Abstract:
BACKGROUND:Previous research has found conflictive results regarding the benefits of inspiratory muscle training (IMT) for cystic fibrosis (CF) patients. Also, involvement of postural stability is a rising concern in chronic lung diseases but its role in CF patients is poorly understood. Our aim was to investigate the effects of IMT in CF patients as well as analysing the factors which may be related to postural stability. METHODS:Thirty-six children aged between 8 and 18 years with CF were randomly allocated to either "comprehensive chest PT" group (PT) or "IMT alongside comprehensive chest PT" group (PT+IMT). Both groups trained for 8 weeks. Dynamic and static postural stability tests on Biodex Balance system®, spirometry, respiratory muscle strength and 6-min walk distance (6MWD) was assessed at baseline and after 8 weeks of training. Determinants of postural stability was also analysed on baseline values. RESULTS:Maximum expiratory pressure (MEP) was found to be an independent predictor for overall limits of stability (LOS) score explaining %26 of variance (R = 0.514, p = 0.003). Overall LOS score, FVC, FEV1, peak expiratory flow, MEP and 6MWD significantly improved in both groups, with no significant differences between groups. Maximum inspiratory pressure (MIP) also improved in both groups but the magnitude of improvement in MIP was greater in PT+IMT group (38 cmH2O vs 13 cmH2O; p < 0.001). CONCLUSIONS:Combining IMT with chest PT failed to provide further improvements, except for MIP, suggesting that a comprehensive chest PT program may be individually effective in improving overall LOS score, spirometry, respiratory muscle strength and 6MWD. TRIAL REGISTRATION:www.ClinicalTrials.gov; registration number: NCT03375684.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Zeren M,Cakir E,Gurses HNdoi
10.1016/j.rmed.2019.01.013subject
Has Abstractpub_date
2019-03-01 00:00:00pages
24-30eissn
0954-6111issn
1532-3064pii
S0954-6111(19)30029-0journal_volume
148pub_type
杂志文章,随机对照试验abstract::Heart-lung transplantation involves denervation of the lungs below the tracheal anastomosis, with associated permanent loss of all pulmonary innervation except post-ganglionic efferent nerves. This is supported by loss of the cough reflex to inhaled USNDW, which also implies that the RARs which mediate this cough mech...
journal_title:Respiratory medicine
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journal_title:Respiratory medicine
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abstract::The Lion Intoximeter 3000 has been used for evidential breath testing in the U.K. for some years. Some individuals with lung diseases have difficulty in providing evidential breath samples using the device. This study describes an investigation that we have carried out on a newer instrument--the Lion Intoxilyzer 6000U...
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:2019-06-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.11.027
更新日期:2007-09-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2007.04.001
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,meta分析,评审
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-06-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2008.07.007
更新日期:2008-12-01 00:00:00
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更新日期:2017-06-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-01-01 00:00:00