Abstract:
:Pentastomids comprise a highly specialized taxon of arthropod-like parasites that probably became adapted to the lungs of amphibians and reptiles early in their long evolutionary history. Few other macroparasites exploit this particular niche. Pentastomids are often large, long-lived and yet they cause little observable pathology in lungs, despite being haematophagous. The lungs of all tetrapods are lined with pulmonary surfactant, a remarkable biological material consisting of a complex mixture of phospholipids, neutral lipids and proteins that has the unique ability to disperse over the air-liquid lining of the lung. In the lower tetrapods it acts as an anti-glue preventing adhesion of respiratory surfaces when lungs collapse during swallowing prey or upon expiration. In mammals, pulmonary surfactant also plays a critical role regulating the activity of alveolar macrophages, the predominant phagocytes of the lower airways and alveoli. This review outlines the evidence suggesting that lung-dwelling pentastomids, and also nymphs encysted in the tissues of mammalian intermediate hosts, evade immune surveillance and reduce inflammation by coating the chitinous cuticle with a their own stage-specific surfactant. The lipid composition of surfactant derived from lung instars of the pentastomid Porocephalus crotali cultured in vitro is very similar to that recovered from the lung of its snake host. Pentastomid surfactant, visualised as lamellate droplets within sub-parietal cells, is delivered to the cuticle via chitin-lined efferent ducts that erupt at a surface density of < 400 mm(-2). The fidelity of the system, which ensures that every part of the cuticle surface is membrane-coated, testifies to its strategic importance. Two other extensive glands discharge membrane-associated (hydrophobic?) proteins onto the hooks and head; some have been purified and partly characterized but their role in minimising inflammatory responses is, as yet, undetermined.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Riley J,Henderson RJsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
S89-105eissn
0031-1820issn
1469-8161journal_volume
119 Supplpub_type
杂志文章,评审相关文献
PARASITOLOGY文献大全abstract::The development of microgamonts was studied in the small intestine of a 2-day-old cat after oral inoculation with 10(7) bradyzoites of Sarcocystis hirsuta. The cat was given bradyzoites in 2 doses at 2 h apart and killed 4 h later. Gamonts were seen in parasitophorous vacuoles of goblet cells in the epithelium of the ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000057115
更新日期:1983-02-01 00:00:00
abstract::The presence of introduced hosts can increase or decrease infections of co-introduced parasites in native species of conservation concern. In this study, we compared parasite abundance, intensity, and prevalence between native Awaous stamineus and introduced poeciliid fishes by a co-introduced nematode parasite (Camal...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182016001001
更新日期:2016-10-01 00:00:00
abstract::We cloned and expressed Echinostoma caproni HSP70 in Escherichia coli. This molecule presents an open reading frame (ORF) of 655 amino acids, and a theoretical molecular weight of 71 kDa. E. caproni HSP70 protein showed a high homology to other helminth molecules, major differences being located in the C-terminal regi...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182008004927
更新日期:2008-10-01 00:00:00
abstract::African sleeping sickness is a parasitic disease transmitted through the bites of tsetse flies of the genus Glossina. We constructed mechanistic models for the basic reproduction number, R0, of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, respectively the causative agents of West and East African h...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182010001496
更新日期:2011-04-01 00:00:00
abstract::The radiation-attenuated schistosome vaccine induces a high level of protective immunity in rodents. In order to assess its potential relevance to man, we have tested its efficacy in the non-human primate Papio anubis. A vaccination regime consisting of 3 exposures of approximately 9000 cercariae irradiated with 30 or...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000065057
更新日期:1996-01-01 00:00:00
abstract::The localization of adult Schistosoma mansoni originating from Guadeloupe (West Indies) was analysed in the natural host Rattus rattus in experimental and natural infections. A transfer of schistosomes from the porto-mesenteric system to the lungs occurs between the 4th and the 20th weeks post-infection, with a peak b...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000060790
更新日期:1992-02-01 00:00:00
abstract::Trials were carried out to study the humoral immune response of blackflies to filariae following infection using the intrathoracic injection technique. An induced 66 kDa protein was abundant in the haemolymph of the European species Simulium ornatum following infection with bovine Onchocerca lienalis. This protein was...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000076538
