当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > From hydrofluoroalkane pressurized metered dose inhalers (pMDIs) and comparability with chlorofluorocarbon pMDIs.

From hydrofluoroalkane pressurized metered dose inhalers (pMDIs) and comparability with chlorofluorocarbon pMDIs.

Abstract：

:Fluticasone propionate pressurized metered dose inhalers (pMDIs) containing the hydrofluoroalkane (HFA) propellant, HFA 134a, are being developed to replace existing chlorofluorocarbon (CFC) pMDIs. This is part of the ongoing worldwide project to limit the damage to the earth's ozone layer. The in vivo performance and dose proportionality of fluticasone propionate HFA 134a pMDIs was examined for fluticasone propionate doses of 400, 1000 and 2000 microg using the 50, 125 and 250 microg strength pMDIs, respectively. The 125 and 250 microg strength HFA 134a pMDIs were compared with corresponding fluticasone propionate CFC pMDIs. Twenty-three healthy subjects participated in this single dose, randomized, five-way, cross-over study. Serial blood samples were collected 24 h post-dose to measure fluticasone propionate plasma concentrations. Twenty-four hour urinary-free cortisol was also measured before and after dosing. A dose-proportional increase in plasma fluticasone propionate concentrations was observed with increasing dose for the HFA 134a pMDIs. This was associated with a dose-related decrease in urinary cortisol excretion. Similar or lower fluticasone propionate systemic exposure was observed with the HFA 134a pMDIs compared to the corresponding CFC inhalers. The differences in systemic exposure observed for the HFA 134a and CFC pMDIs were too small to produce a differential effect on urinary cortisol excretion. Since fluticasone propionate has negligible oral bioavailability, the systemic exposure, which arises only from pulmonary absorption, is a measure of lung deposition. There was a good correlation between the in vitro fine particle mass produced by the different strengths and types of pMDI and the systemic exposure to fluticasone propionate. Therefore, the fluticasone propionate HFA 134a pMDI is an acceptable pharmaceutical alternative to the current CFC pMDI, producing similar lung deposition and no increase in systemic exposure at microgram equivalent doses.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Kunka R,Andrews S,Pimazzoni M,Callejas S,Ziviani L,Squassante L,Daley-Yates PT

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

S10-6

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(00)90148-3

journal_volume

94 Suppl B

pub_type

临床试验,杂志文章,随机对照试验

相关文献

RESPIRATORY MEDICINE文献大全
  • Short-term effects of nCPAP on nasal mucociliary clearance and mucus transportability in healthy subjects.

    abstract：:Nasal mucociliary clearance is a primary defense mechanism of the upper airways and may be acutely affected by nasal continuous positive airway pressure (nCPAP). nCPAP treatment is effective and safe. However, it can cause nasal side effects and contribute to a low compliance to the treatment. The aim of this study wa...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.03.042

    authors： de Oliveira LR,Albertini Yagi CS,Figueiredo AC,Saldiva PH,Lorenzi-Filho G

    更新日期：2006-01-01 00:00:00

  • Patient journey and treatment patterns in adults with IPF based on health care data in Sweden from 2001 to 2015.

    abstract：BACKGROUND:For patients with idiopathic pulmonary fibrosis (IPF), there is limited real-world data on patient journey and treatment patterns. AIM:To explore predictors of early diagnosis and treatment initiation, and treatment patterns in IPF patients using linked data from Swedish registers and electronic medical rec...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.06.001

    authors： Sköld CM,Arnheim-Dahlström L,Bartley K,Janson C,Kirchgaessler KU,Levine A,Ferrara G

    更新日期：2019-08-01 00:00:00

  • Bacterial extracts for the prevention of acute exacerbations in chronic obstructive pulmonary disease: a point of view.

    abstract：:Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.11.002

    authors： Cazzola M,Rogliani P,Curradi G

    更新日期：2008-03-01 00:00:00

  • Prognostic significance of hemostatic parameters in patients with lung cancer.

    abstract：:There is a subclinical activation of coagulation and fibrinolysis system in lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In this prospective study, our purpose was to investigate the prognostic significance of hemostatic markers in patients ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2003.07.001

    authors： Unsal E,Atalay F,Atikcan S,Yilmaz A

    更新日期：2004-02-01 00:00:00

  • Impact of patient education and self-management on morbidity in asthmatics and patients with chronic obstructive pulmonary disease.

