当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Airway inflammation in obstructive sleep apnea: is leptin the missing link?

Airway inflammation in obstructive sleep apnea: is leptin the missing link?

Abstract：

BACKGROUND:Local and systemic inflammation is implicated in the pathophysiology of Obstructive Sleep Apnea (OSA). Exhaled breath condensate (EBC) is a non-invasive sampling method for the lower airways. However, it is important to consider the potential effect of the systemic origin whereas systemic inflammation is significantly elevated. This prospective study was designed to investigate whether airway inflammation is significantly related to plasma leptin levels in OSA patients. Simultaneously, it was designed to investigate whether inflammatory variables predict parameters expressing disease severity and finally whether smoking habit affect the above measurements. PATIENTS & METHODS:About 45 OSA patients (mean AHI 40+/-25, 28 smokers) and 25 healthy controls (AHI<5, 15 smokers) were studied and underwent overnight diagnostic polysomnography. We measured pH, 8-isoprostane, TNF-alpha and IL-6 in EBC and leptin in plasma. Plausible associations between leptin and inflammatory parameters were analyzed after adjustment for proper variables. Similar associations between inflammatory variables and parameters of disease severity were also performed. RESULTS:An increased level of leptin and respective increase of inflammatory variables was found. No significant association was observed between parameters of EBC and plasma leptin levels. A part of the parameters of disease severity is significantly associated with pH and 8-isoprostane. Smoking did not seem to be a critical confounding factor for evaluation of the above measurements. CONCLUSIONS:Increased levels of leptin were not associated with the observed airway inflammation in OSA. The observed airway inflammation seemed to be independent of smoking habit with limited association with disease severity.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Antonopoulou S,Loukides S,Papatheodorou G,Roussos C,Alchanatis M

doi

10.1016/j.rmed.2008.04.021

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1399-405

issue

10

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(08)00174-1

journal_volume

102

pub_type

杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • The association between exhaled nitric oxide and sleep apnea: the role of BMI.

    abstract：BACKGROUND:Obstructive sleep apnea syndrome is associated with airway inflammation. Measurement of exhaled nitric oxide is a non-invasive method for evaluation of airway diseases. It seems that obesity is an exacerbating factor for airway inflammation. We aimed to evaluate the changes of exhaled nitric oxide after slee...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.05.010

    authors： JalilMirmohammadi S,Mehrparvar AH,Safaei S,Samimi E,Torab Jahromi M

    更新日期：2014-08-01 00:00:00

  • A retrospective analysis of practice patterns in the management of acute asthma attack across Turkey.

    abstract：OBJECTIVE:To evaluate patient characteristics and practice patterns in the management of acute asthma attack at tertiary care centers across Turkey. METHODS:A total of 294 patients (mean age: 50.4 ± 15.1 years; females: 80.3%) diagnosed with persistent asthma were included in this retrospective study upon their admiss...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2010.07.005

    authors： Türktaş H,Bavbek S,Misirligil Z,Gemicioğlu B,Mungan D

    更新日期：2010-12-01 00:00:00

  • Combining triple therapy and pulmonary rehabilitation in patients with advanced COPD: a pilot study.

    abstract：BACKGROUND:The synergistic interactions between pharmacotherapy and pulmonary rehabilitation has been provided, but it remains to be established whether this may also apply to more severe patients. OBJECTIVES:We have examined whether tiotropium enhances the effects of exercise training in patients with advanced COPD (...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2009.10.005

    authors： Pasqua F,Biscione G,Crigna G,Auciello L,Cazzola M

    更新日期：2010-03-01 00:00:00

  • Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept.

    abstract：:Rheumatoid arthritis (RA)-associated constrictive bronchiolitis is a severe condition with no established efficient treatment. A 55-year-old woman with seropositive RA developed rapidly progressive constrictive bronchiolitis confirmed by lung biopsy. Her clinical condition worsened despite steroids and azathioprine. T...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2004.09.001

    authors： Cortot AB,Cottin V,Miossec P,Fauchon E,Thivolet-Béjui F,Cordier JF

    更新日期：2005-04-01 00:00:00

  • Randomized trial of non-invasive ventilation combined with exercise training in patients with chronic hypercapnic failure due to chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Non-invasive ventilation and exercise training might prove beneficial in the management of COPD patients. OBJETIVE:to compare the combined use of exercise training and non-invasive ventilation with the two interventions separately in chronic respiratory failure due to chronic obstructive pulmonary disease. ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2014.10.005

    authors： Márquez-Martín E,Ruiz FO,Ramos PC,López-Campos JL,Azcona BV,Cortés EB

    更新日期：2014-12-01 00:00:00

  • The effect of mouth leak and humidification during nasal non-invasive ventilation.