更新日期:1994-12-01 00:00:00
abstract::The outcome of a parasite infection is the result of the interaction between the host and the parasite. In the system we studied, there are 3 critical stages for the outcome of infection of the (intermediate) host, the copepod Macrocyclops albidus, with the cestode Schistocephalus solidus. During the establishment pha...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001001275
更新日期:2002-04-01 00:00:00
abstract::In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs ...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182007002971
更新日期:2007-10-01 00:00:00
abstract::As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cel...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182009991533
更新日期:2010-03-01 00:00:00
abstract::Toxocariasis is a common helminthic infection that has a worldwide distribution. However, data from Lebanon about the prevalence of this infection are non-existent. We conducted a Toxocara seroprevalence study with 150 subjects attending the outpatient clinics at the American University of Beirut Medical Center betwee...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182005009637
更新日期:2006-05-01 00:00:00
abstract::Endotoxaemia has been described in cases of Human African trypanosomiasis (HAT), but it is unclear if this phenomenon influences inflammatory pathology either in the periphery or central nervous system (CNS). We studied endotoxin concentrations in the plasma and cerebrospinal fluid (CSF) of Trypanosoma brucei rhodesie...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182016002158
更新日期:2017-04-01 00:00:00
abstract::Nematodes are amongst the most successful and abundant organisms on the planet with approximately 30 000 species described, although the actual number of species is estimated to be one million or more. Despite sharing a relatively simple and invariant body plan, there is considerable diversity within the phylum. Nemat...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182014000304
更新日期:2014-08-01 00:00:00
abstract::Most of our knowledge about the process of penetration of skin, by cercariae of Schistosoma mansoni, has been gained from studies carried out in vivo with laboratory animals. Human skin is significantly different from that of other animals but there are obvious practical difficulties in directly studying attachment an...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s003118200100885x
更新日期:2002-01-01 00:00:00
abstract::Renal infections by parasitic ciliates were studied in adult snails of Helix aspersa aspersa and Helix aspersa maxima collected from 2 mixed rearing system-based heliciculture farms located in Galicia (NW Spain). The occurrence of ciliates was also examined in slugs (Deroceras reticulatum) invading the greenhouses whe...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009006040
更新日期:2009-06-01 00:00:00
abstract::The host recognition and invasion process of Myxobolus cerebralis actinospores (triactinomyxon, TAM) was studied on a genetic level. A small-scale in vitro assay was developed to activate a large number of TAMs simultaneously, and to monitor the host invasion in the absence of live fish. The transcriptomes of non-acti...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182008005398
更新日期:2009-04-01 00:00:00
abstract::Early in the history of schistosomiasis research, children under 5 years of age were known to be infected. Although this problem was recognized over 100 years ago, insufficient action has been taken to address this issue. Under current policy, such infected children only receive their first antiparasitic treatment (pr...
journal_title:Parasitology
pub_type: 历史文章,杂志文章,评审
doi:10.1017/S0031182017000014
更新日期:2017-10-01 00:00:00
abstract::An apparatus for artificial feeding of Rhipicephalus appendiculatus nymphae was modified to improve feeding performance. Heparinized blood was supplied above a treated artificial membrane while the ticks attached below on its undersurface. The feeding apparatus was incubated at 37 degrees C in an atmosphere of 3% CO2 ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000065963
更新日期:1995-11-01 00:00:00
abstract::American trypanosamiasis occurs in nature as a sylvatic cycle, where Trypanosoma cruzi interacts with wild triatomines and mammalian reservoirs, such as marsupials, rodents, armadillos and other animals. Due to difficulties in trying to isolate T. cruzi stocks from the sylvatic cycle, very few studies have been perfor...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098003709
更新日期:1999-02-01 00:00:00
abstract::In recent years, a malaria infection of humans in South East Asia, originally diagnosed as a known human-infecting species, Plasmodium malariae, has been identified as a simian parasite, Plasmodium knowlesi. This species had been subject to considerable investigation in monkeys since the 1930s. With the development of...
