Abstract:
UNLABELLED:Amiodarone-induced pulmonary toxicity (APT) is a serious adverse event that can lead to death. The aims of our study are to determine factors associated with mortality and to describe outcome and sequelae of patients with APT. METHODS:Forty-six patients with APT were divided into two groups according to survival at day 90 for a clinical, functional, biological and radiological comparaison. We then evaluated the evolution of 15 survivors at a median of three months [1-6 months] and/or 12 months [8-36 months]. RESULTS:Mortality of APT at day 90 was 37% (17 patients) and was linked to the speed of onset of symptoms and a high HRCT alveolar score. Angiotensin system antagonist treatment was prescribed significantly more in the survival group (p = 0.042, HR 0.34 (95% CI 0.12-0.96)). In surviving patients, dyspnea, vital capacity and HRCT alveolar score improved significantly while HRCT fibrosis score deteriorated gradually during the first six months. At the end of the study, all the surviving patients presented functional and/or radiological sequelae. CONCLUSIONS:Severity of APT is linked to the extent and speed of onset of pulmonary damage. After the initial episode, the patients who survived improved slowly but with persistent sequelae.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Mankikian J,Favelle O,Guillon A,Guilleminault L,Cormier B,Jonville-Béra AP,Perrotin D,Diot P,Marchand-Adam Sdoi
10.1016/j.rmed.2014.01.014subject
Has Abstractpub_date
2014-04-01 00:00:00pages
638-46issue
4eissn
0954-6111issn
1532-3064pii
S0954-6111(14)00057-2journal_volume
108pub_type
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