Schistosoma mansoni: evidence for a role of serum factors in protecting artificially transformed schistosomula against antibody-mediated killing in vitro.

Abstract:

:Artificially transformed schistosomula of Schistosoma mansoni develop a consistent but small protection against the lethal effects of antibody plus complement when cultured for 24 h in a chemically defined medium. In contrast, they become rapidly resistant to antibody plus complement, when cultured in the presence of a complex medium consisting of equal parts of heat-inactivated rabbit serum and Earle's/lactalbumin or in defined medium supplemented with small amounts of heat-inactivated rabbit serum. Sephadex G-200 gel filtration revealed that the protective factor in rabbit serum is a macromolecule with a molecular weight between 7 and 19 S. Parasites cultured at 10 degrees C or in the presence of 200 microgram of puromycin show less serum-induced protection against the lethal effects of antibody plus complement than do controls.

journal_name

Parasitology

journal_title

Parasitology

authors

Tavares CA,Soares RC,Coelho PM,Gazzinelli G

doi

10.1017/s0031182000049404

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

225-43

issue

2

eissn

0031-1820

issn

1469-8161

journal_volume

77

pub_type

杂志文章
  • Neoglycosylated liposomes as efficient ligands for the evaluation of specific sugar receptors on macrophages in health and in experimental leishmaniasis.

    abstract::Receptors interacting with terminal sugars as ligands are involved in the binding of Leishmania donovani promastigotes to the macrophage surface and their subsequent internalization. Mannose and glucose are specifically involved in the binding process. Decreased binding occurs to macrophages already infected with L. d...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000076253

    authors: Dutta M,Bandyopadhyay R,Basu MK

    更新日期:1994-08-01 00:00:00

  • Health policy impacts on malaria transmission in Costa Rica.

    abstract::Costa Rica is near malaria elimination. This achievement has followed shifts in malaria health policy. Here, we evaluate the impacts that different health policies have had on malaria transmission in Costa Rica from 1913 to 2018. We identified regime shifts and used regression models to measure the impact of different...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020000621

    authors: Chaves LF,Ramírez Rojas M,Prado M,Garcés JL,Salas Peraza D,Marín Rodríguez R

    更新日期:2020-08-01 00:00:00

  • Contrasting regulation of fecundity in two abomasal nematodes of Svalbard reindeer (Rangifer tarandus platyrhynchus).

    abstract::Stability of trichostrogylid populations indicates that some form of density-dependent regulation occurs which could act through fecundity. We present evidence for intraspecific density-dependent effects in 1 of 2, dominant, abomasal nematodes species (Ostertagia gruehneri) of Svalbard reindeer (Rangifer tarandus plat...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001007818

    authors: Irvine RJ,Stien A,Dallas JF,Halvorsen,Langvatn R,Albon SD

    更新日期:2001-06-01 00:00:00

  • The epidemiology of canine leishmaniasis: transmission rates estimated from a cohort study in Amazonian Brazil.

    abstract::We estimate the incidence rate, serological conversion rate and basic case reproduction number (R0) of Leishmania infantum from a cohort study of 126 domestic dogs exposed to natural infection rates over 2 years on Marajó Island, Pará State, Brazil. The analysis includes new methods for (1) determining the number of s...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182097001200

    authors: Quinnell RJ,Courtenay O,Garcez L,Dye C

    更新日期:1997-08-01 00:00:00

  • A Cooperia punctata gene family encoding 14 kDa excretory-secretory antigens conserved for trichostrongyloid nematodes.

    abstract::A polymorphic set of 14 kDa excretory-secretory (E-S) antigen-encoding cDNAs, with similarity to a previously characterized 15 kDa E-S antigen of Haemonchus contortus, was cloned from Cooperia punctata. Five cDNAs encoding predicted proteins of 70-80% identity were sequenced. Genomic analyses of individuals proved the...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001008770

    authors: Yatsuda AP,De Vries E,Vieira Bressan MC,Eysker M

    更新日期:2001-12-01 00:00:00

  • Strongyloides ratti: studies of 75Se-labelled larvae of the homogonic strain in female hosts.

    abstract::A prediction of the hypothesis of Wilson (1977, 1980 a, b) to account for larval migration of homogonic Strongyloides ratti in the host is that the pattern of invasion of the mammary gland of a lactating rat will be quantitatively similar on both sides and independent of the point of entry into the body. Twenty-one su...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000052744

    authors: Wilson PA,Simpson NE

    更新日期:1982-06-01 00:00:00

  • Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library.

