Effects of inspiratory muscle training on postural stability, pulmonary function and functional capacity in children with cystic fibrosis: A randomised controlled trial.

Abstract:

BACKGROUND:Previous research has found conflictive results regarding the benefits of inspiratory muscle training (IMT) for cystic fibrosis (CF) patients. Also, involvement of postural stability is a rising concern in chronic lung diseases but its role in CF patients is poorly understood. Our aim was to investigate the effects of IMT in CF patients as well as analysing the factors which may be related to postural stability. METHODS:Thirty-six children aged between 8 and 18 years with CF were randomly allocated to either "comprehensive chest PT" group (PT) or "IMT alongside comprehensive chest PT" group (PT+IMT). Both groups trained for 8 weeks. Dynamic and static postural stability tests on Biodex Balance system®, spirometry, respiratory muscle strength and 6-min walk distance (6MWD) was assessed at baseline and after 8 weeks of training. Determinants of postural stability was also analysed on baseline values. RESULTS:Maximum expiratory pressure (MEP) was found to be an independent predictor for overall limits of stability (LOS) score explaining %26 of variance (R = 0.514, p = 0.003). Overall LOS score, FVC, FEV1, peak expiratory flow, MEP and 6MWD significantly improved in both groups, with no significant differences between groups. Maximum inspiratory pressure (MIP) also improved in both groups but the magnitude of improvement in MIP was greater in PT+IMT group (38 cmH2O vs 13 cmH2O; p < 0.001). CONCLUSIONS:Combining IMT with chest PT failed to provide further improvements, except for MIP, suggesting that a comprehensive chest PT program may be individually effective in improving overall LOS score, spirometry, respiratory muscle strength and 6MWD. TRIAL REGISTRATION:www.ClinicalTrials.gov; registration number: NCT03375684.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Zeren M,Cakir E,Gurses HN

doi

10.1016/j.rmed.2019.01.013

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

24-30

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(19)30029-0

journal_volume

148

pub_type

杂志文章,随机对照试验
  • Pulmonary reflexes after human heart-lung transplantation.

    abstract::Heart-lung transplantation involves denervation of the lungs below the tracheal anastomosis, with associated permanent loss of all pulmonary innervation except post-ganglionic efferent nerves. This is supported by loss of the cough reflex to inhaled USNDW, which also implies that the RARs which mediate this cough mech...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/s0954-6111(06)80248-9

    authors: Hathaway T,Higenbottam T,Lowry R,Wallwork J

    更新日期:1991-01-01 00:00:00

  • The long term outcome of patients with unexplained chronic cough.

    abstract:INTRODUCTION:Up to 40% of patients seen in a cough clinic have unexplained chronic cough. The long term outcome of these patients is uncertain. OBJECTIVE:To determine the long-term outcome in patients diagnosed with unexplained chronic cough. METHODS:We have performed a longitudinal study of symptoms, airway inflamma...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2012.11.018

    authors: Yousaf N,Montinero W,Birring SS,Pavord ID

    更新日期:2013-03-01 00:00:00

  • A study to investigate the ability of subjects with chronic lung diseases to provide evidential breath samples using the Lion Intoxilyzer 6000 UK breath alcohol testing device.

    abstract::The Lion Intoximeter 3000 has been used for evidential breath testing in the U.K. for some years. Some individuals with lung diseases have difficulty in providing evidential breath samples using the device. This study describes an investigation that we have carried out on a newer instrument--the Lion Intoxilyzer 6000U...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1053/rmed.2000.0797

    authors: Honeybourne D,Moore AJ,Butterfield AK,Azzan L

    更新日期:2000-07-01 00:00:00

  • Lactate dehydrogenase isoenzyme analysis for the diagnosis of pleural effusion in haemato-oncological patients.

    abstract::This study aimed to evaluate the utility of the pleural fluid lactate dehydrogenase (LDH) isoenzyme algorithm for the differential diagnosis of pleural fluid in patients with haematological malignancies. Twenty consecutive haemato-oncological patients with pleural effusion, hospitalized in the Haematology Department d...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/s0954-6111(99)90315-3

    authors: Lossos IS,Intrator O,Berkman N,Breuer R

    更新日期:1999-05-01 00:00:00

  • Analysis of the factors related to mortality in patients with bronchiectasis.

