Nematode Hsp90: highly conserved but functionally diverse.

abstract：:Prevention of heartworm disease caused by Dirofilaria immitis in domestic dogs and cats relies on a single drug class, the macrocyclic lactones (MLs). Recently, it has been demonstrated that ML-resistant D. immitis are circulating in the Mississippi Delta region of the USA, but the prevalence and impact of these resis...

journal_title：Parasitology

authors： Wolstenholme AJ,Evans CC,Jimenez PD,Moorhead AR

更新日期：2015-09-01 00:00:00

abstract：:The kinetoplastid parasite Trypanosoma brucei causes African trypanosomiasis in both humans and animals. Infections place a significant health and economic burden on developing nations in sub-Saharan Africa, but few effective anti-parasitic treatments are currently available. Hence, there is an urgent need to identify...

journal_title：Parasitology

authors： Dickie EA,Young SA,Smith TK

更新日期：2019-04-01 00:00:00

abstract：:Plant cysteine proteinases (CPs) from Carica papaya kill parasitic and free-living nematodes in vitro by hydrolysis of the worm cuticle, a mechanism that is different to all commercially available synthetic anthelmintics. We have developed a cheap and effective, rapid-throughput Caenorhabditis elegans-based assay for ...

journal_title：Parasitology

authors： Phiri AM,DE Pomerai DI,Buttle DJ,Behnke JM

更新日期：2017-04-01 00:00:00

abstract：:Levamisole (Lms) is an anthelminthic drug with immunomodulatory activity. Chagas disease (CD) is caused by Trypanosoma cruzi and there is very low access to the drugs available, benznidazole (Bz) and nifurtimox, both far from ideal. In a drug-repurposing strategy to test potential activity as antiparasitic and immunom...

journal_title：Parasitology

authors： Rocha Simões-Silva M,Brandão Peres R,Britto C,Machado Cascabulho C,de Melo Oliveira G,Nefertiti da Gama A,França da Silva C,Lima da Costa K,Finamore Araújo P,Diego de Souza Campos J,Meuser Batista M,Cristina Demarque K,da Cruz Mo

更新日期：2019-07-01 00:00:00

abstract：:Potential mechanisms of immunoregulation have been investigated for the capacity to generate heterogeneity in the outcome of infection with helminth parasites. We have developed a mathematical model of the interaction between T cell and parasite populations, based on the assumption that activation of a Th1 CD4+ T cell...

journal_title：Parasitology

authors： Schweitzer AN,Anderson RM

更新日期：1992-12-01 00:00:00

abstract：:Host nutrition plays an important role in determining the development and success of parasitic infections. While studies of vertebrate hosts are accumulating, little is known about how host nutrition affects parasites of invertebrate hosts. Crithidia bombi is a gut trypanosome parasite of the bumble bee, Bombus terres...

journal_title：Parasitology

authors： Logan A,Ruiz-González MX,Brown MJ

更新日期：2005-06-01 00:00:00

abstract：:The multicopy mini-exon-derived RNA (med RNA) locus of Leishmania donovani was enzymatically amplified by the polymerase chain reaction (PCR). The major 180 bp PCR product contained conserved med RNA gene sequences flanking the variable intergenic spacer from the med RNA gene tandem repeat. The oligonucleotide primers...

journal_title：Parasitology

authors： Hassan MQ,Ghosh A,Ghosh SS,Gupta M,Basu D,Mallik KK,Adhya S

更新日期：1993-12-01 00:00:00

abstract：:Eimerian oocysts were found in 98% of 422 faeces samples from goats in SE England. It was found that 74% of the samples contained thousands or tens of thousands of oocysts/g. Kids less than 1 year old had higher oocyst counts than yearling or adult goats. Nine species of Eimeria were identified, and 65% of the samples...

journal_title：Parasitology

authors： Norton CC

更新日期：1986-04-01 00:00:00

abstract：:Protective immunity against larval Taenia crassiceps has been shown to rely on T cells; however, the roles of the specific subsets of T cells during infection are not known. To investigate a possible role for gamma delta T cells, this study investigated larval infection in delta-chain knock-out C57BL/6 (deltaKO) and w...

journal_title：Parasitology

authors： Toenjes SA,Spolski RJ,Mooney KA,Kuhn RE

更新日期：1999-10-01 00:00:00

abstract：:Trypanosoma evansi and Trypanosoma vivax are the most extensively distributed trypanosomes responsible for diseases in livestock. Western blot and indirect immunofluorescence assays revealed a high immunological cross-reaction between these two parasites. An antigen with an apparent molecular mass of 64 kDa (p64), whi...

