Impairment of growth of Leishmania donovani by Trypanosoma brucei during co-culture.

Abstract:

:Cells of Leishmania donovani in co-culture with Trypanosoma brucei, were severely affected in their growth, resulting in swelling and subsequent lysis. Similar effects were also observed when Crithidia luciliae or Phytomonas sp. were co-cultured with T. brucei. Direct contact between the cells under investigation and T. brucei was necessary because T. brucei did not hamper the growth of the other trypanosomatids, when separated by a filter with 0.2 microns pore size. Examination of this phenomenon at the ultrastructural level, in a co-culture of L. donovani and T. brucei, suggests that the plasma membrane permeability is increased in the former, as a result of a close cellular contact between the two cell types.

journal_name

Parasitology

journal_title

Parasitology

authors

Coppens I,Ter Kuile BH,Opperdoes FR

doi

10.1017/s0031182000074564

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

393-8

eissn

0031-1820

issn

1469-8161

journal_volume

105 ( Pt 3)

pub_type

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