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Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection.

Abstract：

:Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV-8 latency-associated nuclear antigen 1 (LANA-1) was demonstrated. Using two nested polymerase chain reactions (PCR) to amplify part of the open reading frame (ORF) 65 and ORF 73, we failed to detect HHV-8 DNA in all samples studied. These results argue strongly against a role for HHV-8 in the pathogenesis of iPAH.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Bresser P,Cornelissen MI,van der Bij W,van Noesel CJ,Timens W

doi

10.1016/j.rmed.2006.08.015

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

854-6

issue

4

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(06)00410-0

journal_volume

101

pub_type

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