Schistosoma mansoni: larval damage and role of effector cell(s) in the synergy between vaccine immunity and praziquantel treatment.

abstract：:Human cysticercosis is a public health problem caused by Taenia solium metacestodes; thus, eradication of T. solium transmission by vaccination is an urgent requirement. The Cc48 mimotope from T. solium cysticerci was tested expressed in phage particles (mCc48) and chemically synthesized (sCc48) as a vaccine candidate...

journal_title：Parasitology

authors： Manhani MN,Tilelli CQ,Ribeiro VDS,Goulart LR,Costa-Cruz JM

更新日期：2020-10-01 00:00:00

abstract：:The 'Muguga cocktail' live vaccine, delivered by an infection and treatment protocol, has been widely deployed in Eastern, Central and Southern Africa to protect cattle against East Coast fever, caused by Theileria parva. The vaccine contains 3 component stocks (Muguga, Serengeti-transformed and Kiambu 5). In a previo...

journal_title：Parasitology

authors： Oura CA,Bishop R,Asiimwe BB,Spooner P,Lubega GW,Tait A

更新日期：2007-08-01 00:00:00

abstract：:Infection of breeding hens with Eimeria maxima induces production of Eimeria-specific IgG antibodies which are transferred to hatchlings via the egg yolk and confer a high degree of maternal immunity against homologous challenge and partial immunity to infection with another important species, Eimeria tenella. As an e...

journal_title：Parasitology

authors： Smith NC,Wallach M,Petracca M,Braun R,Eckert J

更新日期：1994-12-01 00:00:00

abstract：:Most, if not all, organisms face attack by natural enemies and will be selected to evolve some form of defence. Resistance may have costs as well as its obvious benefits. These costs may be associated with actual defence or with the maintenance of the defensive machinery irrespective of whether a challenge occurs. In ...

journal_title：Parasitology

authors： Kraaijeveld AR,Ferrari J,Godfray HC

更新日期：2002-01-01 00:00:00

abstract：:Infection of intermediate hosts with eggs of taeniid parasites results in a larval infestation known as cysticercosis. A number of studies have indicated that cysticercosis is associated with immunosuppression, although little is known about the mechanisms involved. In the present study, mice infected with the larvae ...

journal_title：Parasitology

authors： Villa OF,Kuhn RE

更新日期：1996-06-01 00:00:00

abstract：:Potential mechanisms of immunoregulation have been investigated for the capacity to generate heterogeneity in the outcome of infection with helminth parasites. We have developed a mathematical model of the interaction between T cell and parasite populations, based on the assumption that activation of a Th1 CD4+ T cell...

journal_title：Parasitology

authors： Schweitzer AN,Anderson RM

更新日期：1992-12-01 00:00:00

abstract：:Trophically transmitted parasites must trade-off own growth on one hand and energy drain from the intermediate host on the other hand, since killing the host before transmission to the next host is a dead end for both parasites and hosts. This challenge becomes especially intriguing when multiple parasites find themse...

journal_title：Parasitology

authors： Nordeide JT,Matos F

更新日期：2016-09-01 00:00:00

abstract：:This study describes morphological changes during capsule formation of Trichinella spiralis with emphasis on nuclei within the capsule. The nuclei of the pre-existing muscle cell may become hypertrophied or degrade soon after the entrance of newborn larvae. Cytoplasm associated with these hypertrophied nuclei was baso...

journal_title：Parasitology

authors： Matsuo A,Wu Z,Nagano I,Takahashi Y

更新日期：2000-08-01 00:00:00

abstract：:Plant cysteine proteinases (CPs) from Carica papaya kill parasitic and free-living nematodes in vitro by hydrolysis of the worm cuticle, a mechanism that is different to all commercially available synthetic anthelmintics. We have developed a cheap and effective, rapid-throughput Caenorhabditis elegans-based assay for ...

journal_title：Parasitology

authors： Phiri AM,DE Pomerai DI,Buttle DJ,Behnke JM

更新日期：2017-04-01 00:00:00

abstract：:We describe a laboratory model using Eimeria falciformis and E. pragensis to investigate some of the interactions in double-species infections of Eimeria. Mice were given trickle infections by oral inoculation of 100 sporulated oocysts of one species at 3 or 4 day intervals throughout the experiments and, once immunit...