    abstract:BACKGROUND:Bronchiectasis is a common disabling but rarely fatal disease. However the long-term prognosis and risk factors for mortality are not well known. OBJECTIVE:The aim of this study was to determine prospectively the survival and predictive factors of mortality in patients with bronchiectasis, during 4-year fol...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2007.02.002

    authors: Onen ZP,Gulbay BE,Sen E,Yildiz OA,Saryal S,Acican T,Karabiyikoglu G

    更新日期:2007-07-01 00:00:00

  • Statins: cause of fibrosis or the opposite? Effect of cardiovascular drugs in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND AND OBJECTIVE:Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with poor prognosis despite the recent availability of two antifibrotic drugs. Patients are more susceptible to cardiovascular comorbidities. In this study, we aimed to determine the impact of concom...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2020.106259

    authors: M Lambert E,A Wuyts W,Yserbyt J,De Sadeleer LJ

    更新日期:2020-11-26 00:00:00

  • Effects of positive end-expiratory pressure (PEEP) in cardiac surgery patients.

    abstract::The role of positive end-expiratory pressure (PEEP) in the postoperative course of cardiac surgery patients remains questionable. In this prospective study, we examined the effect of different levels of PEEP on arterial oxygenation, SvO2 and PvO2 values, and on haemodynamic indices, during the early postoperative peri...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0954-6111(98)90388-2

    authors: Michalopoulos A,Anthi A,Rellos K,Geroulanos S

    更新日期:1998-06-01 00:00:00

  • Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection.

    abstract::Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2006.08.015

    authors: Bresser P,Cornelissen MI,van der Bij W,van Noesel CJ,Timens W

    更新日期:2007-04-01 00:00:00

  • Chronic obstructive lung disease and respiratory muscle function: the role of nutrition and exercise training in cystic fibrosis.

    abstract::Malnutrition may be an extremely important complicating factor in patients with a variety of chronic lung diseases. The impact of malnutrition on lung disease and respiratory muscle function has been extensively studied in patients with chronic lung disease due to cystic fibrosis (CF). In patients with CF it appears t...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/0954-6111(93)90127-l

    authors: Heijerman HG

    更新日期:1993-08-01 00:00:00

  • Is inhalation rate important for a dry powder inhaler? Using the In-Check Dial to identify these rates.

    abstract::The fraction of the emitted dose from an inhaler that has the potential to be deposited into the lungs is known as the fine particle dose (also the respirable dose). During inhalation all dry powder inhalers require a 'force' to be created inside the device so that a fine particle dose is generated from the formulatio...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1053/rmed.2003.1351

    authors: Chrystyn H

    更新日期:2003-02-01 00:00:00

  • The effect of a time delay on the measurement of capillary blood gases.

    abstract::Patients using domiciliary nasal ventilation, or long-term oxygen, require regular assessment which could be carried out in the home. Blood gas analysis may be regarded as an essential part of the assessment. The present study investigated the effect of a 1-h time delay on the measurement of capillary blood gases. Fou...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/s0954-6111(96)90207-3

    authors: Bird CM,Revill SM,Vara DD,Morgan MD

    更新日期:1996-02-01 00:00:00

  • Salmeterol provides prolonged protection against exercise-induced bronchoconstriction in a majority of subjects with mild, stable asthma.

    abstract::In patients with asthma, exercise-induced symptoms are well recognized and frequently limiting. Currently available beta 2-receptor agonists have a short duration of action and breakthrough symptoms may occur. We studied the efficacy of the recently developed long acting inhaled beta 2-agonist salmeterol with respect ...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0954-6111(93)90070-g

    authors: Newnham DM,Ingram CG,Earnshaw J,Palmer JB,Dhillon DP

    更新日期:1993-08-01 00:00:00

  • An economic analysis of pharmacological treatment of COPD in Spain.

    abstract:BACKGROUND:COPD is a prevalent disease that generates high use of resources. The objective of this study was to quantify the economic consequences of non-adherence to GOLD guidelines for the management of COPD patients. METHOD:An economic model was generated to compare different scenarios of observed vs. expected cost...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2008.11.019

    authors: Miravitlles M,Brosa M,Velasco M,Crespo C,Gobartt E,Diaz S,González-Rojas N

    更新日期:2009-05-01 00:00:00

  • The effects of chronic obstructive airways disease on the ability to drive and to use a roadside alcolmeter.