    abstract：BACKGROUND:Poor mask fit and mouth leak are associated with nasal symptoms and poor sleep quality in patients receiving domiciliary non-invasive ventilation (NIV) through a nasal mask. Normal subjects receiving continuous positive airways pressure demonstrate increased nasal resistance following periods of mouth leak. ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2007.05.005

    authors： Tuggey JM,Delmastro M,Elliott MW

    更新日期：2007-09-01 00:00:00

  • Influence of salmeterol/fluticasone via single versus separate inhalers on exacerbations in severe/very severe COPD.

    abstract：BACKGROUND:Patients with severe or very severe chronic obstructive pulmonary disease (COPD) frequently suffer repeated exacerbations generating high health care utilization costs. Combined corticosteroid and bronchodilator treatment using a single inhaler might - via improved compliance - reduce exacerbation rates. OB...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2012.12.020

    authors： Hagedorn C,Kässner F,Banik N,Ntampakas P,Fielder K

    更新日期：2013-04-01 00:00:00

  • Respiratory care in familial dysautonomia: Systematic review and expert consensus recommendations.

    abstract：BACKGROUND:Familial dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type-III) is a rare genetic disease caused by impaired development of sensory and afferent autonomic nerves. As a consequence, patients develop neurogenic dysphagia with frequent aspiration, chronic lung disease, and chemorefl...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2018.06.017

    authors： Kazachkov M,Palma JA,Norcliffe-Kaufmann L,Bar-Aluma BE,Spalink CL,Barnes EP,Amoroso NE,Balou SM,Bess S,Chopra A,Condos R,Efrati O,Fitzgerald K,Fridman D,Goldenberg RM,Goldhaber A,Kaufman DA,Kothare SV,Levine J,Levy

    更新日期：2018-08-01 00:00:00

  • Reversibility tests in chronic obstructive airways disease: their predictive value with reference to benefit from domiciliary nebuliser therapy.

    abstract：:The role of short-term tests of reversibility in selecting patients with COAD for long-term nebuliser therapy is uncertain. In a double-blind placebo-controlled crossover study we have examined the correlation between short-term reversibility and response to a home nebuliser. We studied 20 patients with severe COAD (m...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(06)80097-1

    authors： Teale C,Morrison JF,Jones PC,Muers MF

    更新日期：1991-07-01 00:00:00

  • Aerosol delivery of nebulised budesonide in young children with asthma.

    abstract：BACKGROUND:Lung deposition of inhaled steroids, likely to be of benefit in the anti-inflammatory treatment of asthma in young children, is low. This is explained by age specific anatomical and physiological characteristics as well as poor cooperation with aerosol therapy. However, total lung deposition and the ratio of...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.04.029

    authors： Schueepp KG,Devadason SG,Roller C,Minocchieri S,Moeller A,Hamacher J,Wildhaber JH

    更新日期：2009-11-01 00:00:00

  • Cardiovascular disease in asthma and COPD: a population-based retrospective cross-sectional study.

    abstract：:We conducted a large population-based retrospective cross-sectional study for determining the extent of clinically recognized chronic obstructive pulmonary disease (COPD) and asthma, and the prevalence of associated cardiovascular diseases (CVDs), using information obtained from the Health Search Database (HSD) owned ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.07.021

    authors： Cazzola M,Calzetta L,Bettoncelli G,Cricelli C,Romeo F,Matera MG,Rogliani P

    更新日期：2012-02-01 00:00:00

  • Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation.

    abstract：OBJECTIVE:To assess whether tumor necrosis factor (TNF) antagonism can attenuate eosinophilic airway inflammation in patients with mild-to-moderate allergic asthma. DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:National Institutes of Health (NIH) Clinical Center. PATIENTS:Twenty-six patients wit...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2005.02.031

    authors： Rouhani FN,Meitin CA,Kaler M,Miskinis-Hilligoss D,Stylianou M,Levine SJ

    更新日期：2005-09-01 00:00:00

  • Needle-track metastases and prophylactic radiotherapy for mesothelioma.

    abstract：BACKGROUND:Mesothelioma invades the tracts made by chest instrumentation. Prophylactic radiotherapy is effective at preventing malignant seeding at these sites. METHODS:We assessed the use and effectiveness of radiotherapy at our centre in 39 of the 40 patients identified with mesothelioma between January 2000 and Sep...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.09.034

    authors： West SD,Foord T,Davies RJ

    更新日期：2006-06-01 00:00:00

  • Comparison of mannitol and citric acid cough provocation tests.

