Abstract:
:The objective of this study was to compare bronchial challenge tests with two substances [histamine (H) and methacholine (M)] and two methods of measuring the effect parameter FEV1 and pulmonary impedance [with the forced oscillation technique (FOT)] in order to determine which test is the shortest, and gives the least (drug) load to the patient. Furthermore, it was considered whether the result of one type of challenge test could be transferred to the result of another type of test. It was hypothesized that, since the FOT technique requires no forced manoeuvres of the subjects and therefore does not affect the airway patency, there must be differences in the provocation concentrations for reaching the conventional thresholds of 20% decrease in FEV1 (PC20 FEV1) and 40% increase in airway resistance measured at 8 Hz oscillation frequency (PC40 Rrs8). It was further hypothesized that the interindividual correlations between thresholds for both drugs will be low, because both drugs set off different mechanisms for bronchoconstriction. Bronchial challenge tests were performed in 23 stable asthmatics (15 males and 8 females; mean +/- SD age 30.3 +/- 11.6 years). Their mean control FEV1 was 85.2 +/- 12.6% predicted. For both drugs, PC40 Rrs8 was three-fold lower than PC20 FEV1. The within-drug correlation between log PC20 FEV1 (H,M) and log PC40 Rrs8 (H,M) was quite good [r(H) = 0.73, r(M) = 0.68]. The between-drug correlation of log PC20 FEV1 (H) and log PC20 FEV1 (M) was equally good. However, the 'between-drug' correlation of log PC40 Rrs8 (H) and log PC40 Rrs8 (M) was low (r = 0.36).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Weersink EJ,vd Elshout FJ,van Herwaarden CV,Folgering Hdoi
10.1016/0954-6111(95)90007-1subject
Has Abstractpub_date
1995-05-01 00:00:00pages
351-6issue
5eissn
0954-6111issn
1532-3064pii
0954-6111(95)90007-1journal_volume
89pub_type
临床试验,杂志文章,随机对照试验abstract::The purpose was to compare the short-term cost-effectiveness of intensive vs conventional education and supervision for the self-management of mild asthmatic patients. Consecutive newly diagnosed asthmatic patients (n = 162) were randomized into an intervention group (IG) and a control group (CG) with 1 yr of treatmen...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0954-6111(98)90113-5
更新日期:1998-02-01 00:00:00
abstract:STUDY OBJECTIVES:Penicillin resistance has been reported in various studies to have no impact on the outcome of pneumococcal pneumonia. However, the importance of cephalosporin resistance has not been systematically studied. We conducted an analysis of patients with high-level cephalosporin-resistant Streptococcus pneu...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1053/rmed.2002.1358
更新日期:2002-10-01 00:00:00
abstract:INTRODUCTION:To date endurance and strength training are established and evidence-based exercise methods in patients with chronic obstructive pulmonary disease (COPD). There is an unmet need for further research in new and complementary exercise modalities. Additional whole body vibration training during pulmonary reha...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2011.10.021
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Exercise induced asthma may symptomatically be difficult to differentiate from exercise related obstruction in the upper airways, sometimes leading to diagnostic confusion and inappropriate treatment. Larynx accounts for a significant fraction of total airway resistance, but its role as a limiting factor for...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.05.024
更新日期:2009-12-01 00:00:00
abstract:RATIONALE:Infradiagnosis of chronic obstructive pulmonary disease (COPD) may be related to the lack of knowledge about the disease and/or the scarce use of diagnostic procedures. This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of sp...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.02.024
更新日期:2006-11-01 00:00:00
abstract::There is an increasing body of evidence suggesting that altered vascular permeability may be an important component of the pathogenesis of acute mountain sickness (AMS). Vascular endothelial growth factor (VEGF) is a potent permeability factor subject to hypoxic regulation but its role in the pathogenesis of AMS is ye...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.06.014
更新日期:2007-03-01 00:00:00
abstract::Long-acting bronchodilators in combination with inhaled corticosteroids (ICS) are recommended to decrease the risk of recurrent exacerbations in patients with Global initiative for chronic Obstructive Lung Disease (GOLD) stage 3-4 chronic obstructive pulmonary disease (COPD). There is increasing concern about the clin...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rmed.2014.01.002
更新日期:2014-04-01 00:00:00
abstract::Patients using domiciliary nasal ventilation, or long-term oxygen, require regular assessment which could be carried out in the home. Blood gas analysis may be regarded as an essential part of the assessment. The present study investigated the effect of a 1-h time delay on the measurement of capillary blood gases. Fou...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(96)90207-3
更新日期:1996-02-01 00:00:00
abstract:INTRODUCTION:Combination inhaled corticosteroid/long-acting bronchodilator (ICS/LABA) therapy reduces the exacerbation rate and improves spirometry and quality of life in COPD. We hypothesized that ICS/LABA therapy also improves small airway function measured by FOT. METHODS:14 subjects with COPD were commenced on com...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.10.004
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:Although smoking cessation is strongly indicated by international guidelines as an effective therapeutic tool for patients with COPD and Asthma, a large proportion of them do not quit smoking and they are regarded as a "difficult" target group. AIM:To study the effectiveness of an intensive smoking cessat...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2014.01.007
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Recent studies have shown strong evidence that bronchiolitis obliterans is the major long-term sequelae of exposure to sulfur mustard (SM). This study is the first to examine the histopathologic spectrum of changes in a large number of surgical lung biopsies from patients exposed to SM. METHOD:Fifteen patie...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rmed.2008.01.016
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS:We prospectively evaluated 23 bronch...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2016.08.027
更新日期:2016-10-01 00:00:00
