Levofloxacin 750-mg for 5 days for the treatment of hospitalized Fine Risk Class III/IV community-acquired pneumonia patients.

Abstract:

BACKGROUND:The efficacy and safety of 750-mg, 5-day levofloxacin was recently shown to be comparable to 500-mg, 10-day levofloxacin in a randomized, double-blind, multicentre clinical trial for mild-to-severe community-acquired pneumonia (CAP). This subgroup analysis attempted to compare the safety and efficacy of a short-course levofloxacin regimen with traditional levofloxacin dosing for PSI Class III/IV patients. METHODS:This retrospective, subgroup analysis focused on Pneumonia Severity Index Class III and IV patients enrolled in the study. Measurements included clinical and microbiological success rates, adverse events, and symptom resolution by day 3 of therapy. RESULTS:Of the 528 patients in the ITT population, 219 (41.5%) were categorized as PSI Class III/IV and included in this analysis. Among the clinically evaluable patients, 90.8% (69/76) of patients treated with the 750-mg regimen achieved clinical success, compared with 85.5% (71/83) treated with 500-mg levofloxacin (95% CI,-15.9 to 5.4). Eradication rates in the microbiologically evaluable population were comparable for the 750- and 500-mg regimens (88.9% vs 87.5%, respectively; 95% CI,-18.3 to 15.6). Both regimens were well tolerated and had comparable safety profiles. A greater proportion of patients in the 750-mg treatment group experienced resolution of fever (48.4% vs 34.0%; P=.046) and purulent sputum (48.4% vs 27.5%; P=.007) by day 3 of therapy. CONCLUSIONS:The 750-mg, 5-day levofloxacin course achieved comparable clinical and microbiologic efficacy to the 500-mg, 10-day regimen. By day 3 of therapy, a greater proportion of patients in the 750-mg group had objective and subjective resolution of fever. Further research is needed to determine the economic significance of short-course levofloxacin therapy.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Shorr AF,Khashab MM,Xiang JX,Tennenberg AM,Kahn JB

doi

10.1016/j.rmed.2006.03.019

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

2129-36

issue

12

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(06)00165-X

journal_volume

100

pub_type

杂志文章,随机对照试验
  • Asthma and COPD in an Italian adult population: role of BMI considering the smoking habit.

    abstract::Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2013.04.021

    authors: Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

    更新日期:2013-09-01 00:00:00

  • Analysis of the factors related to mortality in patients with bronchiectasis.

    abstract:BACKGROUND:Bronchiectasis is a common disabling but rarely fatal disease. However the long-term prognosis and risk factors for mortality are not well known. OBJECTIVE:The aim of this study was to determine prospectively the survival and predictive factors of mortality in patients with bronchiectasis, during 4-year fol...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2007.02.002

    authors: Onen ZP,Gulbay BE,Sen E,Yildiz OA,Saryal S,Acican T,Karabiyikoglu G

    更新日期:2007-07-01 00:00:00

  • Bronchoalveolar lavage for the diagnosis of Pulmonary Langerhans cell histiocytosis.

    abstract:BACKGROUND:The histologic diagnosis of Pulmonary Langerhans cell histiocytosis (PLCH) is invasive and can cause complications. To confirm the diagnosis of PLCH, guidelines therefore recommend measuring CD1a-positive bronchoalveolar lavage fluid (BALF) cells despite its poor sensitivity and specificity. Thus, an improve...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2016.09.004

    authors: Lommatzsch M,Bratke K,Stoll P,Mülleneisen N,Prall F,Bier A,Virchow JC

    更新日期:2016-10-01 00:00:00

  • Artificial pneumothorax by the Veress cannula: efficacy and safety.

    abstract::In 16 patients with pulmonary fibrosis, an artificial pneumothorax was introduced using the Veress cannula and the Saugman water manometer. Atmospheric air was introduced by fractionated insufflation to a total volume of 800 ml (median). The interpleural space was found on the first attempt, and in all cases, fraction...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0954-6111(97)90253-5

    authors: Faurschou P,Viskum K

    更新日期:1997-08-01 00:00:00

  • The efficacy of smoking cessation strategies in people with chronic obstructive pulmonary disease: results from a systematic review.

    abstract::Smoking cessation is the most effective way to reduce the risk of developing chronic obstructive pulmonary disease (COPD). It prevents or delays the development of airflow limitation and also reduces its progression. The objective of this study was to systematically review the effects of interventions for smoking cess...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.rmed.2004.06.001

    authors: Wagena EJ,van der Meer RM,Ostelo RJ,Jacobs JE,van Schayck CP

    更新日期:2004-09-01 00:00:00

  • Use of the QuantiFERON-TB Gold test in Japanese patients with sarcoidosis.

