Magnetic resonance imaging in dogs with neuroangiostrongyliasis (rat lungworm disease).

Abstract:

:The magnetic resonance imaging (MRI) appearance of the brain and spinal cord in humans with neuroangiostrongyliasis (NA) due to Angiostrongylus cantonensis infection has been well reported. Equivalent studies in animals are lacking. This case series describes clinical and MRI findings in 11 dogs with presumptively or definitively diagnosed NA. MRI of the brain and/or spinal cord was performed using high-field (1.5 T) or low-field (0.25 T) scanners using various combinations of transverse, sagittal, dorsal and three-dimensional (3D) T1-weighted (T1W), transverse, sagittal and dorsal T2-weighted (T2W), T2W fluid-attenuated inversion recovery (FLAIR) and T2*-weighted (T2*W) gradient echo (GRE), dorsal T2W short tau inversion recovery (STIR) and post-gadolinium transverse, sagittal, dorsal and 3D T1W and transverse T2W FLAIR sequences. In 4/6 cases where the brain was imaged, changes consistent with diffuse meningoencephalitis were observed. Evidence of meningeal involvement was evident even when not clinically apparent. The spinal cord was imaged in 9 dogs, with evidence of meningitis and myelitis detected in regions consistent with the observed neuroanatomical localization. Pathognomonic changes of neural larva migrans, as described in some human patients with NA, were not detected. NA should be considered in the differential diagnosis of dogs with MRI evidence of focal or diffuse meningitis, myelitis and/or encephalitis, especially in areas where A. cantonensis is endemic. If not precluded by imaging findings suggestive of brain herniation, cerebrospinal fluid (CSF) collection for cytology, fluid analysis, real-time polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA) testing should be considered mandatory in such cases after the MRI studies.

journal_name

Parasitology

journal_title

Parasitology

authors

Wun MK,Malik R,Yu J,Chow KE,Lau M,Podadera JM,Webster N,Lee R,Šlapeta J,Davies S

doi

10.1017/S0031182020001742

subject

Has Abstract

pub_date

2020-09-21 00:00:00

pages

1-8

eissn

0031-1820

issn

1469-8161

pii

S0031182020001742

pub_type

杂志文章
  • Differential impact of a shared nematode parasite on two gamebird hosts: implications for apparent competition.

    abstract::If the deleterious effects of non-specific parasites are greater on vulnerable host species than on reservoir host species then exclusion of the vulnerable host through apparent competition is more likely. Evidence suggests that such a mechanism occurs in interactions between the ring-necked pheasant (Phasianus colchi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001007247

    authors: Tompkins DM,Greenman JV,Hudson PJ

    更新日期:2001-02-01 00:00:00

  • Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis.

    abstract::Of the 7 genetic assemblages of the parasite Giardia duodenalis only 2 (A and B) are known to cause infections in humans. These assemblages have been characterized in detail at the genomic level but few studies have examined differences in the proteins expressed. Employing one and two-dimensional PAGE we have identifi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004988

    authors: Steuart RF,O'Handley R,Lipscombe RJ,Lock RA,Thompson RC

    更新日期:2008-12-01 00:00:00

  • The effect of non-immune stresses on the development of Strongyloides ratti.

    abstract::Strongyloides ratti is a parasitic nematode of rats. The host immune response against S. ratti affects the development of its free-living generation, favouring the development of free-living adult males and females at the expense of directly developing, infective 3rd-stage larvae. However, how the host immune response...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182005007675

    authors: Crook M,Viney ME

    更新日期:2005-09-01 00:00:00

  • Glasgow encounters with tropical diseases.

    abstract::The period 1875-1925 was remarkable in the history of parasitology mainly for the elucidation of the life cycles of parasites causing important parasitic diseases and the incrimination of vectors in their transmission. These discoveries were made by a small number of scientists working in the tropics a number of whom ...

    journal_title:Parasitology

    pub_type: 社论,历史文章

    doi:10.1017/S0031182017000956

    authors: Cox FEG

    更新日期:2017-10-01 00:00:00

  • Echinococcus granulosus: intraspecific genetic variation assessed by a DNA repetitive element.

