Abstract:
BACKGROUND:An Expert Forum was held at the 2014 European Respiratory Society International Congress to address issues involved in the management of Pseudomonas aeruginosa infection in patients with non-cystic fibrosis bronchiectasis (NCFB). Multiple studies have found that chronic P. aeruginosa infection is associated with more severe disease and higher morbidity and mortality. OVERVIEW:Participants discussed appropriate management of P. aeruginosa infection at three stages: 1) first isolation, including eradication protocols; 2) during exacerbations; and 3) during chronic infection, including long-term antibiotic therapy to reduce the severity of symptoms and frequency of exacerbations. Topics covered included frequency of sputum cultures, antibiotic treatment at first isolation and for exacerbations, optimal use of inhaled antibiotics, indications for long-term therapy, and treatment regimens that may reduce the frequency or severity of symptoms. Electronic polling and roundtable discussions followed by expert insights were used to address these topics. Significant diversity in management practices was reported among different countries and centres, and in many cases clinical management was at variance with published guidelines. CONCLUSIONS:This Expert Forum identified standardised terminology, clinician training, additional research into management strategies, and the development of new drugs as areas requiring improvement for the optimal management of P. aeruginosa in NCFB.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Wilson R,Aksamit T,Aliberti S,De Soyza A,Elborn JS,Goeminne P,Hill AT,Menendez R,Polverino Edoi
10.1016/j.rmed.2016.06.007subject
Has Abstractpub_date
2016-08-01 00:00:00pages
179-89eissn
0954-6111issn
1532-3064pii
S0954-6111(16)30131-7journal_volume
117pub_type
杂志文章,评审abstract::Summary beta2-adrenoreceptor agonists are able to modulate various aspects of airway cell functions involved in the inflammatory and repair processes characterizing a variety of respiratory disorders. Human bronchial epithelial cells (HBECs), which can act as immune effector cells and express beta2-adrenoreceptors, we...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2007-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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