Methods used in clinical development of novel anti-asthma therapies.

abstract：BACKGROUND:Bacteria expressing phosphorylcholine (ChoP) co-opt host-expressed platelet-activating factor receptor (PAFR) to adhere to lower airway cells. Cigarette smoke and rhinovirus (RV) infection upregulate PAFR-dependent bacterial adhesion to airway cells in vitro, and in healthy adults smoking increases the propo...

journal_title：Respiratory medicine

authors： Suri R,Mallia P,Martin JE,Footitt J,Zhu J,Trujillo-Torralbo MB,Johnston SL,Grigg J

更新日期：2014-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) may be one of the pathophysiologic links in the association between obstructive sleep apnea-hypopnea and cardiovascular disease. Morning serum VEGF levels are increased in children with obstructive sleep apnea. However, release of VEGF by platelets and leukocytes during blood ...

journal_title：Respiratory medicine

authors： Kaditis AG,Alexopoulos EI,Karadonta I,Kostadima E,Kiropoulos T,Gourgoulianis K,Syrogiannopoulos GA

更新日期：2006-05-01 00:00:00

abstract：STUDY OBJECTIVES:The process of intermittent hypoxia-reoxygenation produces airway inflammation and endothelial dysfunction that favors the development of cardiovascular disorders in obstructive sleep apnea syndrome (OSAS). Nitric oxide (NO) is an important mediator in airway inflammation and the regulation of endothel...

journal_title：Respiratory medicine

authors： Fortuna AM,Miralda R,Calaf N,González M,Casan P,Mayos M

更新日期：2011-04-01 00:00:00

abstract：AIM:To examine tobacco use among teenagers, identify factors related to tobacco use, as well as evaluate the outcome of a smoking prevention program. METHODS:From age 7/8 to 14/15, annual questionnaires about asthma and allergy have been completed in the OLIN paediatric study in Northern Sweden. From 12/13 years, ques...

journal_title：Respiratory medicine

authors： Hedman L,Bjerg A,Perzanowski M,Sundberg S,Rönmark E

更新日期：2007-03-01 00:00:00

abstract：:The objective of this study was to describe asthma exacerbation self-management in children and adolescents. We used a cross-sectional study population enrolled in the International Study of Asthma and Allergies in Childhood (ISAAC) in Bordeaux. Subjects answered an additional questionnaire on utilization of health se...

journal_title：Respiratory medicine

authors： Raherison C,Tunon-de-Lara JM,Vernejoux JM,Taytard A

更新日期：2000-11-01 00:00:00

abstract：:Several epidemiological studies have indicated that building dampness affects the respiratory health of the inhabitants. In this study we investigated the relationship between building dampness and respiratory symptoms in young Swedish adults. In 1993, as a part of the European Community Respiratory Health Survey stag...

journal_title：Respiratory medicine

authors： Gunnbjörnsdottir MI,Norbäck D,Plaschke P,Norrman E,Björnsson E,Janson C

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Trends in prevalence of asthma and allergic diseases are still controversial, and rarely studied among adolescents at midpoint of puberty. METHODS:In 2000, a questionnaire was mailed to adolescents (n = 18,158) attending 9th grade at school and living in Västra Götaland County, Sweden. Eight years later, th...

journal_title：Respiratory medicine

authors： Kim JL,Brisman J,Aberg MA,Forslund HB,Winkvist A,Torén K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Exhaled breath condensate (EBC) is simple to collect and as such a non-invasive method that has attracted substantial interest in the last few years. However, several methodological concerns have been raised and it has been difficult to reproduce results between different centres. Because of low concentratio...

journal_title：Respiratory medicine

authors： Tufvesson E,Bjermer L

更新日期：2006-01-01 00:00:00

abstract：:Prolonged cough is a common problem in patients seen in general practice. Using a simple method of sputum induction and processing of sputum samples, we determined whether eosinophilic airway inflammation could be a cause of undiagnosed prolonged cough. Eighty-two patients who had had cough for more than 1 month were ...

journal_title：Respiratory medicine

authors： Rytilä P,Metso T,Petäys T,Sohlman A,Työlahti H,Kohonen-Jalonen P,Kiviniemi P,Haahtela T