    abstract::A 186 bp Echinococcus granulosus-specific repetitive element, TREg, was used to assess genetic variation between strains. In G7 genotype (pig strain) it has the characteristics of a satellite DNA element with a copy number of 23000 per haploid genome. Analysis, by sequencing of TREg monomers, showed a great degree of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001008575

    authors: Rosenzvit MC,Canova SG,Kamenetzky L,Guarnera EA

    更新日期:2001-10-01 00:00:00

  • Characterization of an atypical antigen from Sarcoptes scabiei containing an MADF domain.

    abstract::We have cloned a cDNA encoding a novel antigen from a Sarcoptes scabiei (Acari) cDNA library by immunoscreening with sera from S. scabiei-infected dogs. The antigen is encoded by a 2,157 bp mRNA with a predicted open reading frame of 719 amino acids (molecular weight 79 kDa). Our sequence analysis identified the prese...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008747

    authors: Ljunggren EL,Bergström K,Morrison DA,Mattsson JG

    更新日期:2006-01-01 00:00:00

  • Down-regulation of murine susceptibility to cerebral malaria by inoculation with third-stage larvae of the filarial nematode Brugia pahangi.

    abstract::In areas where malaria is endemic, helminthic infections, caused by intestinal or filarial parasites, commonly coexist with malaria in the same individual. This study investigates the course of Plasmodium berghei malaria infection in CBA/J mice inoculated with irradiated attenuated 3rd-stage larvae (L3) of Brugia paha...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182096008566

    authors: Yan Y,Inuo G,Akao N,Tsukidate S,Fujita K

    更新日期:1997-04-01 00:00:00

  • High polymorphism in Plasmodium vivax merozoite surface protein-5 (MSP5).

    abstract::A key issue relating to developing multi-component anti-malarial vaccines, lies in studying Plasmodium vivax surface proteins' genetic variation. The present work was aimed at amplifying, cloning and sequencing the gene encoding P. vivax merozoite surface protein 5 (PvMSP5) in samples obtained from infected patients f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001168

    authors: Gomez A,Suarez CF,Martinez P,Saravia C,Patarroyo MA

    更新日期:2006-12-01 00:00:00

  • A genetic investigation of virulence in a rodent malaria parasite.

    abstract::The genetic basis of virulence in a line (YM) of Plasmodium yoelii yoelii was investigated in a cross with a mild line (A/C). The blood forms of the virulent line developed extensively in mature erythrocytes of mice, causing death of the host within 7 days; infections with the mild line were normally restricted to ret...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000048484

    authors: Walliker D,Sanderson A,Yoeli M,Hargreaves BJ

    更新日期:1976-04-01 00:00:00

  • The relationship between pathology and resistance to reinfection with Schistosoma mansoni in mice: a causal mechanism of resistance in chronic infections.

    abstract::The development of resistance in mice to reinfection with Schistosoma mansoni was recorded during an early chronic infection, and compared with hepatic portal pathological and vascular changes. The latter were assessed using a microsphere injection technique. The degree of acquired resistance was directly dependent on...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000053476

    authors: McHugh SM,Coulson PS,Wilson RA

    更新日期:1987-02-01 00:00:00

  • Nitric oxide interaction with IL-10, MIP-1alpha, MCP-1 and RANTES over the in vitro granuloma formation against different Schistosoma mansoni antigenic preparations on human schistosomiasis.

    abstract::Nitric oxide (NO) produced by cytokine-activated macrophages is reported to be cytotoxic against the helminth Schistosoma mansoni, although this is a controversial issue. Previous work in our laboratory identified a fraction of S. mansoni soluble adult worm antigenic preparation (SWAP), named PIII, able to elicit sign...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099005636

    authors: Oliveira DM,Silva-Teixeira DN,Gustavson S,Oliveira SM,Goes AM

    更新日期:2000-04-01 00:00:00

  • Proteomics at the schistosome-mammalian host interface: any prospects for diagnostics or vaccines?

    abstract::Since 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The p...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182012000339

    authors: Wilson RA

    更新日期:2012-08-01 00:00:00

  • Inhibition by anti-malarial drugs of haemoglobin denaturation and iron release in acidified red blood cell lysates--a possible mechanism of their anti-malarial effect?

    abstract::Intraerythrocytic malaria parasites ingest the cytosol of their host cell and digest it inside their acid food vacuoles. Acidified (pH 4-5.5, 37 degrees C) human red blood cell lysates were used to simulate this process, measuring the denaturation of haemoglobin (Hb) and the release of iron, in the absence or presence...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000075910

    authors: Gabay T,Krugliak M,Shalmiev G,Ginsburg H

    更新日期:1994-05-01 00:00:00

  • Mating interactions between Schistosoma mansoni and S. margrebowiei.

