aspiculuris tianjinensis, previously known only from China, while worms from Mus musculus from a range of loc...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015000864

    authors: Behnke JM,Stewart A,Bajer A,Grzybek M,Harris PD,Lowe A,Ribas A,Smales L,Vandegrift KJ

    更新日期:2015-10-01 00:00:00

  • Diversity, distribution and biogeographical origins of Plasmodium parasites from the New Zealand bellbird (Anthornis melanura).

    abstract::Understanding the origin of invasive parasites and ecological transmission barriers on the distribution of mosquito-borne pathogens is enriched by molecular phylogenetic approaches now that large databases are becoming available. Here we assess the biogeographical relationships among haemosporidian blood parasites and...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011001491

    authors: Baillie SM,Brunton DH

    更新日期:2011-12-01 00:00:00

  • The impact of co-infections on the haematological profile of East African Short-horn Zebu calves.

    abstract::The cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Livestock (IDEAL) study ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013001625

    authors: Van Wyk IC,Goddard A,de C Bronsvoort BM,Coetzer JA,Handel IG,Hanotte O,Jennings A,Lesosky M,Kiara H,Thumbi SM,Toye P,Woolhouse MW,Penzhorn BL

    更新日期:2014-03-01 00:00:00

  • Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta.

    abstract::The host-parasite relationship is exquisitely specific. In exploiting the host niche, a variety of helminth parasites have been shown to directly manipulate their hosts' immune responses. We assessed the ability of a whole-worm extract of Hymenolepis diminuta to modulate immune cell activation. Immune cells isolated f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004006985

    authors: Wang A,McKay DM

    更新日期:2005-05-01 00:00:00

  • First evidence of the presence of Anisakis simplex in Crangon crangon and Contracaecum osculatum in Gammarus sp. by in situ examination of the stomach contents of cod (Gadus morhua) from the southern Baltic Sea.

    abstract::Cod (Gadus morhua), an important fish species in the Baltic Sea, is the paratenic host for many parasite species, including the zoonotic nematodes, Anisakis sp. and Contracaecum osculatum. We aimed to identify which invertebrate species (found in situ in the fish stomach) are responsible for infection of cod with zoon...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182019001124

    authors: Pawlak J,Nadolna-Ałtyn K,Szostakowska B,Pachur M,Bańkowska A,Podolska M

    更新日期:2019-11-01 00:00:00

  • Effect of fox, pig, sheep, and poultry bile on the establishment of domestic and sylvatic species of Trichinella in rats.

    abstract::Most sylvatic species of Trichinella are known to have poor infectivity to rats, but in the present study oral administration of bile from other hosts appeared to modify this infectivity. A total of 75 rats were inoculated in groups of 25 with 3 species of Trichinella (T. spiralis, T. nativa, and T. nelsoni) and each ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200300307x

    authors: Theodoropoulos G,Styliara M,Petrakos M,Kapel CM

    更新日期:2003-05-01 00:00:00

  • In vitro susceptibility of Tanzanian wild isolates of Plasmodium falciparum to artemisinin, chloroquine, sulfadoxine/pyrimethamine and mefloquine.

    abstract::A 30-h in vitro susceptibility test of Plasmodium falciparum wild isolates to artemisinin, chloroquine, sulfadoxine/pyrimethamine and mefloquine was performed in Kibaha, Tanzania. A sigmoid Emax model was fitted to all data for each isolate and drug combination. Artemisinin and mefloquine exhibited 100% growth inhibit...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:

    authors: Alin MH

    更新日期:1997-06-01 00:00:00

  • Electron microscopy of Eimeria acervulina macrogametogony and oocyst wall formation.

    abstract::Macrogametogony and the formation of the oocyst wall has been examined in Eimeria acervulina. Macrogametes develop within a parasitophorous vacuole. Within the cytoplasm can be observed wall-forming bodies of Type I (WFBI) and Type II (WFBII), a nucleus, mitochondria, canaliculi and polysaccharide granules. WFBII are ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000001074

    authors: Pittilo RM,Ball SJ

    更新日期:1984-08-01 00:00:00

  • Identification of an antigen of Onchocerca volvulus of possible diagnostic use.

    abstract::Adult Onchocerca volvulus worms obtained by enzyme digestion from nodules of infected Mexicans were radio-isotope labelled by the chloramine-T or Bolton-Hunter methods. No antigenic determinants were detected in extracts of worms labelled by the chloramine-T method but 3 antigens were detected in extracts of the Bolto...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000001323

    authors: Philipp M,Gómez-Priego A,Parkhouse RM,Davies MW,Clark NW,Ogilvie BM,Beltrán-Hernández F

    更新日期:1984-10-01 00:00:00

  • Neurophysiology of glutamatergic signalling and anthelmintic action in Ascaris suum: pharmacological evidence for a kainate receptor.

    abstract::Electrophysiological and pharmacological techniques were used to study glutamatergic signalling in the parasitic nematode, Ascaris suum. Glutamate or kainate injections into whole worms produced a paralysed quasi-static posture similar to the waveform in behaving worms. The DE2 motorneuron class is a primary target. S...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098002467

    authors: Davis RE

    更新日期:1998-05-01 00:00:00

  • Individual and combined effects of cadmium and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda).

    abstract::The individual and combined effects of cadmium (Cd) and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the antibody response of fish against metazoan parasites were tested. Eels experimentally infected with the swim bladder nematode Anguillicola crassus were exposed to sublethal concentrations of Cd and PCB 126. Cd was ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200300475x

    authors: Sures B,Knopf K

    更新日期:2004-04-01 00:00:00

  • Transcriptome analysis during the process of in vitro differentiation of Leishmania donovani using genomic microarrays.

    abstract::Leishmania donovani causes visceral disease (kala-azar), a major health problem throughout the tropics with 500 000 new cases every year. Leishmania differentiates from the promastigote to the amastigote form to establish infection in a mammalian host. To understand the process of differentiation, we assessed the glob...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118200700296X

    authors: Srividya G,Duncan R,Sharma P,Raju BV,Nakhasi HL,Salotra P

    更新日期:2007-10-01 00:00:00