Immunological consequences of three doses of heat-killed Mycobacterium vaccae in the immunotherapy of tuberculosis.


:We report the first study of triple-dose immunotherapy with heat-killed Mycobacterium vaccae (SRL 172) combined with short-course, directly observed chemotherapy in newly diagnosed pulmonary tuberculosis patients. The study was carried out in Rosario, Argentina, where single-dose immunotherapy with M. vaccae has previously been shown effective. Twenty-two HIV seronegative patients, sputum-positive for tubercle bacilli, entered a randomised and partly blinded trial. Twelve patients received injections of SRL 172 and 10 patients received placebo on days 1, 30 and 60 of chemotherapy. All patients were followed up clinically, by sputum bacteriology, chest radiography and haematology. Patients receiving SRL 172 showed faster and more complete clinical improvement, accelerated disappearance of bacilli from sputum, better radiological clearance and a more rapid fall in ESR, than did those receiving placebo. Follow-up continued for a year after therapy and no patient failed treatment or relapsed. Special investigations included longitudinal assessments of respiratory bursts and expression of CD11b on separated polymorphonuclear and mononuclear leukocytes. Tumour necrosis factor alpha (TNF-alpha) was measured in the supernates of cultured cells and both TNF-alpha and interleukin-4 (IL-4) were measured in serum samples. Immunotherapy recipients showed a significantly faster return towards normal values in all the immunological parameters, than did placebo recipients. The results are consistent with a regulatory activity on cellular immunity, reducing the influence of Th2 and enhancing Th1 to the benefit of the patients. This could allow a reduced period of chemotherapy without loss of efficacy and help to prevent the development of multi-drug resistance.


Respir Med


Respiratory medicine


Dlugovitzky D,Fiorenza G,Farroni M,Bogue C,Stanford C,Stanford J




Has Abstract


2006-06-01 00:00:00














  • Haemoptysis: aetiology, evaluation and outcome--a prospective study in a third-world country.

    abstract::Haemoptysis is an alarming symptom, and the management depends upon the aetiology. Emergency management depends upon localization of the site of bleeding by roentgenogram, computerized chest tompgraphy and bronchoscopy. We prospectively evaluated 52 patients with haemoptysis admitted to the Chest Hospital, Kuwait for ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Abal AT,Nair PC,Cherian J

    更新日期:2001-07-01 00:00:00

  • Peripheral endothelial function is positively associated with maximal aerobic capacity in patients with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Patients with COPD are frequently diagnosed with cardiovascular disease. Peripheral endothelial dysfunction is an underlying mechanism and can be used as an early marker of cardiovascular impairment. To date, little is known on the association between peripheral endothelial dysfunction, cardiovascular risk f...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Vaes AW,Spruit MA,Theunis J,Wouters EFM,De Boever P

    更新日期:2018-09-01 00:00:00

  • Smoking habits in the Middle East and North Africa: results of the BREATHE study.

    abstract::Few recent comparative data exist on smoking habits in the Middle East and North Africa (MENA) region. The objective of this analysis was to evaluate smoking patterns in a large general population sample of individuals aged ≥ 40 years in ten countries in the region (Algeria, Egypt, Jordan, Lebanon, Morocco, Saudi Arab...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Khattab A,Javaid A,Iraqi G,Alzaabi A,Ben Kheder A,Koniski ML,Shahrour N,Taright S,Idrees M,Polatli M,Rashid N,El Hasnaoui A,BREATHE Study Group.

    更新日期:2012-12-01 00:00:00

  • Changes in management of chronic obstructive pulmonary disease (COPD) in primary care: EMMEPOC study.

    abstract:BACKGROUND:Changes in management of COPD in primary care were studied following a training exercise among Spanish general practitioners (GPs). The exercise involved dissemination of the Spanish Society for Pulmonology and Thoracic Surgery (SEPAR) guidelines. The use of a portable device to perform spirometry tests was ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Soler N,Ballester E,Martín A,Gobartt E,Miravitlles M,Torres A

    更新日期:2010-01-01 00:00:00

  • The effect of an outpatient care on-demand-system on health status and costs in patients with COPD. A randomized trial.

