当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > The efficacy of fluticasone furoate administered in the morning or evening is comparable in patients with persistent asthma.

The efficacy of fluticasone furoate administered in the morning or evening is comparable in patients with persistent asthma.

Abstract：

BACKGROUND:The inhaled corticosteroid fluticasone furoate (FF) is efficacious as a once-daily treatment for the management of asthma. Asthma is associated with circadian changes, with worsening lung function at night. We compared the efficacy of once-daily FF in the morning or evening for the treatment of asthma. METHODS:Adults with persistent bronchial asthma were enrolled into this randomised, repeat-dose, double-blind, double-dummy, placebo-controlled, three-way crossover study. After a 14-day run-in period, patients received either: FF 100 μg in the morning (AM); FF 100 μg in the evening (PM); or placebo, via the ELLIPTA(®) dry powder inhaler. Patients received all three treatments (14 ± 2 day duration) separated by a 14- to 21-day washout period. The primary endpoint was 24-h weighted mean forced expiratory volume in 1 s (FEV1) measured at the end of each 14-day treatment. RESULTS:A total of 28 patients aged between 19 and 67 years were randomised and 21 (75%) completed all three study arms. Once-daily administration of FF 100 μg resulted in an increased 24-hour weighted mean FEV1; differences between the adjusted means for AM and PM FF dosing versus placebo were 0.077 L (90% confidence interval [CI]: 0.001, 0.152) and 0.105 L (90% CI: 0.029, 0.180), respectively (adjusted mean difference: -0.028 L [90% CI: -0.102, 0.045]). AM or PM doses had comparable incidences of adverse events (AEs; 18/23 versus 18/24, respectively), no serious AEs occurred. CONCLUSION:AM and PM doses of once-daily FF 100 μg produced comparable improvements in lung function relative to placebo.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Kempsford RD,Bal J,Baines A,Renaux J,Ravindranath R,Thomas PS

doi

10.1016/j.rmed.2015.12.011

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

18-24

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(15)30102-5

journal_volume

112

pub_type

杂志文章,随机对照试验

相关文献

RESPIRATORY MEDICINE文献大全
  • The role of microRNAs in chronic pseudomonas lung infection in Cystic fibrosis.

    abstract：BACKGROUND:Cystic Fibrosis (CF) is the most common life limiting genetic disorder, characterized by chronic respiratory failure secondary to inflammation and chronic bacterial lung infection. Pseudomonas aeruginosa lung infection is associated with more severe lung disease and rapid progression of respiratory failure w...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.04.012

    authors： Fesen K,Silveyra P,Fuentes N,Nicoleau M,Rivera L,Kitch D,Graff GR,Siddaiah R

    更新日期：2019-05-01 00:00:00

  • Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.

    abstract：BACKGROUND:Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [<65 versus ≥65 years] and...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.07.005

    authors： Chaudhuri R,McSharry C,Heaney LG,Niven R,Brightling CE,Menzies-Gow AN,Bucknall C,Mansur AH,Lee W,Shepherd M,Spears M,Cowan DC,Husi H,Thomson NC,BTS Severe Asthma Network.

    更新日期：2016-09-01 00:00:00

  • Are the results of early long-term trials of sodium cromoglycate valid?

    abstract：:The first long-term study of sodium cromoglycate, reported in 1972, demonstrated the effectiveness of sodium cromoglycate in controlling asthma. The trial had various limitations, but more recent trials have been designed so that they overcome some of these problems. Results of these trials validate the results obtain...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0954-6111(89)80244-6

    authors： Turner-Warwick M

    更新日期：1989-05-01 00:00:00

  • Therapeutic equivalence of inhaled beclomethasone dipropionate with CFC and non-CFC (HFA 134a) propellants both delivered via the Easibreathe inhaler for the treatment of paediatric asthma.

    abstract：:Chlorofluorocarbon (CFC)-containing inhalers for use in the treatment of asthma are to be phased out under the terms of the Montreal Protocol (1). In this multi-centre, randomized, double-blind study, the therapeutic equivalence of two formulations of beclomethasone dipropionate (BDP) containing CFC or non-CFC (HFA134...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1053/rmed.1999.0678

    authors： Farmer IS,Middle M,Savic J,Perri VL,Herdman MJ

    更新日期：2000-01-01 00:00:00

  • A novel approach of using educational pharmaceutical pictogram for improving inhaler techniques in patients with asthma.

