当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Increased serum VDBP as a risk predictor for steroid resistance in asthma patients.

Increased serum VDBP as a risk predictor for steroid resistance in asthma patients.

Abstract：

BACKGROUND:Asthmatic symptoms usually can be controlled with corticosteroids, but partly asthmatic patients do not respond to corticosteroids, steroid resistance (SR) play a significant role in the poorly responding. However, no approach can accurately predict steroid responsiveness in asthma patients, so prediction of SR with noninvasive means has become a critical issue. OBJECTIVE:The aim of this study was to evaluate the difference in serum proteomes between steroid-sensitive asthma (SSA) and steroid-resistant asthma (SRA) patients and identify potential biomarkers for the prediction of SR in asthma patients. METHODS:We performed a proteomic approach of fluorescence-based difference gel electrophoresis (DIGE) and mass spectrometry to identify biomarkers in the serum obtained from SRA and SSA patients (n = 6 in each group). The interesting biomarker was further studied using western blot and enzyme-linked immunosorbent assays (ELISA). RESULTS:Seven differentially expressed proteins between SSA and SRA group were identified. Among them, vitamin D-binding protein (VDBP) attracted our further attention as the greatest changed protein. Serum VDBP was significantly up-regulated in SRA group compared with SSA group, and the differential expression was confirmed with western blot analysis. The ELISA data showed the serum level of VDBP was significantly higher in SRA group than that in SSA and control group (496.50 ± 204.62 vs. 279.73 ± 163.65, 241.93 ± 98.58 μg/ml, respectively, p < 0.01). Correlation analysis indicated serum VDBP was positively correlated with neutrophils% and monocytes% (p < 0.05), but inversely correlate with serum 25OHD (p < 0.05). Regression analysis showed increased serum VDBP was a risk predictor of SRA, and serum 25OHD was an independent influential factor of serum VDBP. Using the receiver operating characteristic curve, we determined the area under the curve (AUC) of VDBP was 0.792, and the optimal serum cutoff value of VDBP was 355.8 μg/ml, which can discriminate SRA from asthma patients with 65.2% sensitivity and 83.7% specificity. CONCLUSIONS:This study provides a novel overview of the difference in serum proteomes of SSA and SRA. We suppose serum VDBP may serve as a useful biomarker for predicting SR in asthma patients, and may participate in the pathogenesis of SRA.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Jiang H,Chi X,Zhang X,Wang J

doi

10.1016/j.rmed.2016.03.011

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

111-6

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(16)30041-5

journal_volume

114

pub_type

杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • Inspired fraction of carbon dioxide in oxygen supply to chronic pulmonary disease.

    abstract：:Hypoxemic patients with chronic obstructive pulmonary disease (COPD) are at risk of carbon dioxide (CO(2)) retention during oxygen therapy and hypercapnia in COPD is associated with an ominous prognosis. Rebreathing with oxygen mask is possible in practice and possibly affects CO(2) retention due to an increased inspi...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.08.015

    authors： Fremault A,Silva M,Beaucage F,Berckmans D,Decramer M

    更新日期：2008-12-01 00:00:00

  • Airway inflammation in obstructive sleep apnea: is leptin the missing link?

    abstract：BACKGROUND:Local and systemic inflammation is implicated in the pathophysiology of Obstructive Sleep Apnea (OSA). Exhaled breath condensate (EBC) is a non-invasive sampling method for the lower airways. However, it is important to consider the potential effect of the systemic origin whereas systemic inflammation is sig...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.04.021

    authors： Antonopoulou S,Loukides S,Papatheodorou G,Roussos C,Alchanatis M

    更新日期：2008-10-01 00:00:00

  • Long-term experience after transition from parenteral prostanoids to oral agents in patients with pulmonary hypertension.

    abstract：BACKGROUND:Long-term follow-up after transition to oral agents from parenteral prostanoid therapy has not been well characterized. METHODS:We reviewed our long-term experience after oral transitioning in patients with pulmonary hypertension. Patients were weaned off parenteral therapy based on a pre-determined outpati...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.12.020

    authors： Diaz-Guzman E,Heresi GA,Dweik RA,Minai OA

    更新日期：2008-05-01 00:00:00

  • Validation of an activity monitor during sleep in patients with chronic respiratory disorders.

    abstract：INTRODUCTION:Objective of this study was to validate an activity monitor (DynaPort MoveMonitor [MM], McRoberts, The Hague, The Netherlands) against night-vision video analysis during sleep. METHODS:Twenty patients (65 ± 11 years old, mean body-mass-index: 27 ± 6 kg/m(2)) with different chronic lung diseases were recru...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.12.017

    authors： Gloeckl R,Damisch T,Prinzen J,van Lummel R,Pengel E,Schoenheit-Kenn U,Kenn K

