Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept.

Abstract:

:Rheumatoid arthritis (RA)-associated constrictive bronchiolitis is a severe condition with no established efficient treatment. A 55-year-old woman with seropositive RA developed rapidly progressive constrictive bronchiolitis confirmed by lung biopsy. Her clinical condition worsened despite steroids and azathioprine. Treatment with etanercept-a tumor necrosis factor (TNF)-alpha inhibitor-combined with methotrexate, resulted in a marked improvement of both her clinical condition and pulmonary function tests. Treatment with TNF-alpha inhibitors and methotrexate may be proposed in RA-associated constrictive bronchiolitis, a severe condition hitherto not amenable to improvement.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Cortot AB,Cottin V,Miossec P,Fauchon E,Thivolet-Béjui F,Cordier JF

doi

10.1016/j.rmed.2004.09.001

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

511-4

issue

4

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(04)00336-1

journal_volume

99

pub_type

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