Abstract:
:The complex life-cycles of parasitic animals are a product of exploiting the process of development to generate organisms with different biological potentials within a species. Successive stages of the parasite adapt to functions such as host invasion and transmission, and to the colonization of a variety of niches, often involving different hosts, tissues or cells. Understanding the molecular basis of adaptive biology among parasites is a major challenge that lies at the heart of research in contemporary parasitology. Differences in scale at the levels of genomic complexity and cell biology exist between most parasitic protozoa and helminths, rendering a cautionary note to making generalized observations. The two principal approaches used to gain insights into adaptive specializations are to start with a biological activity and identify the molecule, or select molecules with particular properties and deduce function. Both have their part to play, with their inherent advantages and limitations, and both are illustrated with examples of studies on adaptive biology among parasitic nematodes.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Bianco AE,Maizels RMdoi
10.1017/s0031182000083451subject
Has Abstractpub_date
1989-01-01 00:00:00pages
S113-23eissn
0031-1820issn
1469-8161journal_volume
99 Supplpub_type
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