    abstract:BACKGROUND:Traditionally, outpatient visits for COPD are fixed, pre-planned by the pulmonologist. This is not a patient centered method, nor, in times of increasing COPD prevalence and resource constraints, perhaps the optimal method. OBJECTIVES:This pilot study, determined the effect of an on-demand-system, patient i...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Berkhof FF,Hesselink AM,Vaessen DL,Uil SM,Kerstjens HA,van den Berg JW

    更新日期:2014-08-01 00:00:00

  • Randomized comparison of the efficacy and safety of ciclesonide and budesonide in adolescents with severe asthma.

    abstract:BACKGROUND:The aim of the study was to investigate the efficacy and safety of ciclesonide compared with budesonide in adolescents with severe asthma. METHODS:In this randomized, double-blind, double-dummy, parallel-group study, patients aged 12-17 years with severe asthma were treated with budesonide 400 microg once d...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vermeulen JH,Gyurkovits K,Rauer H,Engelstätter R

    更新日期:2007-10-01 00:00:00

  • Variation in lung cancer survival rates between countries: do differences in data reporting contribute?

    abstract:BACKGROUND:Mortality rates from lung cancer are known to vary considerably between countries. Differences in patients, disease, investigation and treatment are thought to account for some survival shortfalls but it is not known whether differences in collection or processing of data also contribute. METHODOLOGY:We sea...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Butler CA,Darragh KM,Currie GP,Anderson WJ

    更新日期:2006-09-01 00:00:00

  • The impact of carrying supplemental oxygen on exercise capacity and dyspnea in patients with interstitial lung disease.

    abstract:BACKGROUND:May patients with interstitial lung disease (ILD) require supplementary oxygen (O2) therapy to maintain normoxia. However, ambulatory O2 delivery devices are constraining and cumbersome. The physiologic and symptomatic impact of these devices on ILD patients is unknown. METHODS:We conducted a prospective st...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Ramadurai D,Riordan M,Graney B,Churney T,Olson AL,Swigris JJ

    更新日期:2018-05-01 00:00:00

  • Dental caries is associated with lower respiratory tract infections: A population-based cohort study.

    abstract:INTRODUCTION:Dental caries and respiratory tract infections are among the most common infectious diseases worldwide and they both are appearing in the respiratory system. However, their relations are still unclear. This study investigated the association of dental caries on the risk of lower respiratory tract infection...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Mehtonen IT,Rantala AK,Hugg TT,Jaakkola MS,Jaakkola JJK

    更新日期:2019-01-01 00:00:00

  • Clinical audit of subjects with snoring & sleep apnoea/hypopnoea syndrome fitted with mandibular repositioning splint.

    abstract::Snoring and obstructive sleep apnoea/hypopnoea syndrome (OSAHS) are often treated with mandibular repositioning splints (MRS), but the efficacy and satisfaction of them has not been comprehensively addressed. A survey on the use of and satisfaction with MRS was posted to 177 patients referred by a hospital orthodontic...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Izci B,McDonald JP,Coleman EL,Mackay TW,Douglas NJ,Engleman HM

    更新日期:2005-03-01 00:00:00

  • Acupuncture in treatment of stable asthma.

    abstract::Previous studies of acupuncture in asthma have reported conflicting results, some claiming benefit for some patients. We conducted a randomized, double-blind (patient and evaluator) study in 23 non-smoking asthmatics (10 M; 13 F) aged 43 +/- 15 years with forced expiratory volume in 1 s (FEV1) 59 +/- 16% pred. After i...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Biernacki W,Peake MD

    更新日期:1998-09-01 00:00:00

  • Comparison of titrable thermoplastic versus custom-made mandibular advancement device for the treatment of obstructive sleep apnoea.

    abstract:BACKGOUND AND OBJECTIVES:The disadvantages of custom-made mandibular advancement devices (MAD) for obstructive sleep apnoea (OSA) therapy are the cost and delay required to manufacture the device. This study aimed to evaluate the efficacy of a titrable, thermoplastic MAD compared to a custom-made MAD for OSA therapy. ...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章


    authors: Gagnadoux F,Nguyen XL,Le Vaillant M,Priou P,Meslier N,Eberlein A,Kun-Darbois JD,Chaufton C,Villiers B,Levy M,Trzépizur W,Launois S

    更新日期:2017-10-01 00:00:00

  • Reduced IgG levels found during acute eosinophilic pneumonia, which normalize during recovery from disease.