    abstract：:The effect of patient education on morbidity in asthmatics and COPD patients has not previously been investigated in a single study. We randomized 78 asthmatics and 62 COPD patients after ordinary outpatient management. Intervention consisted of educational group sessions and individual sessions administered by a trai...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/rmed.1999.0749

    authors： Gallefoss F,Bakke PS

    更新日期：2000-03-01 00:00:00

  • Dyspnea and emotional states in health and disease.

    abstract：:Anxiety and depression can increase the intensity of dyspnea out of proportion to the impairment in cardiorespiratory function and may contribute to the degree of disability associated with dyspnea. The effect of anxiety/depression on the sensory and affective components of reported dyspnea in patients with respirator...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2012.12.018

    authors： Scano G,Gigliotti F,Stendardi L,Gagliardi E

    更新日期：2013-05-01 00:00:00

  • Inhibitory effects of Montelukast on mediator release by nasal epithelial cells from asthmatic subjects with or without allergic rhinitis.

    abstract：AIMS:This study tested inhibitory effects of in vitro Montelukast treatment on nasal airway epithelial cells (AEC) cultured from asthmatic patients treated with Montelukast with and without concomitant allergic rhinitis. We further examined the effect of Montelukast withdrawal in these patients on cytokine release from...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.09.006

    authors： Scaife A,Miller D,Spiteri-Cornish D,Turner SW,Devereux GS,Walsh GM

    更新日期：2013-12-01 00:00:00

  • Are airways structural abnormalities more frequent in children with recurrent lower respiratory tract infections?

    abstract：UNLABELLED:We report bronchoscopic changes observed in children with recurrent lower airways infections (RLAI) and findings in control children undergoing bronchoscopy for causes other than RLAI. PATIENTS AND METHODS:Retrospective case-control cohorts study. The clinical records of children who had fiberoptic bronchos...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.02.014

    authors： Santiago-Burruchaga M,Zalacain-Jorge R,Vazquez-Cordero C

    更新日期：2014-05-01 00:00:00

  • Pulmonary alveolar proteinosis: new insights from a single-center cohort of 70 patients.

    abstract：BACKGROUND:Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the intra-alveolar accumulation of surfactant lipids and proteins. The aim of the study is to describe the epidemiologic, clinical, physiologic, and laboratory features of PAP in a large single-center cohort of patients with PAP. STUDY...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.08.018

    authors： Bonella F,Bauer PC,Griese M,Ohshimo S,Guzman J,Costabel U

    更新日期：2011-12-01 00:00:00

  • Computed tomographic evaluation of the role of craniofacial and upper airway morphology in obstructive sleep apnea in Chinese.

    abstract：OBJECTIVES:To evaluate the relationship between cephalometric parameters, upper airway morphological factors and obstructive sleep apnea (OSA) in Chinese subjects. DESIGN:Polysomnogram (PSG) were performed and scored using standard criteria. Supine lateral cephalometric parameters and pharyngeal cross-sectional areas ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2003.10.009

    authors： Lam B,Ooi CG,Peh WC,Lauder I,Tsang KW,Lam WK,Ip MS

    更新日期：2004-04-01 00:00:00

  • Effects of inspiratory muscle training on postural stability, pulmonary function and functional capacity in children with cystic fibrosis: A randomised controlled trial.

    abstract：BACKGROUND:Previous research has found conflictive results regarding the benefits of inspiratory muscle training (IMT) for cystic fibrosis (CF) patients. Also, involvement of postural stability is a rising concern in chronic lung diseases but its role in CF patients is poorly understood. Our aim was to investigate the ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2019.01.013

    authors： Zeren M,Cakir E,Gurses HN

    更新日期：2019-03-01 00:00:00

  • Family clusters of pulmonary tuberculosis in a suburban area of Japan.

    abstract：:A survey was conducted in a metropolitan suburb to examine family clusters of pulmonary tuberculosis patients and related factors. Firstly, a descriptive study was done based on the review of tuberculosis registration cards over a 11-yr period. Of 1106 cases, 109 (9.9%) were found to occur in households which had alre...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(93)90093-f

    authors： Kondo T,Hotta I,Yamanaka K,Sakakibara H,Miyao M,Yamada S

    更新日期：1993-04-01 00:00:00

  • Bronchoscopic balloon dilatation in the management of bronchial stenosis following lung transplantation.

    abstract：BACKGROUND:Bronchial stenosis (BS) is currently found in 7-15% of lung transplantation (LT) recipients. Current treatment strategies have included Nd:Yag laser, cryotherapy, bougie dilatation and stent placement. Bronchoscopic balloon dilatation has been used as alternative treatment in a few cases with controversial r...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.04.019

    authors： De Gracia J,Culebras M,Alvarez A,Catalán E,De la Rosa D,Maestre J,Canela M,Román A

