A mathematical modelling approach for treatment and control of Echinococcus multilocularis.

Abstract:

:Alveolar echinococcosis (AE) is a zoonotic parasitic diseases caused by a cestode parasite known as Echinococcus multilocularis. The parasite has a wildlife cycle with definitive hosts (foxes) and small mammals as intermediate hosts (rodents) while humans are the accidental hosts. Parasite infection pressure relation to time of the year and age dependent infection pressure for parasite abundance also depend on the urbanization. The aim of current work is forecasting the thresholds via the computational analysis of the disease spread which is a useful approach since it can help to design the experimental settings with better planning and efficiency. Network analysis when interlinked with the computational techniques provides better insight into the spatial and temporal heterogeneities. In the present study, a mathematical framework that describes the transmission dynamics and control measures of E. multilocularis in foxes is documented. We used treatment of foxes with baits for the prevention of the E. multilocularis infection. A novel approach of networking, called Petri net (PN), based on density dependent differential equations, is utilized during this research. The accurate description of the transmission of the parasite and the effect of drug on it is provided to the readers in this article. The transitions, which are difficult to analyse theoretically, are presented with the aid of the discrete approach of networking. A discrete mathematical framework can prove to be an accurate and robust tool to analyse and control the parasite dynamics.

journal_name

Parasitology

journal_title

Parasitology

authors

Khan A,Ahmed H,Sohail A,Alam F,Simsek S

doi

10.1017/S0031182019001720

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

376-381

issue

3

eissn

0031-1820

issn

1469-8161

pii

S0031182019001720

journal_volume

147

pub_type

杂志文章
  • Some observations on the sexual differentiation of Eimeria tenella using single sporozoite infections in chicken embryos.

    abstract::Unsporulated oocysts were recovered from the allantoic cavity of 5 chicken embryos inoculated with a single sporozoite of Eimeria tenella; some of these oocysts sporulated. Both macrogametes and microgametes are required for the formation of viable oocysts. The results conclusively demonstrate the bisexual nature of t...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000047016

    authors: Shirley MW,Millard BJ

    更新日期:1976-12-01 00:00:00

  • Maternal transfer of antibodies induced by infection with Eimeria maxima partially protects chickens against challenge with Eimeria tenella.

    abstract::Infection of breeding hens with Eimeria maxima induces production of Eimeria-specific IgG antibodies which are transferred to hatchlings via the egg yolk and confer a high degree of maternal immunity against homologous challenge and partial immunity to infection with another important species, Eimeria tenella. As an e...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000076423

    authors: Smith NC,Wallach M,Petracca M,Braun R,Eckert J

    更新日期:1994-12-01 00:00:00

  • Female mice mate preferentially with non-parasitized males.

    abstract::If parasitic infection is a driving force in female mate choice, then females should preferentially select parasite-free males. The role of infection on female mate choice in mammals was assessed using a 3-chambered apparatus. A female CD-1 mouse was allowed to choose between 2 tethered male mice, 1 uninfected and 1 i...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200200224x

    authors: Ehman KD,Scott ME

    更新日期:2002-11-01 00:00:00

  • Current status of vaccination against African trypanosomiasis.

    abstract::Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigenic variation of the parasite surface coat has been considered the major obstacle in the development...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182010000223

    authors: Magez S,Caljon G,Tran T,Stijlemans B,Radwanska M

    更新日期:2010-12-01 00:00:00

  • Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis.

    abstract::Of the 7 genetic assemblages of the parasite Giardia duodenalis only 2 (A and B) are known to cause infections in humans. These assemblages have been characterized in detail at the genomic level but few studies have examined differences in the proteins expressed. Employing one and two-dimensional PAGE we have identifi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004988

    authors: Steuart RF,O'Handley R,Lipscombe RJ,Lock RA,Thompson RC

    更新日期:2008-12-01 00:00:00

  • The schistosome in the mammalian host: understanding the mechanisms of adaptation.

    abstract::In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182007002971

    authors: Kusel JR,Al-Adhami BH,Doenhoff MJ

    更新日期:2007-10-01 00:00:00

  • Simple epidemiological model predicts the relationships between prevalence and abundance in ixodid ticks.

