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Exhaled nitric oxide measurements: correction equation to compare hand-held device to stationary analyzer.

Abstract：

INTRODUCTION:Exhaled nitric oxide (FE(NO)) is a reliable non-invasive marker of airway inflammation. In 2003 FE(NO) chemiluminescence analyzer (NIOX; Aerocrine AB, Solna, Sweden) was approved by U.S. Food and Drug Administration for monitoring asthma therapy. Recently, the same company developed a portable device using electrochemical sensors (NIOX-MINO; Aerocrine AB). The aim of our study was to compare NIOX-MINO FE(NO) values to those obtained by NIOX and to calculate a correction equation. METHODS:Two adequate measurements obtained by NIOX and NIOX-MINO were recorded in 32 subjects (16 females, mean age 41 years). RESULTS:FE(NO) values measured by NIOX-MINO were systematically higher than those obtained by NIOX (47.1ppb, IC 95% 35.2-59.1 and 36.9ppb, IC 95% 25.0-49.0, respectively). There was a significant correlation (r=0.998, p<0.001) between FE(NO) measured by the two analyzers and the following conversion equation was calculated as: FE(NO(NIOX))=-1.656(SE=0.61)+0.808(SE=0.009)x FE(NO(NIOX-MINO)) DISCUSSION: FE(NO) values measured by the portable nitric oxide analyzer are reliable and strongly correlated with values obtained by the standard stationary device, with a systematic difference observed between the two instruments' values that can be described by the conversion equation we provided. This equation will help clinicians and researchers to compare data obtainable by the two analyzers.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Pizzimenti S,Bugiani M,Piccioni P,Heffler E,Carosso A,Guida G,Rolla G

doi

10.1016/j.rmed.2008.04.006

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

1272-5

issue

9

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(08)00140-6

journal_volume

102

pub_type

杂志文章

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