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Patient eligibility for anti-fibrotic therapy in idiopathic pulmonary fibrosis can be altered by use of different sets of reference values for calculation of FVC percent predicted.

Abstract：

:Antifibrotic drugs for idiopathic pulmonary fibrosis patients in England and Scotland are only available to those with FVC percent predicted (FVC%pred) less than or equal to 80%. The prescribing guidance does not state which set of reference values should be used and we show that a patient's FVC%pred can change by 4-6% depending on the choice of reference. We calculated FVC%pred for a group of 528 IPF patients using three different sets of reference values. 90% of patients with FVC%pred 80-85% calculated using European Community Coal and Steel (ECSC) reference values fall into the eligible range when NHANES reference values are used.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Ward K,Spurr L,Goldman NR,Margaritopoulos GA,Kokosi M,Renzoni E,Chua F,Maher TM,Ward S,Wells AU

doi

10.1016/j.rmed.2016.10.007

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

131-133

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(16)30260-8

journal_volume

120

pub_type

信件

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