更新日期：2002-01-01 00:00:00

abstract：:Pneumocystis carinii colonization was studied in 90 men using the polymerase chain reaction. These comprised ten heterosexual controls; ten HIV-seronegative homosexual controls; 20 HIV-seropositive homosexuals with blood CD4 count > 400 x 10(6) l-1; 20 HIV-seropositive homosexuals with CD4 < 400 x 10(6) l-1; ten HIV-s...

journal_title：Respiratory medicine

authors： Leigh TR,Kangro HO,Gazzard BG,Jeffries DJ,Collins JV

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost-utility of the treatment with a long acting beta-agonist (LABA) and inhaled corticosteroid (ICS) combination inhaler [salmeterol xinafoate (SAL)/fluticasone propionate (FP) combination inhaler (SFC) (Advair(®))] to continuing on current ICS dose (no ICS dose change) or increased ICS dose ...

journal_title：Respiratory medicine

authors： Ismaila AS,Risebrough N,Li C,Corriveau D,Hawkins N,FitzGerald JM,Su Z

更新日期：2014-09-01 00:00:00

abstract：:Gemcitabine is a newer pyrimidine analog used for the treatment of solid tumors. Though generally considered safe, it can cause pulmonary toxicity, which is generally mild and reversible. The purpose of this publication is to document a case of adult respiratory distress syndrome (ARDS) caused by Gemcitabine administr...

journal_title：Respiratory medicine

authors： Davidoff S,Shah RD,Arunabh T

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Mortality rates from lung cancer are known to vary considerably between countries. Differences in patients, disease, investigation and treatment are thought to account for some survival shortfalls but it is not known whether differences in collection or processing of data also contribute. METHODOLOGY:We sea...

journal_title：Respiratory medicine

authors： Butler CA,Darragh KM,Currie GP,Anderson WJ

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:To assess the exercise capacity, exercise habits, and lung function of preterm born children with bronchopulmonary dysplasia (BPD) compared to term born controls at school age. METHODS:Cardiopulmonary exercise test (CPET) by cycle ergometer and pulmonary function test were performed in children with BPD (n =...

journal_title：Respiratory medicine

authors： Prenzel F,Vogel M,Siekmeyer W,Körner A,Kiess W,Vom Hove M

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma. MATERIAL AND METHODS:Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohort...

journal_title：Respiratory medicine

authors： Sundh J,Wireklint P,Hasselgren M,Montgomery S,Ställberg B,Lisspers K,Janson C

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Computed tomography (CT) has been used for non-invasive quantitative assessment of airway dimensions, potentially showing airway remodeling, in asthma. However, most studies have examined either only one airway or only airways in anatomically unidentified cross-sections. Using software capable of precisely i...

journal_title：Respiratory medicine

authors： Shimizu K,Hasegawa M,Makita H,Nasuhara Y,Konno S,Nishimura M

更新日期：2010-12-01 00:00:00

abstract：:Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...

journal_title：Respiratory medicine

authors： Cazzola M,Rogliani P,Curradi G

更新日期：2008-03-01 00:00:00

abstract：:This retrospective study reviews the patterns of P. cepacia pulmonary infection in 75 of a total of 872 mainly adults with cystic fibrosis, registered here during the 4 years 1987-1990; 35 (47%) were female. During this period, 55 patients acquired P. cepacia and the annual incidence and prevalence rates have remained...

journal_title：Respiratory medicine

authors： Taylor RF,Gaya H,Hodson ME

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The total serum IgE level is a marker of immunological activity in allergic bronchopulmonary aspergillosis (ABPA), and a 35% decline beyond six weeks is traditionally taken as criteria for remission. The aim of this study was to evaluate the magnitude and clinical significance of decline in serum Ig...

journal_title：Respiratory medicine

authors： Agarwal R,Gupta D,Aggarwal AN,Saxena AK,Saikia B,Chakrabarti A,Jindal SK

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Continuous, non-invasive assessment of alveolar ventilation achieved by transcutaneous PCO(2) (PtcCO(2)) monitoring is clearly superior to intermittent, invasive blood gas analyses in patients receiving nocturnal non-invasive positive pressure ventilation (NPPV), but the reliability and accuracy of PtcCO(2)-...

journal_title：Respiratory medicine

authors： Storre JH,Magnet FS,Dreher M,Windisch W

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:We report bronchoscopic changes observed in children with recurrent lower airways infections (RLAI) and findings in control children undergoing bronchoscopy for causes other than RLAI. PATIENTS AND METHODS:Retrospective case-control cohorts study. The clinical records of children who had fiberoptic bronchos...