    abstract:BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFE...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2007.09.013

    authors: Inui N,Suda T,Chida K

    更新日期:2008-02-01 00:00:00

  • The relation of rhinitis to recurrent cough and wheezing: a longitudinal study.

    abstract:BACKGROUND:Recurrent cough can be a clinical manifestation of rhinitis. However, it remains unclear if the association between rhinitis and recurrent cough among children is independent of asthma. OBJECTIVE:The aim of the present study was to determine, in a large longitudinal cohort, whether rhinitis is significantly...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2005.03.025

    authors: Sherrill DL,Guerra S,Minervini MC,Wright AL,Martinez FD

    更新日期:2005-11-01 00:00:00

  • The effect of an outpatient care on-demand-system on health status and costs in patients with COPD. A randomized trial.

    abstract:BACKGROUND:Traditionally, outpatient visits for COPD are fixed, pre-planned by the pulmonologist. This is not a patient centered method, nor, in times of increasing COPD prevalence and resource constraints, perhaps the optimal method. OBJECTIVES:This pilot study, determined the effect of an on-demand-system, patient i...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.rmed.2014.05.011

    authors: Berkhof FF,Hesselink AM,Vaessen DL,Uil SM,Kerstjens HA,van den Berg JW

    更新日期:2014-08-01 00:00:00

  • Anxiety, depression and personality traits in severe, prednisone-dependent asthma.

    abstract:BACKGROUND:Anxiety and depression are prevalent in patients with asthma, and associated with more exacerbations and increased health care utilization. Since psychiatric intervention might improve asthma control, we examined whether patients with severe, prednisone-dependent asthma are at higher risk of these disorders ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2013.12.012

    authors: Amelink M,Hashimoto S,Spinhoven P,Pasma HR,Sterk PJ,Bel EH,ten Brinke A

    更新日期:2014-03-01 00:00:00

  • Pulmonary reflexes after human heart-lung transplantation.

    abstract::Heart-lung transplantation involves denervation of the lungs below the tracheal anastomosis, with associated permanent loss of all pulmonary innervation except post-ganglionic efferent nerves. This is supported by loss of the cough reflex to inhaled USNDW, which also implies that the RARs which mediate this cough mech...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/s0954-6111(06)80248-9

    authors: Hathaway T,Higenbottam T,Lowry R,Wallwork J

    更新日期:1991-01-01 00:00:00

  • Monitoring of bronchial asthma.

    abstract::Assessment of asthma severity is important for disease management. Analysis of symptoms past and present, and previous and actual lung function measurements (including variability) is the usual method of evaluation and classification of asthma disease severity and activity. However, symptoms and lung function alterati...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0954-6111(97)90003-2

    authors: Dahl R,Martinati LC,Boner AL

    更新日期:1997-11-01 00:00:00

  • Practical evaluation of asthma exacerbation self-management in children and adolescents.

    abstract::The objective of this study was to describe asthma exacerbation self-management in children and adolescents. We used a cross-sectional study population enrolled in the International Study of Asthma and Allergies in Childhood (ISAAC) in Bordeaux. Subjects answered an additional questionnaire on utilization of health se...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1053/rmed.2000.0888

    authors: Raherison C,Tunon-de-Lara JM,Vernejoux JM,Taytard A

    更新日期:2000-11-01 00:00:00

  • Chronic obstructive lung disease and respiratory muscle function: the role of nutrition and exercise training in cystic fibrosis.

    abstract::Malnutrition may be an extremely important complicating factor in patients with a variety of chronic lung diseases. The impact of malnutrition on lung disease and respiratory muscle function has been extensively studied in patients with chronic lung disease due to cystic fibrosis (CF). In patients with CF it appears t...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/0954-6111(93)90127-l

    authors: Heijerman HG

    更新日期:1993-08-01 00:00:00

  • Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A.

    abstract::Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the tre...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0954-6111(89)80196-9

    authors: Alton EW,Johnson M,Turner-Warwick M

    更新日期:1989-07-01 00:00:00

  • Post-9/11 sarcoidosis in WTC-exposed firefighters and emergency medical service workers.

