Abstract:
:Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened basal lamina and in the perivascular area, which also contained macrophages and neutrophilic granulocytes. Rarely, lymphocytes were observed attached to the outer membrane of the host neurone which contained a Toxoplasma tissue cyst and within the inflammatory infiltrate associated with a disintegrating cyst. An hypothesis is presented which combines these morphological observations to explain the events associated with tissue cyst associated recrudescence of latent Toxoplasma infection in mouse brain.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Sims TA,Hay Jdoi
10.1017/s0031182000063873subject
Has Abstractpub_date
1995-02-01 00:00:00pages
123-7eissn
0031-1820issn
1469-8161journal_volume
110 ( Pt 2)pub_type
杂志文章相关文献
PARASITOLOGY文献大全abstract::Twelve populations of bats were examined to determine the extent of interspecific associations in determining the species richness of intestinal helminth infracommunities. The pool of helminth species which was available to individual bats ranged from 2 to 21. The 'summed binomial' distribution was determined to under...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059370
更新日期:1991-08-01 00:00:00
abstract::A novel repetitive DNA sequence in the sheep parasitic nematode Trichostrongylus colubriformis was cloned and sequenced. A 1.1 kb repetitive sequence (Tc15) which hybridized with DNA from T. colubriformis but not with DNA from two other parasitic nematodes, Haemonchus contortus and Ostertagia circumcincta, or sheep wa...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000078379
更新日期:1994-09-01 00:00:00
abstract::Early in the history of schistosomiasis research, children under 5 years of age were known to be infected. Although this problem was recognized over 100 years ago, insufficient action has been taken to address this issue. Under current policy, such infected children only receive their first antiparasitic treatment (pr...
journal_title:Parasitology
pub_type: 历史文章,杂志文章,评审
doi:10.1017/S0031182017000014
更新日期:2017-10-01 00:00:00
abstract::Small RNAs are important regulators of gene expression. They were first identified in Caenorhabditis elegans, but it is now apparent that the main small RNA silencing pathways are functionally conserved across diverse organisms. Availability of genome data for an increasing number of parasitic nematodes has enabled bi...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182019001689
更新日期:2020-07-01 00:00:00
abstract::Diagnostic PCR primers for Trichinella were constructed. Twelve pairs of primers were designed based on the sequences of random amplified polymorphic DNA, and 4 pairs of primers were designed based on the reported sequences of complementary DNA encoding excretory-secretory glycoproteins. With these primers, 31 samples...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098002881
更新日期:1998-08-01 00:00:00
abstract::Cryptosporidia are important protozoan parasites of vertebrates, and a number of species and genotypes, with different host ranges, have been described. In this study a protocol was established for the detection and the genetic characterization of Cryptosporidium spp. isolated from various types of surface waters (riv...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001001317
更新日期:2002-04-01 00:00:00
abstract::In an interconnected world, the international pet trade on wild animals is becoming increasingly important. As a consequence, non-native parasite species are introduced, which affect the health of wildlife and contribute to the loss of biodiversity. Because the investigation of parasite diversity within vulnerable hos...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182016002183
更新日期:2017-04-01 00:00:00
abstract::The current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL). Although contributory mechanisms studied in laboratory-raised Sb-R parasites include an up-regulation of drug efflux pumps and increased thiols, their role in c...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182007003150
更新日期:2007-11-01 00:00:00
abstract::Immunological and structural changes in the thymus and pronephros of Cyprinus carpio infected with the blood fluke, Sanguinicola inermis for 30 days, and exposed to 0.5 mg NH4+/1 for 48 and 168 h were investigated. Ultrastructural observations revealed cell disruption and highly vacuolated cytoplasm in the thymus. Of ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001007260
更新日期:2001-03-01 00:00:00
abstract::The cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Livestock (IDEAL) study ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182013001625
更新日期:2014-03-01 00:00:00
abstract::Host nutrition plays an important role in determining the development and success of parasitic infections. While studies of vertebrate hosts are accumulating, little is known about how host nutrition affects parasites of invertebrate hosts. Crithidia bombi is a gut trypanosome parasite of the bumble bee, Bombus terres...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182005007304
更新日期:2005-06-01 00:00:00
abstract::Post-mesocyclic development of Trypanosoma brucei in the tsetse fly in its migration from midgut to salivary glands, was revisited by sequential microdissection, morphometry and DNA-cytofluorometry. This development started by day 6 after the infective feed, with passage of mesocyclic midgut trypomastigotes through pr...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182099004217
更新日期:1999-05-01 00:00:00
abstract::Hybridization events between Schistosoma species (Digenea, Platyhelminthes) are reported with increasing frequency, largely due to improved access to molecular tools. Nevertheless, little is known about the distribution and frequency of hybrid schistosomes in nature. Screening for hybrids on a large scale is complicat...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182018000525
更新日期:2018-04-01 00:00:00
abstract::Like in other trypanosomatids D-glucose is a crucial source of energy to Trypanosoma rangeli, a non-pathogenic parasite that in Central and South America infects triatomine vectors and different mammalian species, including humans. In several trypanosome species, D-glucose transporters were already described and clone...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182006000989
更新日期:2006-12-01 00:00:00
