Abstract:
OBJECTIVES:To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). METHODS:Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD. RESULTS:Twenty randomized-controlled trials were included in this review. The following outcomes showed significant improvement with theophylline compared with placebo: FEV1 and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% CI 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18 mmHg; 95% CI 1.23-5.13 and WMD -2.36mmHg; 95% CI -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% CI 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% CI 1.47-39.94). CONCLUSION:This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Ram FS,Jardin JR,Atallah A,Castro AA,Mazzini R,Goldstein R,Lacasse Y,Cendon Sdoi
10.1016/j.rmed.2004.10.009subject
Has Abstractpub_date
2005-02-01 00:00:00pages
135-44issue
2eissn
0954-6111issn
1532-3064pii
S0954-6111(04)00394-4journal_volume
99pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:To analyse the relationship between symptoms at different times during the 24-hour day and outcomes in COPD. METHODS:Observational cross-sectional study in a patients from 7 Latin American countries. The frequency of symptoms in the morning, at night and during the day was explored by means of standardised ...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rmed.2017.11.018
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00
abstract::Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management, and inhaler selection can have a profound impact on drug delivery and medication adherence, as well as on treatment outcomes. Although multiple delivery systems, such as pressurized metered-dose inhalers, dry powder inhalers, slow-...
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::Asthma has become an important public health issue worldwide and certain groups, such as children, are at particular risk of the disease. Often asthma remains under-diagnosed and under-treated. Despite these worrying trends, the disease management approach to asthma control can help most asthma patients achieve a 'nor...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:
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更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:We have observed that Doctors often perceive that cystic fibrosis (CF) is exceptionally rare in non-whites, and that this bias has repeatedly resulted in diagnostic delay. We therefore compared the age at diagnosis, genetic features and relative prevalence of CF in non-whites and white patients in the West M...
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1053/rmed.2003.1351
更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2007.10.023
更新日期:2008-05-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/s0954-6111(06)80252-0
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2020.105995
更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2008.04.006
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2009.11.003
更新日期:2010-04-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.rmed.2006.12.004
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0954-6111(99)90068-9
更新日期:1999-01-01 00:00:00
abstract::The increasing prevalence of allergic sensitization to indoor allergens such as dust mites, pets and cockroaches is the result of the changes in indoor environments induced by human activities. The Westernized lifestyle and the increasing time spent indoors determine a reduction in natural air ventilation and, consequ...
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pub_type: 杂志文章
doi:10.1053/rmed.2000.0922
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:During military service young men (age 19-21 years) are exposed to many predisposing factors for asthma. We aimed to study the short-term prognosis of asthma after the military service. METHODS:All 216 men with verified asthma in 2004-2005 from the register of the Central Military Hospital were included in ...
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pub_type: 杂志文章
doi:10.1016/j.rmed.2009.05.022
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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doi:10.1016/j.rmed.2013.10.004
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:This study evaluated the dose-response and dosing interval of the novel long-acting muscarinic receptor antagonist (LAMA) GSK573719 in patients with COPD. METHODS:This randomized, double-blind, placebo-controlled, 3-way cross-over, incomplete block study evaluated 5 once-daily doses of GSK573719 (62.5-1000 ...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rmed.2012.03.012
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2008.10.001
更新日期:2009-03-01 00:00:00
abstract::The accuracy of prescriptions for bronchodilator drugs was monitored before and after an educational circular to the medical staff of five medical wards. The circular contained model prescriptions for beta-agonists alone and combined with ipratropium bromide. There was a significant improvement overall in the accuracy...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(89)80207-0
更新日期:1989-07-01 00:00:00
abstract::This retrospective study reviews the patterns of P. cepacia pulmonary infection in 75 of a total of 872 mainly adults with cystic fibrosis, registered here during the 4 years 1987-1990; 35 (47%) were female. During this period, 55 patients acquired P. cepacia and the annual incidence and prevalence rates have remained...
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pub_type: 杂志文章
doi:10.1016/0954-6111(93)90090-m
更新日期:1993-04-01 00:00:00
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doi:10.1016/j.rmed.2018.10.009
更新日期:2018-12-01 00:00:00