Abstract:
:Clones of Trypanosoma congolense which express resistance to the widely used trypanocide isometamidium chloride accumulate less of the drug than clones which are sensitive to drug treatment. A mathematical model has been developed which was able to predict theoretical lines representing the uptake kinetics in trypanosomes which were sensitive to isometamidium, as well as for resistant trypanosomes in which reduced accumulation was a result of either reduced uptake or enhanced efflux of the drug. Data from drug uptake experiments were then fitted to these theoretical lines. While the value for drug efflux could not be separated from the dissociation constant of the trypanosomes for isometamidium, it was demonstrated that reduced accumulation is not a result of reduced uptake of isometamidium by drug-resistant trypanosomes.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Sutherland IA,Mounsey A,Eisler M,Holmes PHdoi
10.1017/s0031182000073728subject
Has Abstractpub_date
1992-08-01 00:00:00pages
91-5eissn
0031-1820issn
1469-8161journal_volume
105 ( Pt 1)pub_type
杂志文章相关文献
PARASITOLOGY文献大全abstract::A mathematical model of the parasitic phase of the life-cycle of Ostertagia ostertagi in calves is described. The model is used in the re-analysis of previously published data from a long-term trickle infection experiment in which groups of calves were infected daily with graded doses of 3rd-stage (L3) larvae. The res...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000057802
更新日期:1987-10-01 00:00:00
abstract::The statistical aggregation of parasites among hosts is often described empirically by the negative binomial (Poisson-gamma) distribution. Alternatively, the Poisson-lognormal model can be used. This has the advantage that it can be fitted as a generalized linear mixed model, thereby quantifying the sources of aggrega...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001007740
更新日期:2001-05-01 00:00:00
abstract::Understanding disease transmission is important to species management and human health. Host body condition, nutrition and disease susceptibility interact in a complex manner, and while the individual effects of these variables are well known, our understanding of how they interact and translate to population dynamics...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182012001667
更新日期:2013-03-01 00:00:00
abstract::Toxocariasis is a common helminthic infection that has a worldwide distribution. However, data from Lebanon about the prevalence of this infection are non-existent. We conducted a Toxocara seroprevalence study with 150 subjects attending the outpatient clinics at the American University of Beirut Medical Center betwee...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182005009637
更新日期:2006-05-01 00:00:00
abstract::The ribosomal RNA (rRNA) gene units of Schistosoma mansoni and S. rodhaini, of the lateral spined egg group, have been studied. The schistosome rRNA gene unit consists of a regular interspersion of the two genes encoding the large and small rRNA units with two spacers. The large spacer is not transcribed while the sma...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059709
更新日期:1989-02-01 00:00:00
abstract::Nitric oxide (NO) produced by cytokine-activated macrophages is reported to be cytotoxic against the helminth Schistosoma mansoni, although this is a controversial issue. Previous work in our laboratory identified a fraction of S. mansoni soluble adult worm antigenic preparation (SWAP), named PIII, able to elicit sign...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182099005636
更新日期:2000-04-01 00:00:00
abstract::The biological parameters which generate seasonal fluctuations in the size of populations of Caryophyllaeus laticeps are examined in detail. A mathematical model is formulated to describe the dynamics of the adult parasite within the fish host Abramis brama, and the predictions of the model are compared with observed ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000049490
更新日期:1976-06-01 00:00:00
abstract::As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cel...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182009991533
更新日期:2010-03-01 00:00:00
abstract::Past and more recent research has examined the ultrastructure, metabolism, cell biology, genomics and post-genomics of schistosome schistosomula. These areas are considered and discussed in this review with particular emphasis on (1) the early migration phases through the host, (2) interaction of the host immune respo...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182006001648
更新日期:2007-04-01 00:00:00
abstract::Sexual size dimorphism (SSD) in mammals reveals the extent of sexual selection, which may in turn explain why males are often more infected by parasites than females and that parasites may contribute to the association between SSD and male-biased mortality. Here, we investigated the relationship between SSD in small m...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004005840
更新日期:2004-10-01 00:00:00
abstract::Chemotactic responses of Strongyloides stercoralis infective larvae (L3) to sodium chloride (NaCl) were investigated by recording larval tracks on a saline gradient in agarose. On agarose, larvae migrated randomly, whereas when placed at 0.01 m NaCl larvae moved to approximately 1.1 m NaCl where they turned, headed do...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182003003433
更新日期:2003-08-01 00:00:00
abstract::Neospora caninum infection is a significant cause of abortion in cattle. We investigated the tissue distribution of N. caninum in aborted bovine fetuses and dam blood samples by a nested PCR assay, and compared the nested PCR with ELISA in the diagnosis of N. caninum infection. In total, 26 aborted fetuses and 813 blo...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009990813
更新日期:2009-09-01 00:00:00
abstract::In this study, we describe the molecular analysis of zinc-metalloproteases from the abomasal nematode Ostertagia ostertagi which were exclusively recognized by local antibodies of immune cattle. Full-length or partial coding sequences of 4 different zinc-metalloprotease cDNAs of Ostertagia (met-1, -2, -3 and -4) were ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004006274
更新日期:2005-01-01 00:00:00
abstract::Renal infections by parasitic ciliates were studied in adult snails of Helix aspersa aspersa and Helix aspersa maxima collected from 2 mixed rearing system-based heliciculture farms located in Galicia (NW Spain). The occurrence of ciliates was also examined in slugs (Deroceras reticulatum) invading the greenhouses whe...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009006040
更新日期:2009-06-01 00:00:00
