An in silico structure-based approach to anti-infective drug discovery.

abstract：:SUMMARY The necessity to easily establish Histomonas meleagridis cultures has been underlined extensively by many researchers in order to gain more insights in the biology of H. meleagridis. In addition the occurrence of different protozoa in the caeca of birds impedes, however, the isolation and propagation of H. mel...

journal_title：Parasitology

authors： Pham AD,Mast J,DE Gussem JK,McDougald LR,Goddeeris BM

更新日期：2013-09-01 00:00:00

abstract：:The global seroprevalence of latent toxoplasmosis is estimated to be higher than 30%. The presence of slowly dividing parasites in tissue cysts located mainly in immunoprivileged organs was long considered asymptomatic. Recently, many studies have shown that latent Toxoplasma infections could have serious impacts on h...

journal_title：Parasitology

authors： Flegr J,Escudero DQ

更新日期：2016-12-01 00:00:00

abstract：:Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigenic variation of the parasite surface coat has been considered the major obstacle in the development...

journal_title：Parasitology

authors： Magez S,Caljon G,Tran T,Stijlemans B,Radwanska M

更新日期：2010-12-01 00:00:00

abstract：:Human cysticercosis is a public health problem caused by Taenia solium metacestodes; thus, eradication of T. solium transmission by vaccination is an urgent requirement. The Cc48 mimotope from T. solium cysticerci was tested expressed in phage particles (mCc48) and chemically synthesized (sCc48) as a vaccine candidate...

journal_title：Parasitology

authors： Manhani MN,Tilelli CQ,Ribeiro VDS,Goulart LR,Costa-Cruz JM

更新日期：2020-10-01 00:00:00

abstract：:Eggs of Neoheterocotyle rhinobatidis, Troglocephalus rhinobatidis and Merizocotyle icopae (Monogenea: Monocotylidae) from the shovelnose ray Rhinobatos typus (Rhinobatidae) have a distinct hatching pattern linked to light periodicity. Larvae of these 3 monogenean species emerge only during daylight when exposed to nat...

journal_title：Parasitology

authors： Chisholm LA,Whittington ID

更新日期：2000-09-01 00:00:00

abstract：:Sequence comparisons have recently shown that the Schistosoma mansoni protein Sm32 is similar to asparaginyl endoproteinases, a novel family of cysteine proteinases, of which the legumains from legumes are the best characterized. By synthesizing and employing fluorogenic peptide substrates for the specific detection o...

journal_title：Parasitology

authors： Dalton JP,Hola-Jamriska L,Brindley PJ

更新日期：1995-12-01 00:00:00

abstract：:During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specific antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1, IgM and IgA. The maximum increase is respectively 2...

journal_title：Parasitology

authors： Bout D,Rousseaux R,Carlier Y,Capron A

更新日期：1980-04-01 00:00:00

abstract：:DNA barcoding is now a common tool in parasitology and epidemiology, which require good methods for identification not only of parasites and pathogens but vectors and reservoirs. This special issue presents some advances and challenges in barcoding of microbes, parasites, and their vectors and reservoirs. DNA barcodin...

journal_title：Parasitology

authors： Morand S

更新日期：2018-04-01 00:00:00

abstract：:Cells of Leishmania donovani in co-culture with Trypanosoma brucei, were severely affected in their growth, resulting in swelling and subsequent lysis. Similar effects were also observed when Crithidia luciliae or Phytomonas sp. were co-cultured with T. brucei. Direct contact between the cells under investigation and ...

journal_title：Parasitology

authors： Coppens I,Ter Kuile BH,Opperdoes FR

更新日期：1992-12-01 00:00:00

abstract：:Fourth-stage larvae of Ascaris suum, recovered from piglets at 11-22 days post-infection (p.i.), were examined by light microscopy for changes in the somatic musculature. During this time the estimated total number of muscle cells in the body increases from approximately 600 to 21 000 cells. This non-eutelic developme...