    更新日期：2015-02-01 00:00:00

  • What characterizes patients who are unable to tolerate continuous positive airway pressure (CPAP) treatment?

    abstract：:Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnoea syndrome (OSAS), but many patients find this treatment intolerable. The aim of this study was to characterize patients who were unable to tolerate CPAP treatment (non-complaint) as opposed to those who continued using CP...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0703

    authors： Janson C,Nöges E,Svedberg-Randt S,Lindberg E

    更新日期：2000-02-01 00:00:00

  • Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome.

    abstract：STUDY OBJECTIVES:The process of intermittent hypoxia-reoxygenation produces airway inflammation and endothelial dysfunction that favors the development of cardiovascular disorders in obstructive sleep apnea syndrome (OSAS). Nitric oxide (NO) is an important mediator in airway inflammation and the regulation of endothel...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.12.004

    authors： Fortuna AM,Miralda R,Calaf N,González M,Casan P,Mayos M

    更新日期：2011-04-01 00:00:00

  • Altered antioxidant status in peripheral skeletal muscle of patients with COPD.

    abstract：:Despite the growing field of interest in the role of pulmonary oxidative stress in chronic obstructive pulmonary disease (COPD), barely any data are available with respect to antioxidant capacity in the peripheral musculature of these patients. The main objective of this study was to assess in detail the antioxidant s...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2004.05.018

    authors： Gosker HR,Bast A,Haenen GR,Fischer MA,van der Vusse GJ,Wouters EF,Schols AM

    更新日期：2005-01-01 00:00:00

  • Effects of positive end-expiratory pressure (PEEP) in cardiac surgery patients.

    abstract：:The role of positive end-expiratory pressure (PEEP) in the postoperative course of cardiac surgery patients remains questionable. In this prospective study, we examined the effect of different levels of PEEP on arterial oxygenation, SvO2 and PvO2 values, and on haemodynamic indices, during the early postoperative peri...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(98)90388-2

    authors： Michalopoulos A,Anthi A,Rellos K,Geroulanos S

    更新日期：1998-06-01 00:00:00

  • A profile of volatile organic compounds in breath discriminates COPD patients from controls.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is an inflammatory condition characterized by oxidative stress and the formation of volatile organic compounds (VOCs) secreted via the lungs. We recently developed a methodological approach able to identify profiles of VOCs in breath unique for patient groups. Her...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.10.018

    authors： Van Berkel JJ,Dallinga JW,Möller GM,Godschalk RW,Moonen EJ,Wouters EF,Van Schooten FJ

    更新日期：2010-04-01 00:00:00

  • Elevated level of circulating matrix metalloproteinase-9 in patients with lung cancer.

    abstract：:The 72 kDa matrix metalloproteinase (MMP-2) and the 92 kDa matrix metalloproteinase (MMP-9), are type IV collagenases that have been implicated as important factors in cancer invasion and metastasis formation. We have used quantitative zymography and computer-assisted image analysis to measure the levels of MMP-9 and ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2000.0923

    authors： Hrabec E,Strek M,Nowak D,Hrabec Z

    更新日期：2001-01-01 00:00:00

  • Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis.

    abstract：INTRODUCTION:Idiopathic bronchiectasis is a poorly defined disease characterised by persistent inflammation, infection and progressive lung damage. Natural killer (NK) cells provide a major defense against infection, through the interaction of their surface receptors, including the activating and inhibitory killer immu...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.05.017

    authors： McDonnell MJ,Anwar GA,Rutherford RM,De Soyza A,Worthy S,Corris PA,Lordan JL,Bourke S,Afolabi G,Ward C,Middleton P,Middleton D

    更新日期：2014-08-01 00:00:00

  • Exhaled nitric oxide and exercise tolerance in severe COPD patients.

    abstract：:To answer the question as to whether pulmonary rehabilitation programs (PRP) induced increase in exercise tolerance (ET) is associated with increased levels of exhaled nitric oxide (eNO) in COPD patients of different degrees of severity, we designed a prospective and controlled study. Forty-seven stable COPD patients ...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1053/rmed.2001.1286

    authors： Clini E,Bianchi L,Foglio K,Vitacca M,Ambrosino N

    更新日期：2002-05-01 00:00:00

  • Military service-aggravated asthma improves at two-year follow-up.

    abstract：BACKGROUND:During military service young men (age 19-21 years) are exposed to many predisposing factors for asthma. We aimed to study the short-term prognosis of asthma after the military service. METHODS:All 216 men with verified asthma in 2004-2005 from the register of the Central Military Hospital were included in ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.05.022

    authors： Lindström I,Koponen P,Luukkonen R,Pallasaho P,Kauppi P,Latvala J,Karjalainen A,Lauerma A