    abstract：RATIONALE:Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory approval and can be performed utilizing a simple disposable inhaler in a standardized manner. OBJECTIV...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.09.011

    authors： Nurmi HM,Lätti AM,Brannan JD,Koskela HO

    更新日期：2019-01-01 00:00:00

  • The 24 h duration of bronchodilator action of the salmeterol/fluticasone combination inhaler.

    abstract：INTRODUCTION:The duration of bronchodilator action of the long-acting beta agonist salmeterol when administered in the evening has not been investigated. In this study we have investigated whether a single evening dose of salmeterol, administered from the combination salmeterol/fluticasone (SFC) Accuhaler significantly...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.rmed.2004.10.001

    authors： Masoli M,Weatherall M,Ayling J,Williams M,Beasley R

    更新日期：2005-05-01 00:00:00

  • Bacterial extracts for the prevention of acute exacerbations in chronic obstructive pulmonary disease: a point of view.

    abstract：:Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.11.002

    authors： Cazzola M,Rogliani P,Curradi G

    更新日期：2008-03-01 00:00:00

  • Respiratory movement and pain thresholds in airway environmental sensitivity, asthma and COPD.

    abstract：INTRODUCTION:Patients with "sensory hyperreactivity" (SHR) have airway environmental sensitivity, chronic cough and dyspnoea. Cough, chest discomfort and sense of difficulties getting air are some of the symptoms these patients seek medical attendance for. The patients have increased cough sensitivity to inhaled capsai...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.03.011

    authors： Johansson EL,Ternesten-Hasséus E,Olsén MF,Millqvist E

    更新日期：2012-07-01 00:00:00

  • Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking.

    abstract：:The imbalance between oxidants and antioxidants is known to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most frequent factor responsible for development of COPD by leading to oxidant overload in the lower airways, due to presence of its own oxida...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0574

    authors： Nowak D,Kasielski M,Antczak A,Pietras T,Bialasiewicz P

    更新日期：1999-06-01 00:00:00

  • Risk factors for development of asthma in children and adolescents: findings from a longitudinal population study.

    abstract：BACKGROUND:The prevalence of asthma appears to be on the increase, and risk factors are not well established. To investigate risk factors for the development of asthma, a population sample of children and adolescents, aged 7-17 years at enrolment, were studied in 1986. Initial examinations were repeated at follow-up in...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(96)90021-9

    authors： Ulrik CS,Backer V,Hesse B,Dirksen A

    更新日期：1996-11-01 00:00:00

  • Prophylactic use of tranexamic acid for prevention of bleeding during transbronchial lung biopsies - A randomized, double-blind, placebo-controlled trial.

    abstract：BACKGROUND:Although massive bleeding following transbronchial lung biopsies (TBLB) is rare, even minor hemorrhage may prolong the procedure and result in inadequate sampling. Tranexamic acid (TXA) is an antifibrinolytic agent, which reduces bleeding in numerous scenarios, however, its prophylactic use in mitigating pos...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106162

    authors： Kuint R,Levy L,Cohen Goichman P,Huszti E,Abu Rmeileh A,Shriki O,Abutbul A,Fridlender ZG,Berkman N

    更新日期：2020-11-01 00:00:00

  • Prognostic value of six minute walk test in cystic fibrosis adults.

    abstract：BACKGROUND:The 6 min walk test (6MWT) provides prognostic information in various respiratory diseases, but limited data exist in cystic fibrosis (CF) adults. METHODS:Consecutive CF adults who performed 6MWT at Cochin Hospital (Paris, France) over 12 years were analyzed. The cut-off 6 min walking distance (6MWD) value ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.10.001

    authors： Martin C,Chapron J,Hubert D,Kanaan R,Honoré I,Paillasseur JL,Aubourg F,Dinh-Xuan AT,Dusser D,Fajac I,Burgel PR

    更新日期：2013-12-01 00:00:00

  • Agreement between spirometry and tracheal auscultation in assessing bronchial responsiveness in asthmatic children.

    abstract：:We have recently found that changes in lung sounds correspond well with a 20% fall in the forced expiratory volume in 1 s (FEV1) after methacholine challenge in asthmatic children. Up to now, little was known about the agreement between a 20% fall in FEV1 and a change in lung sounds after repeated bronchial challenge....

