A study to investigate the ability of subjects with chronic lung diseases to provide evidential breath samples using the Lion Intoxilyzer 6000 UK breath alcohol testing device.

abstract：BACKGROUND:Patients with idiopathic pulmonary fibrosis (IPF) present an important ventilatory limitation reducing their exercise capacity. Non-invasive ventilatory support has been shown to improve exercise capacity in patients with obstructive diseases; however, its effect on IPF patients remains unknown. OBJECTIVE:T...

journal_title：Respiratory medicine

authors： Moderno EV,Yamaguti WP,Schettino GP,Kairalla RA,Martins MA,Carvalho CR,Carvalho CR

更新日期：2010-01-01 00:00:00

abstract：:The effect of patient education on morbidity in asthmatics and COPD patients has not previously been investigated in a single study. We randomized 78 asthmatics and 62 COPD patients after ordinary outpatient management. Intervention consisted of educational group sessions and individual sessions administered by a trai...

journal_title：Respiratory medicine

authors： Gallefoss F,Bakke PS

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The prevalence of asthma appears to be on the increase, and risk factors are not well established. To investigate risk factors for the development of asthma, a population sample of children and adolescents, aged 7-17 years at enrolment, were studied in 1986. Initial examinations were repeated at follow-up in...

journal_title：Respiratory medicine

authors： Ulrik CS,Backer V,Hesse B,Dirksen A

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:A clinical stability (CS) evaluation is thought to be important in community-acquired pneumonia (CAP) treatment, but evidence concerning the time to CS (TCS) remains lacking. METHODS:Among consecutive patients hospitalized with pneumococcal pneumonia, relationships between TCS and other clinical outcomes we...

journal_title：Respiratory medicine

authors： Takada K,Matsumoto S,Kojima E,Iwata S,Ninomiya K,Tanaka K,Goto D,Shimizu T,Nohara K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:International guidelines recommend simple spirometry for bronchiectasis patients. However, pulmonary pathophysiology of bronchiectasis is very complex and still poorly understood. Our objective was to characterize lung function in bronchiectasis and identify specific functional sub-groups. METHODS:This was ...

journal_title：Respiratory medicine

authors： Radovanovic D,Santus P,Blasi F,Sotgiu G,D'Arcangelo F,Simonetta E,Contarini M,Franceschi E,Goeminne PC,Chalmers JD,Aliberti S

更新日期：2018-12-01 00:00:00

abstract：:In this economic evaluation, conducted alongside a randomized, double-blind clinical trial, economic data were collected from 339 patients with moderate-persistent asthma randomized to receive twice-daily, double-blind treatment with budesonide/formoterol 160/4.5 microg in a single inhaler (n=166) or fluticasone propi...

journal_title：Respiratory medicine

authors： Ericsson K,Bantje TA,Huber RM,Borg S,Bateman ED

更新日期：2006-04-01 00:00:00

abstract：:The principals of rehabilitation medicine are to prevent muscle atrophy and improve mobility. Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with muscle atrophy and yet many patients do not undergo pulmonary rehabilitation until they have been in stable health for some time. We investigat...

journal_title：Respiratory medicine

authors： Murphy N,Bell C,Costello RW

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:There is little information available on the features of initial presentation of bronchiectasis and documentation of the onset and progress of symptoms leading up to this. Therefore a study was performed on a large cohort of adult patients presenting to Monash Medical Centre (MMC) to survey the course of the...

journal_title：Respiratory medicine

authors： King PT,Holdsworth SR,Freezer NJ,Villanueva E,Holmes PW

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:To date endurance and strength training are established and evidence-based exercise methods in patients with chronic obstructive pulmonary disease (COPD). There is an unmet need for further research in new and complementary exercise modalities. Additional whole body vibration training during pulmonary reha...

journal_title：Respiratory medicine

authors： Gloeckl R,Heinzelmann I,Baeuerle S,Damm E,Schwedhelm AL,Diril M,Buhrow D,Jerrentrup A,Kenn K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:COPD patients who remain hypercapnic after acute respiratory failure requiring mechanical ventilation have a poor prognosis. Long-term nocturnal non-invasive ventilation (NIV) may be beneficial for these patients. We hypothesized that stable patients on long-term NIV would experience clinical worsening after...