journal_title:Parasitology
pub_type: 历史文章,杂志文章,评审
doi:10.1017/S0031182016001888
更新日期:2018-01-01 00:00:00
abstract::Toxoplasmosis is largely present in rural areas but its spatial distribution in this environment remains poorly known. In particular, it is unclear if areas of high density of cats, the only hosts excreting Toxoplasma gondii, constitute foci of high prevalence. To improve our understanding of the spatial distribution ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182013001522
更新日期:2014-02-01 00:00:00
abstract::The transmission success of Onchocerca volvulus is thought to be influenced by a variety of regulatory or density-dependent processes that act at various points in the two-host life-cycle. This paper examines one component of the life-cycle, namely, the ingestion of microfilariae by the simuliid vector, to assess the ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000078586
更新日期:1994-01-01 00:00:00
abstract::By means of conventional light microscopical and counting procedures, estimations have been made of the average number and size of ovarian balls from unfertilized and fertilized female Moniliformis dubius. The observations were made on worms recovered from experimental primary infections lasting 1, 2, 3, 4, 5, 8, 11, ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000051337
更新日期:1976-08-01 00:00:00
abstract::Avian malaria is a mosquito-borne disease caused by Plasmodium spp. protozoa. Although these parasites have been extensively studied in North America and Eurasia, knowledge on the diversity of Plasmodium, its vectors and avian hosts in Africa is scarce. In this study, we report on natural malarial infections in free-r...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182020000566
更新日期:2020-08-01 00:00:00
abstract::The evolution of host specificity and the potential trade-off between being a generalist and a specialist are central issues in the evolutionary ecology of parasites. Different species of parasites or even different populations of the same species often show different degrees of host specificity. However, less is know...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009991107
更新日期:2010-02-01 00:00:00
abstract::The blackcap (Sylvia atricapilla) is a common Palearctic migratory warbler, and haemosporidian parasites are common in this species. However, genetic and phenotypic diversity of haemosporidians in warblers has been insufficiently investigated and poorly linked. We addressed this issue by combining molecular and micros...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182009991235
更新日期:2010-02-01 00:00:00
abstract::The multicopy mini-exon-derived RNA (med RNA) locus of Leishmania donovani was enzymatically amplified by the polymerase chain reaction (PCR). The major 180 bp PCR product contained conserved med RNA gene sequences flanking the variable intergenic spacer from the med RNA gene tandem repeat. The oligonucleotide primers...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000068086
更新日期:1993-12-01 00:00:00
abstract::Recent studies of the forces behind the diversification of parasite assemblages have shed light on many aspects of parasite biodiversity. By using only parasite species richness as their measure of diversity, however, previous investigations have ignored the relatedness among parasite species and the taxonomic structu...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182004005050
更新日期:2004-06-01 00:00:00
abstract::The major transaminase in Heligmosomoides polygyrus, Panagrellus redivivus and rat liver was the 2-oxoglutarate-glutamate system, with relatively few amino acids acting as donors for the pyruvate-alanine and oxaloacetate-aspartate systems. The relative effectiveness of the different amino acid donors in the three tran...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000081191
更新日期:1986-12-01 00:00:00
abstract::The flatworm nervous system employs a wide repertoire of neuroactive substances, including small chemical messengers, the so called classical transmitters, and several types of neuropeptides. A large body of research accumulated over four decades has provided a wealth of information on the tissue localization and effe...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182005008565
更新日期:2005-01-01 00:00:00