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(99)90298-6

    authors： Sprikkelman AB,Schouten JP,Lourens MS,Heymans HS,van Aalderen WM

    更新日期：1999-02-01 00:00:00

  • Distribution of emphysema in heavy smokers: impact on pulmonary function.

    abstract：PURPOSE:To investigate impact of distribution of computed tomography (CT) emphysema on severity of airflow limitation and gas exchange impairment in current and former heavy smokers participating in a lung cancer screening trial. MATERIALS AND METHODS:In total 875 current and former heavy smokers underwent baseline lo...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2009.08.004

    authors： Gietema HA,Zanen P,Schilham A,van Ginneken B,van Klaveren RJ,Prokop M,Lammers JW

    更新日期：2010-01-01 00:00:00

  • Evaluation of bronchoalveolar lavage fluid from ARDS patients with regard to apoptosis.

    abstract：BACKGROUND:Apoptosis is thought to play an important role in the development of acute respiratory distress syndrome (ARDS). We evaluated the bronchoalveolar lavage (BAL) fluid from ARDS patients focusing on apoptosis. METHODS:The study enrolled 31 ARDS patients and 20 healthy controls. BAL fluid levels of caspase-clea...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.10.001

    authors： Lee KS,Choi YH,Kim YS,Baik SH,Oh YJ,Sheen SS,Park JH,Hwang SC,Park KJ

    更新日期：2008-03-01 00:00:00

  • Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.

    abstract：BACKGROUND:Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [<65 versus ≥65 years] and...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.07.005

    authors： Chaudhuri R,McSharry C,Heaney LG,Niven R,Brightling CE,Menzies-Gow AN,Bucknall C,Mansur AH,Lee W,Shepherd M,Spears M,Cowan DC,Husi H,Thomson NC,BTS Severe Asthma Network.

    更新日期：2016-09-01 00:00:00

  • The expression of pro- and anti-apoptotic Bcl-2 family proteins in peribronchiolar lymphocytes from patients with diffuse panbronchiolitis.

    abstract：:Diffuse panbronchiolitis (DPB) is a distinctive form of small airway disease, which is characterized by chronic inflammation with lymphocyte infiltration around bronchioles. The aim of this study was to evaluate the importance of factors related to apoptosis in peribronchiolar lymphocytes of DPB. We employed immunohis...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.02.011

    authors： Kadota J,Mizunoe S,Mukae H,Mito K,Kishi K,Tokimatsu I,Nagai H,Tomono K,Kohno S,Nasu M

    更新日期：2006-11-01 00:00:00

  • Impact of LABA/LAMA combination on exercise endurance and lung hyperinflation in COPD: A pair-wise and network meta-analysis.

    abstract：BACKGROUND:The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we ca...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rmed.2017.06.020

    authors： Calzetta L,Ora J,Cavalli F,Rogliani P,O'Donnell DE,Cazzola M

    更新日期：2017-08-01 00:00:00

  • Recombinant tissue plasminogen activator in the treatment of pleural infections in adults.

    abstract：BACKGROUND:Intrapleural recombinant tissue plasminogen activator (r-TPA) has been successfully evaluated in pediatric patients with complicated parapneumonic pleural effusion (CPE) and pleural empyema (PE). Yet, there is no data concerning r-TPA in adults with CPE/PE. The aim of our study was to investigate the efficac...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.08.012

    authors： Froudarakis ME,Kouliatsis G,Steiropoulos P,Anevlavis S,Pataka A,Popidou M,Mikroulis D,Pneumatikos I,Bouros D

    更新日期：2008-12-01 00:00:00

  • Clinical equivalence of salmeterol/fluticasone propionate in combination (50/100 microg twice daily) when administered via a chlorofluorocarbon-free metered dose inhaler or dry powder inhaler to patients with mild-to-moderate asthma.

    abstract：:This multi-centre, randomized, double-blind, double-dummy, parallel-group study was designed to investigate the hypothesis of equivalent efficacy and comparable safety of two inhaled presentations of salmeterol/fluticasone propionate combination product (SALM/FP) 50/100 microg administered twice daily to patients with...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1053/rmed.2000.1008

    authors： Bateman ED,Silins V,Bogolubov M

    更新日期：2001-02-01 00:00:00

  • Effects of corticosteroids on bone turnover.

    abstract：:The pathophysiology of corticosteroid-induced osteoporosis is complex, but centres around a primary inhibition of osteoblastic activity compounded by the effects of secondary hyperparathyroidism. The preservation of the microanatomy of bone in the early stages of the disease, coupled with strategies to prevent the eme...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(05)80252-5

    authors： Hosking DJ

    更新日期：1993-02-01 00:00:00