Antiparasitic effects of ethanolic extracts of Piper arboreum and Jatropha gossypiifolia leaves on cercariae and adult worms of Schistosoma mansoni.

Abstract:

:New treatment strategies for schistosomiasis should be evaluated, since resistant strains to the only available drug, Praziquantel, have already been described. Thus, we demonstrated antiparasitic effects of ethanolic extracts of Jatropha gossypiifolia and Piper arboreum on cercariae and adult worms of Schistosoma mansoni. The bioassays were performed at 0-10 000 μg mL-1 concentration for 0-72 h. Adult worms were stained with carmine to assess external and internal damage. The chemical screening was performed using high-performance liquid chromatography. P. arboreum displayed the best cercaricidal effect, with a 100% reduction in viability in just 60 min. The extract of J. gossypiifolia was more effective against adult worms, with 100% viability reduction of male and female worms after 12 and 24 h, respectively. P. arboreum and J. gossypiifolia were equally effective in inhibiting the oviposition of S. mansoni (93% reduction) and causing damage to internal and external structures in adult worms. Flavonoids were identified in both the extracts and phenolic compounds and amides only in P. arboreum. Thus, for the first time, it was proven that ethanolic extracts of P. arboreum and J. gossypiifolia leaves are biologically active against cercariae and adult worms of S. mansoni in vitro.

journal_name

Parasitology

journal_title

Parasitology

authors

da Silva Alves RR,Mendes Rodrigues JG,Teles-Reis A,Araújo Nogueira R,Correia Lima Licá I,Sampaio Lira MG,da Silva Alves R,Silva-Souza N,Aguiar Dos Santos Andrade TJ,Silva Miranda G

doi

10.1017/S003118202000181X

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1689-1699

issue

14

eissn

0031-1820

issn

1469-8161

pii

S003118202000181X

journal_volume

147

pub_type

杂志文章
  • Plasmodium vivax Duffy binding protein: a modular evolutionary proposal.

    abstract::The population of malaria-causing parasites is characterized by great genetic diversity. Knowledge of the polymorphism generation mechanism is a central issue for developing effective vaccines against malaria and understanding the parasite population structure. Plasmodium vivax genetic diversity has been explained in ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182003004773

    authors: Martinez P,Suarez CF,Cardenas PP,Patarroyo MA

    更新日期:2004-04-01 00:00:00

  • The recruitment of mast cells, exclusively of the mucosal phenotype, into granulomatous lesions caused by the pentastomid parasite Porocephalus crotali: recruitment is irrespective of site.

    abstract::Adults of the porocephalid pentastomid Porocephalus crotali infect the lung of rattlesnake definitive hosts and larvae develop in rat intermediate hosts. In the latter, nymphs encyst within a variety of tissue sites (commonly abdominal fat bodies and lungs) and each becomes the focus of an eosinophilic granuloma. From...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000074801

    authors: McHardy P,Riley J,Huntley JF

    更新日期:1993-01-01 00:00:00

  • Social structure of the mara (Dolichotis patagonum) as a determinant of gastro-intestinal parasitism.

    abstract::A one-year study of gastro-intestinal parasitism in a free-ranging population of maras at Whipsnade Wild Animal Park, UK, revealed a strong relationship between membership of social units and both intensity and prevalence of infection. The mara, a hystricomorph rodent from southern Argentina, has a social organization...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182097002205

    authors: Porteous IS,Pankhurst SJ

    更新日期:1998-03-01 00:00:00

  • Seroprevalence of toxocariasis in Lebanon: a pilot study.

    abstract::Toxocariasis is a common helminthic infection that has a worldwide distribution. However, data from Lebanon about the prevalence of this infection are non-existent. We conducted a Toxocara seroprevalence study with 150 subjects attending the outpatient clinics at the American University of Beirut Medical Center betwee...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005009637

    authors: Kanafani ZA,Skoury A,Araj GF,El-Khoury M,Sawaya RA,Atweh SF,Kanj SS

    更新日期:2006-05-01 00:00:00

  • Towards a mechanistic understanding of competence: a missing link in diversity-disease research.

    abstract::Biodiversity loss may increase the risk of infectious disease in a phenomenon known as the dilution effect. Circumstances that increase the likelihood of disease dilution are: (i) when hosts vary in their competence, and (ii) when communities disassemble predictably, such that the least competent hosts are the most li...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020000943

    authors: Stewart Merrill TE,Johnson PTJ

    更新日期:2020-09-01 00:00:00

  • Similarity and structure of the ectoparasite communities of rockfish species from the southern Chilean coast in a temporal scale.

