Abstract:
BACKGROUND:Poor mask fit and mouth leak are associated with nasal symptoms and poor sleep quality in patients receiving domiciliary non-invasive ventilation (NIV) through a nasal mask. Normal subjects receiving continuous positive airways pressure demonstrate increased nasal resistance following periods of mouth leak. This study explores the effect of mouth leak during pressure-targeted nasal NIV, and whether this results in increased nasal resistance and consequently a reduction in effective ventilatory support. METHODS:A randomised crossover study of 16 normal subjects was performed on separate days. Comparison was made of the effect of 5 min of mouth leak during daytime nasal NIV with and without heated humidification. Expired tidal volume (V(T)), nasal resistance (R(N)), and patient comfort were measured. RESULTS:Mean change (Delta) in V(T) and R(N) were significantly less following mouth leak with heated humidification compared to the without (DeltaV(T) -36+/-65 ml vs. -88+/-50 ml, p<0.001; DeltaR(N) +0.9+/-0.4 vs. +2.0+/-0.7 cm H(2)O l s(-1), p<0.001). Baseline comfort was worse without humidification (5.3+/-0.4 vs. 6.2+/-0.4, p<0.01), and only deteriorated following mouth leak without humidification. CONCLUSIONS:In normal subjects, heated humidification during nasal NIV attenuates the adverse effects of mouth leak on effective tidal volume, nasal resistance and improves overall comfort. Heated humidification should be considered as part of an approach to patients who are troubled with nasal symptoms, once leak has been minimised.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Tuggey JM,Delmastro M,Elliott MWdoi
10.1016/j.rmed.2007.05.005subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1874-9issue
9eissn
0954-6111issn
1532-3064pii
S0954-6111(07)00192-8journal_volume
101pub_type
杂志文章,随机对照试验abstract::Smoking cessation is the most effective way to reduce the risk of developing chronic obstructive pulmonary disease (COPD). It prevents or delays the development of airflow limitation and also reduces its progression. The objective of this study was to systematically review the effects of interventions for smoking cess...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
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journal_title:Respiratory medicine
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,随机对照试验
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