    abstract：BACKGROUND:Proper inhaler technique is essential to maximize the benefit of medications and improve asthma outcomes. OBJECTIVE:To evaluate newly developed pictogram-incorporated medals and their utility on improving the inhaler techniques in asthmatic patients. METHODS:A prospective, an open label, randomized control...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2018.09.004

    authors： Almomani BA,Mokhemer E,Al-Sawalha NA,Momany SM

    更新日期：2018-10-01 00:00:00

  • Levofloxacin 750-mg for 5 days for the treatment of hospitalized Fine Risk Class III/IV community-acquired pneumonia patients.

    abstract：BACKGROUND:The efficacy and safety of 750-mg, 5-day levofloxacin was recently shown to be comparable to 500-mg, 10-day levofloxacin in a randomized, double-blind, multicentre clinical trial for mild-to-severe community-acquired pneumonia (CAP). This subgroup analysis attempted to compare the safety and efficacy of a sh...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2006.03.019

    authors： Shorr AF,Khashab MM,Xiang JX,Tennenberg AM,Kahn JB

    更新日期：2006-12-01 00:00:00

  • Evaluation of multidimensional COPD-related subjective fatigue following a pulmonary rehabilitation programme.

    abstract：INTRODUCTION:Subjective fatigue has been recognised as an important, multi-component symptom in COPD. Pulmonary Rehabilitation (PR) improves fatigue component of the Chronic Respiratory Questionnaire, a quality of life (QoL) measure. However, it is not clear if all fatigue dimensions are affected equally. This study ai...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.09.003

    authors： Lewko A,Bidgood PL,Jewell A,Garrod R

    更新日期：2014-01-01 00:00:00

  • Tuberculin reactivity: prevalence and predictors in BCG-vaccinated young Norwegian adults.

    abstract：:We studied tuberculin reactivity in young Norwegian adults and its possible dependency on age, gender, previous BCG vaccination, smoking habits, occupational exposure, diet as well as years of education as a measure of socio-economic status. Responders of a random sample of men and women aged 20-44 years living in Ber...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2002.1386

    authors： Jentoft HF,Omenaas E,Eide GE,Gulsvik A

    更新日期：2002-12-01 00:00:00

  • Effectiveness of an exercise training programme COPD in primary care: A randomized controlled trial.

    abstract：BACKGROUND:Pulmonary rehabilitation is very effective in improving exercise capacity, dyspnea and quality of life in the small group of patients with moderate to severe COPD. Given that little is known about exercise training in the large group of patients with mild to moderate COPD, we assessed the effectiveness of an...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2020.105943

    authors： Fastenau A,van Schayck OC,Winkens B,Aretz K,Gosselink R,Muris JW

    更新日期：2020-01-01 00:00:00

  • Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: a cross-sectional population-based study in Korea.

    abstract：BACKGROUND:Previous investigations have suggested that genetic variations are associated with reduced lung function in early childhood. This study was conducted to evaluate the association between IL13+2044G-->A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function i...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.08.009

    authors： Park HW,Lee JE,Kim SH,Kim YK,Min KU,Kim YY,Cho SH

    更新日期：2009-02-01 00:00:00

  • Haemoptysis: aetiology, evaluation and outcome--a prospective study in a third-world country.

    abstract：:Haemoptysis is an alarming symptom, and the management depends upon the aetiology. Emergency management depends upon localization of the site of bleeding by roentgenogram, computerized chest tompgraphy and bronchoscopy. We prospectively evaluated 52 patients with haemoptysis admitted to the Chest Hospital, Kuwait for ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1053

    authors： Abal AT,Nair PC,Cherian J

    更新日期：2001-07-01 00:00:00

  • Immunological consequences of three doses of heat-killed Mycobacterium vaccae in the immunotherapy of tuberculosis.

    abstract：:We report the first study of triple-dose immunotherapy with heat-killed Mycobacterium vaccae (SRL 172) combined with short-course, directly observed chemotherapy in newly diagnosed pulmonary tuberculosis patients. The study was carried out in Rosario, Argentina, where single-dose immunotherapy with M. vaccae has previ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2005.09.026

    authors： Dlugovitzky D,Fiorenza G,Farroni M,Bogue C,Stanford C,Stanford J

    更新日期：2006-06-01 00:00:00

  • Dyspnea and emotional states in health and disease.

    abstract：:Anxiety and depression can increase the intensity of dyspnea out of proportion to the impairment in cardiorespiratory function and may contribute to the degree of disability associated with dyspnea. The effect of anxiety/depression on the sensory and affective components of reported dyspnea in patients with respirator...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2012.12.018

    authors： Scano G,Gigliotti F,Stendardi L,Gagliardi E

    更新日期：2013-05-01 00:00:00

  • Comparison of mannitol and citric acid cough provocation tests.