    abstract:INTRODUCTION:The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested "greater than expected" numbers of post-9/11 cases in some workers. We undertook this study to estimate t...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2017.06.004

    authors: Webber MP,Yip J,Zeig-Owens R,Moir W,Ungprasert P,Crowson CS,Hall CB,Jaber N,Weiden MD,Matteson EL,Prezant DJ

    更新日期:2017-11-01 00:00:00

  • Efficacy and safety of once-daily fluticasone furoate/vilanterol (100/25 mcg) versus twice-daily fluticasone propionate/salmeterol (250/50 mcg) in COPD patients.

    abstract:BACKGROUND:Fluticasone furoate/vilanterol (FF/VI) is an inhaled corticosteroid/long-acting beta2-agonist (ICS/LABA), recently approved as once-daily maintenance therapy for COPD. We compared the lung function effects of FF/VI with those of twice-daily fluticasone propionate/salmeterol (FP/SAL). METHODS:Three 12 week s...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.rmed.2014.05.008

    authors: Dransfield MT,Feldman G,Korenblat P,LaForce CF,Locantore N,Pistolesi M,Watkins ML,Crim C,Martinez FJ

    更新日期:2014-08-01 00:00:00

  • Monoclonal antibodies for severe asthma: Pharmacokinetic profiles.

    abstract::Several monoclonal antibodies (mAbs) (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) are currently approved for the treatment of severe asthma. They have complex pharmacokinetic profiles. These profiles are unique in that they are dependent on their structure as well as can be markedly influenced by...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.rmed.2019.05.005

    authors: Matera MG,Calzetta L,Rogliani P,Cazzola M

    更新日期:2019-07-01 00:00:00

  • Smoking habits in the Middle East and North Africa: results of the BREATHE study.

    abstract::Few recent comparative data exist on smoking habits in the Middle East and North Africa (MENA) region. The objective of this analysis was to evaluate smoking patterns in a large general population sample of individuals aged ≥ 40 years in ten countries in the region (Algeria, Egypt, Jordan, Lebanon, Morocco, Saudi Arab...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/S0954-6111(12)70011-2

    authors: Khattab A,Javaid A,Iraqi G,Alzaabi A,Ben Kheder A,Koniski ML,Shahrour N,Taright S,Idrees M,Polatli M,Rashid N,El Hasnaoui A,BREATHE Study Group.

    更新日期:2012-12-01 00:00:00

  • Should we consider paranasal and chest computed tomography in severe asthma patients?

    abstract:BACKGROUND:It is essential to recognize and treat findings that can simulate or worsen symptoms to improve asthma control and thereby to reduce costs. Guidelines highlight a paranasal (PS) and chest computed tomography (CT) scan as a tool for disease evaluation and, although they suggest its indication in patients whom...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2020.106013

    authors: Zamarron E,Romero D,Fernández-Lahera J,Villasante C,Pinilla I,Barranco P,Dominguez-Ortega J,Álvarez-Sala Walther R R

    更新日期:2020-08-01 00:00:00

  • Neuromuscular electrical stimulation improves clinical and physiological function in COPD patients.

    abstract:BACKGROUND:Neuromuscular electrical stimulation (NMES) improves muscle performance and exercise tolerance in chronic obstructive pulmonary disease (COPD) patients. In contrast, no study has assessed the effect of NMES on dynamic hyperinflation (DH) in COPD. This study investigated the effect of short-term, high-frequen...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.rmed.2013.12.013

    authors: Vieira PJ,Chiappa AM,Cipriano G Jr,Umpierre D,Arena R,Chiappa GR

    更新日期:2014-04-01 00:00:00

  • Assessment and provision of home nebulizers for chronic obstructive pulmonary disease (COPD) in the Yorkshire region of the U.K.

    abstract::A survey was undertaken to determine the current practice in the Yorkshire Health Region for the assessment and provision of home nebulizers for adults with chronic obstructive pulmonary disease (COPD). A detailed postal questionnaire on assessment methods was sent to each of the 22 consultant physicians in respirator...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/0954-6111(95)90070-5

    authors: Hosker HS,Teale C,Greenstone MA,Muers MF

    更新日期:1995-01-01 00:00:00

  • Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis.

    abstract:BACKGROUND:An Expert Forum was held at the 2014 European Respiratory Society International Congress to address issues involved in the management of Pseudomonas aeruginosa infection in patients with non-cystic fibrosis bronchiectasis (NCFB). Multiple studies have found that chronic P. aeruginosa infection is associated ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.rmed.2016.06.007

    authors: Wilson R,Aksamit T,Aliberti S,De Soyza A,Elborn JS,Goeminne P,Hill AT,Menendez R,Polverino E