    abstract::An M13 phage random 12-mers peptide library was used to screen cathepsin L mimotopes of Fasciola hepatica and to evaluate their immunogenicity in sheep. Seven clones showed positive reactivity to a rabbit anti-cathepsin L1/L2 antiserum in ELISA, and their amino acid sequences deduced by DNA sequencing were tentatively...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118200800471X

    authors: Villa-Mancera A,Quiroz-Romero H,Correa D,Ibarra F,Reyes-Pérez M,Reyes-Vivas H,López-Velázquez G,Gazarian K,Gazarian T,Alonso RA

    更新日期:2008-10-01 00:00:00

  • The influence of health education on the prevalence of intestinal parasites in a low-income community of Campos dos Goytacazes, Rio de Janeiro State, Brazil.

    abstract::In a recent study by our group on the prevalence of intestinal parasitic infections and on the knowledge, attitudes and practices of local residents of Campos dos Goytacazes, Rio de Janeiro, Brazil, we observed that about 50% of the inhabitants were parasitized and had some knowledge of intestinal parasitic infections...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011002253

    authors: Pereira AP,Alencar MF,Cohen SC,Souza-Júnior PR,Cecchetto F,Mathias LS,Santos CP,Almeida JC,de Moraes Neto AH

    更新日期:2012-05-01 00:00:00

  • Morphological characterization of Cryptosporidium parvum life-cycle stages in an in vitro model system.

    abstract::Cryptosporidium parvum is a zoonotic protozoan parasite that mainly affects the ileum of humans and livestock, with the potential to cause severe enteric disease. We describe the complete life cycle of C. parvum in an in vitro system. Infected cultures of the human ileocecal epithelial cell line (HCT-8) were observed ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009990837

    authors: Borowski H,Thompson RC,Armstrong T,Clode PL

    更新日期:2010-01-01 00:00:00

  • Isolation, fractionation and partial characterization of the tegumental surface from protoscoleces of the hydatid organism, Echinococcus granulosus.

    abstract::Several approaches were adopted for the disruption and removal of the tegumental surface from protoscoleces of the horse strain of the hydatid organism, Echinococcus granulosus. The effectiveness of each method and the purity of subsequent microthrix-enriched fractions obtained by differential centrifugation were eval...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000049064

    authors: McManus DP,Barrett NJ

    更新日期:1985-02-01 00:00:00

  • What has proteomics taught us about Leishmania development?

    abstract::Leishmania are obligatory intracellular parasitic protozoa that cycle between sand fly mid-gut and phagolysosomes of mammalian macrophages. They have developed genetically programmed changes in gene and protein expression that enable rapid optimization of cell function according to vector and host environments. During...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182012000157

    authors: Tsigankov P,Gherardini PF,Helmer-Citterich M,Zilberstein D

    更新日期:2012-08-01 00:00:00

  • Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.

    abstract::We examined the mechanism of action and compared the anthelmintic efficacy of cysteine proteinases from papaya, pineapple, fig, kiwi fruit and Egyptian milkweed in vitro using the rodent gastrointestinal nematode Heligmosomoides polygyrus. Within a 2 h incubation period, all the cysteine proteinases, with the exceptio...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004006225

    authors: Stepek G,Buttle DJ,Duce IR,Lowe A,Behnke JM

    更新日期:2005-02-01 00:00:00

  • The number and size of ovarian balls of Moniliformis (Acanthocephala) from laboratory rats.

    abstract::By means of conventional light microscopical and counting procedures, estimations have been made of the average number and size of ovarian balls from unfertilized and fertilized female Moniliformis dubius. The observations were made on worms recovered from experimental primary infections lasting 1, 2, 3, 4, 5, 8, 11, ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000051337

    authors: Crompton DW,Arnold S

    更新日期:1976-08-01 00:00:00

  • An agent-based model of exposure to human toxocariasis: a multi-country validation.

    abstract::Seroprevalence data illustrate that human exposure to Toxocara is frequent. Environmental contamination with Toxocara spp. eggs is assumed to be the best indicator of human exposure, but increased risk of exposure has also been associated with many other factors. Reported associations are inconsistent, however, and th...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000310

    authors: Kanobana K,Devleesschauwer B,Polman K,Speybroeck N

    更新日期:2013-07-01 00:00:00

  • In vitro influence of Theileria annulata on the functions of bovine dendritic cells for stimulation of T lymphocyte proliferation.