    abstract::The understanding of the patterns and processes underlying the structure of parasite communities has progressed significantly in the last years; however, much of the evidence available to date on parasite community comes from unconfirmed studies. In this study the ectoparasite communities of 2 related rockfishes, Seba...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006000370

    authors: González MT,Oliva ME

    更新日期:2006-09-01 00:00:00

  • Differentiation of Schistosoma mansoni from S. rodhaini using cloned DNA probes.

    abstract::The ribosomal RNA (rRNA) gene units of Schistosoma mansoni and S. rodhaini, of the lateral spined egg group, have been studied. The schistosome rRNA gene unit consists of a regular interspersion of the two genes encoding the large and small rRNA units with two spacers. The large spacer is not transcribed while the sma...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000059709

    authors: Walker TK,Simpson AJ,Rollinson D

    更新日期:1989-02-01 00:00:00

  • Experimental combination therapy using low doses of benznidazole and allopurinol in mouse models of Trypanosoma cruzi chronic infection.

    abstract::This study evaluated the effectiveness of low doses of benznidazole (BNZ) on continuous administration (BNZc), combined with allopurinol (ALO), in C57BL/6J and C3H/HeN mice infected with Trypanosoma cruzi Nicaragua strain and T. cruzi Sylvio-X10/4 clone. TcN-C57BL/6J was also treated with intermittent doses of BNZ (BN...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182018001567

    authors: Rial MS,Scalise ML,López Alarcón M,Esteva MI,Búa J,Benatar AF,Prado NG,Riarte AR,Fichera LE

    更新日期:2019-03-01 00:00:00

  • Parasite biodiversity and its determinants in coastal marine teleost fishes of Brazil.

    abstract::Recent studies of the forces behind the diversification of parasite assemblages have shed light on many aspects of parasite biodiversity. By using only parasite species richness as their measure of diversity, however, previous investigations have ignored the relatedness among parasite species and the taxonomic structu...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004005050

    authors: Luque JL,Mouillot D,Poulin R

    更新日期:2004-06-01 00:00:00

  • A novel member of the ligand-gated chloride channel gene family from Haemonchus contortus.

    abstract::Ligand-gated chloride channels (LGCCs) are key components of the nervous system of parasitic nematodes and important targets for anthelmintics. Here, we describe the isolation and characterization of a novel member of the LGCC gene family (HcLGCC1) from the parasitic nematode Haemonchus contortus. Sequence analysis re...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007004088

    authors: Forrester SG,Siddiqui SZ

    更新日期:2008-04-01 00:00:00

  • The three-spined stickleback-Schistocephalus solidus system: an experimental model for investigating host-parasite interactions in fish.

    abstract::Plerocercoids of the pseudophyllidean cestode Schistocephalus solidus infect the three-spined stickleback Gasterosteus aculeatus, with important consequences for the biology of host fish. Techniques for culturing the parasite in vitro and generating infective stages that can be used to infect sticklebacks experimental...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009991466

    authors: Barber I,Scharsack JP

    更新日期:2010-03-01 00:00:00

  • Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen.

    abstract::Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs....

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182016000652

    authors: Barratt J,Chan D,Sandaradura I,Malik R,Spielman D,Lee R,Marriott D,Harkness J,Ellis J,Stark D

    更新日期:2016-08-01 00:00:00

  • Temperature gradient gel electrophoresis (TGGE) analysis of riboprints from Trypanosoma cruzi.

    abstract::To test the homogeneity of 18S sequences within Trypanosoma cruzi, riboprint profiles were separated by temperature gradient gel electrophoresis (TGGE). Upon interpretation of melting curves of fragments within a riboprint profile, there appeared to be two 18S sequence types within each stock examined. Two similar typ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098002972

    authors: Stothard JR,Frame IA,Carrasco HJ,Miles MA

    更新日期:1998-09-01 00:00:00

  • Glucose transport in Acanthocheilonema viteae.