journal_title：Parasitology

authors： O'Grady RT

更新日期：1984-02-01 00:00:00

abstract：:We investigated changes in the behaviour of Stagnicola elodes associated with the emergence of Plagiorchis elegans cercariae. Within 15 min of the reduction in light intensity, which triggered the onset of cercarial emergence, infected snails moved to the top of the water column and remained there for 2-3 h. Seventy-n...

journal_title：Parasitology

authors： Lowenberger CA,Rau ME

更新日期：1994-07-01 00:00:00

abstract：:Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened bas...

journal_title：Parasitology

authors： Sims TA,Hay J

更新日期：1995-02-01 00:00:00

abstract：:The levels of superoxide dismutase (SOD) were determined in detergent-soluble, somatic and excretion-secretion (E-S) preparations from adult Fasciola hepatica using the xanthine oxidase system and visualized in substrate gels. Compared to detergent-soluble and somatic extracts, E-S products showed the highest SOD acti...

journal_title：Parasitology

authors： Piacenza L,Radi R,Goñi F,Carmona C

更新日期：1998-12-01 00:00:00

abstract：:Flow cytometric analysis of the binucleated protozoan parasite Giardia intestinalis gave DNA histograms with a broad G1 peak and a definable G2 + M peak with twice the DNA content of G1. Twenty-four hour treatment with metronidazole arrested cell cycle progression of susceptible trophozoites in the G2 + M phase, but h...

journal_title：Parasitology

authors： Hoyne GF,Boreham PF,Parsons PG,Ward C,Biggs B

更新日期：1989-12-01 00:00:00

abstract：:Nematodes are amongst the most successful and abundant organisms on the planet with approximately 30 000 species described, although the actual number of species is estimated to be one million or more. Despite sharing a relatively simple and invariant body plan, there is considerable diversity within the phylum. Nemat...

journal_title：Parasitology

authors： Gillan V,Devaney E

更新日期：2014-08-01 00:00:00

abstract：:We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones ...

journal_title：Parasitology

authors： De Roode JC,Read AF,Chan BH,Mackinnon MJ

更新日期：2003-11-01 00:00:00

abstract：:Members of the phylum Microspora are a group of unusual, obligate intracellular eukaryotic parasites that infect a wide range of hosts. However, there are a limited number of microsporidial infections reported in avian hosts, and no parasite species has been defined as an avian pathogen. A microsporidian organism was ...

journal_title：Parasitology

authors： Snowden KF,Logan K,Phalen DN

更新日期：2000-07-01 00:00:00

abstract：:Changes during development in the elemental contents (Ca, P, K, Mg and S) of male and female Schistosoma mansoni from both mixed and single sex infections have been measured for the first time. In mixed infections, there is a significant difference between the calcium content of male and female worms; female worms hav...

journal_title：Parasitology

authors： Shaw MK,Erasmus DA

更新日期：1983-06-01 00:00:00

abstract：:An egg-adapted line of Eimeria necatrix has now been passaged 40 times in the chorio-allantoic membranes of embryonated eggs. Between the 21st and 40th passage in eggs the parasite was subjected to a selection for precocious development, and its pre-patent period in this host is now 123-125 h. The parasite continued t...

journal_title：Parasitology

authors： Shirley MW,Bellatti MA,Millard BJ

更新日期：1982-04-01 00:00:00

abstract：:Neospora caninum is the causative agent of bovine neosporosis. A N. caninum cytoplasmic dynein LC8 light chain (NcDYNLL) protein was characterized in this study. Cytoplasmic dyneins, including DYNLLs, belong to the microtubule minus-end-directed motor proteins and are involved in many cellular processes. Previous micr...

journal_title：Parasitology

authors： Cao L,Fetterer R,Qu G,Zhang X,Tuo W

更新日期：2018-12-18 00:00:00

abstract：:Steroids have been shown to be beneficial in patients and mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection; however, the mechanism for this beneficial effect is unknown. We speculated that the effect of steroids in eosinophilic meningitis caused by A. cantonensis infection may be media...