journal_title：Respiratory medicine

authors： Funk GC,Breyer MK,Burghuber OC,Kink E,Kirchheiner K,Kohansal R,Schmidt I,Hartl S

更新日期：2011-03-01 00:00:00

abstract：:The fraction of the emitted dose from an inhaler that has the potential to be deposited into the lungs is known as the fine particle dose (also the respirable dose). During inhalation all dry powder inhalers require a 'force' to be created inside the device so that a fine particle dose is generated from the formulatio...

journal_title：Respiratory medicine

authors： Chrystyn H

更新日期：2003-02-01 00:00:00

abstract：:We report the first study of triple-dose immunotherapy with heat-killed Mycobacterium vaccae (SRL 172) combined with short-course, directly observed chemotherapy in newly diagnosed pulmonary tuberculosis patients. The study was carried out in Rosario, Argentina, where single-dose immunotherapy with M. vaccae has previ...

journal_title：Respiratory medicine

authors： Dlugovitzky D,Fiorenza G,Farroni M,Bogue C,Stanford C,Stanford J

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a disorder characterized by repetitive obstructions of the upper airway. Individuals with OSA experience intermittent hypoxia, hypercapnia, and arousals during sleep, resulting in increased sympathetic activation. Chemoreflex activation, arising from the resultant oscillatory...

journal_title：Respiratory medicine

authors： Hargens TA,Guill SG,Aron A,Zedalis D,Gregg JM,Nickols-Richardson SM,Herbert WG

更新日期：2009-07-01 00:00:00

abstract：:Exposure to air pollution is associated with adverse health effects, with particulate matter (PM) and ozone (O(3)) both indicated to be of considerable importance. Diesel engine exhaust (DE) and O(3) generate substantial inflammatory effects in the airways. However, as yet it has not been determined whether a subseque...

journal_title：Respiratory medicine

authors： Bosson J,Pourazar J,Forsberg B,Adelroth E,Sandström T,Blomberg A

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major ...

journal_title：Respiratory medicine

authors： Horikiri T,Hara H,Saito N,Araya J,Takasaka N,Utsumi H,Yanagisawa H,Hashimoto M,Yoshii Y,Wakui H,Minagawa S,Ishikawa T,Shimizu K,Numata T,Arihiro S,Kaneko Y,Nakayama K,Matsuura T,Matsuura M,Fujiwara M,Okayasu I,I

更新日期：2017-01-01 00:00:00

abstract：:We have recently found that changes in lung sounds correspond well with a 20% fall in the forced expiratory volume in 1 s (FEV1) after methacholine challenge in asthmatic children. Up to now, little was known about the agreement between a 20% fall in FEV1 and a change in lung sounds after repeated bronchial challenge....

journal_title：Respiratory medicine

authors： Sprikkelman AB,Schouten JP,Lourens MS,Heymans HS,van Aalderen WM

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:There has not been a comprehensive multi-center study investigating the microbial profile of community acquired pneumonia (CAP) in Taiwan. METHODS:A prospective study of adult CAP patients requiring hospitalization between December 2001 and April 2002 was carried out in 13 hospitals in Taiwan. Etiology was ...

journal_title：Respiratory medicine

authors： Lauderdale TL,Chang FY,Ben RJ,Yin HC,Ni YH,Tsai JW,Cheng SH,Wang JT,Liu YC,Cheng YW,Chen ST,Fung CP,Chuang YC,Cheng HP,Lu DC,Liu CJ,Huang IW,Hung CL,Hsiao CF,Ho M

更新日期：2005-09-01 00:00:00

abstract：:In this study we aimed to estimate direct medical costs of Chronic Obstructive Pulmonary Disease (COPD) by disease type; chronic bronchitis and emphysema. This study estimates direct costs in 1996 dollars using a prevalence approach and both aggregate and microcosting. A societal perspective is taken using prevalence,...

