当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease.

Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease.

Abstract：

BACKGROUND:Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. OBJECTIVE:To investigate the effect of long-term AD on clinical, biochemical and radiological changes in N-ERD patients. METHODS:The study group consisted of twenty-three individuals with N-ERD who underwent AD, followed by ingestion of 325 mg aspirin twice daily. Twenty patients completed the 52 weeks of AD. The following evaluations were conducted at baseline and in the 52nd week of AD: (i) clinical: asthma exacerbations, Asthma Control Test (ACT), Visual Analogue Scale (VAS) for the assessment of nasal symptoms; (ii) blood and induced sputum supernatant (ISS) periostin, (iii) phenotypes based on induced sputum (IS) cells, (iiii) ISS and nasal lavage (NL) concentration of prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), tetranor-PGD-M, tetranor-PGE-M, 8-iso-PGE2, leukotriene B4 (LTB4), LTC4, LTD4 and LTE4, and urine LTE4. RESULTS:A significant improvement was observed in ACT (P = 0.02) and VAS score (P = 0.008) in the 52nd week of AD. ISS periostin and IS eosinophil count decreased significantly in the 52nd week of AD (P = 0.04 and P = 0.01, respectively). ISS and NL eicosanoid concentrations did not change following long-term AD. CONCLUSION:and Clinical Relevance: AD is associated with a decrease in sputum periostin biosynthesis, which may prevent the recruitment of eosinophils into respiratory tissue and be one of explanation of the clinical benefits of AD. Long-term aspirin administration does not lead to an imbalance between pro- and anti-inflammatory ISS eicosanoids.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Tyrak KE,Kupryś-Lipińska I,Czarnobilska E,Jakieła B,Pajdzik K,Ćmiel A,Plutecka H,Koziej M,Gawrońska A,Konduracka E,Kuna P,Sanak M,Mastalerz L

doi

10.1016/j.rmed.2019.04.021

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

51-59

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(19)30149-0

journal_volume

152

pub_type

杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis.

    abstract：:Primary ciliary dyskinesia (PCD) is a genetic condition resulting in bronchiectasis. Exhaled gas nitric oxide (FE(NO)) is reduced in PCD. A model of pulmonary NO exchange dynamics can be used to demonstrate relative contributions of bronchial (J'aw(NO)) and peripheral airway (Calv(NO)) NO to the final FE(NO) concentra...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.12.004

    authors： Shoemark A,Wilson R

    更新日期：2009-05-01 00:00:00

  • Short-term effects of nCPAP on nasal mucociliary clearance and mucus transportability in healthy subjects.

    abstract：:Nasal mucociliary clearance is a primary defense mechanism of the upper airways and may be acutely affected by nasal continuous positive airway pressure (nCPAP). nCPAP treatment is effective and safe. However, it can cause nasal side effects and contribute to a low compliance to the treatment. The aim of this study wa...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.03.042

    authors： de Oliveira LR,Albertini Yagi CS,Figueiredo AC,Saldiva PH,Lorenzi-Filho G

    更新日期：2006-01-01 00:00:00

  • Re-examination of the diagnostic criteria of tropical pulmonary eosinophilia.

    abstract：:There is no agreement on the minimum absolute eosinophil count essential for the diagnosis of tropical pulmonary eosinophilia (TPE) at present. The aim of this study was to determine this figure as well as to evaluate the other diagnostic criteria of TPE. The response to diethylcarbamazine (DEC) was tested in 98 patie...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(99)90106-3

    authors： Cooray JH,Ismail MM

    更新日期：1999-09-01 00:00:00

  • Initial characteristics and outcome of hospitalized patients with amiodarone pulmonary toxicity.

    abstract：UNLABELLED:Amiodarone-induced pulmonary toxicity (APT) is a serious adverse event that can lead to death. The aims of our study are to determine factors associated with mortality and to describe outcome and sequelae of patients with APT. METHODS:Forty-six patients with APT were divided into two groups according to sur...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.01.014

    authors： Mankikian J,Favelle O,Guillon A,Guilleminault L,Cormier B,Jonville-Béra AP,Perrotin D,Diot P,Marchand-Adam S

    更新日期：2014-04-01 00:00:00

  • Methods used in clinical development of novel anti-asthma therapies.

    abstract：:In recent years, it has become increasingly important to get as much as possible information on clinical efficacy already in the early phases of drug development. For proof of concept (POC) studies testing novel anti-inflammatory drugs in asthma, there are several validated exacerbation models, inducing various aspect...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.10.018

    authors： Diamant Z,Boot D,Kamerling I,Bjermer L

    更新日期：2008-03-01 00:00:00

  • Bronchoscopic balloon dilatation in the management of bronchial stenosis following lung transplantation.