abstract::The localization and distribution of neuropeptides in the nervous system of the liver fluke, Fasciola hepatica at different stages in the development of the adult fluke have been determined by an indirect immunofluorescence technique, using antisera to 19 vertebrate peptides and the invertebrate neuropeptide, FMRFamid...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000062132
更新日期:1989-04-01 00:00:00
abstract::Feulgen-pararosaniline (SO2) staining was performed on stages in the life-cycle of Isospora (Toxoplasma) gondii, Eimeria tenella, Sarcocystis cruzi and Plasmodium berghei. The fluorescence emission of the stained DNA in nuclei of these stages was examined and compared with absorption microscopy measurements at 560 nm ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000054305
更新日期:1984-02-01 00:00:00
abstract::The development of a successful vaccine depends not only on the production of the vaccine itself, but also on the design pf the vaccination programme. This involves a better understanding of the epidemiology of the disease to be controlled, the delivery system to be used and the costs involved. This review focuses on ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000001499
更新日期:1995-01-01 00:00:00
abstract::Costa Rica is near malaria elimination. This achievement has followed shifts in malaria health policy. Here, we evaluate the impacts that different health policies have had on malaria transmission in Costa Rica from 1913 to 2018. We identified regime shifts and used regression models to measure the impact of different...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182020000621
更新日期:2020-08-01 00:00:00
abstract::The relative importance of temporal and spatial effects was assessed in helminth communities of bank voles (Myodes glareolus) in 3 woodland sites in N.E. Poland in the late summers of 1999 and 2002. Among common species the rank order of sites in relation to prevalence and abundance of infection was maintained between...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182008004484
更新日期:2008-07-01 00:00:00
abstract::The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically ill, immunosuppressed or post-cancer patients often exceed 50%. A set of six systemic clinical azol...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182018000562
更新日期:2018-12-01 00:00:00
abstract::This study reports that inhibition of Leishmania Topo-I with the minor groove-binding ligands (MGBLs) Hoechst 33342 (Ho342) blocks parasite growth in culture by mechanisms involving DNA breakage. While Ho342 inhibited the replication of several species of Leishmania in a dose- and time-dependent manner, Ho258 was not ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182002002524
更新日期:2003-01-01 00:00:00
abstract::Schistosomula of Schistosoma mansoni were incubated in RPMI 1640 medium containing 10% fetal calf serum, 10% human portal venous or 10% human peripheral venous sera in the presence of bromodeoxyuridine (BrdU) in order to measure differences in cell proliferation. The rates of cell proliferation as expressed by BrdU la...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098003096
更新日期:1998-10-01 00:00:00
abstract::Many marine fisheries in South American Atlantic coasts (SAAC) are threatened by overfishing and under serious risk of collapsing. The SAAC comprises a diversity of environments, possesses a complex oceanography and harbours a vast biodiversity that provide an enormous potential for using parasites as biological tags ...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/S0031182013002138
更新日期:2015-01-01 00:00:00
abstract::The current World Health Organization strategic plan targets the elimination of schistosomiasis as a public health problem by 2025 and accurate diagnostics will play a pivotal role in achieving this goal. DNA-based detection methods provide a viable alternative to some of the commonly used tests, notably microscopy an...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S003118201700021X
更新日期:2017-07-01 00:00:00
abstract::The gastrointestinal nematode Heligmosomoides polygyrus bakeri shows enhanced survival in mice with colitis. As the antibody response plays an important role in antiparasitic immunity, antibodies against male and female L4 H. polygyrus were examined in mice with and without colitis. Levels of specific antibodies in th...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182020001201
更新日期:2020-11-01 00:00:00
abstract::The genomes of more than 20 helminths have now been sequenced. Here we perform a meta-analysis of all sequenced genomes of nematodes and Platyhelminthes, and attempt to address the question of what are the defining characteristics of helminth genomes. We find that parasitic worms lack systems for surface antigenic var...
journal_title:Parasitology
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0031182014001449
更新日期:2015-02-01 00:00:00
abstract::Bat flies are obligate ectoparasites of bats and it has been hypothesized that they may be involved in the transmission of Bartonella species between bats. A survey was conducted to identify whether Cyclopodia greefi greefi (Diptera: Nycteribiidae) collected from Ghana and 2 islands in the Gulf of Guinea harbour Barto...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182011002113
更新日期:2012-03-01 00:00:00
abstract::Ticks have numerous natural enemies, but only a few species have been evaluated as tick biocontrol agents (BCAs). Some laboratory results suggest that several bacteria are pathogenic to ticks, but their mode of action and their potential value as biocontrol agents remain to be determined. The most promising entomopath...
journal_title:Parasitology
pub_type: 杂志文章,评审
doi:10.1017/s0031182004005219
更新日期:2004-01-01 00:00:00
abstract::In an experiment to study the infectivity, growth and virulence of Schistocephalus solidus in their first intermediate host, copepods of the species Macrocyclops albidus were kept singly and exposed to up to 9 coracidia. Eleven or 14 days post-infection (p.i.) the presence and growth of the cestode larvae relative to ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182097001406
更新日期:1997-09-01 00:00:00
abstract::Treatment of BALB/c or MF1 mice with cyclosporin A (CsA) around the time of infection with Schistosoma mansoni conferred almost complete protection. The migration kinetics of L-[75Se]selenomethionine-labelled infective cercariae were investigated by compressed tissue autoradiography. Similar levels of skin penetration...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000060340
更新日期:1991-02-01 00:00:00