Use of the QuantiFERON-TB Gold test in Japanese patients with sarcoidosis.

Abstract:

BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFERON-TB Gold results in Japanese sarcoidosis patients. PATIENTS AND METHODS:The QuantiFERON-TB Gold test, an enzyme-linked immunosorbent assay, was used to assess the levels of interferon-gamma resulting from immune responses to M. tuberculosis-specific antigens, namely early secretory antigen target 6 and culture filtrate protein 10, in 90 Japanese sarcoidosis patients. RESULTS:The QuantiFERON-TB Gold result was positive in 3 of the 90 patients tested. CONCLUSION:The positivity rate of QuantiFERON-TB Gold was 3.3% in Japanese sarcoidosis patients.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Inui N,Suda T,Chida K

doi

10.1016/j.rmed.2007.09.013

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

313-5

issue

2

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(07)00401-5

journal_volume

102

pub_type

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