    abstract：BACKGROUND:Bronchial stenosis (BS) is currently found in 7-15% of lung transplantation (LT) recipients. Current treatment strategies have included Nd:Yag laser, cryotherapy, bougie dilatation and stent placement. Bronchoscopic balloon dilatation has been used as alternative treatment in a few cases with controversial r...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.04.019

    authors： De Gracia J,Culebras M,Alvarez A,Catalán E,De la Rosa D,Maestre J,Canela M,Román A

    更新日期：2007-01-01 00:00:00

  • The natural history of community-acquired pneumonia in COPD patients: a population database analysis.

    abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease (COPD) are at higher risk of developing Community-Acquired Pneumonia (CAP) than patients in the general population. However, no studies have been performed in general practice assessing longitudinal incidence rates for CAP in COPD patients or risk factors f...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.04.008

    authors： Müllerova H,Chigbo C,Hagan GW,Woodhead MA,Miravitlles M,Davis KJ,Wedzicha JA

    更新日期：2012-08-01 00:00:00

  • Budesonide added to formoterol contributes to improved exercise tolerance in patients with COPD.

    abstract：BACKGROUND:Breathlessness and exercise intolerance frequently impact the daily life of patients with COPD. METHODS:This double-blind, multicentre, three-period crossover study randomised 111 patients with COPD (mean age 64 years, mean FEV(1) 38% of predicted normal) to budesonide/formoterol 320/9 microg, formoterol 9 ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2010.07.006

    authors： Worth H,Förster K,Eriksson G,Nihlén U,Peterson S,Magnussen H

    更新日期：2010-10-01 00:00:00

  • Impact of LABA/LAMA combination on exercise endurance and lung hyperinflation in COPD: A pair-wise and network meta-analysis.

    abstract：BACKGROUND:The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we ca...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rmed.2017.06.020

    authors： Calzetta L,Ora J,Cavalli F,Rogliani P,O'Donnell DE,Cazzola M

    更新日期：2017-08-01 00:00:00

  • Bronchoalveolar lavage quality influences the T4/T8 ratio in sarcoidosis.

    abstract：BACKGROUND:Sarcoidosis is characterised by a T-lymphocytic alveolitis with a typically increased T4/T8 ratio. The diagnostic value of this ratio is under debate. AIM OF THE WORK:We prospectively evaluated the influence of BAL pre-lavage and the impact of bronchial contamination on BAL differential cell count in 108 BA...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.11.027

    authors： Reichenberger F,Kleiber B,Baschiera B,Bubendorf L,Brutsche M,Dalquen P,Tamm M

    更新日期：2007-09-01 00:00:00

  • Measuring lung volumes in advanced asbestosis: comparability of plethysmographic and radiographic versus helium rebreathing and single breath methods.

    abstract：:Total lung capacity was measured in 16 workers with pulmonary asbestosis using four standard methods: body plethysmography, radiographic lung area, helium dilution by multiple breath and by single breath (alveolar volume). All men had irregular opacities of ILO profusion category 2/1 or greater and four had pleural pl...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(93)90138-p

    authors： Kilburn KH,Miller A,Warshaw RH

    更新日期：1993-02-01 00:00:00

  • The disease management approach to controlling asthma.

    abstract：:Asthma has become an important public health issue worldwide and certain groups, such as children, are at particular risk of the disease. Often asthma remains under-diagnosed and under-treated. Despite these worrying trends, the disease management approach to asthma control can help most asthma patients achieve a 'nor...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Haahtela T

    更新日期：2002-02-01 00:00:00

  • Acute exacerbation of interstitial pneumonia following surgical lung biopsy.

    abstract：STUDY OBJECTIVES:Surgical lung biopsy (SLB) plays an important role in the diagnosis of interstitial pneumonia, however, the occurrence of acute respiratory failure following SLB remains largely unreported. We evaluated the incidence, clinical features, therapy and prognosis of acute exacerbation of interstitial pneumo...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.02.002

    authors： Kondoh Y,Taniguchi H,Kitaichi M,Yokoi T,Johkoh T,Oishi T,Kimura T,Nishiyama O,Kato K,du Bois RM

    更新日期：2006-10-01 00:00:00

  • Trends in the prevalence of asthma, rhinitis, and eczema in 15 year old adolescents over an 8 year period.