journal_title：Parasitology

authors： Shehu K,Nowell F

更新日期：1998-11-01 00:00:00

abstract：:Life-cycle stages of the microsporidia Nosema bombycis, the pathogen causing silkworm pebrine, were separated and purified by an improved method of Percoll-gradient centrifugation. Soluble protein fractions of late sporoblasts (spore precursor cells) and mature spores were analysed by two-dimensional polyacrylamide ge...

journal_title：Parasitology

authors： Cai S,Lu X,Qiu H,Li M,Feng Z

更新日期：2011-08-01 00:00:00

abstract：:Cryptosporidia are important protozoan parasites of vertebrates, and a number of species and genotypes, with different host ranges, have been described. In this study a protocol was established for the detection and the genetic characterization of Cryptosporidium spp. isolated from various types of surface waters (riv...

journal_title：Parasitology

authors： Ward PI,Deplazes P,Regli W,Rinder H,Mathis A

更新日期：2002-04-01 00:00:00

abstract：:Toxoplasma gondii has a unique enzyme, a NTPase, which has a wide specificity toward NTP. In the present study, we produced a monoclonal antibody (IgG1, 6C6) against the enzyme which could recognize NTPase isozymes among several strains of T. gondii. Three avirulent strains of T. gondii, ME49, Beverley and Nakayama, w...

journal_title：Parasitology

authors： Kikuchi T,Furuta T,Kojima S

更新日期：2001-01-01 00:00:00

abstract：:Renal infections by parasitic ciliates were studied in adult snails of Helix aspersa aspersa and Helix aspersa maxima collected from 2 mixed rearing system-based heliciculture farms located in Galicia (NW Spain). The occurrence of ciliates was also examined in slugs (Deroceras reticulatum) invading the greenhouses whe...

journal_title：Parasitology

authors： Segade P,Kher CP,Lynn DH,Iglesias R

更新日期：2009-06-01 00:00:00

abstract：:We investigated changes in the behaviour of Stagnicola elodes associated with the emergence of Plagiorchis elegans cercariae. Within 15 min of the reduction in light intensity, which triggered the onset of cercarial emergence, infected snails moved to the top of the water column and remained there for 2-3 h. Seventy-n...

journal_title：Parasitology

authors： Lowenberger CA,Rau ME

更新日期：1994-07-01 00:00:00

abstract：:Part of Robert T. Leiper's (1881-1969) lasting legacy in medical helminthology is grounded on his pioneering work on schistosomiasis (Bilharzia). Having undertaken many expeditions to the tropics, his fascination with parasite life cycles typically allowed him to devise simple preventive measures that curtailed transm...

journal_title：Parasitology

authors： Stothard JR,Kabatereine NB,Archer J,Al-Shehri H,Tchuem-Tchuenté LA,Gyapong M,Bustinduy AL

更新日期：2017-10-01 00:00:00

abstract：:The protein composition of Schistosoma mansoni was analysed by electrophoresis in polyacrylamide slab gel in the presence of sodium dodecyl sulphate. A high degree of identity existed between protein patterns obtain from immature and adult parasites of the two sexes. Some stage-and sex-specific components were indenti...

journal_title：Parasitology

authors： Ruppel A,Cioli D

更新日期：1977-12-01 00:00:00

abstract：:The localization of adult Schistosoma mansoni originating from Guadeloupe (West Indies) was analysed in the natural host Rattus rattus in experimental and natural infections. A transfer of schistosomes from the porto-mesenteric system to the lungs occurs between the 4th and the 20th weeks post-infection, with a peak b...

journal_title：Parasitology

authors： Imbert-Establet D,Combes C

更新日期：1992-02-01 00:00:00

abstract：:The twin concepts of zooprophylaxis and the dilution effect originated with vector-borne diseases (malaria), were driven forward by studies on Lyme borreliosis and have now developed into the mantra "biodiversity protects against disease". The basic idea is that by diluting the assemblage of transmission-competent hos...

journal_title：Parasitology

authors： Randolph SE,Dobson AD

更新日期：2012-06-01 00:00:00

abstract：:Dr David Livingstone died on May 1st 1873. He was 60 years old and had spent much of the previous 30 years walking across large stretches of Southern Africa, exploring the terrain he hoped could provide new environments in which Europeans and Africans could cohabit on equal terms and bring prosperity to a part of the ...

