Abstract:
BACKGROUND:Systemic inflammation is associated with impaired lung function in healthy adults as well as in patients with lung disease. The mechanism for this association is unknown and it is unclear if systemic inflammation leads to impaired lung function or if poor lung function leads to inflammation. We explored the temporal associations between blood C-reactive protein (CRP), fibrinogen, and white blood cells, and lung function in young adults. METHODS:Spirometry, plethysmography, and diffusion capacity were measured in a population-based cohort at ages 32 and 38 years. High-sensitivity CRP, fibrinogen, and white blood cells were measured at the same ages. RESULTS:Higher levels of CRP and, to a lesser extent, fibrinogen were associated with lower lung volumes in cross-sectional analyses at both ages 32 and 38 years. Higher CRP and fibrinogen at age 32 were associated with higher FEV1 and FEV1/FVC at age 38, but not other measures of lung function. Lower lung volumes (total lung capacity, functional residual capacity, and residual volume) but not airflow obstruction (FEV1/FVC) at age 32 were associated with higher CRP at age 38. Associations between age 32 lung function and fibrinogen at follow-up were weaker, but consistent. There were no longitudinal associations between white blood cells and lung function. CONCLUSIONS:We found no evidence that systemic inflammation causes a decline in lung function. However, lower lung volumes were associated with higher CRP and fibrinogen at follow-up indicating that pulmonary restriction may be a risk factor for systemic inflammation. The mechanism for this association remains unclear.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Hancox RJ,Gray AR,Sears MR,Poulton Rdoi
10.1016/j.rmed.2015.12.007subject
Has Abstractpub_date
2016-02-01 00:00:00pages
54-9eissn
0954-6111issn
1532-3064pii
S0954-6111(15)30098-6journal_volume
111pub_type
杂志文章abstract::Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition worldwide and is associated with significant mortality. This paper gives an overview of the relevant literature regarding care needs in advanced COPD from the perspective of the patient or carer, and aims to explore the appropriateness of a p...
journal_title:Respiratory medicine
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Respiratory medicine
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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