    abstract::Previous studies of mating interactions between schistosome species from different evolutionary lineages in mice showed that mating is not random: heterospecific pairs form but, given the choice, the preference is for homospecific partners. Mating competition and change of mate were also demonstrated. Schistosoma mans...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182002002111

    authors: Cosgrove CL,Southgate VR

    更新日期:2002-09-01 00:00:00

  • Maltose utilization by extracellular hydrolysis followed by glucose transport in Trichomonas vaginalis.

    abstract::The amitochondriate parasitic protist Trichomonas vaginalis can utilize either glucose or maltose as carbon and energy source. The mechanisms of maltose utilization were explored with uptake experiments using radio-isotope labelled maltose in combination with the silicone-oil centrifugation technique and enzymatic ass...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000081026

    authors: ter Kuile BH,Müller M

    更新日期:1995-01-01 00:00:00

  • CYP51 as drug targets for fungi and protozoan parasites: past, present and future.

    abstract::The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically ill, immunosuppressed or post-cancer patients often exceed 50%. A set of six systemic clinical azol...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182018000562

    authors: Lepesheva GI,Friggeri L,Waterman MR

    更新日期:2018-12-01 00:00:00

  • Host associations and turnover of haemosporidian parasites in manakins (Aves: Pipridae).

    abstract::Parasites of the genera Plasmodium and Haemoproteus (Apicomplexa: Haemosporida) are a diverse group of pathogens that infect birds nearly worldwide. Despite their ubiquity, the ecological and evolutionary factors that shape the diversity and distribution of these protozoan parasites among avian communities and geograp...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017000208

    authors: Fecchio A,Svensson-Coelho M,Bell J,Ellis VA,Medeiros MC,Trisos CH,Blake JG,Loiselle BA,Tobias JA,Fanti R,Coffey ED,DE Faria IP,Pinho JB,Felix G,Braga EM,Anciães M,Tkach V,Bates J,Witt C,Weckstein JD,Ricklefs RE,

    更新日期:2017-06-01 00:00:00

  • Parasitism and phenotypic change in colonial hosts.

    abstract::Changes in host phenotype are often attributed to manipulation that enables parasites to complete trophic transmission cycles. We characterized changes in host phenotype in a colonial host–endoparasite system that lacks trophic transmission (the freshwater bryozoan Fredericella sultana and myxozoan parasite Tetracapsu...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000899

    authors: Hartikainen H,Fontes I,Okamura B

    更新日期:2013-09-01 00:00:00

  • Detection of Neospora caninum in aborted bovine fetuses and dam blood samples by nested PCR and ELISA and seroprevalence in Beijing and Tianjin, China.

    abstract::Neospora caninum infection is a significant cause of abortion in cattle. We investigated the tissue distribution of N. caninum in aborted bovine fetuses and dam blood samples by a nested PCR assay, and compared the nested PCR with ELISA in the diagnosis of N. caninum infection. In total, 26 aborted fetuses and 813 blo...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009990813

    authors: Yao L,Yang N,Liu Q,Wang M,Zhang W,Qian WF,Hu YF,Ding J

    更新日期:2009-09-01 00:00:00

  • Factors influencing infections in Rhipicephalus appendiculatus ticks fed on cattle infected with Theileria parva.

    abstract::A large database on the transmission of a stabilate of the Theileria parva Muguga stock from one breed of cattle using two stocks of Rhipicephalus appendiculatus, Muguga and Ol Pejeta was developed and analysed. Factors associated with the ticks and cattle, and the infections developing in cattle were studied in relat...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000082020

    authors: Young AS,Dolan TT,Morzaria SP,Mwakima FN,Norval RA,Scott J,Sherriff A,Gettinby G

    更新日期:1996-09-01 00:00:00

  • Phylogenetic relationships of the family Campulidae (Trematoda) based on 18S rRNA sequences.

    abstract::Traditionally, the family Campulidae has been associated either with the family Fasciolidae, parasites of ruminants, or the Acanthocolpidae, parasites of fishes, based on morphological similarities. Since morphology does not seem to resolve clearly the problem of the relationships of campulids, we have used the sequen...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098003126

    authors: Fernandez M,Littlewood DT,Latorre A,Raga JA,Rollinson D

    更新日期:1998-10-01 00:00:00

  • Field evidence for density-dependent facilitation amongst Ixodes ricinus ticks feeding on sheep.

