Abstract:
:Artificially transformed schistosomula of Schistosoma mansoni develop a consistent but small protection against the lethal effects of antibody plus complement when cultured for 24 h in a chemically defined medium. In contrast, they become rapidly resistant to antibody plus complement, when cultured in the presence of a complex medium consisting of equal parts of heat-inactivated rabbit serum and Earle's/lactalbumin or in defined medium supplemented with small amounts of heat-inactivated rabbit serum. Sephadex G-200 gel filtration revealed that the protective factor in rabbit serum is a macromolecule with a molecular weight between 7 and 19 S. Parasites cultured at 10 degrees C or in the presence of 200 microgram of puromycin show less serum-induced protection against the lethal effects of antibody plus complement than do controls.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Tavares CA,Soares RC,Coelho PM,Gazzinelli Gdoi
10.1017/s0031182000049404subject
Has Abstractpub_date
1978-10-01 00:00:00pages
225-43issue
2eissn
0031-1820issn
1469-8161journal_volume
77pub_type
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