    abstract::The uptake of glucose by Acanthocheilonema viteae was studied in vitro. The process was selective for the D-isomer and saturatable with a Km of 2 mM. The rate of glucose transport/utilization was inhibited by 2-deoxyglucose, mannose, 5-thioglucose and dipyridamole but, unlike mammalian systems, was not impaired by cyt...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000063307

    authors: Hayes DJ,Selwood DL

    更新日期:1990-10-01 00:00:00

  • Coccidia of the domestic goat Capra hircus, with notes on Eimeria ovinoidalis and E. bakuensis (syn. E. ovina) from the sheep Ovis aries.

    abstract::Eimerian oocysts were found in 98% of 422 faeces samples from goats in SE England. It was found that 74% of the samples contained thousands or tens of thousands of oocysts/g. Kids less than 1 year old had higher oocyst counts than yearling or adult goats. Nine species of Eimeria were identified, and 65% of the samples...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000064052

    authors: Norton CC

    更新日期:1986-04-01 00:00:00

  • Purification of a 64 kDa antigen from Trypanosoma evansi that exhibits cross-reactivity with Trypanosoma vivax.

    abstract::Trypanosoma evansi and Trypanosoma vivax are the most extensively distributed trypanosomes responsible for diseases in livestock. Western blot and indirect immunofluorescence assays revealed a high immunological cross-reaction between these two parasites. An antigen with an apparent molecular mass of 64 kDa (p64), whi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001001214

    authors: Uzcanga G,Mendoza M,Aso PM,Bubis J

    更新日期:2002-03-01 00:00:00

  • Responses to larval Taenia taeniaeformis in mice with severe combined immunodeficiency (scid).

    abstract::Responses to Taenia taeniaeformis infection were studied in mice with severe combined immunodeficiency (scid), which lack functional T and B lymphocytes. In the early phase of infection, accumulation of polymorphonuclear leucocytes (PML) occurred around the larvae in the liver of scid mice and their immunocompetent co...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061825

    authors: Ishiwata K,Oku Y,Ito M,Kamiya M

    更新日期:1992-04-01 00:00:00

  • Molecular identification of Taenia spp. in the Eurasian lynx (Lynx lynx) from Finland.

    abstract::Cestodes of the genus Taenia are parasites of mammals, with mainly carnivores as definitive and herbivores as intermediate hosts. Various medium-sized cats, Lynx spp., are involved in the life cycles of several species of Taenia. The aim of the present study was to identify Taenia tapeworms in the Eurasian lynx (Lynx ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012002120

    authors: Lavikainen A,Haukisalmi V,Deksne G,Holmala K,Lejeune M,Isomursu M,Jokelainen P,Näreaho A,Laakkonen J,Hoberg EP,Sukura A

    更新日期:2013-04-01 00:00:00

  • Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen.

    abstract::Serology is an important tool for the diagnosis of alveolar echinococcosis (AE) in humans. In order to improve serodiagnostic performance, we have developed an in vitro-produced Echinococcus mulilocularis metacestode vesicle fluid (EmVF) antigen for application in an immunoblot assay. Immunoblot analysis of EmVF revea...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006002083

    authors: Müller N,Frei E,Nuñez S,Gottstein B

    更新日期:2007-06-01 00:00:00

  • Experimental infections with Cooperia oncophora (Railliet, 1918) in calves. Results of single infections with two graded dose levels of larvae.

    abstract::Two experiments were carried out in which calves reared parasite-free were infected with a single dose of 3rd-stage larvae of Cooperia oncophora. In the first experiment the calves received 20 000 or 200 000 infective larvae and they were autopsied 28 or 56 days after the infection. In the second experiment the doses ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000051192

    authors: Borgsteede FH,Hendriks J

    更新日期:1979-06-01 00:00:00

  • Subtype analysis of Cryptosporidium parvum isolates from calves on farms around Belgrade, Serbia and Montenegro, using the 60 kDa glycoprotein gene sequences.

    abstract::Cryptosporidium parvum is composed of multiple subtypes, which appear to be zoonotic or anthroponotic. Therefore, in order to understand the molecular epidemiology of this species and to control the zoonotic transmission, it is essential to identify the isolates at the subtype level. In the present study, 60.2% of 103...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001508

    authors: Misic Z,Abe N

    更新日期:2007-03-01 00:00:00

  • Field evidence for density-dependent facilitation amongst Ixodes ricinus ticks feeding on sheep.