    abstract::The present study was performed on antigen-presenting cells (APCs) of Theileria annulata transformed dendritic cells (TaDCs) and monocyte-derived dendritic cells (MoDCs) to compare differences in antigen presentation and stimulation of T lymphocyte proliferation. Antigen presentation for T lymphocyte proliferation was...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182019001227

    authors: Rashid M,Liu J,Guan G,Wang J,Li Z,Hassan MA,Rashid MI,Mukhtar MU,Luo J,Yin H

    更新日期:2020-01-01 00:00:00

  • Sympatric western lowland gorillas, central chimpanzees and humans are infected with different trichomonads.

    abstract::We investigated intestinal trichomonads in western lowland gorillas, central chimpanzees and humans cohabiting the forest ecosystem of Dzanga-Sangha Protected Area in Central African Republic, using the internal transcribed spacer (ITS) region and SSU rRNA gene sequences. Trichomonads belonging to the genus Tetratrich...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182019001343

    authors: Petrželková KJ,Smejkalová P,Céza V,Pafčo B,Shutt-Phillips KA,Todd A,Jirků-Pomajbíková K,Benavides J,Modrý D,Čepička I

    更新日期:2020-02-01 00:00:00

  • Soil-transmitted helminth infections in school children from Cocle Province, Republic of Panama.

    abstract::A survey was carried out to determine values for the prevalence and intensity of infection of intestinal helminths in children living in Cocle Province, Republic of Panama. The data set consisted of the results of microscopic examinations (modified Kato Katz technique) of stool samples collected in November 1987 from ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000058741

    authors: Robertson LJ,Crompton DW,Walters DE,Nesheim MC,Sanjur D,Walsh EA

    更新日期:1989-10-01 00:00:00

  • Comparison of the efficacy of tea tree (Melaleuca alternifolia) oil with other current pharmacological management in human demodicosis: A Systematic Review.

    abstract::Various treatments are found to be moderately effective in managing Demodex-related diseases except tea tree oil (TTO) and terpinen-4-ol (T4O), which showed superior miticidal and anti-inflammatory effects in numerous clinical studies. Their possible effects include lowering mite counts, relieving Demodex-related symp...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118202000150X

    authors: Lam NSK,Long XX,Li X,Yang L,Griffin RC,Doery JC

    更新日期:2020-12-01 00:00:00

  • Proteomics at the schistosome-mammalian host interface: any prospects for diagnostics or vaccines?

    abstract::Since 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The p...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182012000339

    authors: Wilson RA

    更新日期:2012-08-01 00:00:00

  • The virus infecting the parasitoid Leptopilina boulardi exerts a specific action on superparasitism behaviour.

    abstract::Parasites often induce behavioural changes in their host. However, it is not necessarily easy to determine whether these changes are representative of an adaptation of the parasite (parasite manipulation), an adaptive response of the host or a side-effect of infection. In a solitary parasitoid of Drosophila larvae (Le...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006009930

    authors: Varaldi J,Petit S,Boulétreau M,Fleury F

    更新日期:2006-06-01 00:00:00

  • Detection of eight Cryptosporidium genotypes in surface and waste waters in Europe.

    abstract::Cryptosporidia are important protozoan parasites of vertebrates, and a number of species and genotypes, with different host ranges, have been described. In this study a protocol was established for the detection and the genetic characterization of Cryptosporidium spp. isolated from various types of surface waters (riv...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001001317

    authors: Ward PI,Deplazes P,Regli W,Rinder H,Mathis A

    更新日期:2002-04-01 00:00:00

  • Evaluation of salinomycin isolated from Streptomyces albus JSY-2 against the ciliate, Ichthyophthirius multifiliis.

    abstract::The present study was undertaken to investigate the antiparasitic activity of extracellular products of Streptomyces albus. Bioactivity-guided isolation of chloroform extracts affording a compound showing potent activity. The structure of the compound was elucidated as salinomycin (SAL) by EI-MS, 1H NMR and 13C NMR. I...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182018001919

    authors: Yao JY,Gao MY,Jia YY,Wu YX,Yin WL,Cao Z,Yang GL,Huang HB,Wang CF,Shen JY,Gu ZM

