Abstract:
:Summary beta2-adrenoreceptor agonists are able to modulate various aspects of airway cell functions involved in the inflammatory and repair processes characterizing a variety of respiratory disorders. Human bronchial epithelial cells (HBECs), which can act as immune effector cells and express beta2-adrenoreceptors, were used to test the effects of different concentrations (0.1-100.0 nM) of salmeterol (Salm) on adhesion molecule expression and chemokine/cytokine release. HBECs, freshly isolated from resected bronchi at the time of surgery in ex-smokers with lung cancer, constitutively expressed over 3 times more ICAM-1 than VCAM-1 (P<0.05) and secreted greater amounts of IL-8 than of GM-CSF or RANTES (P<0.001). Stimulation of HBECs with IL-4, TNF-alpha or IL-4 plus TNF-alpha-upregulated ICAM-1 expression (P<0.05) and increased GM-CSF and IL-8 secretion (P<0.05). Similarly, VCAM-1 expression was significantly increased by IL-4 plus TNF-alpha, while RANTES release was significantly enhanced by IL-4 or by IL-4 plus TNF-alpha (P<0.05), but not by TNF-alpha alone (P>0.05). Dose-response curves showed that Salm, at concentration >1.0 nM, was effective in inhibiting adhesion molecule expression and cytokine release by HBECs (P<0.05). At a Salm concentration of 10 nM the degree of inhibition observed was similar for ICAM-1 and VCAM-1 expression (37.2 +/- 9.3% and 32.9 +/- 9.6%, respectively; P>0.05), but higher for RANTES (88.4 +/- 4.4%), as compared to IL-8 (21.8 +/- 7.0%) or GM-CSF (30.1 +/- 6.6%; P<0.05, each comparison). Thus, adhesion molecules and cytokines may be expressed/released at very different levels by unstimulated or stimulated HBECs and those activities appear to be modulated by Salm.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Sabatini F,Silvestri M,Sale R,Serpero L,Di Blasi P,Rossi GAdoi
10.1016/s0954-6111(03)00137-9subject
Has Abstractpub_date
2003-09-01 00:00:00pages
1052-60issue
9eissn
0954-6111issn
1532-3064pii
S0954-6111(03)00137-9journal_volume
97pub_type
杂志文章abstract:OBJECTIVE:To determine the characteristics of persons with cognitive impairment being able to self-manage in chronic obstructive pulmonary disease (COPD). METHODS:In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance this systematic review examined all studies in E...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2017.06.006
更新日期:2017-08-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.05.022
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2017.11.004
更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2013.12.012
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0954-6111(94)90170-8
更新日期:1994-01-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.04.007
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0954-6111(98)90093-2
更新日期:1998-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2020.106100
更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2012.08.005
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2009.11.008
更新日期:2010-04-01 00:00:00
abstract::Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.04.021
更新日期:2013-09-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rmed.2015.05.012
更新日期:2015-08-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2014.12.017
更新日期:2015-02-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2006.12.002
更新日期:2007-07-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2009.01.006
更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2010.06.013
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2009.11.003
更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2019.05.022
更新日期:2019-01-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,meta分析
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2007.12.010
更新日期:2008-05-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2007.11.002
更新日期:2008-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2017.03.017
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2016.08.005
更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0954-6111(06)80291-x
更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2019.105820
更新日期:2020-01-01 00:00:00