    abstract：BACKGROUND:Trends in prevalence of asthma and allergic diseases are still controversial, and rarely studied among adolescents at midpoint of puberty. METHODS:In 2000, a questionnaire was mailed to adolescents (n = 18,158) attending 9th grade at school and living in Västra Götaland County, Sweden. Eight years later, th...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.02.011

    authors： Kim JL,Brisman J,Aberg MA,Forslund HB,Winkvist A,Torén K

    更新日期：2014-05-01 00:00:00

  • Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis.

    abstract：BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.03.031

    authors： Jacob J,Odink A,Brun AL,Macaluso C,de Lauretis A,Kokosi M,Devaraj A,Desai S,Renzoni E,Wells AU

    更新日期：2018-05-01 00:00:00

  • Comparative effectiveness of mepolizumab and omalizumab in severe asthma: An indirect treatment comparison.

    abstract：BACKGROUND:Severe asthma is a heterogeneous disease. Patients with both eosinophilic and allergic asthma phenotypes may be eligible for treatment with mepolizumab and omalizumab. Evidence on the relative effectiveness of these treatments in this 'overlap' population would be informative for clinical and payer decision ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2016.12.009

    authors： Cockle SM,Stynes G,Gunsoy NB,Parks D,Alfonso-Cristancho R,Wex J,Bradford ES,Albers FC,Willson J

    更新日期：2017-02-01 00:00:00

  • Endoscopic closure of acquired oesophagorespiratory fistulas with cardiac septal defect occluders or vascular plugs.

    abstract：OBJECTIVES:To report an endoscopic treatment for inoperable oesophagorespiratory fistulas (ORFs). PATIENTS AND METHODS:Six patients with inoperable acquired tracheobronchial-oesophageal fistulas (four males and two females; mean age, 70.2 ± 10.28 years) were included. Cardiac septal defect occluders or vascular plugs ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2015.04.014

    authors： Li J,Gao X,Chen J,Lao M,Wang S,Zeng G

    更新日期：2015-08-01 00:00:00

  • Cardiopulmonary exercise testing and second-line pulmonary function tests to detect obstructive pattern in symptomatic smokers with borderline spirometry.

    abstract：BACKGROUND:The need for additional research on symptomatic smokers with normal spirometry has been recently emphasized. Albeit not meeting criteria for Chronic obstructive pulmonary disease (COPD) diagnosis, symptomatic smokers may experience activity limitation, evidence of airway disease, and exacerbations. We, there...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.04.006

    authors： Di Marco F,Terraneo S,Job S,Rinaldo RF,Sferrazza Papa GF,Roggi MA,Santus P,Centanni S

    更新日期：2017-06-01 00:00:00

  • Increased angiogenic factors in exhaled breath condensate of children with severe asthma - New markers of disease progression?

    abstract：:Asthma progression is associated with airway remodeling and neo-vascularization. However, role of angiogenesis in these changes remains unclear and available data still incomplete. In this pilot study we verify usefulness of proteome profiler assay in screening of angiogenesis-related factors in exhaled breath condens...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.08.005

    authors： Grzela K,Litwiniuk M,Krejner A,Zagorska W,Grzela T

    更新日期：2016-09-01 00:00:00

  • Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study.

    abstract：BACKGROUND:In a 1-year, randomized, open-label study in patients with moderate-to-severe allergic (immunoglobulin E (IgE)-mediated) asthma, adding omalizumab to best standard care (BSC) significantly improved efficacy outcomes compared with BSC alone (control). We assessed the efficacy of omalizumab in the subgroup of ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2008.06.002

    authors： Niven R,Chung KF,Panahloo Z,Blogg M,Ayre G

    更新日期：2008-10-01 00:00:00

  • Long-term prognosis of immediate hypersensitivity type of occupational laryngitis.

    abstract：:The present study investigated, for the first time, the long-term prognosis of hypersensitivity type of occupational laryngitis (OL). Thirteen patients with OL diagnosed in 1990-1993 at the Finnish Institute of Occupational Health participated in a questionnaire follow-up study. The records of the primary diagnostic i...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.07.015

    authors： Hannu T,Sala E,Toskala E

    更新日期：2009-01-01 00:00:00

  • Interstitial lung abnormalities are associated with increased mortality in smokers.