    更新日期:2016-08-01 00:00:00

  • Cytokine levels in the sera of patients with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder. Cytokines contribute an important but yet undefined role to its pathogenesis. OBJECTIVES:The present study aims to compare serum levels of cytokines involved in Th-1 and Th-2 immunity, such as interleukins (IL) IL-2, IL-4, IL-8, IL-10, in...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2005.06.016

    authors: Tsoutsou PG,Gourgoulianis KI,Petinaki E,Germenis A,Tsoutsou AG,Mpaka M,Efremidou S,Molyvdas PA

    更新日期:2006-05-01 00:00:00

  • Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects.

    abstract::Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.rmed.2015.10.006

    authors: Tao H,Yang JJ,Zhou X,Deng ZY,Shi KH,Li J

    更新日期:2016-01-01 00:00:00

  • Respiratory movement and pain thresholds in airway environmental sensitivity, asthma and COPD.

    abstract:INTRODUCTION:Patients with "sensory hyperreactivity" (SHR) have airway environmental sensitivity, chronic cough and dyspnoea. Cough, chest discomfort and sense of difficulties getting air are some of the symptoms these patients seek medical attendance for. The patients have increased cough sensitivity to inhaled capsai...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2012.03.011

    authors: Johansson EL,Ternesten-Hasséus E,Olsén MF,Millqvist E

    更新日期:2012-07-01 00:00:00

  • The salmeterol/fluticasone combination is more effective than fluticasone plus oral montelukast in asthma.

    abstract::The aim of this study was to compare the efficacy and safety of salmeterol/fluticasone propionate combination product (SFC) with fluticasone propionate (FP) plus oral montelukast (M) over 12 weeks in symptomatic asthma patients. The study was a multinational, randomised, double-blind, double-dummy, parallel-group desi...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/rmed.2003.1436

    authors: Ringdal N,Eliraz A,Pruzinec R,Weber HH,Mulder PG,Akveld M,Bateman ED,International Study Group.

    更新日期:2003-03-01 00:00:00

  • Clinical audit of subjects with snoring & sleep apnoea/hypopnoea syndrome fitted with mandibular repositioning splint.

    abstract::Snoring and obstructive sleep apnoea/hypopnoea syndrome (OSAHS) are often treated with mandibular repositioning splints (MRS), but the efficacy and satisfaction of them has not been comprehensively addressed. A survey on the use of and satisfaction with MRS was posted to 177 patients referred by a hospital orthodontic...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.rmed.2004.07.007

    authors: Izci B,McDonald JP,Coleman EL,Mackay TW,Douglas NJ,Engleman HM

    更新日期:2005-03-01 00:00:00

  • Family clusters of pulmonary tuberculosis in a suburban area of Japan.

    abstract::A survey was conducted in a metropolitan suburb to examine family clusters of pulmonary tuberculosis patients and related factors. Firstly, a descriptive study was done based on the review of tuberculosis registration cards over a 11-yr period. Of 1106 cases, 109 (9.9%) were found to occur in households which had alre...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1016/0954-6111(93)90093-f

    authors: Kondo T,Hotta I,Yamanaka K,Sakakibara H,Miyao M,Yamada S

    更新日期:1993-04-01 00:00:00

  • Real-life effectiveness of extrafine beclometasone dipropionate/formoterol in adults with persistent asthma according to smoking status.

    abstract:BACKGROUND:The efficacy and safety of extrafine beclomethasone dipropionate 100 μg/formoterol 6 μg (BDP/F HFA) pressurized metered dose inhaler (pMDI) in patients with moderate-to-severe persistent asthma, has been demonstrated in randomised controlled trials (RCTs). The aim of this prospective observational study was ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.rmed.2012.01.010

    authors: Brusselle G,Peché R,Van den Brande P,Verhulst A,Hollanders W,Bruhwyler J

    更新日期:2012-06-01 00:00:00

  • What characterizes patients who are unable to tolerate continuous positive airway pressure (CPAP) treatment?

    abstract::Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnoea syndrome (OSAS), but many patients find this treatment intolerable. The aim of this study was to characterize patients who were unable to tolerate CPAP treatment (non-complaint) as opposed to those who continued using CP...

    journal_title:Respiratory medicine

    pub_type: 杂志文章

    doi:10.1053/rmed.1999.0703

    authors: Janson C,Nöges E,Svedberg-Randt S,Lindberg E

    更新日期:2000-02-01 00:00:00