journal_title：Parasitology

authors： Uzcanga G,Mendoza M,Aso PM,Bubis J

更新日期：2002-03-01 00:00:00

abstract：:A guinea-pig immunoglobulin-G linked agarose column was used to detect the immunoglobulin-G binding proteins (IGBP) in the ixodid ticks, Rhipicephalus appendiculatus, Amblyomma variegatum and Ixodes hexagonus. IGBPs were found in salivary gland extract (SGE) of the unfed ticks of all 3 species. The sizes of the IGBPs,...

journal_title：Parasitology

authors： Wang H,Nuttall PA

更新日期：1995-08-01 00:00:00

abstract：:Susceptability of Ascaridia galli to benzimidazole (BZ) was investigated using faecal egg count reduction test (FECRT), in ovo larval development test (LDT) and genetic markers (mutations at codons 167, 198 and 200 of β-tubulin gene). Six flocks (F1-F6) of a commercial laying hen farm with different number of exposure...

journal_title：Parasitology

authors： Tarbiat B,Jansson DS,Tydén E,Höglund J

更新日期：2017-09-01 00:00:00

abstract：:Trichomonas vaginalis induces cellular damage to the host cells (cytotoxicity) through the proteolytic activity of multiple proteinases of the cysteine type (CPs). Some CPs are modulated by environmental factors such as iron, zinc, polyamines, etc. Thus, the goal of this study was to assess the effect of glucose on T....

journal_title：Parasitology

authors： Miranda-Ozuna JFT,Rivera-Rivas LA,Cárdenas-Guerra RE,Hernández-García MS,Rodríguez-Cruz S,González-Robles A,Chavez-Munguía B,Arroyo R

更新日期：2019-08-01 00:00:00

abstract：:Steroids have been shown to be beneficial in patients and mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection; however, the mechanism for this beneficial effect is unknown. We speculated that the effect of steroids in eosinophilic meningitis caused by A. cantonensis infection may be media...

journal_title：Parasitology

authors： Tsai HC,Chen YH

更新日期：2020-10-02 00:00:00

abstract：OBJECTIVE:Unravelling the determinants of parasite life-history traits in natural settings is complex. Here, we deciphered the relationships between biotic, abiotic factors and the variation in 4 life-history traits (body size, egg presence, egg number and egg size) in the fish ectoparasite Tracheliastes polycolpus. We...

journal_title：Parasitology

authors： Loot G,Poulet N,Brosse S,Tudesque L,Thomas F,Blanchet S

更新日期：2011-06-01 00:00:00

abstract：:Interactions between infections of Trichinella spiralis and Nippostrongylus brasiliensis were studied in the NIH strain of mouse which is known to react strongly to T. spiralis. The course of N. brasiliensis infection in this strain of mouse is described and expulsion is shown to be accelerated in immunized mice and i...

journal_title：Parasitology

authors： Kennedy MW

更新日期：1980-02-01 00:00:00

abstract：:The tegumental surface of Schistosoma mansoni sporocysts is the site of both nutritive and immunological interactions with haemolymph cells and plasma of Biomphalaria glabrata, the schistosome intermediate host. Within minutes of being placed in host plasma, sporocysts acquire plasma antigens, and within 3 h host plas...

journal_title：Parasitology

authors： Bayne CJ,Loker ES,Yui MA

更新日期：1986-06-01 00:00:00

abstract：:Sodium fluoride (NaF) is an anion that has been previously shown to block the moulting process of Ascaris suum larvae. This study describes moulting and development-specific protein expression profiles of A. suum lung-stage L3 (AsLL3) following NaF exposure. AsLL3s cultured in the presence or absence of NaF were prepa...

journal_title：Parasitology

authors： Islam MK,Miyoshi T,Yamada M,Alim MA,Huang X,Motobu M,Tsuji N

更新日期：2006-10-01 00:00:00

abstract：:An ultrastructural study has been performed on radiation-attenuated parasites fixed in situ during their extended stay in the lungs. At day 7 post-infection all parasites were located within blood vessels. In contrast to normally migrating parasites, at days 13 and 21 post-infection the majority of radiation-attenuate...

journal_title：Parasitology

authors： Mastin A,Bickle QD,Wilson RA

更新日期：1985-08-01 00:00:00

abstract：:The transmission-blocking monoclonal antibody 13.1, which recognizes the ookinete surface antigen Pbs21 of Plasmodium berghei, and an IgG2a isotype control antibody 26.37 were purified by caprylic acid and ammonium sulphate precipitation. Fab fragments were prepared by papain digestion. IgG but not Fab from antibody 1...

