Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay.


:Antigen detection is a useful adjunct for the diagnosis of histoplasmosis. The purpose of this study was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83.3%) blastomycosis cases using the second-generation assay vs. 13 of 19 (68%) and 4 of 6 (66.7%), respectively, in the original assay. Ten-fold concentration permitted detection of antigen in an additional case of histoplasmosis and another with blastomycosis, for an overall sensitivity of 23 of 25 (92.0%). Specificity was 98.2% in both assays in controls with other pulmonary infections. These findings support the diagnostic utility of the second-generation assay in patients with pulmonary histoplasmosis and blastomycosis.


Respir Med


Respiratory medicine


Hage CA,Davis TE,Egan L,Parker M,Fuller D,Lemonte AM,Durkin M,Connelly P,Joseph Wheat L,Blue-Hnidy D,Knox KS




Has Abstract


2007-01-01 00:00:00














  • Exploring the care needs of patients with advanced COPD: an overview of the literature.

    abstract::Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition worldwide and is associated with significant mortality. This paper gives an overview of the relevant literature regarding care needs in advanced COPD from the perspective of the patient or carer, and aims to explore the appropriateness of a p...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Gardiner C,Gott M,Payne S,Small N,Barnes S,Halpin D,Ruse C,Seamark D

    更新日期:2010-02-01 00:00:00

  • Stepping down from combination asthma therapy: The predictors of outcome.

    abstract:BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章


    authors: Koskela HO,Purokivi MK,Kokkarinen J

    更新日期:2016-08-01 00:00:00

  • Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects.

    abstract::Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Tao H,Yang JJ,Zhou X,Deng ZY,Shi KH,Li J

    更新日期:2016-01-01 00:00:00

  • Ethnic and racial differences in the presence of idiopathic pulmonary fibrosis at death.

    abstract:BACKGROUND:In studies of idiopathic pulmonary fibrosis (IPF), whites makeup the vast majority of subjects. Whether ethnic/racial differences in idiopathic pulmonary fibrosis occur in the general population is unknown. METHODS:To compare the presence of IPF between ethnic/racial groups of U.S. decedents from 1989 to 20...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Swigris JJ,Olson AL,Huie TJ,Fernandez-Perez ER,Solomon J,Sprunger D,Brown KK

    更新日期:2012-04-01 00:00:00

  • Compliance in subcutaneous and sublingual allergen immunotherapy: A nationwide study.

    abstract:INTRODUCTION:Allergic rhino-conjunctivitis is a highly prevalent condition. In moderate to severe cases, allergen immunotherapy (AIT) is a cost-effective therapeutic option. Previous data have reported a large difference in treatment compliance of subcutaneously (SCIT) and sublingually (SLIT) administered AIT. METHODS...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Borg M,Løkke A,Hilberg O

    更新日期:2020-01-01 00:00:00

  • Long-term non-invasive ventilation in COPD after acute-on-chronic respiratory failure.

    abstract:BACKGROUND:COPD patients who remain hypercapnic after acute respiratory failure requiring mechanical ventilation have a poor prognosis. Long-term nocturnal non-invasive ventilation (NIV) may be beneficial for these patients. We hypothesized that stable patients on long-term NIV would experience clinical worsening after...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Funk GC,Breyer MK,Burghuber OC,Kink E,Kirchheiner K,Kohansal R,Schmidt I,Hartl S

    更新日期:2011-03-01 00:00:00

  • Bronchial responsiveness to histamine and methacholine measured with forced expirations and with the forced oscillation technique.

    abstract::The objective of this study was to compare bronchial challenge tests with two substances [histamine (H) and methacholine (M)] and two methods of measuring the effect parameter FEV1 and pulmonary impedance [with the forced oscillation technique (FOT)] in order to determine which test is the shortest, and gives the leas...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weersink EJ,vd Elshout FJ,van Herwaarden CV,Folgering H

    更新日期:1995-05-01 00:00:00

  • TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Bhushan B,Guleria R,Misra A,Luthra K,Vikram NK

    更新日期:2009-03-01 00:00:00

  • Predicting the need for ICU admission in community-acquired pneumonia.

    abstract:BACKGROUND:Multiple criteria have been proposed to define community-acquired pneumonia (CAP) severity and predict ICU admission. Validity studies have found differing results. We tested four models to assess severe CAP built upon the criteria included in the 2007 IDSA/ATS guidelines, hypothesizing that a model providin...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Gearhart AM,Furmanek S,English C,Ramirez J,Cavallazzi R

    更新日期:2019-08-01 00:00:00

  • Acupuncture in treatment of stable asthma.

    abstract::Previous studies of acupuncture in asthma have reported conflicting results, some claiming benefit for some patients. We conducted a randomized, double-blind (patient and evaluator) study in 23 non-smoking asthmatics (10 M; 13 F) aged 43 +/- 15 years with forced expiratory volume in 1 s (FEV1) 59 +/- 16% pred. After i...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Biernacki W,Peake MD