    abstract::Engorged Ixodes ricinus nymphs collected from sheep resident in an upland UK field site were significantly lighter than nymphs that engorged on previously tick-naïve sheep, indicating that site-resident sheep continually exposed to ticks acquired anti-tick resistance. The weights of engorged nymphs that fed on natural...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001001081

    authors: Ogden NH,Casey AN,French NP,Adams JD,Woldehiwet Z

    更新日期:2002-02-01 00:00:00

  • Immunomodulatory agents in the laboratory and clinic.

    abstract::This paper reviews naturally occurring and synthetic compounds that either enhance immune defences or lower both natural and acquired immunity. Immunomodulatory agents used both for laboratory study and clinically for the management of immunologically based diseases are considered. ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000075326

    authors: Nüssler AK,Thomson AW

    更新日期:1992-01-01 00:00:00

  • Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections.

    abstract::We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182003004001

    authors: De Roode JC,Read AF,Chan BH,Mackinnon MJ

    更新日期:2003-11-01 00:00:00

  • Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of Tacuarembó, Uruguay.

    abstract::Cystic echinococcosis (CE) is a high prevalence zoonosis among the rural population of Tacuarembó (Uruguay). The correlation between serological data and the incidence of risk factors was studied in a survey carried out in 1998 among rural communities where 480 individuals were examined by means of abdominal sonograph...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004006717

    authors: Hernández A,Cardozo G,Dematteis S,Baz A,Trias N,Nuñez H,Barragué A,López L,Fuentes J,López O,Ferreira C

    更新日期:2005-04-01 00:00:00

  • Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp.

    abstract::Ascarid parasites infect a variety of hosts and regular anthelmintic treatment is recommended for all species. Parascaris spp. is the only ascarid species with widespread anthelmintic resistance, which allows for the study of resistance mechanisms. The purpose of this study was to establish an in vitro drug exposure p...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020000189

    authors: Scare JA,Dini P,Norris JK,Steuer AE,Scoggin K,Gravatte HS,Howe DK,Slusarewicz P,Nielsen MK

    更新日期:2020-05-01 00:00:00

  • Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.

    abstract::The phenotypic activity of two 5-nitroindazolinones, i.e. 2-benzyl-1-propyl (22) and 2-benzyl-1-butyl (24) derivatives, previously proposed as anti-Trypanosoma cruzi prototypes, was presently assayed on bloodstream trypomastigotes (BT) of the moderately drug-resistant Y strain. Further exploration of putative targets ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016001098

    authors: Fonseca-Berzal C,DA Silva CF,Menna-Barreto RF,Batista MM,Escario JA,Arán VJ,Gómez-Barrio A,Soeiro Mde N

    更新日期:2016-09-01 00:00:00

  • Differentiation of Schistosoma mansoni from S. rodhaini using cloned DNA probes.

    abstract::The ribosomal RNA (rRNA) gene units of Schistosoma mansoni and S. rodhaini, of the lateral spined egg group, have been studied. The schistosome rRNA gene unit consists of a regular interspersion of the two genes encoding the large and small rRNA units with two spacers. The large spacer is not transcribed while the sma...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000059709

    authors: Walker TK,Simpson AJ,Rollinson D

    更新日期:1989-02-01 00:00:00

  • Development of a practical immunochromatographic test with recombinant P50 for the diagnosis of Babesia gibsoni infection in dogs.

    abstract::An immunochromatographic test (ICT), using recombinant truncated P50 (P50t), for the detection of antibodies to Babesia gibsoni was developed and evaluated. Whereas all sera from specific pathogen-free dogs were clearly negative, all sera from dogs experimentally infected with B. gibsoni were clearly positive in the I...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008401

    authors: Verdida RA,Xuan X,Fukumoto S,Huang X,Zhou J,Igarashi I,Claveria FG,Nagasawa H

    更新日期:2005-12-01 00:00:00

  • Re-evaluation of the life cycle of Eimeria maxima Tyzzer, 1929 in chickens (Gallus domesticus).

    abstract::A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the Eimeria maxima life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million E. maxima oocysts (APU1), and were necropsied...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017002153

    authors: Dubey JP,Jenkins MC

    更新日期:2018-07-01 00:00:00