Kinetic modelling of isometamidium chloride (Samorin) uptake by Trypanosoma congolense.

Abstract:

:Clones of Trypanosoma congolense which express resistance to the widely used trypanocide isometamidium chloride accumulate less of the drug than clones which are sensitive to drug treatment. A mathematical model has been developed which was able to predict theoretical lines representing the uptake kinetics in trypanosomes which were sensitive to isometamidium, as well as for resistant trypanosomes in which reduced accumulation was a result of either reduced uptake or enhanced efflux of the drug. Data from drug uptake experiments were then fitted to these theoretical lines. While the value for drug efflux could not be separated from the dissociation constant of the trypanosomes for isometamidium, it was demonstrated that reduced accumulation is not a result of reduced uptake of isometamidium by drug-resistant trypanosomes.

journal_name

Parasitology

journal_title

Parasitology

authors

Sutherland IA,Mounsey A,Eisler M,Holmes PH

doi

10.1017/s0031182000073728

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

91-5

eissn

0031-1820

issn

1469-8161

journal_volume

105 ( Pt 1)

pub_type

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