    更新日期：2007-01-01 00:00:00

  • Continuous positive airway pressure ventilation for respiratory failure associated with Pneumocystis carinii pneumonia.

    abstract：:The value of continuous positive airway pressure (CPAP) ventilation via a tight fitting face mask was assessed in eight HIV-1 antibody-positive patients with Pneumocystis carinii pneumonia who were in hypoxaemic respiratory failure. All patients were conscious, able to protect their airway and not hypercapnic. Treatme...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(06)80291-x

    authors： Miller RF,Semple SJ

    更新日期：1991-03-01 00:00:00

  • Chronic respiratory symptoms, spirometry and knowledge of COPD among general population.

    abstract：RATIONALE:Infradiagnosis of chronic obstructive pulmonary disease (COPD) may be related to the lack of knowledge about the disease and/or the scarce use of diagnostic procedures. This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of sp...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.02.024

    authors： Miravitlles M,de la Roza C,Morera J,Montemayor T,Gobartt E,Martín A,Alvarez-Sala JL

    更新日期：2006-11-01 00:00:00

  • Flextube reflectometry for localization of upper airway narrowing--a preliminary study in models and awake subjects.

    abstract：:The aim of this study was to examine an acoustic reflection method using a flexible tube for identifying the obstructive site of the upper airway in snorers and patients with obstructive sleep apnoea (OSA). As a preliminary study it was performed n models and subjects in the awake state. Flextube narrowing was produce...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1116

    authors： Faber CE,Grymer L,Norregaard O,Hilberg O

    更新日期：2001-08-01 00:00:00

  • Changes in forced expiratory volume in 1 second over time in patients with controlled asthma at baseline.

    abstract：BACKGROUND:A predominant feature of asthma is an accelerated rate of decline in forced expiratory volume in 1 s (FEV1), but data on the variability and factors associated with this change in patients with controlled asthma are largely unknown. METHODS:140 patients with controlled asthma were enrolled based on the Glob...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.04.014

    authors： Matsunaga K,Ichikawa T,Oka A,Morishita Y,Kanai K,Hiramatsu M,Akamatsu H,Kawabata H,Kikuchi T,Akamatsu K,Hirano T,Kou Y,Nakanishi M,Minakata Y,Yamamoto N

    更新日期：2014-07-01 00:00:00

  • Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A.

    abstract：:Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the tre...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(89)80196-9

    authors： Alton EW,Johnson M,Turner-Warwick M

    更新日期：1989-07-01 00:00:00

  • Changes in management of chronic obstructive pulmonary disease (COPD) in primary care: EMMEPOC study.

    abstract：BACKGROUND:Changes in management of COPD in primary care were studied following a training exercise among Spanish general practitioners (GPs). The exercise involved dissemination of the Spanish Society for Pulmonology and Thoracic Surgery (SEPAR) guidelines. The use of a portable device to perform spirometry tests was ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2009.08.003

    authors： Soler N,Ballester E,Martín A,Gobartt E,Miravitlles M,Torres A

    更新日期：2010-01-01 00:00:00

  • A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD.

    abstract：BACKGROUND:This study evaluated the dose-response and dosing interval of the novel long-acting muscarinic receptor antagonist (LAMA) GSK573719 in patients with COPD. METHODS:This randomized, double-blind, placebo-controlled, 3-way cross-over, incomplete block study evaluated 5 once-daily doses of GSK573719 (62.5-1000 ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2012.03.012

    authors： Donohue JF,Anzueto A,Brooks J,Mehta R,Kalberg C,Crater G

    更新日期：2012-07-01 00:00:00

  • Asthma and gastro-oesophageal reflux: can the response to anti-reflux therapy be predicted?

    abstract：:The aim of the study was to investigate which features predict favourable response to omeprazole therapy in asthmatics with gastro-oesophageal reflux (GER). The study population consisted of 52 outpatient asthmatics with GER who had completed an intervention where they were randomized to receive omeprazole 40 mg once ...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/rmed.2001.1055

    authors： Kiljander T,Salomaa ER,Hietanen E,Helenius H,Liippo K,Terho EO

    更新日期：2001-05-01 00:00:00

  • Cost-benefit impact of free asthma medication provision for the pediatric population.

