Abstract:
:The development of resistance in mice to reinfection with Schistosoma mansoni was recorded during an early chronic infection, and compared with hepatic portal pathological and vascular changes. The latter were assessed using a microsphere injection technique. The degree of acquired resistance was directly dependent on the patent worm burden and the time post-infection. Strong correlations were noted between the development of resistance and the appearance of parasite eggs in the lungs and spleens of infected hosts. Weaker associations were present between resistance and other aspects of the disease pathology, such as portal hypertension and organ weights. The appearance of injected microspheres in the lungs and spleens correlated well with the appearance of eggs in those organs and with the development of resistance. The levels of resistance had risen and microspheres were detected in the lungs, before the development of major extra-hepatic, porta-systemic collateral vessels. It is concluded that intra-hepatic vascular alterations may be a causal factor in the development of resistance, preventing the sequestration of migrating schistosomula in the liver. It is estimated that as much as 70-75% of the recorded resistance can be attributed to this immunologically non-specific mechanism.
journal_name
Parasitologyjournal_title
Parasitologyauthors
McHugh SM,Coulson PS,Wilson RAdoi
10.1017/s0031182000053476subject
Has Abstractpub_date
1987-02-01 00:00:00pages
81-91eissn
0031-1820issn
1469-8161journal_volume
94 ( Pt 1)pub_type
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