Abstract：
RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of inflammation in the lungs and repair of injured tissues. Impaired efferocytosis contributes to the pathogenesis of chronic lung diseases such as emphysema and cystic fibrosis. We hypothesized that efferocytosis would also be reduced in alveolar macrophages isolated from subjects with IPF. METHODS:Efferocytosis, was evaluated using Wright-Giemsa stained cell preparations isolated from the bronchoalveolar lavage (BAL) fluid of patients with IPF (n = 5), nonspecific interstitial pneumonitis (n = 6), cryptogenic organizing pneumonia (n = 4) and eosinophilic pneumonia (EP) (n = 5). RESULTS:Uningested apoptotic cells were significantly higher in BAL fluid from patients with IPF compared to other forms of interstitial lung disease. Macrophages isolated from patients with eosinophilic pneumonia had significantly fewer phagocytic ingestions than macrophages from the other three groups. CONCLUSION:Efferocytosis by alveolar macrophages was significantly lower in subjects with IPF compared to subjects with other interstitial pneumonia. Dysregulated efferocytosis may contribute to the pathogenesis of IPF.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Morimoto K,Janssen WJ,Terada Mdoi
10.1016/j.rmed.2012.08.020subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1800-3issue
12eissn
0954-6111issn
1532-3064pii
S0954-6111(12)00316-2journal_volume
106pub_type
杂志文章abstract：BACKGROUND:Intermittent ICS treatment with SABA in response to symptoms, is an emerging strategy for control of mild-to-moderate asthma, and recurrent wheezing. This systematic revue compares the efficacy of daily vs. intermittent ICS among preschoolers, children and adults with persistent wheezing and mild to moderate...
journal_title：Respiratory medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.rmed.2013.05.005
更新日期：2013-08-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is now the most common indication for single lung transplantation. In long-term follow-up, obliterative bronchiolitis is a major problem. The aim of the present study was to perform a long-term follow-up of the pulmonary function and to examine the effect of development of ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(96)90148-1
更新日期：1996-10-01 00:00:00
abstract：:Primary ciliary dyskinesia (PCD) is a genetic condition resulting in bronchiectasis. Exhaled gas nitric oxide (FE(NO)) is reduced in PCD. A model of pulmonary NO exchange dynamics can be used to demonstrate relative contributions of bronchial (J'aw(NO)) and peripheral airway (Calv(NO)) NO to the final FE(NO) concentra...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.12.004
更新日期：2009-05-01 00:00:00
abstract：RATIONALE:COPD is a debilitating disease with increasing mortality worldwide. The BODE index evaluates disease severity and the St George's Respiratory Questionnaire (SGRQ) measures health status. OBJECTIVE:To identify the relationship between BODE index and the SGRQ and to test the predictive value of both tools agai...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2011.01.007
更新日期：2011-06-01 00:00:00
abstract：:In the Department of Respiratory Medicine, North Staffordshire Hospital, patients fulfilling the Department of Health criteria for long-term oxygen therapy (LTOT) attend a practical teaching session on the use of their oxygen concentrator before commencing therapy. In the present study, we have audited the prescribing...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90422-x
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. OBJECTIVE:To investigate the effect of long-term AD on cli...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.04.021
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Although smoking cessation is strongly indicated by international guidelines as an effective therapeutic tool for patients with COPD and Asthma, a large proportion of them do not quit smoking and they are regarded as a "difficult" target group. AIM:To study the effectiveness of an intensive smoking cessat...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2014.01.007
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient characteristics associated with all-cause mortality in asthma. METHODS:Asthma patients aged ≥18 years and...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.105919
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:It is essential to recognize and treat findings that can simulate or worsen symptoms to improve asthma control and thereby to reduce costs. Guidelines highlight a paranasal (PS) and chest computed tomography (CT) scan as a tool for disease evaluation and, although they suggest its indication in patients whom...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.106013
更新日期：2020-08-01 00:00:00
abstract：RATIONALE:Exercise-induced bronchoconstriction (EIB) increases in cold and dry air and decreases in humid air in subjects with asthma. Few reports have reported on the effect of humid environment upon exercise capacity in subjects with EIB. OBJECTIVE:The primary aim of the present study was to examine the effect of ch...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2005.12.001
更新日期：2006-09-01 00:00:00
abstract：INTRODUCTION:Multiple Breath Washout (MBW) to measure Lung Clearance Index (LCI) is increasingly being used as a secondary endpoint in multicentre bronchiectasis studies. LCI data quality control or "over-reading" is resource intensive and the impact is unclear. OBJECTIVES:To assess the proportion of MBW tests deemed ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.10.030
更新日期：2018-12-01 00:00:00
abstract：:Gastroesophageal reflux (GER) may induce respiratory symptoms (RS) through inhalation of acid gastric contents. To characterize the airway inflammation associated with this condition, 20 children [7.4 (0.9) yr old] with "difficult to treat" RS and a positive 24-h oesophageal pH monitoring (pHm) were studied and bronch...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.05.011
更新日期：2006-02-01 00:00:00
abstract：STUDY OBJECTIVE:Acute rejection (AR) of the allograft is a major clinical problem after lungtransplantation. Repeated episodes of AR increase the risk of developing obliterative bronchiolitis, the main cause of mortality in this patient group. It is believed that AR is caused by T-lymphocytes reacting to donor antigens...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2003.09.007
更新日期：2004-02-01 00:00:00
abstract：:Pulmonary hypertension is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome. The aim of this study was to further characterize the exercise intolerance, dyspnoea and ventilatory inefficiency of patients with pulmonary fibrosis in the pres...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.08.005