abstract::Asthma has become an important public health issue worldwide and certain groups, such as children, are at particular risk of the disease. Often asthma remains under-diagnosed and under-treated. Despite these worrying trends, the disease management approach to asthma control can help most asthma patients achieve a 'nor...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested "greater than expected" numbers of post-9/11 cases in some workers. We undertook this study to estimate t...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2017.06.004
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Although the utility of blind biopsy in the detection of metastasis in the carina has been reported, submucosal fine needle aspiration (SMFNA) has not been evaluated. We investigated how SMFNA of the main carina and upper-lobe carina in addition to blind biopsy affect management of patients with NSCLC. METH...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2011.05.013
更新日期:2011-10-01 00:00:00
abstract::Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.04.021
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a common respiratory condition and the fourth leading cause of death in Canada. However, little is known about the impact of COPD on the lives and attitudes of individuals living with this condition. The purpose of this study was to determine whether Canadian...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.01.018
更新日期:2009-07-01 00:00:00
abstract::The oxygen cost diagram (OCD) is a simple scale for quantifying a patient's evaluation of his tolerance to exercise frequently used in clinical trials; it has been shown to be well correlated with objective measures of capacity of ambulation such as the 6 min walk test (6' W). This study aimed to determine whether the...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(99)90266-4
更新日期:1999-11-01 00:00:00
abstract::Intrapulmonary percussive ventilation (IPV) is a ventilatory technique that delivers bursts of high-flow respiratory gas into the lung at high rates, intended for treating acute respiratory failure and for mobilization of secretions. We performed a study, aimed at assessing the physiological response to IPV, on patien...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2006.01.010
更新日期:2006-09-01 00:00:00
abstract::Capsaicin has long been known to act selectively on a subpopulation of neurons to produce initial excitation, followed by a prolonged neuroinhibitory action commonly referred to as 'capsaicin desensitization'. This property has been exploited extensively as a tool with which to investigate the role of these nerves in ...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/s0954-6111(06)80252-0
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Mounting data suggest that immune cell abnormalities participate in the pathogenesis of pulmonary arterial hypertension (PAH). OBJECTIVE:To determine whether the T lymphocyte subset composition in the systemic circulation and peripheral lung is altered in PAH. METHODS:Flow cytometric analyses were performed...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.10.004
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To assess the incidence and determinants of the triple inhaled therapy in chronic obstructive pulmonary disease (COPD) primary care patients. METHODS:Data derived from the Health Search Database (HSD) gathering information on 700 Italian general practitioners. A cohort of COPD patients, prescribed for the fi...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2019.05.022
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:We investigated the real-world effectiveness of several drugs (including short- and long-acting beta-agonists [SABAs and LABAs], inhaled corticosteroids [ICS], and antibiotics) in preventing severe asthma exacerbations by carrying-out a large observational study based on the healthcare utilization databases o...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2016.05.004
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [<65 versus ≥65 years] and...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2016.07.005
更新日期:2016-09-01 00:00:00
abstract::The aim of this study was to examine an acoustic reflection method using a flexible tube for identifying the obstructive site of the upper airway in snorers and patients with obstructive sleep apnoea (OSA). As a preliminary study it was performed n models and subjects in the awake state. Flextube narrowing was produce...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1116
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Although rabbits are becoming popular as pets, data about the characteristics of allergic sensitization to rabbit allergens in patients without professional exposure are scarce. AIMS OF THE STUDY:To determine the characteristics of allergic sensitization to pet rabbits, and the role of direct and indirect e...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.11.008
更新日期:2007-02-01 00:00:00
abstract::The purpose of this study was to explore respiratory health effects of indoor exposures to aldehydes and volatile organic compounds (VOCs) in elderly living in a population-based representative sample of French dwellings and to compare them to the rest of the occupants of the dwellings. Twenty VOCs were objectively me...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.07.015
更新日期:2013-10-01 00:00:00
abstract:INTRODUCTION:The duration of bronchodilator action of the long-acting beta agonist salmeterol when administered in the evening has not been investigated. In this study we have investigated whether a single evening dose of salmeterol, administered from the combination salmeterol/fluticasone (SFC) Accuhaler significantly...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.rmed.2004.10.001
更新日期:2005-05-01 00:00:00
abstract::Myeloperoxidase (MPO) and human neutrophil lipocalin (HNL) are proteins which are stored in neutrophil granulocytes, in the primary and secondary granules, respectively. These granules or their contents of MPO and HNL are secreted upon activation of the cells, and measurement of these soluble markers in biological flu...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2000.0776
更新日期:2000-06-01 00:00:00
abstract:RATIONALE:Asthma is a heterogeneous disease, and a great majority of pediatric patients with asthma demonstrate atopic characteristics and develop a Th2 type cytokine response. Nonatopic asthma, on the other hand, is seen more rarely. METHODS:In this study, levels of IL-5, IL-8 and MMP-9 were measured in exhaled breat...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2015.04.004
更新日期:2015-06-01 00:00:00