    更新日期:1998-09-01 00:00:00

  • Experience of totally implantable venous access devices (TIV ADs) in adults with cystic fibrosis over a 13-year period.

    abstract::Totally implantable venous intravenous access devices (TIVADs) have an essential role in the frequent delivery of antibiotics in cystic fibrosis (CF) patients. This study at the Royal Brompton Hospital (RBH) reports the experience of TIVADs in patients attending the RBH adult CF unit implanted at the RBH and elsewhere...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Kariyawasam HH,Pepper JR,Hodson ME,Geddes DM

    更新日期:2000-12-01 00:00:00

  • Rabbit allergens: a significant risk for allergic sensitization in subjects without occupational exposure.

    abstract:BACKGROUND:Although rabbits are becoming popular as pets, data about the characteristics of allergic sensitization to rabbit allergens in patients without professional exposure are scarce. AIMS OF THE STUDY:To determine the characteristics of allergic sensitization to pet rabbits, and the role of direct and indirect e...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Liccardi G,Piccolo A,Dente B,Salzillo A,Noschese P,Gilder JA,Russo M,D'Amato G

    更新日期:2007-02-01 00:00:00

  • Respiratory drugs and macrolides prevent asthma exacerbations: A real-world investigation.

    abstract:OBJECTIVE:We investigated the real-world effectiveness of several drugs (including short- and long-acting beta-agonists [SABAs and LABAs], inhaled corticosteroids [ICS], and antibiotics) in preventing severe asthma exacerbations by carrying-out a large observational study based on the healthcare utilization databases o...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Arfè A,Blasi F,Merlino L,Corrao G

    更新日期:2016-10-01 00:00:00

  • Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients.

    abstract:BACKGROUND:Combination therapy with inhaled corticosteroids (ICS) and long-acting β(2)-adrenergic agonists (LABA) is reported to have superior effects on controlling asthma symptoms to ICS alone; however, there is no molecular-based evidence to explain the clinical effects. Here, the effect of the ICS/LABA combination ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Essilfie-Quaye S,Ito K,Ito M,Kharitonov SA,Barnes PJ

    更新日期:2011-12-01 00:00:00

  • Chronic cough in Vocal Cord Dysfunction: Description of a clinical entity.

    abstract:BACKGROUND AND AIM:Vocal Cord Dysfunction (VCD) and chronic cough (CC) are challenging conditions which lead to significant quality of life impairment. The underlying mechanisms are poorly understood, but laryngeal dysfunction may be common to both conditions. The aim of this study was to determine the characteristics ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Vertigan AE,Kapela SL,Gibson PG

    更新日期:2020-07-01 00:00:00

  • Medication adherence and persistence in the last year of life in COPD patients.

    abstract:OBJECTIVE:To examine medication adherence and persistence among COPD patients during their last year of life. DATA SOURCE:National VA databases were used to identify patients who had COPD and died between 1999 and 2003. STUDY DESIGN:We examined use of inhaled corticosteroids (ICS), long acting beta(2) agonists (LABA)...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Jung E,Pickard AS,Salmon JW,Bartle B,Lee TA

    更新日期:2009-04-01 00:00:00

  • Gas trapping is associated with severe exacerbation in asthmatic children.

    abstract:BACKGROUND:Gas trapping suggesting small airway disease is observed in adult asthmatic suffering from severe asthma. The aim of the study was to assess whether gas trapping could be evidenced in asthmatic children with/without severe exacerbation and with/without symptoms during the past three months. METHODS AND PATI...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Mahut B,Peiffer C,Bokov P,Beydon N,Delclaux C

    更新日期:2010-08-01 00:00:00

  • Effects of allergen exposure on methacholine and AMP-induced air trapping in pollen-sensitive subjects.

    abstract:BACKGROUND:The effect of pro-inflammatory stimuli on bronchoconstrictor-induced air trapping has not been studied. OBJECTIVE:To determine the effect of natural allergen exposure, a pro-inflammatory stimulus, on methacholine- and adenosine 5'-monophospate (AMP)-induced air trapping. METHODS:Airway responsiveness to me...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Lopez V,Prieto L,Perez C,Barato D,Marin J

    更新日期:2011-06-01 00:00:00

  • Asthma and COPD in an Italian adult population: role of BMI considering the smoking habit.

    abstract::Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

    更新日期:2013-09-01 00:00:00

  • Non-invasive ventilation at home improves survival and decreases healthcare utilization in medicare beneficiaries with Chronic Obstructive Pulmonary Disease with chronic respiratory failure.

    abstract:BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease with chronic respiratory failure (COPD-CRF) experience high mortality and healthcare utilization. Non-invasive home ventilation (NIVH) is increasingly used in such patients. We examined the associations between NIVH and survival, hospitalizations, and emerg...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Frazier WD,Murphy R,van Eijndhoven E