    abstract::We tested whether the prevalence of ticks can be predicted reliably from a simple epidemiological model that takes into account only mean abundance and its variance. We used data on the abundance and distribution of larvae and nymphs of 2 ixodid ticks parasitic on small mammals (Apodemus agrarius, Apodemus flavicollis...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001296

    authors: Stanko M,Krasnov BR,Miklisova D,Morand S

    更新日期:2007-01-01 00:00:00

  • Future trends in diagnosis using laboratory-on-a-chip technologies.

    abstract::There has been an enormous growth in the development of biotechnological applications, where advances in the techniques of microelectronic fabrication and the technologies of miniaturization and integration in semiconductor industries are being applied to the production of Laboratory-on-a-Chip devices. The aim of this...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182099004126

    authors: Talary MS,Burt JP,Pethig R

    更新日期:1998-01-01 00:00:00

  • Killing of schistosomula of Schistosoma mansoni by macrophages: induction by T-cell clone-derived lymphokines and interferon-gamma.

    abstract::The induction of schistosomulicidal activity of peritoneal macrophages by concanavalin A-stimulated supernatants from long-term T-cell clones and by interferon-gamma (IFN-gamma) was investigated in detail. Optimal conditions of in vitro macrophage activation by T-cell clone supernatants were established. Macrophages f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200006409x

    authors: Kubelka CF,Ruppel A,Krammer PH,Gemsa D

    更新日期:1986-04-01 00:00:00

  • Identification and characterization of an asparaginyl proteinase (legumain) from the parasitic nematode, Haemonchus contortus.

    abstract::Asparaginyl proteinases (or legumains) are a recently identified, novel class of cysteine proteinase which specifically hydrolyse peptide bonds after asparagine residues. Legumains have been implicated in the activation of cysteine proteases, particularly cathepsin B-like proteinases which are thought to help degrade ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006000229

    authors: Oliver EM,Skuce PJ,McNair CM,Knox DP

    更新日期:2006-08-01 00:00:00

  • Conventional PCR for molecular diagnosis of human strongyloidiasis.

    abstract::Strongyloidiasis is frequently asymptomatic and diagnosis of latent infection is difficult due to limitations of current parasitological and serological methods. This study aimed to verify the use of conventional polymerase chain reaction (PCR) assay for molecular diagnosis of Strongyloides stercoralis infection. Fres...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013002035

    authors: Sitta RB,Malta FM,Pinho JR,Chieffi PP,Gryschek RC,Paula FM

    更新日期:2014-04-01 00:00:00

  • Comparative efficacy of immunization with inactivated whole tachyzoites versus a tachyzoite-bradyzoite mixture against neosporosis in mice.

    abstract::The worldwide economic impact of Neospora caninum infection has caused the development of effective vaccines to become one of the main goals in the field of neosporosis research. In this study, the protection conferred by antigens from inactivated whole tachyzoites (TZ) and a tachyzoite-bradyzoite mixture (TZ-BZ) of N...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011001156

    authors: Rojo-Montejo S,Collantes-Fernández E,Rodríguez-Marcos S,Pérez-Zaballos F,López-Pérez I,Prenafeta A,Ortega-Mora LM

    更新日期:2011-09-01 00:00:00

  • The feeding behaviour of larvae, nymphs and adults of Rhipicephalus appendiculatus.

    abstract::The pre-feeding and feeding periods of larvae, nymphs and adults of Rhipicephalus appendiculatus on rabbits (Oryctolagus cuniculus) were investigated. Larvae and nymphs required at least 8-9 days after hatching and moulting respectively before they could attach and start feeding, while adults required at least 6-9 day...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000043195

    authors: Tukahirwa EM

    更新日期:1976-02-01 00:00:00

  • Resistance towards monensin is proposed to be acquired in a Toxoplasma gondii model by reduced invasion and egress activities, in addition to increased intracellular replication.

    abstract::Monensin (Mon) is an anticoccidial polyether ionophore widely used to control coccidiosis. The extensive use of polyether ionophores on poultry farms resulted in widespread resistance, but the underlying resistance mechanisms are unknown in detail. For analysing the mode of action by which resistance against polyether...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017001512

    authors: Thabet A,Schmidt J,Baumann S,Honscha W,VON Bergen M,Daugschies A,Bangoura B