journal_title：Parasitology

authors： Ranawaka GR,Alejo-Blanco AR,Sinden RE

更新日期：1994-07-01 00:00:00

abstract：:Vitellogenin synthesis by the fat body has been monitored using in vitro culture and immunoprecipitation. This system was found to be efficient for measuring vitellogenin production in both non-infected Tenebrio molitor and those infected with Hymenolepis diminuta. In fat bodies from infected beetles, vitellogenin pro...

journal_title：Parasitology

authors： Webb TJ,Hurd H

更新日期：1996-04-01 00:00:00

abstract：:We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones ...

journal_title：Parasitology

authors： De Roode JC,Read AF,Chan BH,Mackinnon MJ

更新日期：2003-11-01 00:00:00

abstract：:Multiple infections, those by more than one parasite in the same erythrocyte, may be adaptive for the malarial parasite as a means to ensure fertility. Alternatively they may simply be the consequence of a non-adaptive process forcing several parasites to compete for resources in one host cell. Avian hosts infected wi...

journal_title：Parasitology

authors： Martínez-de la Puente J,Merino S,Tomás G,Moreno J,Morales J,Lobato E

更新日期：2006-01-01 00:00:00

abstract：:Parasites of the genera Plasmodium and Haemoproteus (Apicomplexa: Haemosporida) are a diverse group of pathogens that infect birds nearly worldwide. Despite their ubiquity, the ecological and evolutionary factors that shape the diversity and distribution of these protozoan parasites among avian communities and geograp...

journal_title：Parasitology

authors： Fecchio A,Svensson-Coelho M,Bell J,Ellis VA,Medeiros MC,Trisos CH,Blake JG,Loiselle BA,Tobias JA,Fanti R,Coffey ED,DE Faria IP,Pinho JB,Felix G,Braga EM,Anciães M,Tkach V,Bates J,Witt C,Weckstein JD,Ricklefs RE,

更新日期：2017-06-01 00:00:00

abstract：:Host location by parasites can be achieved by either active or passive mechanisms. In spite of their significance, the efficacy of these methods has been little researched. High fecundity in parasites is discussed in terms of the role it plays in dispersal and transmission. Some concepts developed by mainstream behavi...

journal_title：Parasitology

authors： Rea JG,Irwin SW

更新日期：1994-01-01 00:00:00

abstract：:Sex ratio theory posits that the adaptive proportion of male to female gametocytes of a malaria parasite within the vertebrate host depends on the degree of inbreeding within the vector. Gametocyte sex ratio could be phenotypically flexible, being altered based on the infection's clonal diversity, and thus likely inbr...

journal_title：Parasitology

authors： Osgood SM,Schall JJ

更新日期：2004-01-01 00:00:00

abstract：:An electron microscopical examination has been made of the fine structure and disposition of pancreatic polypeptide immunoreactive cells associated with the egg-forming apparatus in Diclidophora merlangi. The cell bodies are positioned in the parenchyma surrounding the ootype and taper to axon-like processes that exte...

journal_title：Parasitology

authors： Halton DW,Brennan GP,Maule AG,Shaw C,Johnston CF,Fairweather I

更新日期：1991-06-01 00:00:00

abstract：:Cytoadherence of Plasmodium falciparum-infected erythrocytes to melanoma cells was analysed using strains or isolates of parasites expressing or not expressing knobs (K+ or K- phenotype) on the erythrocyte surface. Both K+ and K- parasites had the capacity to cytoadhere to melanoma cells. Using a panel of melanoma cel...

journal_title：Parasitology

authors： Ruangjirachuporn W,Afzelius BA,Paulie S,Wahlgren M,Berzins K,Perlmann P

更新日期：1991-06-01 00:00:00

abstract：:Electrophoresis of secretions collected from Globodera pallida revealed a smeared region between 25 and 50 kDa, and a single band of < 20 kDa. The secretions were used to raise an antiserum (LW1). Immunoblotting of parasite homogenates with LW1 differentiated G. pallida from its sibling species G. rostochiensis and re...

journal_title：Parasitology

authors： Duncan LH,Robertson L,Robertson WM,Kusel JR

更新日期：1997-10-01 00:00:00

abstract：:To test the homogeneity of 18S sequences within Trypanosoma cruzi, riboprint profiles were separated by temperature gradient gel electrophoresis (TGGE). Upon interpretation of melting curves of fragments within a riboprint profile, there appeared to be two 18S sequence types within each stock examined. Two similar typ...

journal_title：Parasitology

authors： Stothard JR,Frame IA,Carrasco HJ,Miles MA

更新日期：1998-09-01 00:00:00