    abstract：OBJECTIVE:The aim of this study was to investigate whether smokers with incidental findings of interstitial lung abnormalities have an increased mortality during long-term follow-up, and review the contributing causes of death. METHODS:Baseline CT scans of 1990 participants from the Danish Lung Cancer Screening Trial ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2018.02.001

    authors： Hoyer N,Wille MMW,Thomsen LH,Wilcke T,Dirksen A,Pedersen JH,Saghir Z,Ashraf H,Shaker SB

    更新日期：2018-03-01 00:00:00

  • Effects of allergen exposure on methacholine and AMP-induced air trapping in pollen-sensitive subjects.

    abstract：BACKGROUND:The effect of pro-inflammatory stimuli on bronchoconstrictor-induced air trapping has not been studied. OBJECTIVE:To determine the effect of natural allergen exposure, a pro-inflammatory stimulus, on methacholine- and adenosine 5'-monophospate (AMP)-induced air trapping. METHODS:Airway responsiveness to me...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.11.023

    authors： Lopez V,Prieto L,Perez C,Barato D,Marin J

    更新日期：2011-06-01 00:00:00

  • The cost of COPD exacerbations: a university hospital--based study in Greece.

    abstract：BACKGROUND:Hospitalization attributed to severe exacerbations is the major cost driver of Chronic Obstructive Pulmonary Disease (COPD). Given that in Greece no previous studies have addressed the economic burden of COPD, the aim of the study was to examine the hospitalization cost of COPD patients with severe exacerbat...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.09.020

    authors： Geitona M,Hatzikou M,Steiropoulos P,Alexopoulos EC,Bouros D

    更新日期：2011-03-01 00:00:00

  • Haemoptysis: aetiology, evaluation and outcome--a prospective study in a third-world country.

    abstract：:Haemoptysis is an alarming symptom, and the management depends upon the aetiology. Emergency management depends upon localization of the site of bleeding by roentgenogram, computerized chest tompgraphy and bronchoscopy. We prospectively evaluated 52 patients with haemoptysis admitted to the Chest Hospital, Kuwait for ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1053

    authors： Abal AT,Nair PC,Cherian J

    更新日期：2001-07-01 00:00:00

  • Altered ventilatory responses to exercise testing in young adult men with obstructive sleep apnea.

    abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a disorder characterized by repetitive obstructions of the upper airway. Individuals with OSA experience intermittent hypoxia, hypercapnia, and arousals during sleep, resulting in increased sympathetic activation. Chemoreflex activation, arising from the resultant oscillatory...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.01.010

    authors： Hargens TA,Guill SG,Aron A,Zedalis D,Gregg JM,Nickols-Richardson SM,Herbert WG

    更新日期：2009-07-01 00:00:00

  • Does dipyrone have any effect on respiratory function in COPD patients?

    abstract：OBJECTIVE:Dipyrone (Novalgin) is an effective analgesic, antipyretic agent also with spasmolytic effects on various types of smooth muscles. It has recently been reported that dipyrone relaxes tracheal smooth muscle of guinea pig. In this present study, we aimed to investigate whether this and previously reported in vi...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.09.002

    authors： Gulmez SE,Tulunay FC,Beder S,Kayacan O,Karnak D

    更新日期：2006-05-01 00:00:00

  • Coughing can relieve or exacerbate symptoms in asthmatic patients.

    abstract：:From about 1190 to the present day opposing views have been expressed about the effects of coughing in patients with asthma. Some accounts have stated that it brought relief and others that it exacerbated asthma, whereas others thought that it could have both effects. In the present investigation, 187 patients with a ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(06)80246-5

    authors： Young S,Bitsakou H,Carić D,McHardy GJ

    更新日期：1991-01-01 00:00:00

  • A high incidence of asthma and respiratory symptoms in 4-11 year old children.

    abstract：:A study assessing the prevalence of respiratory symptoms in two primary schools in Birmingham, U.K. was performed. A questionnaire was delivered to pupils in both schools after which three open days were conducted in one of the schools, where probable asthmatics were identified and referred to their General Practition...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(06)80007-7

    authors： Ayres JG,Pansari S,Weller PH,Sykes A,Williams J,Butler N,Low D

    更新日期：1992-09-01 00:00:00

  • What characterizes patients who are unable to tolerate continuous positive airway pressure (CPAP) treatment?

    abstract：:Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnoea syndrome (OSAS), but many patients find this treatment intolerable. The aim of this study was to characterize patients who were unable to tolerate CPAP treatment (non-complaint) as opposed to those who continued using CP...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0703

    authors： Janson C,Nöges E,Svedberg-Randt S,Lindberg E

    更新日期：2000-02-01 00:00:00