    更新日期:2018-03-01 00:00:00

  • Dissection of the hierarchy and synergism of the bile derived signal on Cryptosporidium parvum excystation and infectivity.

    abstract::Bile salts have been identified as an important trigger for excystation of Cryptosporidium oocysts but the hierarchy or synergism of this signal in relation to other triggers involved in excystation is poorly understood. In addition to excystation, bile salts have also been reported to increase the invasiveness of spo...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012000984

    authors: King BJ,Keegan AR,Phillips R,Fanok S,Monis PT

    更新日期:2012-10-01 00:00:00

  • First report of Trypanosoma dionisii (Trypanosomatidae) identified in Australia.

    abstract::Trypanosomes are blood-borne parasites that can infect a variety of different vertebrates, including animals and humans. This study aims to broaden scientific knowledge about the presence and biodiversity of trypanosomes in Australian bats. Molecular and morphological analysis was performed on 86 blood samples collect...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020001845

    authors: Austen JM,Van Kampen E,Egan SL,O'Dea MA,Jackson B,Ryan UM,Irwin PJ,Prada D

    更新日期:2020-12-01 00:00:00

  • The effects of age, temperature, light quantity and wavelength on the swimming behaviour of the cercariae of Cryptocotyle lingua (Digenea: Heterophyidae).

    abstract::Laboratory experiments indicated that the active life-span of the cercariae of Cryptocotyle lingua was temperature-dependent. An increase in water temperature and population age both correlated with a tendency for the organisms to become decaudate. The larvae were strongly photoresponsive to lateral light but with tim...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000073789

    authors: Rea JG,Irwin SW

    更新日期:1992-08-01 00:00:00

  • Re-evaluation of the life cycle of Eimeria maxima Tyzzer, 1929 in chickens (Gallus domesticus).

    abstract::A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the Eimeria maxima life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million E. maxima oocysts (APU1), and were necropsied...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017002153

    authors: Dubey JP,Jenkins MC

    更新日期:2018-07-01 00:00:00

  • Effects of parasites upon non-host predator avoidance behaviour in native and invasive gammarids.

    abstract::The acanthocephalan parasite, Polymorphus minutus, manipulates its intermediate hosts' (gammarids) behaviour, presumably to facilitate its transmission to the definitive hosts. A fundamental question is whether this capability has evolved to target gammarids in general, or specifically sympatric gammarids. We assessed...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020002140

    authors: Farahani S,Palsbøll PJ,Pen I,Komdeur J

    更新日期:2020-11-13 00:00:00

  • Magnetic resonance imaging in dogs with neuroangiostrongyliasis (rat lungworm disease).

    abstract::The magnetic resonance imaging (MRI) appearance of the brain and spinal cord in humans with neuroangiostrongyliasis (NA) due to Angiostrongylus cantonensis infection has been well reported. Equivalent studies in animals are lacking. This case series describes clinical and MRI findings in 11 dogs with presumptively or ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020001742

    authors: Wun MK,Malik R,Yu J,Chow KE,Lau M,Podadera JM,Webster N,Lee R,Šlapeta J,Davies S

    更新日期:2020-09-21 00:00:00

  • Changes in the organization of the surface membrane upon transformation of cercariae to schistosomula of the helminth parasite Schistosoma mansoni.

    abstract::Merocyanin 540 (Mc540) is a fluorescent compound which is thought to bind to membranes in which there are substantial amounts of lipid in the lipid-crystalline phase. It is shown here to be of value in detecting the transformation by both mechanical and skin-penetration methods of the cercaria to the schistosomulum. T...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000081671

    authors: Foley M,Kusel JR,Garland PB

    更新日期:1988-02-01 00:00:00

  • Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei.

    abstract::The kinetoplastid parasite Trypanosoma brucei causes African trypanosomiasis in both humans and animals. Infections place a significant health and economic burden on developing nations in sub-Saharan Africa, but few effective anti-parasitic treatments are currently available. Hence, there is an urgent need to identify...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182018001853

    authors: Dickie EA,Young SA,Smith TK

    更新日期:2019-04-01 00:00:00

  • Characterization of a major surface-associated excretory-secretory antigen of Trichinella spiralis larvae with antibodies to keyhole limpet haemocyanin.

