Abstract：
:Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular analysis of the induced sputum. OSAS patients, as compared to control subjects, showed a higher percentage of neutrophils (66.7+/-18.9 vs. 25.8+/-15.6) (P<0.001) and a lower percentage of macrophages (29.4+/-18.4 vs. 70.8+/-15.3) (P<0.001). The percentage of eosinophils and lymphocytes were not significantly different in the two groups. OSAS subjects show bronchial inflammation characterized by a significant increase in neutrophils.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Salerno FG,Carpagnano E,Guido P,Bonsignore MR,Roberti A,Aliani M,Vignola AM,Spanevello Adoi
10.1016/j.rmed.2003.08.003subject
Has Abstractpub_date
2004-01-01 00:00:00pages
25-8issue
1eissn
0954-6111issn
1532-3064pii
S0954-6111(03)00294-4journal_volume
98pub_type
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