journal_title：Respiratory medicine

authors： Wilson L,Devine EB,So K

更新日期：2000-03-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a chronic cardiopulmonary disorder that if left untreated, progresses rapidly and is ultimately fatal. The World Health Organization (WHO) has classified PH into 5 distinct groups according to pathophysiology, hemodynamic characteristics, and clinical presentation. Dysfunction in the nit...

journal_title：Respiratory medicine

authors： Benza R,Mathai S,Nathan SD

更新日期：2017-01-01 00:00:00

abstract：AIM:A high rate of seropositivity for antibodies against Helicobacter pylori has been found in many extra-gastrointestinal diseases. In addition, it has been reported that the risk of chronic bronchitis may be increased in subjects infected with H. pylori. This study was designed to determine the H. pylori seroprevalen...

journal_title：Respiratory medicine

authors： Kanbay M,Gur G,Akcay S,Yilmaz U

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Anti-endothelial cell antibodies (AECA) are circulating antibodies that bind to endothelial antigens and induce endothelial cell damage. AECA have been detected in patients with collagen vascular disease (CVD) and their presence is associated with interstitial lung disease (ILD) in cases of CVD. However, the...

journal_title：Respiratory medicine

authors： Matsui T,Inui N,Suda T,Chida K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Severe asthma is a heterogeneous disease. Patients with both eosinophilic and allergic asthma phenotypes may be eligible for treatment with mepolizumab and omalizumab. Evidence on the relative effectiveness of these treatments in this 'overlap' population would be informative for clinical and payer decision ...

journal_title：Respiratory medicine

authors： Cockle SM,Stynes G,Gunsoy NB,Parks D,Alfonso-Cristancho R,Wex J,Bradford ES,Albers FC,Willson J

更新日期：2017-02-01 00:00:00

abstract：:Ten patients (two male) suffering from acute exacerbations of long-standing chronic obstructive pulmonary disease and admitted in hypoxic, hypercapnic respiratory failure were treated with Nasal Intermittent Positive Pressure Ventilation (NIPPV) plus supplemental oxygen, on a general medical ward. The median (range) p...

journal_title：Respiratory medicine

authors： Conway JH,Hitchcock RA,Godfrey RC,Carroll MP

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFE...

journal_title：Respiratory medicine

authors： Inui N,Suda T,Chida K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease with chronic respiratory failure (COPD-CRF) experience high mortality and healthcare utilization. Non-invasive home ventilation (NIVH) is increasingly used in such patients. We examined the associations between NIVH and survival, hospitalizations, and emerg...

journal_title：Respiratory medicine

authors： Frazier WD,Murphy R,van Eijndhoven E

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...

journal_title：Respiratory medicine

authors： Koskela HO,Purokivi MK,Kokkarinen J

更新日期：2016-08-01 00:00:00

abstract：:The efficacy of a non-steroidal anti-inflammatory agent (nedocromil sodium, NS) has been assessed in young children born prematurely who had recurrent respiratory symptoms at follow-up. In a randomized, double-blind cross-over trial, either two puffs of NS (2 mg puff-1) or placebo were administered three times a day v...

journal_title：Respiratory medicine

authors： Yüksel B,Greenough A

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Physical activity and health status deteriorate early in the course of chronic obstructive pulmonary disease (COPD). This can only partially be explained by the degree of airflow limitation. Changes in (resting and dynamic) lung volumes are known to be associated with functional impairments and thus might in...

journal_title：Respiratory medicine

authors： Lahaije AJ,van Helvoort HA,Dekhuijzen PN,Vercoulen JH,Heijdra YF

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...

journal_title：Respiratory medicine

authors： Bhushan B,Guleria R,Misra A,Luthra K,Vikram NK

更新日期：2009-03-01 00:00:00

abstract：:Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management, and inhaler selection can have a profound impact on drug delivery and medication adherence, as well as on treatment outcomes. Although multiple delivery systems, such as pressurized metered-dose inhalers, dry powder inhalers, slow-...

journal_title：Respiratory medicine

authors： Mahler DA

更新日期：2020-01-01 00:00:00