Abstract：
BACKGROUND:Exercise induced asthma may symptomatically be difficult to differentiate from exercise related obstruction in the upper airways, sometimes leading to diagnostic confusion and inappropriate treatment. Larynx accounts for a significant fraction of total airway resistance, but its role as a limiting factor for airflow during exercise has been hampered by lack of diagnostic tools. We aimed to study laryngeal function in exercising humans by transnasal laryngoscopy. METHODS:Continuous video recording of the larynx was performed in parallel with continuous film recording of the upper part of the body and recording of breath sounds in subjects running to respiratory distress or exhaustion on a treadmill. RESULTS:A successful examination was obtained in 20 asymptomatic volunteers and 151 (91%) of 166 young patients with a history of inspiratory distress or stridor during exercise. At rest, six patients had abnormal laryngeal findings. During exercise, a moderate or severe adduction of laryngeal structures was observed in parallel with increasing inspiratory distress in 113 (75%) patients. In 109 of these, adduction started within supraglottic structures, followed by adduction of the vocal cords in 88. In four patients, laryngeal adduction started in the vocal cords, involving supraglottic structures secondarily in three. CONCLUSION:Larynx can safely be studied throughout a maximum intensity exercise treadmill test. A characteristic laryngeal response pattern to exercise was visualised in a large proportion of patients with suspected upper airway obstruction. Laryngoscopy during ongoing symptoms is recommended for proper assessment of these patients.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Røksund OD,Maat RC,Heimdal JH,Olofsson J,Skadberg BT,Halvorsen Tdoi
10.1016/j.rmed.2009.05.024subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1911-8issue
12eissn
0954-6111issn
1532-3064pii
S0954-6111(09)00187-5journal_volume
103pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.rmed.2005.06.011
更新日期：2006-03-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,多中心研究
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更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2008-06-01 00:00:00
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2009-05-01 00:00:00
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更新日期：2009-04-01 00:00:00
