Abstract：
BACKGROUND:Interleukin-32(IL-32)γ is a pro-inflammatory cytokine involved in the development and severity of chronic inflammatory diseases, but its role in asthma is unclear. OBJECTIVE:This study was conducted to evaluate the relationship of IL-32γ levels in sputum with the severity of asthma. METHODS:IL-32γ levels in the supernatant of induced sputum obtained from 89 patients with stable asthma were measured using a sandwich enzyme-linked immunosorbent assay (ELISA). The relationships between sputum IL-32γ levels and baseline forced expiratory volume in 1 s (FEV1% pred.), inflammatory cell profiles in sputum, and annual frequency of asthma exacerbation were determined. RESULTS:IL-32γ was detected in the sputum of 25 of 89 (28.1%) asthma patients, and the levels of sputum were negatively correlated with FEV1% pred. (ρ = -0.312, p = 0.003). The annual exacerbation rate was significantly higher in this group than in the IL-32-negative group (n = 64) (p = 0.03). Sputum IL-32γ levels correlated well with the annual exacerbation rate (ρ = 0.261, p = 0.014), but there were no differences in the inflammatory cell profiles in the induced sputum of IL-32-positive and IL-32-negative patients. CONCLUSION:The level of IL-32γ in induced sputum may be associated with asthma severity and related with higher risk of asthma exacerbation.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Kwon JW,Chang HS,Heo JS,Bae DJ,Lee JU,Jung CA,Son JH,Park JS,Kim SH,Min KU,Park CSdoi
10.1016/j.rmed.2017.06.005subject
Has Abstractpub_date
2017-08-01 00:00:00pages
85-90eissn
0954-6111issn
1532-3064pii
S0954-6111(17)30171-3journal_volume
129pub_type
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