    更新日期:2020-12-30 00:00:00

  • Impact of patient education and self-management on morbidity in asthmatics and patients with chronic obstructive pulmonary disease.

    abstract::The effect of patient education on morbidity in asthmatics and COPD patients has not previously been investigated in a single study. We randomized 78 asthmatics and 62 COPD patients after ordinary outpatient management. Intervention consisted of educational group sessions and individual sessions administered by a trai...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gallefoss F,Bakke PS

    更新日期:2000-03-01 00:00:00

  • Clinical characteristics and prediction of pulmonary hypertension in severe emphysema.

    abstract:BACKGROUND:We explored the prevalence, clinical and physiologic correlates of pulmonary hypertension (PH), and screening strategies in patients with severe emphysema evaluated for the National Emphysema Treatment Trial (NETT). METHODS:Patients undergoing Doppler echocardiography (DE) and right heart catheterization we...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Minai OA,Fessler H,Stoller JK,Criner GJ,Scharf SM,Meli Y,Nutter B,DeCamp MM,NETT Research Group.

    更新日期:2014-03-01 00:00:00

  • The cost effectiveness of Nucleic Acid Amplification Techniques for the diagnosis of tuberculosis.

    abstract:BACKGROUND:There is wide variation in the techniques deployed to diagnose tuberculosis in the UK, with little agreement on which tools or strategies are cost effective. This analysis therefore comprehensively evaluated the cost effectiveness of currently available diagnostic strategies for routine diagnosis of TB in th...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Hughes R,Wonderling D,Li B,Higgins B

    更新日期:2012-02-01 00:00:00

  • Inhalation of swine-house dust increases the concentrations of interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-1ra) in peripheral blood.

    abstract::Inhalation of dust in swine confinement buildings causes airway inflammation and systemic symptoms. The proinflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) increase in bronchoalveolar and nasal lavage fluid, and in serum. The aim of this investigation was to study changes in the...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Wang Z,Manninen A,Malmberg P,Larsson K

    更新日期:1998-08-01 00:00:00

  • Factors influencing decline in quality of life in smokers without airflow obstruction: The COPDGene study.

    abstract:INTRODUCTION:Current and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respira...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Parekh TM,Bhatia S,Cherrington A,Kim YI,Lambert A,Iyer A,Regan EA,DeMeo DL,Han M,Dransfield MT

    更新日期:2020-01-01 00:00:00

  • Effects of inspiratory muscle training on postural stability, pulmonary function and functional capacity in children with cystic fibrosis: A randomised controlled trial.

    abstract:BACKGROUND:Previous research has found conflictive results regarding the benefits of inspiratory muscle training (IMT) for cystic fibrosis (CF) patients. Also, involvement of postural stability is a rising concern in chronic lung diseases but its role in CF patients is poorly understood. Our aim was to investigate the ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Zeren M,Cakir E,Gurses HN

    更新日期:2019-03-01 00:00:00

  • Clinical significance of isolation of nontuberculous mycobacteria in pulmonary tuberculosis patients.

    abstract:BACKGROUND:Clinical significance of isolation of nontuberculous mycobacteria (NTM) from respiratory specimens in patients with pulmonary tuberculosis is unknown. This study aimed to investigate the prevalence and clinical impact of NTM in pulmonary tuberculosis patients. METHODS:We retrospectively reviewed data of pat...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Huang CT,Tsai YJ,Shu CC,Lei YC,Wang JY,Yu CJ,Lee LN,Yang PC,Tami Group.

    更新日期:2009-10-01 00:00:00

  • Respiratory syncytial virus prophylaxis--the story so far.

    abstract::Respiratory syncytial virus (RSV) is a common and highly contagious pathogen that infects nearly all children by the age of 2 years. It is responsible for significant morbidity and mortality worldwide among certain high-risk paediatric populations. Therapy is sub-optimal for RSV, thus treatment focuses on ameliorating...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Simoes EA,Groothuis JR

    更新日期:2002-04-01 00:00:00

  • Randomized controlled trial of community-based, post-rehabilitation exercise in COPD.

    abstract:PURPOSE:Although pulmonary rehabilitation (PR) improves function in people with chronic obstructive pulmonary disease (COPD), a community-based exercise program may be necessary to maintain functional capacity. We aimed to determine the effectiveness of a post-rehabilitation, community-based maintenance program on exer...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Butler SJ,Desveaux L,Lee AL,Beauchamp MK,Brusco NK,Wang W,Goldstein RS,Brooks D

    更新日期:2020-01-01 00:00:00

  • The impact of cognitive impairment on self-management in chronic obstructive pulmonary disease: A systematic review.

    abstract:OBJECTIVE:To determine the characteristics of persons with cognitive impairment being able to self-manage in chronic obstructive pulmonary disease (COPD). METHODS:In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance this systematic review examined all studies in E...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Baird C,Lovell J,Johnson M,Shiell K,Ibrahim JE

    更新日期:2017-08-01 00:00:00