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Myeloid and plasmacytoid dendritic cell (DC) subsets have been recently identified in the human lung based on their differential expression of Blood DC Antigens 1-3 (BDCAs). We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells. METHODS:Using an i...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.02.006
更新日期：2009-06-01 00:00:00
abstract：:Malnutrition may be an extremely important complicating factor in patients with a variety of chronic lung diseases. The impact of malnutrition on lung disease and respiratory muscle function has been extensively studied in patients with chronic lung disease due to cystic fibrosis (CF). In patients with CF it appears t...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/0954-6111(93)90127-l
更新日期：1993-08-01 00:00:00
abstract：RATIONALE:Combination therapy with corticosteroid and long-acting β(2)-agonists (LABA) in a single inhaler is associated with superior effects on airway function and exercise performance in COPD compared with LABA monotherapy. The physiological effects of adding inhaled corticosteroid monotherapy to maintenance broncho...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2011.08.021
更新日期：2011-12-01 00:00:00
abstract：:The purpose of this randomized, double-blind parallel group study was to compare the safety, tolerability and acceptability of Easyhaler and Turbuhaler dry powder inhalers for the delivery of budesonide 800 microg day(-1) in adult asthmatic patients who had already been treated with inhaled corticosteroids for at leas...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/rmed.2001.1261
更新日期：2002-04-01 00:00:00
abstract：:It has been hypothesized that hepatocyte growth factor (HGF) may play an important role in regulating the growth of lung epithelium and in the regeneration of the lung as a paracrine or endocrine factor in idiopathic pulmonary fibrosis (IPF). Based on this background, serum HGF was measured in 31 IPF patients (21 male...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(97)90083-4
更新日期：1997-10-01 00:00:00
abstract：:Although pleural manometry is a relatively simple medical procedure it is only occasionally used to follow pleural pressure (Ppl) changes during a therapeutic thoracentesis and pneumothorax drainage. As some studies showed that pleural pressure monitoring might be associated with significant advantages, pleural manome...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2018.01.014
更新日期：2018-12-01 00:00:00
abstract：:Cyclosporin A (CsA) is an immunomodulator drug that has been used in the treatment of several types of advanced pulmonary interstitial disease. This beneficial effect occurs mainly in circumstances in which alveolitis due to CD4 lymphocytes is absent, suggesting that CsA acts on other types of cells. The present study...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90002-6
更新日期：1998-05-01 00:00:00
abstract：BACKGROUNDS:Cancer immunotherapy using immune checkpoint inhibitors has received a remarkable amount of attention in patients with non-small cell lung cancer (NSCLC). The unique adverse effects known as immune-related adverse events (irAEs) associated with immune checkpoint inhibitors are not known however, and neither...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmed.2018.11.021
更新日期：2019-01-01 00:00:00
abstract：:Surfactant protein-A enhances the phagocytosis and killing of many pathogens, although studying this effect in an assortment of models and different experimental protocols has sometimes yielded conflicting results. In this report, using the human THP-1 cell line as the primary phagocytic cell, we systematically examin...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2003.12.018
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:It has been shown that interleukin (IL)-18 levels in induced sputum are reduced in asthmatic and healthy smokers. However, in chronic obstructive pulmonary disease (COPD) patients, recent data show an overproduction in the lungs and increased serum levels of IL-18, suggesting that IL-18 may be involved in th...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.01.011
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:The usefulness of any questionnaire in clinical management and research trials depends on its ability to indicate a likelihood of treatment success during follow-up. The Minimal Clinically Important Difference (MCID) reflects a clinically relevant change score. The aim of this study was to estimate the MCID f...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2011.05.004
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The current literature suggests a relationship between obstructive sleep apnea (OSA) severity and hematocrit. However, the degree that OSA contributes to clinically significant erythrocytosis is uncertain. The aim of this study is to evaluate this association in a large study sample controlling for multiple ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2017.07.003
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The aim of the study was to investigate the efficacy and safety of ciclesonide compared with budesonide in adolescents with severe asthma. METHODS:In this randomized, double-blind, double-dummy, parallel-group study, patients aged 12-17 years with severe asthma were treated with budesonide 400 microg once d...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.rmed.2007.05.006
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Several animal studies, and one inoculation study in adult asthmatics have shown that interleukin-33 (IL-33) is a major contributor to type-2 inflammation in acute asthma. However, the link between IL-33 and type-2 inflammation has not been shown in naturally occurring asthma exacerbations. OBJECTIVES:To de...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.05.016
更新日期：2018-07-01 00:00:00
abstract：:Snoring and obstructive sleep apnoea/hypopnoea syndrome (OSAHS) are often treated with mandibular repositioning splints (MRS), but the efficacy and satisfaction of them has not been comprehensively addressed. A survey on the use of and satisfaction with MRS was posted to 177 patients referred by a hospital orthodontic...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.07.007
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Genes that contribute to the risk of developing Chronic Obstructive Pulmonary Disease (COPD) have been identified, but an attempt to accurately quantify the total genetic contribution to COPD has to our knowledge never been conducted. METHODS:Hospital discharge diagnoses data on COPD were analysed in 22,422...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2010.05.004
更新日期：2010-12-01 00:00:00
