Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay.

Abstract:

:Antigen detection is a useful adjunct for the diagnosis of histoplasmosis. The purpose of this study was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83.3%) blastomycosis cases using the second-generation assay vs. 13 of 19 (68%) and 4 of 6 (66.7%), respectively, in the original assay. Ten-fold concentration permitted detection of antigen in an additional case of histoplasmosis and another with blastomycosis, for an overall sensitivity of 23 of 25 (92.0%). Specificity was 98.2% in both assays in controls with other pulmonary infections. These findings support the diagnostic utility of the second-generation assay in patients with pulmonary histoplasmosis and blastomycosis.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Hage CA,Davis TE,Egan L,Parker M,Fuller D,Lemonte AM,Durkin M,Connelly P,Joseph Wheat L,Blue-Hnidy D,Knox KS

doi

10.1016/j.rmed.2006.04.017

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

43-7

issue

1

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(06)00228-9

journal_volume

101

pub_type

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