Abstract：
:RANTES has been implicated in the allergic inflammation of asthma by promoting the migration and activation of the inflammatory cells, including eosinophils. The study was undertaken to evaluate RANTES levels in the exhaled breath condensate (EBC) of asthmatics with different degrees of asthma severity. EBC was collected from 33 patients with allergic asthma (11 with steroid-naïve mild asthma, 10 with ICS-treated, stable mild-to-moderate asthma, 12 with ICS-treated unstable, severe asthma) and seven healthy volunteers. In the three groups of asthmatics, RANTES concentrations in EBC were significantly higher compared with healthy volunteers. RANTES levels were significantly higher in patients with unstable asthma than in the two groups with stable disease. We observed statistically significant correlations between the concentrations of RANTES in EBC and F(ENO) in the three studied groups of asthmatics; notably, the correlation between the parameters described above was strong positive in the group of unstable and steroid-naïve stable asthmatics. We also discovered a significantly positive correlation between RANTES in EBC and the serum ECP or blood eosinophil count in the groups of asthmatics with severe, unstable asthma and between RANTES and serum ECP in the group of steroid-naïve stable asthmatics. Measurements of RANTES in EBC may provide another useful diagnostic tool for detecting and monitoring inflammation in patients with asthma.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Zietkowski Z,Tomasiak MM,Skiepko R,Bodzenta-Lukaszyk Adoi
10.1016/j.rmed.2008.03.010subject
Has Abstractpub_date
2008-08-01 00:00:00pages
1198-202issue
8eissn
0954-6111issn
1532-3064pii
S0954-6111(08)00120-0journal_volume
102pub_type
杂志文章abstract：BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-03-01 00:00:00
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更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Respiratory medicine
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pub_type： 杂志文章
doi：10.1053/rmed.2000.0857
更新日期：2000-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2004.10.003
更新日期：2005-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.rmed.2013.04.020
更新日期：2013-08-01 00:00:00
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更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2007-07-01 00:00:00
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2004-10-01 00:00:00
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更新日期：2018-04-01 00:00:00
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更新日期：2013-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
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更新日期：1997-10-01 00:00:00
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更新日期：2017-11-01 00:00:00