    更新日期:2019-04-01 00:00:00

  • Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.

    abstract::The phenotypic activity of two 5-nitroindazolinones, i.e. 2-benzyl-1-propyl (22) and 2-benzyl-1-butyl (24) derivatives, previously proposed as anti-Trypanosoma cruzi prototypes, was presently assayed on bloodstream trypomastigotes (BT) of the moderately drug-resistant Y strain. Further exploration of putative targets ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016001098

    authors: Fonseca-Berzal C,DA Silva CF,Menna-Barreto RF,Batista MM,Escario JA,Arán VJ,Gómez-Barrio A,Soeiro Mde N

    更新日期:2016-09-01 00:00:00

  • Detection of circulating trypanosomal antigens by double antibody ELISA using antibodies to procyclic trypanosomes.

    abstract::A double antibody sandwich ELISA technique has been developed for detection of antigens of African trypanosomes present in the sera of infected mammals. The assay uses a high titre, high affinity rabbit antiserum made to purified membranes of procyclic trypanosomes as "capture" reagent and a mixture of three biotin-la...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000057735

    authors: Liu MK,Pearson TW

    更新日期:1987-10-01 00:00:00

  • The complexity of the sylvatic cycle of Trypanosoma cruzi in Rio de Janeiro state (Brazil) revealed by the non-transcribed spacer of the mini-exon gene.

    abstract::American trypanosamiasis occurs in nature as a sylvatic cycle, where Trypanosoma cruzi interacts with wild triatomines and mammalian reservoirs, such as marsupials, rodents, armadillos and other animals. Due to difficulties in trying to isolate T. cruzi stocks from the sylvatic cycle, very few studies have been perfor...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098003709

    authors: Fernandes O,Mangia RH,Lisboa CV,Pinho AP,Morel CM,Zingales B,Campbell DA,Jansen AM

    更新日期:1999-02-01 00:00:00

  • Variation of transient gene expression within single lineages of Trypanosoma cruzi.

    abstract::The biodiversity of Trypanosoma cruzi is one of the main factors complicating the understanding of its molecular epidemiology. As an alternative to classical genetic methods, investigators have used DNA-mediated transformation techniques to study this diversity. Recently, transient expression data were shown to correl...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099005053

    authors: Laurent JP,Swindle J

    更新日期:1999-12-01 00:00:00

  • Host-parasite relationship between congenital Toxoplasma infection and mouse brain: role of small vessels.

    abstract::Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened bas...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000063873

    authors: Sims TA,Hay J

    更新日期:1995-02-01 00:00:00

  • Purification of a 64 kDa antigen from Trypanosoma evansi that exhibits cross-reactivity with Trypanosoma vivax.

    abstract::Trypanosoma evansi and Trypanosoma vivax are the most extensively distributed trypanosomes responsible for diseases in livestock. Western blot and indirect immunofluorescence assays revealed a high immunological cross-reaction between these two parasites. An antigen with an apparent molecular mass of 64 kDa (p64), whi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001001214

    authors: Uzcanga G,Mendoza M,Aso PM,Bubis J

    更新日期:2002-03-01 00:00:00

  • Dynamic interaction between CD4+ T cells and parasitic helminths: mathematical models of heterogeneity in outcome.

    abstract::Potential mechanisms of immunoregulation have been investigated for the capacity to generate heterogeneity in the outcome of infection with helminth parasites. We have developed a mathematical model of the interaction between T cell and parasite populations, based on the assumption that activation of a Th1 CD4+ T cell...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000074692

    authors: Schweitzer AN,Anderson RM

    更新日期:1992-12-01 00:00:00

  • Widespread infection of the Eastern red-spotted newt (Notophthalmus viridescens) by a new species of Amphibiocystidium, a genus of fungus-like mesomycetozoan parasites not previously reported in North America.

    abstract::Given the worldwide decline of amphibian populations due to emerging infectious diseases, it is imperative that we identify and address the causative agents. Many of the pathogens recently implicated in amphibian mortality and morbidity have been fungal or members of a poorly understood group of fungus-like protists, ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003708

    authors: Raffel TR,Bommarito T,Barry DS,Witiak SM,Shackelton LA

    更新日期:2008-02-01 00:00:00