abstract::Genome sequencing has greatly contributed to our understanding of parasitic protozoa. This is particularly the case for Cryptosporidium species (phylum Apicomplexa) which are difficult to propagate. Because of their polymorphic nature, simple sequence repeats have been used extensively as genotypic markers to differen...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182018000112
更新日期:2018-08-01 00:00:00
abstract::The surface morphology of fixed ovarian balls from female Moniliformis dubius, agd 12, 18, 26, 28, 42, 77, 105 and 118 days, has been examined by means of scanning electron microscopy. The appearance of the surface has been found to be variable between ovarian balls from worms of the same and different ages. Some part...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000056146
更新日期:1980-10-01 00:00:00
abstract::Acetylcholinesterase (AChE) is present in all stages of the life-cycle of schistosomes and is located in muscle and on the surface of the parasite. Metrifonate is a drug that inhibits AChE. We compared the AChEs from three schistosome species (Schistosoma mansoni, Schistosoma haematobium and Schistosoma bovis) that ha...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000068244
更新日期:1994-02-01 00:00:00
abstract::Pentastomids comprise a highly specialized taxon of arthropod-like parasites that probably became adapted to the lungs of amphibians and reptiles early in their long evolutionary history. Few other macroparasites exploit this particular niche. Pentastomids are often large, long-lived and yet they cause little observab...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::Adult Onchocerca volvulus worms obtained by enzyme digestion from nodules of infected Mexicans were radio-isotope labelled by the chloramine-T or Bolton-Hunter methods. No antigenic determinants were detected in extracts of worms labelled by the chloramine-T method but 3 antigens were detected in extracts of the Bolto...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000001323
更新日期:1984-10-01 00:00:00
abstract::The public health significance of hookworm disease is briefly reviewed. The latest evidence confirms that blood loss caused by the worms' feeding activity in the gut is a contributing factor in the development of poor iron status leading to iron-deficiency anaemia. The World Health Organization has identified adolesce...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/s0031182000006454
更新日期:2000-01-01 00:00:00
abstract::The fine structure of the oncosphere of Hymenolepis nana has been investigated by transmission and scanning electron microscopy, together with light microscope observations of JB-4 embedded material. The outer surface of the oncosphere is covered by an epithelial layer, termed the embryonic epithelium. Cell types pres...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s003118200006697x
更新日期:1981-06-01 00:00:00
abstract::The surface coat of the 2nd-stage juveniles (J2) of plant-parasitic nematodes is considered to be involved in interactions with microorganisms in the soil and rhizosphere, as well as with the host plant. Characterization of surface antigens might be important in the development of new nematode control strategies. In t...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182002001907
更新日期:2002-08-01 00:00:00
abstract::Costa Rica is near malaria elimination. This achievement has followed shifts in malaria health policy. Here, we evaluate the impacts that different health policies have had on malaria transmission in Costa Rica from 1913 to 2018. We identified regime shifts and used regression models to measure the impact of different...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182020000621
更新日期:2020-08-01 00:00:00
abstract::Unsporulated oocysts were recovered from the allantoic cavity of 5 chicken embryos inoculated with a single sporozoite of Eimeria tenella; some of these oocysts sporulated. Both macrogametes and microgametes are required for the formation of viable oocysts. The results conclusively demonstrate the bisexual nature of t...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000047016
更新日期:1976-12-01 00:00:00
abstract::Ticks are of vast medical and veterinary public health importance due to direct damage caused by feeding and their roles in transmitting well known and emerging infectious agents. Ticks and tick-borne pathogens stimulate the immune system of the host. Those immune interactions are of importance in tick biology, pathog...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/s0031182004004834
更新日期:2004-01-01 00:00:00
abstract::Solid experimental evidence indicates that EBA-175 is used as a ligand by the Plasmodium falciparum merozoite to bind to human RBC, via different binding processing fragments. Using synthetic peptides and specific receptor-ligand interaction methodology, we have identified 6 high-activity binding sequences from the EB...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s003118209900551x
更新日期:2000-03-01 00:00:00
abstract::The evolution of host specificity and the potential trade-off between being a generalist and a specialist are central issues in the evolutionary ecology of parasites. Different species of parasites or even different populations of the same species often show different degrees of host specificity. However, less is know...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009991107
更新日期:2010-02-01 00:00:00
abstract::The epicontinental fauna of the Iberian Peninsula is strongly influenced by its geographical history. As the possibilities for dispersion of organisms into and from this region were (and still are) limited, the local fauna consists almost exclusively of endemic species. Almost all Iberian freshwater fishes of the fami...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182020000050
更新日期:2020-04-01 00:00:00
abstract::Pinewood nematode, Bursaphelenchus xylophilus, a pine parasitic nematode, poses a serious threat to its host pine forests globally. When dispersal-stage larvae 4 (dauer, DL4) of B. xylophilus enters the new pine, it moults into propagative adult (dauer recovery) and reproduces quickly to kill the host pine. Here, we f...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182019001264
更新日期:2020-01-01 00:00:00
abstract::Post-mesocyclic development of Trypanosoma brucei in the tsetse fly in its migration from midgut to salivary glands, was revisited by sequential microdissection, morphometry and DNA-cytofluorometry. This development started by day 6 after the infective feed, with passage of mesocyclic midgut trypomastigotes through pr...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182099004217
更新日期:1999-05-01 00:00:00