    abstract::Engorged Ixodes ricinus nymphs collected from sheep resident in an upland UK field site were significantly lighter than nymphs that engorged on previously tick-naïve sheep, indicating that site-resident sheep continually exposed to ticks acquired anti-tick resistance. The weights of engorged nymphs that fed on natural...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001001081

    authors: Ogden NH,Casey AN,French NP,Adams JD,Woldehiwet Z

    更新日期:2002-02-01 00:00:00

  • Phylogenetic relationships of the family Campulidae (Trematoda) based on 18S rRNA sequences.

    abstract::Traditionally, the family Campulidae has been associated either with the family Fasciolidae, parasites of ruminants, or the Acanthocolpidae, parasites of fishes, based on morphological similarities. Since morphology does not seem to resolve clearly the problem of the relationships of campulids, we have used the sequen...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098003126

    authors: Fernandez M,Littlewood DT,Latorre A,Raga JA,Rollinson D

    更新日期:1998-10-01 00:00:00

  • Diversity and distribution of Blastocystis sp. subtypes in non-human primates.

    abstract::Blastocystis SSU-rDNA sequence data from 317 captive and free-living non-human primates (NHPs) representing 30 genera of apes, Old and New World (OW and NW) monkeys and prosimians were analysed to investigate subtype (ST) and allele distribution among hosts. Excluding 20 mixed ST infections, 27% of the sequences belon...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000255

    authors: Alfellani MA,Jacob AS,Perea NO,Krecek RC,Taner-Mulla D,Verweij JJ,Levecke B,Tannich E,Clark CG,Stensvold CR

    更新日期:2013-07-01 00:00:00

  • Tick immunobiology.

    abstract::Ticks are of vast medical and veterinary public health importance due to direct damage caused by feeding and their roles in transmitting well known and emerging infectious agents. Ticks and tick-borne pathogens stimulate the immune system of the host. Those immune interactions are of importance in tick biology, pathog...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182004004834

    authors: Brossard M,Wikel SK

    更新日期:2004-01-01 00:00:00

  • Studies on cell-cycle synchronization in the asexual erythrocytic stages of Plasmodium falciparum.

    abstract::Multiplication of Plasmodium parasites within human erythrocytes is essential to malarial disease. The cell-division cycle of this organism, however, is still poorly understood. In other eukaryotes, various techniques for (apparent) cell-cycle synchronization have been used to shed light on the mechanisms involved in ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001466

    authors: Naughton JA,Bell A

    更新日期:2007-03-01 00:00:00

  • The role of ecological opportunity in shaping host-parasite networks.

    abstract::Despite the great interest to quantify the structure of host-parasite interaction networks, the real influence of some factors such as taxonomy, host body size and ecological opportunity remains poorly understood. In this paper, we investigate the general patterns of organization and structure of interactions in two a...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118202000133X

    authors: D'Bastiani E,Campião KM,Boeger WA,Araújo SBL

    更新日期:2020-11-01 00:00:00

  • Health policy impacts on malaria transmission in Costa Rica.

    abstract::Costa Rica is near malaria elimination. This achievement has followed shifts in malaria health policy. Here, we evaluate the impacts that different health policies have had on malaria transmission in Costa Rica from 1913 to 2018. We identified regime shifts and used regression models to measure the impact of different...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020000621

    authors: Chaves LF,Ramírez Rojas M,Prado M,Garcés JL,Salas Peraza D,Marín Rodríguez R

    更新日期:2020-08-01 00:00:00

  • Isolation of Trypanosoma caninum in domestic dogs in Rio de Janeiro, Brazil.

    abstract:SUMMARY:The domestic dog's involvement with different members of the Trypanosomatidae family has been the focus of several studies due to this animal's close proximity to man. Recently this animal has been infected by a new Trypanosoma species (T. caninum), described in Rio de Janeiro and 19 similar isolates were later...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182010000417

    authors: De S Pinto AG,Schubach TM,Figueiredo FB,Baptista C,Fagundes A,Da S Barros JH,De Paula CC,Toma HK,Madeira MF

    更新日期:2010-09-01 00:00:00

  • An introduced pentastomid parasite (Raillietiella frenata) infects native cane toads (Rhinella marina) in Panama.

    abstract::The pentastomid parasite, Raillietiella frenata, is native to Asia where it infects the Asian House gecko, Hemidactylus frenatus. This gecko has been widely introduced and recently R. frenata was found in introduced populations of cane toads (Rhinella marina) in Australia, indicating a host-switch from introduced geck...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182014001759

    authors: Kelehear C,Saltonstall K,Torchin ME

    更新日期:2015-04-01 00:00:00