Levofloxacin 750-mg for 5 days for the treatment of hospitalized Fine Risk Class III/IV community-acquired pneumonia patients.


BACKGROUND:The efficacy and safety of 750-mg, 5-day levofloxacin was recently shown to be comparable to 500-mg, 10-day levofloxacin in a randomized, double-blind, multicentre clinical trial for mild-to-severe community-acquired pneumonia (CAP). This subgroup analysis attempted to compare the safety and efficacy of a short-course levofloxacin regimen with traditional levofloxacin dosing for PSI Class III/IV patients. METHODS:This retrospective, subgroup analysis focused on Pneumonia Severity Index Class III and IV patients enrolled in the study. Measurements included clinical and microbiological success rates, adverse events, and symptom resolution by day 3 of therapy. RESULTS:Of the 528 patients in the ITT population, 219 (41.5%) were categorized as PSI Class III/IV and included in this analysis. Among the clinically evaluable patients, 90.8% (69/76) of patients treated with the 750-mg regimen achieved clinical success, compared with 85.5% (71/83) treated with 500-mg levofloxacin (95% CI,-15.9 to 5.4). Eradication rates in the microbiologically evaluable population were comparable for the 750- and 500-mg regimens (88.9% vs 87.5%, respectively; 95% CI,-18.3 to 15.6). Both regimens were well tolerated and had comparable safety profiles. A greater proportion of patients in the 750-mg treatment group experienced resolution of fever (48.4% vs 34.0%; P=.046) and purulent sputum (48.4% vs 27.5%; P=.007) by day 3 of therapy. CONCLUSIONS:The 750-mg, 5-day levofloxacin course achieved comparable clinical and microbiologic efficacy to the 500-mg, 10-day regimen. By day 3 of therapy, a greater proportion of patients in the 750-mg group had objective and subjective resolution of fever. Further research is needed to determine the economic significance of short-course levofloxacin therapy.


Respir Med


Respiratory medicine


Shorr AF,Khashab MM,Xiang JX,Tennenberg AM,Kahn JB




Has Abstract


2006-12-01 00:00:00














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    pub_type: 杂志文章


    authors: Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

    更新日期:2013-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Onen ZP,Gulbay BE,Sen E,Yildiz OA,Saryal S,Acican T,Karabiyikoglu G

    更新日期:2007-07-01 00:00:00

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    abstract:BACKGROUND:The histologic diagnosis of Pulmonary Langerhans cell histiocytosis (PLCH) is invasive and can cause complications. To confirm the diagnosis of PLCH, guidelines therefore recommend measuring CD1a-positive bronchoalveolar lavage fluid (BALF) cells despite its poor sensitivity and specificity. Thus, an improve...

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    更新日期:2004-09-01 00:00:00

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    更新日期:2003-03-01 00:00:00

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    journal_title:Respiratory medicine

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Kondo T,Hotta I,Yamanaka K,Sakakibara H,Miyao M,Yamada S

    更新日期:1993-04-01 00:00:00

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    pub_type: 杂志文章,多中心研究


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    更新日期:2012-06-01 00:00:00

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    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Janson C,Nöges E,Svedberg-Randt S,Lindberg E

    更新日期:2000-02-01 00:00:00