    abstract::A multi-subunit antigen (native M(r) > 200 kDa, reduced M(r) 97-100 kDa) has been identified in homogenates of Trichinella spiralis larvae using affinity-purified rabbit anti-keyhole limpet haemocyanin (KLH) antibodies and its cross-reactivity with KLH was confirmed by competition blotting. The antigen was not present...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000080793

    authors: Modha J,Robertson WM,Kennedy MW,Kusel JR

    更新日期:1994-11-01 00:00:00

  • High polymorphism in Plasmodium vivax merozoite surface protein-5 (MSP5).

    abstract::A key issue relating to developing multi-component anti-malarial vaccines, lies in studying Plasmodium vivax surface proteins' genetic variation. The present work was aimed at amplifying, cloning and sequencing the gene encoding P. vivax merozoite surface protein 5 (PvMSP5) in samples obtained from infected patients f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001168

    authors: Gomez A,Suarez CF,Martinez P,Saravia C,Patarroyo MA

    更新日期:2006-12-01 00:00:00

  • Methods in coccidiosis research: separation of oocysts from faeces.

    abstract::Factors which may be important in the large-scale extraction of coccidial oocysts from faeces ha.ve been investigated with Eimeria tenella. Age of bird, inoculum, feeding status at the time of inoculation, period of collection, feeding status during collection, collection medium, homogenization and sieving, flotation,...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000046990

    authors: Ryley JF,Meade R,Hazelhurst J,Robinson TE

    更新日期:1976-12-01 00:00:00

  • Introduction to immune cell signalling.

    abstract::The dynamic interaction of cells of the immune system with other cells, antigens and secreted factors determines the nature of an immune response. The response of individual cells is governed by the sequence of intracellular signalling events triggered following the association of cell surface molecules during cell-ce...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182005008115

    authors: Goodridge HS,Harnett MM

    更新日期:2005-01-01 00:00:00

  • Impairment of growth of Leishmania donovani by Trypanosoma brucei during co-culture.

    abstract::Cells of Leishmania donovani in co-culture with Trypanosoma brucei, were severely affected in their growth, resulting in swelling and subsequent lysis. Similar effects were also observed when Crithidia luciliae or Phytomonas sp. were co-cultured with T. brucei. Direct contact between the cells under investigation and ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000074564

    authors: Coppens I,Ter Kuile BH,Opperdoes FR

    更新日期:1992-12-01 00:00:00

  • Impact of number of isoenzyme loci on the robustness of intraspecific phylogenies using multilocus enzyme electrophoresis: consequences for typing of Trypanosoma cruzi.

    abstract::Thirty-one stocks of Trypanosoma cruzi, the agent of Chagas disease, representative of the genetic variability of the 2 principal lineages, that subdivide T. cruzi, were selected on the basis of previous multilocus enzyme electrophoresis analysis using 21 loci. Analyses were performed with lower numbers of loci to exp...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182003003573

    authors: Breniere SF,Barnabe C,Bosseno MF,Tibayrenc M

    更新日期:2003-09-01 00:00:00

  • The serotoninergic, cholinergic and peptidergic components of the nervous system in the monogenean parasite, Diclidophora merlangi: a cytochemical study.

    abstract::Confocal scanning laser microscopy has been employed with immunocytochemical techniques to map the distribution of serotoninergic and peptidergic components in the nervous system of the monogenean gill-parasite, Diclidophora merlangi; results are compared with the distribution of cholinergic components, following hist...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061266

    authors: Maule AG,Halton DW,Johnston CF,Shaw C,Fairweather I

    更新日期:1990-04-01 00:00:00

  • IgG reactivities against recombinant Rhoptry-Associated Protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children.

    abstract::A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic. Blood samples were collected from children (1-4 years) and tested for IgG antibody reactivity against 2 recombinant protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099004825

    authors: Alifrangis M,Lemnge MM,Moon R,Theisen M,Bygbjerg I,Ridley RG,Jakobsen PH

    更新日期:1999-10-01 00:00:00