journal_title：Respiratory medicine

authors： Santiago-Burruchaga M,Zalacain-Jorge R,Vazquez-Cordero C

更新日期：2014-05-01 00:00:00

abstract：:Bronchial asthma is a costly disease and the correlated social impact is ever increasing. The aim of the Social Impact of Respiratory Integrated Outcomes (SIRIO) study was to measure the health resources consumption and the costs generated in 1 year by asthmatic patients investigated in a real-life setting. This botto...

journal_title：Respiratory medicine

authors： Dal Negro RW,Micheletto C,Tosatto R,Dionisi M,Turco P,Donner CF

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:During military service young men (age 19-21 years) are exposed to many predisposing factors for asthma. We aimed to study the short-term prognosis of asthma after the military service. METHODS:All 216 men with verified asthma in 2004-2005 from the register of the Central Military Hospital were included in ...

journal_title：Respiratory medicine

authors： Lindström I,Koponen P,Luukkonen R,Pallasaho P,Kauppi P,Latvala J,Karjalainen A,Lauerma A

更新日期：2009-12-01 00:00:00

abstract：:Myeloperoxidase (MPO) and human neutrophil lipocalin (HNL) are proteins which are stored in neutrophil granulocytes, in the primary and secondary granules, respectively. These granules or their contents of MPO and HNL are secreted upon activation of the cells, and measurement of these soluble markers in biological flu...

journal_title：Respiratory medicine

authors： Schmekel B,Seveus L,Xu SY,Venge P

更新日期：2000-06-01 00:00:00

abstract：INTRODUCTION:To provide optimal care for patients with chronic obstructive pulmonary disease physicians need to understand if their patients benefit from an intervention. The objective of this study was to assess agreement between patients and physicians on health-related quality of life (HRQL) changes in response to r...

journal_title：Respiratory medicine

authors： Puhan MA,Behnke M,Devereaux PJ,Montori VM,Braendli O,Frey M,Schünemann HJ

更新日期：2004-12-01 00:00:00

abstract：:Patients with chronic obstructive pulmonary disease (COPD) are often characterised by a range of characteristic co-morbidities that interfere with their pulmonary disease. In addition to a mere association with co-morbidities, a complex pathophysiological interaction and mutual augmentation occurs between COPD and its...

journal_title：Respiratory medicine

authors： Doehner W,Haeusler KG,Endres M,Anker SD,MacNee W,Lainscak M

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Gas trapping suggesting small airway disease is observed in adult asthmatic suffering from severe asthma. The aim of the study was to assess whether gas trapping could be evidenced in asthmatic children with/without severe exacerbation and with/without symptoms during the past three months. METHODS AND PATI...

journal_title：Respiratory medicine

authors： Mahut B,Peiffer C,Bokov P,Beydon N,Delclaux C

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Sarcoidosis patients often are troubled by dyspnea, exercise limitation, and fatigue. Many patients (up to 50-81%) suffer from sarcoidosis-associated fatigue. The etiology of fatigue in sarcoidosis is still unclear. OBJECTIVE:The aim of this study was to assess the relationship between fatigue and both exer...

journal_title：Respiratory medicine

authors： Strookappe B,De Vries J,Elfferich M,Kuijpers P,Knevel T,Drent M

更新日期：2016-07-01 00:00:00

abstract：:This study aims to investigate the possibility of additional value of leukotriene receptor antagonist (LTA) on dyspnea score, arterial blood gases (ABG), pulmonary function tests (PFTs), and quality of life (St. George QoL) in chronic obstructive pulmonary disease (COPD) patients. In this randomized, prospective, sing...

journal_title：Respiratory medicine

authors： Celik P,Sakar A,Havlucu Y,Yuksel H,Turkdogan P,Yorgancioglu A

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Poor mask fit and mouth leak are associated with nasal symptoms and poor sleep quality in patients receiving domiciliary non-invasive ventilation (NIV) through a nasal mask. Normal subjects receiving continuous positive airways pressure demonstrate increased nasal resistance following periods of mouth leak. ...

journal_title：Respiratory medicine

authors： Tuggey JM,Delmastro M,Elliott MW

更新日期：2007-09-01 00:00:00