    abstract::Subjects with chronic obstructive airways disease may have difficulty with the roadside alcolmeter. Twenty-six subjects with a FEV1/FVC less than 60% were asked to use an alcolmeter simulator. Only ten were able to produce the necessary flow rate of 28 l min-1 for a minimum of 2.7 s, two could produce the same total v...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0954-6111(08)80093-5

    authors: Briggs JE,Patel H,Butterfield K,Honeybourne D

    更新日期:1990-01-01 00:00:00

  • Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease.

    abstract:BACKGROUND:Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. OBJECTIVE:To investigate the effect of long-term AD on cli...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2019.04.021

    authors: Tyrak KE,Kupryś-Lipińska I,Czarnobilska E,Jakieła B,Pajdzik K,Ćmiel A,Plutecka H,Koziej M,Gawrońska A,Konduracka E,Kuna P,Sanak M,Mastalerz L

    更新日期:2019-06-01 00:00:00

  • Bronchoalveolar lavage quality influences the T4/T8 ratio in sarcoidosis.

    abstract:BACKGROUND:Sarcoidosis is characterised by a T-lymphocytic alveolitis with a typically increased T4/T8 ratio. The diagnostic value of this ratio is under debate. AIM OF THE WORK:We prospectively evaluated the influence of BAL pre-lavage and the impact of bronchial contamination on BAL differential cell count in 108 BA...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2006.11.027

    authors: Reichenberger F,Kleiber B,Baschiera B,Bubendorf L,Brutsche M,Dalquen P,Tamm M

    更新日期:2007-09-01 00:00:00

  • Comparison of mannitol and citric acid cough provocation tests.

    abstract:RATIONALE:Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory approval and can be performed utilizing a simple disposable inhaler in a standardized manner. OBJECTIV...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2019.09.011

    authors: Nurmi HM,Lätti AM,Brannan JD,Koskela HO

    更新日期:2019-01-01 00:00:00

  • NT-proBNP in chronic hypercapnic respiratory failure: a marker of disease severity, treatment effect and prognosis.

    abstract:BACKGROUND:Natriuretic peptides are considered as reliable indicators of left-heart failure (HF) and are useful for differential diagnosis of dyspnoea. AIM:We evaluated the clinical significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic hypercapnic respiratory failure (CHRF). ME...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2007.04.001

    authors: Budweiser S,Luchner A,Jörres RA,Heinemann F,Hitzl AP,Schmidbauer K,Riegger G,Pfeifer M

    更新日期:2007-09-01 00:00:00

  • Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study.

    abstract:OBJECTIVE:We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). METHODS:Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2017.10.003

    authors: Pan J,Xu L,Lam TH,Jiang CQ,Zhang WS,Jin YL,Zhu F,Zhu T,Thomas GN,Cheng KK,Adab P

    更新日期:2017-11-01 00:00:00

  • An overview of nine clinical trials of salmeterol in an asthmatic population.

    abstract::In an attempt to establish the protection afforded by regular salmeterol use against induced bronchoconstriction in asthmatic patients, a meta-analysis was conducted on nine double-blind clinical trials that fulfilled the inclusion criteria. In each trial, subjects were randomly assigned to receive either salmeterol 5...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,meta分析

    doi:10.1016/s0954-6111(98)90012-9

    authors: Verberne AA,Fuller R

    更新日期:1998-05-01 00:00:00

  • High levels of PEEP may improve survival in acute respiratory distress syndrome: A meta-analysis.

    abstract:OBJECTIVE:Positive end-expiratory pressure (PEEP) has been viewed as an essential component of mechanical ventilation in acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). However, clinical trials have not yet convincingly demonstrated that high PEEP levels improve survival. The object of this stud...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.rmed.2009.02.008

    authors: Oba Y,Thameem DM,Zaza T

    更新日期:2009-08-01 00:00:00

  • Multinational cohort study of mortality in patients with asthma and severe asthma.

    abstract:BACKGROUND:Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient characteristics associated with all-cause mortality in asthma. METHODS:Asthma patients aged ≥18 years and...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2020.105919

    authors: Engelkes M,de Ridder MA,Svensson E,Berencsi K,Prieto-Alhambra D,Lapi F,Giaquinto C,Picelli G,Boudiaf N,Albers FC,Cockle SM,Bradford ES,Suruki RY,Brusselle GG,Rijnbeek PR,Sturkenboom MC,Verhamme KM

    更新日期:2020-01-01 00:00:00

  • Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study.