    abstract::Clinically there are several different types of eosinophilic pneumonia (EP), but other than for tropical pulmonary eosinophilia, the humoral immune response between different types of EP, such as acute eosinophilic pneumonia (AEP), chronic EP, drug-induced EP, allergic bronchopulmonary aspergillosis, and Churg-Strauss...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Matsuno O,Takenaka R,Hiroshige S,Ono E,Nishitake T,Ueno T,Miyazaki E,Kumamoto T

    更新日期:2008-06-01 00:00:00

  • Interim treatment outcomes in multidrug-resistant tuberculosis using bedaquiline and/or delamanid in South Korea.

    abstract:PURPOSE:The Korea Centers for Disease Control & Prevention has implemented a review process for the approval of new drugs used to treat patients with multidrug-resistant tuberculosis (MDR-TB) since September 2016. Therefore, this study aimed to evaluate the efficacy and safety of these new drugs bedaquiline (Bdq) and d...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Kang H,Jo KW,Jeon D,Yim JJ,Shim TS

    更新日期:2020-06-01 00:00:00

  • Artificial pneumothorax by the Veress cannula: efficacy and safety.

    abstract::In 16 patients with pulmonary fibrosis, an artificial pneumothorax was introduced using the Veress cannula and the Saugman water manometer. Atmospheric air was introduced by fractionated insufflation to a total volume of 800 ml (median). The interpleural space was found on the first attempt, and in all cases, fraction...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章


    authors: Faurschou P,Viskum K

    更新日期:1997-08-01 00:00:00

  • A comparison of surfactant delivery with conventional mechanical ventilation and partial liquid ventilation in meconium aspiration injury.

    abstract::The objective of this study was to compare surfactant (SF) distribution and physiological effects after standard SF delivery during conventional mechanical ventilation (CMV) with that using partial liquid ventilation (PLV). A model of meconium aspiration syndrome (MAS) was developed using two groups of adult rats (n =...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Chappell SE,Wolfson MR,Shaffer TH

    更新日期:2001-07-01 00:00:00

  • Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome.

    abstract:STUDY OBJECTIVES:The process of intermittent hypoxia-reoxygenation produces airway inflammation and endothelial dysfunction that favors the development of cardiovascular disorders in obstructive sleep apnea syndrome (OSAS). Nitric oxide (NO) is an important mediator in airway inflammation and the regulation of endothel...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Fortuna AM,Miralda R,Calaf N,González M,Casan P,Mayos M

    更新日期:2011-04-01 00:00:00

  • Effect of budesonide/formoterol pMDI on COPD exacerbations: a double-blind, randomized study.

    abstract:BACKGROUND:Treatment with an inhaled corticosteroid (ICS) and long-acting bronchodilator is recommended for severe/very severe chronic obstructive pulmonary disease (COPD) patients with repeated exacerbations. This randomized, double-blind, double-dummy, parallel-group, 12-month multicenter study evaluated the effect o...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sharafkhaneh A,Southard JG,Goldman M,Uryniak T,Martin UJ

    更新日期:2012-02-01 00:00:00

  • Identifying patients at risk of late recovery (≥ 8 days) from acute exacerbation of chronic bronchitis and COPD.

    abstract:OBJECTIVES:To identify factors associated with late recovery (≥ 8 days from exacerbation start) in patients with acute exacerbations of chronic bronchitis/COPD (AECB/AECOPD). METHODS:An international, observational, non-interventional study in outpatients with AECB/AECOPD who received treatment for their exacerbation ...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Anzueto A,Miravitlles M,Ewig S,Legnani D,Heldner S,Stauch K

    更新日期:2012-09-01 00:00:00

  • Incidence of tuberculosis among anti-tumor necrosis factor users in patients with a previous history of tuberculosis.

    abstract:BACKGROUND:We aimed to investigate the results of anti-tumor necrosis factor (TNF) therapy in patients with a previous history of tuberculosis (TB). METHODS:A total of 101 patients with a previous history of TB receiving TNF antagonists between December 2004 and September 2012 at the Asan Medical Center in South Korea...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Jo KW,Hong Y,Jung YJ,Yoo B,Lee CK,Kim YG,Yang SK,Byeon JS,Kim KJ,Ye BD,Lee SD,Kim WS,Kim DS,Shim TS

    更新日期:2013-11-01 00:00:00

  • Infections with mimivirus in patients with chronic obstructive pulmonary disease.

