Abstract:
:Oxygen therapy for use in the home can be prescribed in two forms: oxygen concentrators are used to provide long term domiciliary oxygen therapy (LTOT), and oxygen cylinders are used to provide oxygen intermittently for relief of symptoms. In this study prescription and usage of oxygen cylinders in the home were assessed. All patients using oxygen cylinders at home in the London Borough of Tower Hamlets in October 1992 were studied. A questionnaire was sent to each patient; further information was obtained from a questionnaire to the general practitioner and from hospital notes where available. Patients with a diagnosis of chronic obstructive pulmonary disease (COPD) were visited at home to measure oxygen saturation levels (SaO2). The main outcome measures were the proportion of oxygen cylinder users who had undergone a full respiratory assessment and the number who might benefit from LTOT. There were 56 patients using oxygen intermittently, 77% with COPD of which 28% had an SaO2 < or = 92%. In these 56 patients 27% had not been assessed by a hospital physician for their chest disease, 58% used their oxygen at least once a day and on average these patients used three cylinders each per month. Most patients using oxygen cylinders at home have a diagnosis of COPD and use oxygen regularly for short term relief of breathlessness; many have not been assessed by a respiratory physician. Measurement of SaO2 suggested that a significant minority might benefit from LTOT and would certainly warrant further evaluation.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Okubadejo AA,Paul EA,Wedzicha JAdoi
10.1016/s0954-6111(05)80201-xsubject
Has Abstractpub_date
1994-11-01 00:00:00pages
777-85issue
10eissn
0954-6111issn
1532-3064pii
S0954-6111(05)80201-Xjournal_volume
88pub_type
杂志文章abstract::Vascular endothelial growth factor (VEGF) may be one of the pathophysiologic links in the association between obstructive sleep apnea-hypopnea and cardiovascular disease. Morning serum VEGF levels are increased in children with obstructive sleep apnea. However, release of VEGF by platelets and leukocytes during blood ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.09.003
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Gas6 protein is involved in pulmonary embolism (PE) and acute inflammation in animal models. METHODS:We enrolled 82 consecutive patients with acute dyspnea and suspected PE (Geneva score with high (HCP) or low/intermediate clinical probability (LICP)+D-dimer >or=0.5microg/mL) and 29 age-matched healthy volu...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2008.10.018
更新日期:2009-04-01 00:00:00
abstract::Maximal inspiratory (PImax) and expiratory (PEmax) mouth pressures were measured in seven normal adults in both sitting and half-lying positions on 2 days. Analysis of variance did not reveal significant differences between measurements made in the two positions for either PImax or PEmax. Measurements were repeatable ...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0954-6111(06)80081-8
更新日期:1991-05-01 00:00:00
abstract:RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2012.08.020
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Positive end-expiratory pressure (PEEP) has been viewed as an essential component of mechanical ventilation in acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). However, clinical trials have not yet convincingly demonstrated that high PEEP levels improve survival. The object of this stud...
journal_title:Respiratory medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.rmed.2009.02.008
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Chronic pulmonary aspergillosis (CPA) is associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). However, the clinical significance of the positivity of Aspergillus precipitating antibody (APAb), a serodiagnostic test for pulmonary aspergillosis (PA), at th...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2020.105955
更新日期:2020-05-01 00:00:00
abstract::Inhalation of swine dust causes intense airway inflammation with a multifold increase of inflammatory cells and lymphocyte activation as assessed by bronchoalveolar lavage. To further investigate the mechanism for lymphocyte activation the present in vitro study focuses on the lymphocyte response to swine dust in whol...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2000.0828
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:During military service young men (age 19-21 years) are exposed to many predisposing factors for asthma. We aimed to study the short-term prognosis of asthma after the military service. METHODS:All 216 men with verified asthma in 2004-2005 from the register of the Central Military Hospital were included in ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.05.022
更新日期:2009-12-01 00:00:00
abstract::The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with chemoimmunotherapy wh...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1178
更新日期:2001-10-01 00:00:00
abstract::Surfactant protein-A enhances the phagocytosis and killing of many pathogens, although studying this effect in an assortment of models and different experimental protocols has sometimes yielded conflicting results. In this report, using the human THP-1 cell line as the primary phagocytic cell, we systematically examin...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2003.12.018
更新日期:2004-07-01 00:00:00
abstract:INTRODUCTION:Although smoking cessation is strongly indicated by international guidelines as an effective therapeutic tool for patients with COPD and Asthma, a large proportion of them do not quit smoking and they are regarded as a "difficult" target group. AIM:To study the effectiveness of an intensive smoking cessat...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2014.01.007
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Recent studies have shown strong evidence that bronchiolitis obliterans is the major long-term sequelae of exposure to sulfur mustard (SM). This study is the first to examine the histopathologic spectrum of changes in a large number of surgical lung biopsies from patients exposed to SM. METHOD:Fifteen patie...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rmed.2008.01.016
更新日期:2008-06-01 00:00:00
abstract::Antifibrotic drugs for idiopathic pulmonary fibrosis patients in England and Scotland are only available to those with FVC percent predicted (FVC%pred) less than or equal to 80%. The prescribing guidance does not state which set of reference values should be used and we show that a patient's FVC%pred can change by 4-6...
