Parasite development and adaptive specialization.

Abstract:

:The complex life-cycles of parasitic animals are a product of exploiting the process of development to generate organisms with different biological potentials within a species. Successive stages of the parasite adapt to functions such as host invasion and transmission, and to the colonization of a variety of niches, often involving different hosts, tissues or cells. Understanding the molecular basis of adaptive biology among parasites is a major challenge that lies at the heart of research in contemporary parasitology. Differences in scale at the levels of genomic complexity and cell biology exist between most parasitic protozoa and helminths, rendering a cautionary note to making generalized observations. The two principal approaches used to gain insights into adaptive specializations are to start with a biological activity and identify the molecule, or select molecules with particular properties and deduce function. Both have their part to play, with their inherent advantages and limitations, and both are illustrated with examples of studies on adaptive biology among parasitic nematodes.

journal_name

Parasitology

journal_title

Parasitology

authors

Bianco AE,Maizels RM

doi

10.1017/s0031182000083451

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S113-23

eissn

0031-1820

issn

1469-8161

journal_volume

99 Suppl

pub_type

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