journal_title：Parasitology

authors： Tsai HC,Chen YH

更新日期：2020-10-02 00:00:00

abstract：:The respiratory chain of the procyclic stage of Trypanosoma brucei contains the standard complexes I through IV, as well as several alternative enzymes contributing to electron flow. In this work, we studied the function of an alternative NADH : ubiquinone oxidoreductase (NDH2). Depletion of target mRNA was achieved u...

journal_title：Parasitology

authors： Verner Z,Skodová I,Poláková S,Durišová-Benkovičová V,Horváth A,Lukeš J

更新日期：2013-03-01 00:00:00

abstract：:Theileria annulata infects and reversibly transforms bovine leucocytes. The parasite-transformed cells are immortalized, metastatic and express a number of metalloproteinases including matrix metalloproteinase 9 which they secrete. All the metalloproteinases observed on substrate gels are inhibited by tissue inhibitor...

journal_title：Parasitology

authors： Adamson RE,Hall FR

更新日期：1996-11-01 00:00:00

abstract：:Clones of Trypanosoma congolense which express resistance to the widely used trypanocide isometamidium chloride accumulate less of the drug than clones which are sensitive to drug treatment. A mathematical model has been developed which was able to predict theoretical lines representing the uptake kinetics in trypanos...

journal_title：Parasitology

authors： Sutherland IA,Mounsey A,Eisler M,Holmes PH

更新日期：1992-08-01 00:00:00

abstract：:In order to investigate the phenomenon of age-related immunity to visceral leishmaniasis, a 1 year prospective survey was carried out on 5671 people in a Leishmania infantum focus in north-west Iran. The average incidence rate of infection since 1985 was 2.8%/year with all ages equally at risk. One in 13 infections in...

journal_title：Parasitology

authors： Davies CR,Mazloumi Gavgani AS

更新日期：1999-09-01 00:00:00

abstract：:The dynamic interaction of cells of the immune system with other cells, antigens and secreted factors determines the nature of an immune response. The response of individual cells is governed by the sequence of intracellular signalling events triggered following the association of cell surface molecules during cell-ce...

journal_title：Parasitology

authors： Goodridge HS,Harnett MM

更新日期：2005-01-01 00:00:00

abstract：:The twin concepts of zooprophylaxis and the dilution effect originated with vector-borne diseases (malaria), were driven forward by studies on Lyme borreliosis and have now developed into the mantra "biodiversity protects against disease". The basic idea is that by diluting the assemblage of transmission-competent hos...

journal_title：Parasitology

authors： Randolph SE,Dobson AD

更新日期：2012-06-01 00:00:00

abstract：:Strongyloides ratti is a parasitic nematode of rats. The host immune response against S. ratti affects the development of its free-living generation, favouring the development of free-living adult males and females at the expense of directly developing, infective 3rd-stage larvae. However, how the host immune response...

journal_title：Parasitology

authors： Crook M,Viney ME

更新日期：2005-09-01 00:00:00

abstract：:An apparatus for artificial feeding of Rhipicephalus appendiculatus nymphae was modified to improve feeding performance. Heparinized blood was supplied above a treated artificial membrane while the ticks attached below on its undersurface. The feeding apparatus was incubated at 37 degrees C in an atmosphere of 3% CO2 ...

journal_title：Parasitology

authors： Waladde SM,Young AS,Mwaura SN,Njihia GN,Mwakima FN

更新日期：1995-11-01 00:00:00

abstract：:In this article I begin with a few current ideas on some physiological factors that influence mating choice in insects. Emphasis is placed on those proteins produced by the male reproductive accessory glands which increase female fecundity and reduce her receptivity to subsequent males. Strategies used by late-arrivin...

journal_title：Parasitology

authors： Kaufman WR

更新日期：2004-01-01 00:00:00