journal_title:Respiratory medicine
pub_type: 信件
doi:10.1016/j.rmed.2016.10.007
更新日期:2016-11-01 00:00:00
abstract::Subcutaneous emphysema is a common condition occurring after chest injury. It may also be observed in association with pneumothorax or pneumomediastinum as a result of pathological changes in the respiratory tract. Spontaneous subcutaneous emphysema in absence of pneumothorax or pneumomediastinum is rare. We report a ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.04.024
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Pulmonary rehabilitation improves functional capacity and symptoms in the interstitial lung diseases (ILDs), however there is marked variation in outcomes between individuals. The aim of this study was to establish the impact of the aetiology and severity of ILD on response to pulmonary rehabilitation. METH...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2011.11.014
更新日期:2012-03-01 00:00:00
abstract::Abnormal heart rate recovery (HRR) after exercise, a marker of cardiac autonomic dysfunction, is associated with poor prognosis in various populations. As chronic obstructive pulmonary disease (COPD) is associated with cardiac autonomic dysfunction, we tested the hypothesis that patients with COPD have a lower HRR tha...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2004.11.012
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Tracheal collapse is a weakness of the tracheal wall leading to expiratory central airway collapse of more than 50% compared to inspiration. It has previously been discussed whether the collapsibility of the greater airways is a stable or a dynamic condition. Indeed, other well-known lung diseases such as as...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2018.11.018
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Omalizumab is a recombinant humanized monoclonal anti-IgE antibody approved in adults and adolescents with moderate-to-severe persistent allergic asthma inadequately controlled with inhaled corticosteroids (ICS). EXCELS is an ongoing prospective observational cohort study of approximately 5000 omalizumab-tre...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.rmed.2012.09.008
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Familial dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type-III) is a rare genetic disease caused by impaired development of sensory and afferent autonomic nerves. As a consequence, patients develop neurogenic dysphagia with frequent aspiration, chronic lung disease, and chemorefl...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2018.06.017
更新日期:2018-08-01 00:00:00
abstract::Previous studies have shown that chronic hypoxia leads to changes in skeletal muscle structure (fibre size and type) and activities of several bioenergetic enzymes. Whether this occurs also in conditions characterised by intermittent hypoxia, such as the obstructive sleep apnoea syndrome (OSAS), is unknown. To explore...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(03)00034-9
更新日期:2003-07-01 00:00:00
abstract::Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/s0954-6111(02)80032-4
更新日期:2002-08-01 00:00:00
abstract::Previous studies of acupuncture in asthma have reported conflicting results, some claiming benefit for some patients. We conducted a randomized, double-blind (patient and evaluator) study in 23 non-smoking asthmatics (10 M; 13 F) aged 43 +/- 15 years with forced expiratory volume in 1 s (FEV1) 59 +/- 16% pred. After i...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0954-6111(98)90409-7
更新日期:1998-09-01 00:00:00
abstract::In an attempt to establish the protection afforded by regular salmeterol use against induced bronchoconstriction in asthmatic patients, a meta-analysis was conducted on nine double-blind clinical trials that fulfilled the inclusion criteria. In each trial, subjects were randomly assigned to receive either salmeterol 5...
journal_title:Respiratory medicine
pub_type: 杂志文章,meta分析
doi:10.1016/s0954-6111(98)90012-9
更新日期:1998-05-01 00:00:00
abstract::A double-blind, randomized crossover study in 28 asthmatic patients assessed the relative therapeutic index for inhaled formoterol and salbutamol. Pre-drug administration FEV1 (mean 2.08 l) was 49-93% of predicted and reversibility 16-82% after inhalation of salbutamol. Patients inhaled single doses of formoterol (Oxi...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/rmed.2002.1291
更新日期:2002-06-01 00:00:00
abstract::This retrospective study reviews the patterns of P. cepacia pulmonary infection in 75 of a total of 872 mainly adults with cystic fibrosis, registered here during the 4 years 1987-1990; 35 (47%) were female. During this period, 55 patients acquired P. cepacia and the annual incidence and prevalence rates have remained...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/0954-6111(93)90090-m
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Genes that contribute to the risk of developing Chronic Obstructive Pulmonary Disease (COPD) have been identified, but an attempt to accurately quantify the total genetic contribution to COPD has to our knowledge never been conducted. METHODS:Hospital discharge diagnoses data on COPD were analysed in 22,422...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2010.05.004
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Pneumonia is a leading cause of morbidity and mortality in children worldwide; however, its diagnosis can be challenging, especially in settings where skilled clinicians or standard imaging are unavailable. We sought to determine the diagnostic accuracy of lung ultrasound when compared to radiographically-co...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2017.05.007
更新日期:2017-07-01 00:00:00
abstract::Epithelioid haemangioendothelioma of the pulmonary vessels is a rare neoplasm which usually has a minimal clinical expression. The present case report describes an exceptional case with severe inaugural alveolar haemorrhage which led to death by acute respiratory failure within a few weeks. ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(97)90077-9
更新日期:1997-02-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2003.08.003
更新日期:2004-01-01 00:00:00
abstract::The objective of this study was to compare surfactant (SF) distribution and physiological effects after standard SF delivery during conventional mechanical ventilation (CMV) with that using partial liquid ventilation (PLV). A model of meconium aspiration syndrome (MAS) was developed using two groups of adult rats (n =...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1114
更新日期:2001-07-01 00:00:00