    abstract：RATIONALE:Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory approval and can be performed utilizing a simple disposable inhaler in a standardized manner. OBJECTIV...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.09.011

    authors： Nurmi HM,Lätti AM,Brannan JD,Koskela HO

    更新日期：2019-01-01 00:00:00

  • Safety, tolerability and acceptability of two dry powder inhalers in the administration of budesonide in steroid-treated asthmatic patients.

    abstract：:The purpose of this randomized, double-blind parallel group study was to compare the safety, tolerability and acceptability of Easyhaler and Turbuhaler dry powder inhalers for the delivery of budesonide 800 microg day(-1) in adult asthmatic patients who had already been treated with inhaled corticosteroids for at leas...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1053/rmed.2001.1261

    authors： Tukiainen H,Rytilä P,Hämäläinen KM,Silvasti MS,Keski-Karhu J,Finnish Study Group.

    更新日期：2002-04-01 00:00:00

  • Effect of body position on gas exchange in patients with unilateral pleural effusion: influence of effusion volume.

    abstract：:The objective of this study was to evaluate the effect of lateral body position on gas exchange in patients with unilateral pleural effusion, with special reference to the influence of effusion volume. Thirty consecutive patients with unilateral pleural effusion, without evidence of parenchymal pulmonary involvement, ...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0954-6111(95)90091-8

    authors： Romero S,Martín C,Hernández L,Arriero JM,Benito N,Gil J

    更新日期：1995-04-01 00:00:00

  • Single lung transplantation for chronic obstructive pulmonary disease: pulmonary function and impact of bronchiolitis obliterans syndrome.

    abstract：:Chronic obstructive pulmonary disease (COPD) is now the most common indication for single lung transplantation. In long-term follow-up, obliterative bronchiolitis is a major problem. The aim of the present study was to perform a long-term follow-up of the pulmonary function and to examine the effect of development of ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(96)90148-1

    authors： Bjørtuft O,Geiran OR,Fjeld J,Skovlund E,Johansen B,Boe J

    更新日期：1996-10-01 00:00:00

  • Respiratory syncytial virus prophylaxis--the story so far.

    abstract：:Respiratory syncytial virus (RSV) is a common and highly contagious pathogen that infects nearly all children by the age of 2 years. It is responsible for significant morbidity and mortality worldwide among certain high-risk paediatric populations. Therapy is sub-optimal for RSV, thus treatment focuses on ameliorating...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(02)90066-1

    authors： Simoes EA,Groothuis JR

    更新日期：2002-04-01 00:00:00

  • A proposal for a practical treatment guideline designed for the initial two-hours of the management of patients with acute severe asthma and COPD using the principles of evidence-based medicine.

    abstract：:We have proposed a clinical treatment guideline for the management of acute, severe asthma and chronic obstructive pulmonarydisease (COPD) using the principles of evidence-based medicine. The content is based upon practical clinical issues in need of consensus. A previous study has shown that this particular area is i...

    journal_title：Respiratory medicine

    pub_type： 指南,杂志文章,实务指引

    doi：10.1053/rmed.2002.1332

    authors： Phanareth K,Hansen LS,Christensen LK,Laursen LC

    更新日期：2002-09-01 00:00:00

  • Mechanism of capsaicin action: recent learnings.

    abstract：:Capsaicin has long been known to act selectively on a subpopulation of neurons to produce initial excitation, followed by a prolonged neuroinhibitory action commonly referred to as 'capsaicin desensitization'. This property has been exploited extensively as a tool with which to investigate the role of these nerves in ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(06)80252-0

    authors： O'Neill TP

    更新日期：1991-01-01 00:00:00

  • Rounded atelectasis of the lung.

    abstract：:Rounded atelectasis of the lung (RA) is a lesion well described in the medical literature, yet often very difficult to diagnose. In recent years, the widespread use of high-resolution imaging modalities employed in the struggle against cancer, coinciding with the peak of the asbestos epidemic, have boosted the detecti...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2004.10.003

    authors： Stathopoulos GT,Karamessini MT,Sotiriadi AE,Pastromas VG

    更新日期：2005-05-01 00:00:00

  • Three-year follow-up study of allergy in workers in a mushroom factory.

    abstract：:Exposure to mushroom spores may cause many respiratory allergic diseases, however, there has been no serial study in a mushroom factory to address this problem. The aim of this study was to investigate the serial changes in respiratory allergy and the incidence of hypersensitivity pneumonitis (HP) in mushroom workers....