    abstract:INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Vanspauwen MJ,Franssen FM,Raoult D,Wouters EF,Bruggeman CA,Linssen CF

    更新日期:2012-12-01 00:00:00

  • Skeletal muscle changes in patients with obstructive sleep apnoea syndrome.

    abstract::Previous studies have shown that chronic hypoxia leads to changes in skeletal muscle structure (fibre size and type) and activities of several bioenergetic enzymes. Whether this occurs also in conditions characterised by intermittent hypoxia, such as the obstructive sleep apnoea syndrome (OSAS), is unknown. To explore...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Sauleda J,García-Palmer FJ,Tarraga S,Maimó A,Palou A,Agustí AG

    更新日期:2003-07-01 00:00:00

  • Airway inflammation in patients affected by obstructive sleep apnea syndrome.

    abstract::Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Salerno FG,Carpagnano E,Guido P,Bonsignore MR,Roberti A,Aliani M,Vignola AM,Spanevello A

    更新日期:2004-01-01 00:00:00

  • Clinical application of inert gas Multiple Breath Washout in children and adolescents with asthma.

    abstract:INTRODUCTION:Children with asthma often have normal spirometry despite significant disease. The pathology of the small airways in asthma may be assessed using Multiple Breath Washout (MBW) and calculating the Lung Clearance Index (LCI). There are only few studies using MBW in children with asthma and existing data rega...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Zwitserloot A,Fuchs SI,Müller C,Bisdorf K,Gappa M

    更新日期:2014-09-01 00:00:00

  • Long-term non-invasive ventilation in COPD after acute-on-chronic respiratory failure.

    abstract:BACKGROUND:COPD patients who remain hypercapnic after acute respiratory failure requiring mechanical ventilation have a poor prognosis. Long-term nocturnal non-invasive ventilation (NIV) may be beneficial for these patients. We hypothesized that stable patients on long-term NIV would experience clinical worsening after...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Funk GC,Breyer MK,Burghuber OC,Kink E,Kirchheiner K,Kohansal R,Schmidt I,Hartl S

    更新日期:2011-03-01 00:00:00

  • An investigation of the relationship between microbial and particulate indoor air pollution and the sick building syndrome.

    abstract::The sick building syndrome has been the subject of research for approximately 10 years. Although it is often suggested that symptoms in office workers are due to circulating micro-organisms or particles, epidemiological studies investigating the relationship between them have been lacking. This cross-sectional study h...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Harrison J,Pickering CA,Faragher EB,Austwick PK,Little SA,Lawton L

    更新日期:1992-05-01 00:00:00

  • Bronchial responsiveness to histamine and methacholine measured with forced expirations and with the forced oscillation technique.

    abstract::The objective of this study was to compare bronchial challenge tests with two substances [histamine (H) and methacholine (M)] and two methods of measuring the effect parameter FEV1 and pulmonary impedance [with the forced oscillation technique (FOT)] in order to determine which test is the shortest, and gives the leas...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weersink EJ,vd Elshout FJ,van Herwaarden CV,Folgering H

    更新日期:1995-05-01 00:00:00

  • Health status perception and airflow obstruction in five Latin American cities: the PLATINO study.

    abstract:BACKGROUND:COPD is a highly prevalent disease but underdiagnosed, undertreated and possibly under-recognized by patients. Limited information exists regarding patients' perception of COPD severity. We compared patients' general health status perception, degree of breathlessness and physical activity limitation with the...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Montes de Oca M,Tálamo C,Halbert RJ,Perez-Padilla R,Lopez MV,Muiño A,Jardim JR,Valdivia G,Pertuzé J,Moreno D,Menezes AM,PLATINO Team.

    更新日期:2009-09-01 00:00:00

  • Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD.

    abstract:BACKGROUND:The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically sta...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Al-shair K,Dockry R,Mallia-Milanes B,Kolsum U,Singh D,Vestbo J

    更新日期:2009-10-01 00:00:00

  • Coughing can relieve or exacerbate symptoms in asthmatic patients.

    abstract::From about 1190 to the present day opposing views have been expressed about the effects of coughing in patients with asthma. Some accounts have stated that it brought relief and others that it exacerbated asthma, whereas others thought that it could have both effects. In the present investigation, 187 patients with a ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Young S,Bitsakou H,Carić D,McHardy GJ

    更新日期:1991-01-01 00:00:00