    abstract:BACKGROUND:In a 1-year, randomized, open-label study in patients with moderate-to-severe allergic (immunoglobulin E (IgE)-mediated) asthma, adding omalizumab to best standard care (BSC) significantly improved efficacy outcomes compared with BSC alone (control). We assessed the efficacy of omalizumab in the subgroup of ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.rmed.2008.06.002

    authors: Niven R,Chung KF,Panahloo Z,Blogg M,Ayre G

    更新日期:2008-10-01 00:00:00

  • Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation.

    abstract:OBJECTIVE:To assess whether tumor necrosis factor (TNF) antagonism can attenuate eosinophilic airway inflammation in patients with mild-to-moderate allergic asthma. DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:National Institutes of Health (NIH) Clinical Center. PATIENTS:Twenty-six patients wit...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.rmed.2005.02.031

    authors: Rouhani FN,Meitin CA,Kaler M,Miskinis-Hilligoss D,Stylianou M,Levine SJ

    更新日期:2005-09-01 00:00:00

  • Resting and ADL-induced dynamic hyperinflation explain physical inactivity in COPD better than FEV1.

    abstract:BACKGROUND:Physical activity and health status deteriorate early in the course of chronic obstructive pulmonary disease (COPD). This can only partially be explained by the degree of airflow limitation. Changes in (resting and dynamic) lung volumes are known to be associated with functional impairments and thus might in...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.rmed.2013.02.017

    authors: Lahaije AJ,van Helvoort HA,Dekhuijzen PN,Vercoulen JH,Heijdra YF

    更新日期:2013-06-01 00:00:00

  • Evaluation of multidimensional COPD-related subjective fatigue following a pulmonary rehabilitation programme.

    abstract:INTRODUCTION:Subjective fatigue has been recognised as an important, multi-component symptom in COPD. Pulmonary Rehabilitation (PR) improves fatigue component of the Chronic Respiratory Questionnaire, a quality of life (QoL) measure. However, it is not clear if all fatigue dimensions are affected equally. This study ai...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2013.09.003

    authors: Lewko A,Bidgood PL,Jewell A,Garrod R

    更新日期:2014-01-01 00:00:00

  • The effect of massive weight loss on pulmonary function of morbid obese patients.

    abstract:STUDY OBJECTIVES:To test if morbid obesity causes pulmonary function changes and if massive weight loss have effect on pulmonary function (especially in subjects with BMI>or=60 kg/m(2)). PARTICIPANTS:Thirty-nine morbid obese subjects before and after massive weight loss. MEASUREMENTS AND RESULTS:Patients had baseline...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2005.09.021

    authors: Santana AN,Souza R,Martins AP,Macedo F,Rascovski A,Salge JM

    更新日期:2006-06-01 00:00:00

  • Non-reversible airway obstruction in never smokers: results from the Austrian BOLD study.

    abstract:BACKGROUND:The presence of non-reversible airway obstruction (AO) in never smokers has only received limited attention until now. METHODS:We analyzed data from the Austrian Burden of Obstructive Lung Disease (BOLD) study. We defined non-reversible AO as post-bronchodilator FEV(1)/FVC <0.7 which corresponds to COPD I a...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2008.07.007

    authors: Lamprecht B,Schirnhofer L,Kaiser B,Buist S,Studnicka M

    更新日期:2008-12-01 00:00:00

  • Cardiopulmonary exercise testing and second-line pulmonary function tests to detect obstructive pattern in symptomatic smokers with borderline spirometry.

    abstract:BACKGROUND:The need for additional research on symptomatic smokers with normal spirometry has been recently emphasized. Albeit not meeting criteria for Chronic obstructive pulmonary disease (COPD) diagnosis, symptomatic smokers may experience activity limitation, evidence of airway disease, and exacerbations. We, there...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2017.04.006

    authors: Di Marco F,Terraneo S,Job S,Rinaldo RF,Sferrazza Papa GF,Roggi MA,Santus P,Centanni S

    更新日期:2017-06-01 00:00:00

  • Etiology of community-acquired pneumonia treated in an ambulatory setting.

    abstract:BACKGROUND:Very few studies have addressed the etiology of community-acquired pneumonia (CAP) treated in an ambulatory setting. METHODS:Patients were recruited from physicians' offices and from Emergency Rooms in Canada. Pneumonia was defined as two or more respiratory symptoms and signs and a new opacity on chest rad...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.rmed.2004.05.010

    authors: Marrie TJ,Poulin-Costello M,Beecroft MD,Herman-Gnjidic Z

    更新日期:2005-01-01 00:00:00