    更新日期：2009-12-01 00:00:00

  • Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract：OBJECTIVES:To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). METHODS:Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD. RESULTS:Twenty rand...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rmed.2004.10.009

    authors： Ram FS,Jardin JR,Atallah A,Castro AA,Mazzini R,Goldstein R,Lacasse Y,Cendon S

    更新日期：2005-02-01 00:00:00

  • A retrospective analysis of the pathogens in the airways of patients with primary ciliary dyskinesia.

    abstract：INTRODUCTION:Primary ciliary dyskinesia (PCD) is a rare genetically heterogeneous disorder of motile cilia, which leads to recurrent and chronic airway infections. Detailed information about infection causing pathogens is scarce. With this study, we aimed to determine the prevalence and susceptibility of the most commo...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.08.009

    authors： Roden L,Görlich D,Omran H,Peters G,Große-Onnebrink J,Kahl BC

    更新日期：2019-09-01 00:00:00

  • Primary biphasic synovial sarcoma of the pleura.

    abstract：:Synovial sarcoma most commonly occurs in the peri-articular regions of the extremities. The present report describes a rare case of primary biphasic synovial sarcoma of the pleura in an 18-year-old female. The diagnosis was made on the basis of light microscopy, immunohistochemistry, electron microscopy and the charac...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(97)90093-7

    authors： Jawahar DA,Vuletin JC,Gorecki P,Persechino F,Macera M,Magazeh P

    更新日期：1997-10-01 00:00:00

  • Non-invasive ventilation at home improves survival and decreases healthcare utilization in medicare beneficiaries with Chronic Obstructive Pulmonary Disease with chronic respiratory failure.

    abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease with chronic respiratory failure (COPD-CRF) experience high mortality and healthcare utilization. Non-invasive home ventilation (NIVH) is increasingly used in such patients. We examined the associations between NIVH and survival, hospitalizations, and emerg...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106291

    authors： Frazier WD,Murphy R,van Eijndhoven E

    更新日期：2020-12-30 00:00:00

  • The impact of bronchiectasis associated to sinonasal disease on quality of life.

    abstract：BACKGROUND:Bronchiectasis (BQs) is an uncommon disease with the potential to cause devastating complications. All patients with BQs have cough and chronic sputum production that may have a great impact on patient's quality of life. Upper airway symptoms are also frequent in patients with BQs. Associations between upper...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.02.016

    authors： Guilemany JM,Alobid I,Angrill J,Ballesteros F,Bernal-Sprekelsen M,Picado C,Mullol J

    更新日期：2006-11-01 00:00:00

  • Post-9/11 sarcoidosis in WTC-exposed firefighters and emergency medical service workers.

    abstract：INTRODUCTION:The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested "greater than expected" numbers of post-9/11 cases in some workers. We undertook this study to estimate t...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.06.004

    authors： Webber MP,Yip J,Zeig-Owens R,Moir W,Ungprasert P,Crowson CS,Hall CB,Jaber N,Weiden MD,Matteson EL,Prezant DJ

    更新日期：2017-11-01 00:00:00

  • Efficacy of fluticasone propionate/formoterol fumarate in the treatment of asthma: a pooled analysis.

    abstract：BACKGROUND:Fluticasone propionate and formoterol fumarate have been combined in a single inhaler (fluticasone/formoterol; flutiform(®)) for the maintenance treatment of asthma. This pooled analysis assessed the efficacy of fluticasone/formoterol versus fluticasone in patients who previously received inhaled corticoster...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2014.10.019

    authors： Papi A,Price D,Sastre J,Kaiser K,Lomax M,McIver T,Dissanayake S

    更新日期：2015-02-01 00:00:00

  • Evaluation of sleep quality and anxiety-depression parameters in asthmatic children and their mothers.

    abstract：BACKGROUND:Having a child with a chronic disease may cause anxiety and depression and impair the sleep quality in the mothers. The aim of this study was to evaluate sleep quality in asthmatic children and their mothers as well as the status of anxiety-depression in the mothers. METHODS:Study group consisted of 75 asth...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.07.025

    authors： Yuksel H,Sogut A,Yilmaz O,Demet M,Ergin D,Kirmaz C

    更新日期：2007-12-01 00:00:00

  • Single breath N2-test and exhaled nitric oxide in men.

    abstract：:The N(2) slope is an index of inhomogeneous distribution of ventilation and has been suggested to be suited for early testing of chronic obstructive pulmonary disease (COPD) in smokers. The aim of the present study was to examine the association between the fraction of exhaled nitric oxide (FENO) and the N(2) slope in...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.09.037

    authors： Olin AC,Andelid K,Vikgren J,Rosengren A,Larsson S,Bake B,Ekberg-Jansson A