journal_title：Parasitology

authors： Barrett MP,Giordani F

更新日期：2017-10-01 00:00:00

abstract：:An ultrastructural study has been performed on radiation-attenuated parasites fixed in situ during their extended stay in the lungs. At day 7 post-infection all parasites were located within blood vessels. In contrast to normally migrating parasites, at days 13 and 21 post-infection the majority of radiation-attenuate...

journal_title：Parasitology

authors： Mastin A,Bickle QD,Wilson RA

更新日期：1985-08-01 00:00:00

abstract：:The interactions in vivo between Plasmodium berghei sporozoites and Kupffer cells in rat livers were studied by transmission electron microscopy. By 10 and 15 min after inoculation, sporozoites were both free in the liver sinusoids and inside endocytotic vacuoles of the Kupffer cells. The latter cells were very active...

journal_title：Parasitology

authors： Meis JF,Verhave JP,Jap PH,Meuwissen JH

更新日期：1983-04-01 00:00:00

abstract：:Actively immunized mice, whole-body irradiated with 650 or 525 rad., manifested comparable levels of resistance to Schistosoma mansoni compared with unirradiated, immunized mice in spite of a marked reduction in circulating leucocytes (greater than 90%) and platelets (greater than 85%), and despite an abrogation of de...

journal_title：Parasitology

authors： Vignali DA,Bickle QD,Taylor MG

更新日期：1988-02-01 00:00:00

abstract：:A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the Eimeria maxima life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million E. maxima oocysts (APU1), and were necropsied...

journal_title：Parasitology

authors： Dubey JP,Jenkins MC

更新日期：2018-07-01 00:00:00

abstract：:Electrophysiological and pharmacological techniques were used to study glutamatergic signalling in the parasitic nematode, Ascaris suum. Glutamate or kainate injections into whole worms produced a paralysed quasi-static posture similar to the waveform in behaving worms. The DE2 motorneuron class is a primary target. S...

journal_title：Parasitology

authors： Davis RE

更新日期：1998-05-01 00:00:00

abstract：:We have previously reported that the mechanisms of neuromyopathic damage induced by Trypanosoma cruzi are mediated by T cells and are parasite-strain dependent. In the present study our aim was to determine whether the humoral response against muscle and nervous system is also parasite-strain dependent. Of the sera fr...

journal_title：Parasitology

authors： Tekiel VS,Mirkin GA,Gonzalez Cappa SM

更新日期：1997-11-01 00:00:00

abstract：:Responses to Taenia taeniaeformis infection were studied in mice with severe combined immunodeficiency (scid), which lack functional T and B lymphocytes. In the early phase of infection, accumulation of polymorphonuclear leucocytes (PML) occurred around the larvae in the liver of scid mice and their immunocompetent co...

journal_title：Parasitology

authors： Ishiwata K,Oku Y,Ito M,Kamiya M

更新日期：1992-04-01 00:00:00

abstract：:The objectives of this study were (a) to evaluate the sensitivity and specificity of foetal Doppler indices for the prediction of abnormal foetal heart rate (aFHR) at delivery after malaria crisis and (b) to test Doppler parameters against crisis duration for predicting aFHR. Every day during the malaria crisis, the u...

journal_title：Parasitology

authors： Arbeille P,Carles G,Georgescu M,Tobal N,Herault S,Bousquet F,Perrotin F

更新日期：2003-06-01 00:00:00

abstract：:This review focuses on some of the more ground-shifting advances of recent decades, particularly those at the molecular and cellular level that illuminate mechanisms underpinning the natural ecology of tick-host-pathogen interactions and the consequent epidemiology of zoonotic infections in humans. Knowledge of compon...

journal_title：Parasitology

authors： Randolph SE

更新日期：2009-10-01 00:00:00

abstract：:Various treatments are found to be moderately effective in managing Demodex-related diseases except tea tree oil (TTO) and terpinen-4-ol (T4O), which showed superior miticidal and anti-inflammatory effects in numerous clinical studies. Their possible effects include lowering mite counts, relieving Demodex-related symp...

journal_title：Parasitology

authors： Lam NSK,Long XX,Li X,Yang L,Griffin RC,Doery JC

更新日期：2020-12-01 00:00:00