Abstract:
BACKGROUND:Bacteria expressing phosphorylcholine (ChoP) co-opt host-expressed platelet-activating factor receptor (PAFR) to adhere to lower airway cells. Cigarette smoke and rhinovirus (RV) infection upregulate PAFR-dependent bacterial adhesion to airway cells in vitro, and in healthy adults smoking increases the proportion of PAFR positive bronchial epithelial cells. To date the effect of chronic obstructive pulmonary disease (COPD) on smoke-induced PAFR is unknown. We therefore sought to test the hypothesis that bronchial PAFR mRNA expression is increased in smokers with chronic obstructive pulmonary disease (COPD), and further increases after RV infection. METHODS:Endobronchial biopsies were obtained by fibreoptic bronchoscopy from healthy non-smokers, smokers without airway obstruction, and smokers with COPD, before and after infection with rhinovirus (RV) serotype 16. Endobronchial PAFR mRNA expression was assessed by quantitative PCR and expressed as a ratio of glyceraldehyde-3-phosphate dehydrogenase. The distribution of PAFR was assessed by immunohistochemistry. RESULTS:Baseline PAFR mRNA expression was increased (p < 0.05) in smokers (n = 16), and smokers with COPD (n = 14) compared with non-smokers (n = 18). In RV16 infected subjects there was no increase in PAFR mRNA expression in either non-smokers (n = 9), smokers (n = 8), or smokers with COPD (n = 7). PAFR immunoreactivity in all 3 groups was predominately restricted to the bronchial epithelium and submucosal glands. CONCLUSIONS:Endobronchial PAFR mRNA is increased in both smokers without airway obstruction and smokers with COPD. We found preliminary evidence that RV16 infection does not increase PAFR mRNA expression in either smokers or smokers with COPD.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Suri R,Mallia P,Martin JE,Footitt J,Zhu J,Trujillo-Torralbo MB,Johnston SL,Grigg Jdoi
10.1016/j.rmed.2014.03.003subject
Has Abstractpub_date
2014-06-01 00:00:00pages
898-904issue
6eissn
0954-6111issn
1532-3064pii
S0954-6111(14)00111-5journal_volume
108pub_type
杂志文章abstract:BACKGROUND:Spirometry data predict mortality, but are less sensitive to detect dysfunction in small airways as compared to the slope of phase III (the N2 slope) of the single breath nitrogen test. The association between the N2 slope and mortality has been studied with conflicting results. In the present study the prog...
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1079
更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/s0954-6111(98)90511-x
更新日期:1998-04-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2018.10.009
更新日期:2018-12-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2012.03.002
更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-05-01 00:00:00
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-07-01 00:00:00
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2012.03.021
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0954-6111(93)90138-p
更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2018.08.009
更新日期:2018-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
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更新日期:2005-09-01 00:00:00