    更新日期：2006-06-01 00:00:00

  • Ulcerative colitis responsive to smoking and to nicotine chewing gum in a patient with alpha 1 anti-trypsin deficiency.

    abstract：:Ulcerative colitis is one of the few diseases in which smoking appears to confer some benefit (1). We report a patient whose ulcerative colitis deteriorated on several occasions on stopping cigarettes, and improved on restarting smoking. As a result, she continued smoking despite developing airflow limitation and seve...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(95)90235-x

    authors： Watson JP,Lewis RA

    更新日期：1995-10-01 00:00:00

  • Daily vs. intermittent inhaled corticosteroids for recurrent wheezing and mild persistent asthma: a systematic review with meta-analysis.

    abstract：BACKGROUND:Intermittent ICS treatment with SABA in response to symptoms, is an emerging strategy for control of mild-to-moderate asthma, and recurrent wheezing. This systematic revue compares the efficacy of daily vs. intermittent ICS among preschoolers, children and adults with persistent wheezing and mild to moderate...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rmed.2013.05.005

    authors： Rodrigo GJ,Castro-Rodríguez JA

    更新日期：2013-08-01 00:00:00

  • Perceived 10-year change in respiratory health: reliability and predictive ability.

    abstract：OBJECTIVE:To investigate the usefulness of a self-reported respiratory health transition question over 10 years through reliability, ability to capture long-term asthma trajectory and predictive ability. SETTINGS:In two 20-year cohorts (Asthma-E3N, n = 16,371, 61-88 years; EGEA, n = 1254, 27-82 years), perceived 10-ye...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.11.010

    authors： Sanchez M,Varraso R,Bousquet J,Clavel-Chapelon F,Pison C,Kauffmann F,Humbert M,Siroux V

    更新日期：2015-02-01 00:00:00

  • Microrint pulmonary function testing in older adults with an intellectual disability.

    abstract：BACKGROUND:Pulmonary function testing is not feasible in many adults with intellectual disabilities, because of difficulties with understanding and cooperation. AIMS:To investigate feasibility, repeatability and reproducibility of measuring airway resistance using the interrupter technique (MicroRint) in people aged 5...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2009.05.021

    authors： Pouls KP,Alsema LE,van der Laan H,Evenhuis HM,Penning C

    更新日期：2009-12-01 00:00:00

  • Does immunotherapy with heat-killed Mycobacterium vaccae offer hope for the treatment of multi-drug-resistant pulmonary tuberculosis?

    abstract：:The ability of immunotherapy with heat-killed Mycobacterium vaccae (NCTC 11659), as an addition to the available chemotherapy, to improve the outcome in patients with multi-drug-resistant tubercle bacilli (MDRTB) who had not been cured by chemotherapy alone was evaluated in tuberculosis centres in Estonia, Iran, Kuwai...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1053/rmed.2001.1065

    authors： Stanford JL,Stanford CA,Grange JM,Lan NN,Etemadi A

    更新日期：2001-06-01 00:00:00

  • Concurrent presentations of the sarcoidosis, tuberculosis and lymphoma in a single patient.

    abstract：:A 56-year-old female patient, developing ALK-negative anaplastic T cell lymphoma 7 years after the diagnosis of sarcoidosis with clinical and histopathological features of tuberculosis has been presented. We herein present concurrent occurrence of the sarcoidosis, lymphoma and tuberculosis along with the confusing fin...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.09.001

    authors： Tufan A,Ranci O,Sungur A,Topeli A,Haznedaroglu I,Cöplü L

    更新日期：2006-05-01 00:00:00

  • Prognostic value of bronchial provocation and FENO measurement for asthma diagnosis--results of a delayed type of diagnostic study.

    abstract：OBJECTIVES:To compare the prognostic value of FENO with bronchoprovocation testing when the clinical course within the first year after assessment was taken into account; to compare the prognostic values with respect to eosinophilic versus non-eosinophilic inflammatory pattern. METHODS:Cross-sectional diagnostic study...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.11.008

    authors： Schneider A,Faderl B,Schwarzbach J,Welker L,Karsch-Völk M,Jörres RA

    更新日期：2014-01-01 00:00:00

  • Evaluation of a pocket-sized turbine spirometer for clinical use with children.

    abstract：:The results of pulmonary function testing with a turbine spirometer (TS) and a bell spirometer (BS) of a randomized group of 275 patients aged 4-18 years were compared. In the TS, an inexpensive device without graphical display was used. The difference BS minus TS (d) for forced expiratory volume in 1 s (FEV1) was cal...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0954-6111(97)90064-0

    authors： Paul KP,Schultz T

    更新日期：1997-07-01 00:00:00