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1187

    authors： Tanaka H,Saikai T,Sugawara H,Tsunematsu K,Takeya I,Koba H,Matsuura A,Imai K,Abe S

    更新日期：2001-12-01 00:00:00

  • Randomized controlled trial of community-based, post-rehabilitation exercise in COPD.

    abstract：PURPOSE:Although pulmonary rehabilitation (PR) improves function in people with chronic obstructive pulmonary disease (COPD), a community-based exercise program may be necessary to maintain functional capacity. We aimed to determine the effectiveness of a post-rehabilitation, community-based maintenance program on exer...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106195

    authors： Butler SJ,Desveaux L,Lee AL,Beauchamp MK,Brusco NK,Wang W,Goldstein RS,Brooks D

    更新日期：2020-01-01 00:00:00

  • Exhaled nitric oxide and exercise tolerance in severe COPD patients.

    abstract：:To answer the question as to whether pulmonary rehabilitation programs (PRP) induced increase in exercise tolerance (ET) is associated with increased levels of exhaled nitric oxide (eNO) in COPD patients of different degrees of severity, we designed a prospective and controlled study. Forty-seven stable COPD patients ...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1053/rmed.2001.1286

    authors： Clini E,Bianchi L,Foglio K,Vitacca M,Ambrosino N

    更新日期：2002-05-01 00:00:00

  • The impact of cognitive impairment on self-management in chronic obstructive pulmonary disease: A systematic review.

    abstract：OBJECTIVE:To determine the characteristics of persons with cognitive impairment being able to self-manage in chronic obstructive pulmonary disease (COPD). METHODS:In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance this systematic review examined all studies in E...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2017.06.006

    authors： Baird C,Lovell J,Johnson M,Shiell K,Ibrahim JE

    更新日期：2017-08-01 00:00:00

  • What characterizes patients who are unable to tolerate continuous positive airway pressure (CPAP) treatment?

    abstract：:Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnoea syndrome (OSAS), but many patients find this treatment intolerable. The aim of this study was to characterize patients who were unable to tolerate CPAP treatment (non-complaint) as opposed to those who continued using CP...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0703

    authors： Janson C,Nöges E,Svedberg-Randt S,Lindberg E

    更新日期：2000-02-01 00:00:00

  • Factors influencing decline in quality of life in smokers without airflow obstruction: The COPDGene study.

    abstract：INTRODUCTION:Current and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respira...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.105820

    authors： Parekh TM,Bhatia S,Cherrington A,Kim YI,Lambert A,Iyer A,Regan EA,DeMeo DL,Han M,Dransfield MT

    更新日期：2020-01-01 00:00:00

  • Cyclodextrin as a potential drug carrier in salbutamol dry powder aerosols: the in-vitro deposition and toxicity studies of the complexes.

    abstract：:This research was carried out to develop a new carrier in dry powder aerosols. Two types of cyclodextrin were chosen; gamma cyclodextrin (GCD) and dimethyl-beta-cyclodextrin (DMCD) as carriers in dry powder formulations. Salbutamol was used as a model drug and a control formulation containing lactose and the drug was ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1079

    authors： Srichana T,Suedee R,Reanmongkol W

    更新日期：2001-06-01 00:00:00

  • COST-effectiveness of salmeterol/fluticasone propionate combination (Advair(®)) in uncontrolled asthma in Canada.

    abstract：OBJECTIVE:To evaluate the cost-utility of the treatment with a long acting beta-agonist (LABA) and inhaled corticosteroid (ICS) combination inhaler [salmeterol xinafoate (SAL)/fluticasone propionate (FP) combination inhaler (SFC) (Advair(®))] to continuing on current ICS dose (no ICS dose change) or increased ICS dose ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.rmed.2014.06.005

    authors： Ismaila AS,Risebrough N,Li C,Corriveau D,Hawkins N,FitzGerald JM,Su Z

    更新日期：2014-09-01 00:00:00

  • High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival.

    abstract：PURPOSE:Interstitial lung disease is a common extra-articular manifestation of rheumatoid arthritis (RA-ILD) and is associated with significant morbidity and mortality. However, limited data exist regarding predictors of mortality. We sought to examine the prognostic value of the high-resolution computed tomography (HR...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.03.027

    authors： Yunt ZX,Chung JH,Hobbs S,Fernandez-Perez ER,Olson AL,Huie TJ,Keith RC,Janssen WJ,Goldstein BL,Lynch DA,Brown KK,Swigris JJ,Solomon JJ

    更新日期：2017-05-01 00:00:00