    abstract：BACKGROUND:Asthma is a common chronic disease in childhood, resulting in high costs for health care systems and society. As of June 2011, the Brazilian Unified Health System (SUS) provides free asthma medications for the population. This study evaluated the impact of this program on asthma admissions in the population ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.105915

    authors： Koltermann V,Friedrich FO,Fensterseifer AC,Ongaratto R,Pinto LA

    更新日期：2020-04-01 00:00:00

  • Neuromuscular electrical stimulation improves clinical and physiological function in COPD patients.

    abstract：BACKGROUND:Neuromuscular electrical stimulation (NMES) improves muscle performance and exercise tolerance in chronic obstructive pulmonary disease (COPD) patients. In contrast, no study has assessed the effect of NMES on dynamic hyperinflation (DH) in COPD. This study investigated the effect of short-term, high-frequen...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2013.12.013

    authors： Vieira PJ,Chiappa AM,Cipriano G Jr,Umpierre D,Arena R,Chiappa GR

    更新日期：2014-04-01 00:00:00

  • Severe asthma is related to high societal costs and decreased health related quality of life.

    abstract：BACKGROUND:The aim of the present study was to estimate the societal costs and the key cost drivers for patients with severe asthma in Sweden. In addition, health-related quality of life (HRQOL) and morbidity of patients with severe asthma is described. METHODS:The study population comprised adults with severe asthma ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.105860

    authors： Jansson SA,Backman H,Andersson M,Telg G,Lindberg A,Stridsman C,Lundbäck B,Rönmark E

    更新日期：2020-02-01 00:00:00

  • Altered ventilatory responses to exercise testing in young adult men with obstructive sleep apnea.

    abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a disorder characterized by repetitive obstructions of the upper airway. Individuals with OSA experience intermittent hypoxia, hypercapnia, and arousals during sleep, resulting in increased sympathetic activation. Chemoreflex activation, arising from the resultant oscillatory...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.01.010

    authors： Hargens TA,Guill SG,Aron A,Zedalis D,Gregg JM,Nickols-Richardson SM,Herbert WG

    更新日期：2009-07-01 00:00:00

  • Clinical value of detection of metastasis of carina in patients with non-small cell lung cancer.

    abstract：BACKGROUND:Although the utility of blind biopsy in the detection of metastasis in the carina has been reported, submucosal fine needle aspiration (SMFNA) has not been evaluated. We investigated how SMFNA of the main carina and upper-lobe carina in addition to blind biopsy affect management of patients with NSCLC. METH...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.05.013

    authors： Kaynar H,Meral M,Ucar EY,Saglam L,Yildirim U,Gorguner M,Akgun M

    更新日期：2011-10-01 00:00:00

  • Measurement validity of an electronic inspiratory loading device during a loaded breathing task in patients with COPD.

    abstract：:We studied the validity of a recently introduced, handheld, electronic loading device in providing automatically processed information on external inspiratory work, power and breathing pattern during loaded breathing tasks in patients with COPD. Thirty-five patients with moderate to severe COPD performed an endurance ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.01.020

    authors： Langer D,Jacome C,Charususin N,Scheers H,McConnell A,Decramer M,Gosselink R

    更新日期：2013-04-01 00:00:00

  • Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis.

    abstract：:Viral respiratory infections (VRI) can act as triggers for acute asthma exacerbations and contribute significantly to asthma-related healthcare costs. Knowing the patterns of viruses amongst asthmatics can be useful in treating and preventing these exacerbations and help decrease the burden they impose on patients and...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2020.106020

    authors： Feddema JJ,Claassen E

    更新日期：2020-11-01 00:00:00

  • One year nationwide evaluation of 24-locus MIRU-VNTR genotyping on Slovenian Mycobacterium tuberculosis isolates.

    abstract：BACKGROUND:Slovenia is one of the few countries where IS6110 RFLP is applied for genotyping M. tuberculosis at a nationwide level, which has been in effect since 2000. Based on S6110 RFLP clustering, typical risk factors and routes of M. tuberculosis transmission were identified, such as alcohol abuse, homelessness, an...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/S0954-6111(11)70014-2

    authors： Bidovec-Stojkovic U,Zolnir-Dovc M,Supply P

    更新日期：2011-10-01 00:00:00

  • Pathophysiology and treatment of seasonal allergic rhinitis.

    abstract：:Therapeutic approaches to seasonal allergic rhinitis are reviewed in this paper. Pharmacotherapeutic approaches include nonsedative antihistamines, anti-allergic drugs, vasoconstrictors, anticholinergic agents and topical corticosteroids. The choice of treatment depends upon its relative efficacy and safety. Although ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(08)80002-9

    authors： Bousquet J,Chanez P,Michel FB

    更新日期：1990-11-01 00:00:00