Abstract：
BACKGROUND:Patients with idiopathic pulmonary fibrosis (IPF) present an important ventilatory limitation reducing their exercise capacity. Non-invasive ventilatory support has been shown to improve exercise capacity in patients with obstructive diseases; however, its effect on IPF patients remains unknown. OBJECTIVE:The present study assessed the effect of ventilatory support using proportional assist ventilation (PAV) on exercise capacity in patients with IPF. METHODS:Ten patients (61.2+/-9.2 year-old) were submitted to a cardiopulmonary exercise testing, plethysmography and three submaximal exercise tests (60% of maximum load): without ventilatory support, with continuous positive airway pressure (CPAP) and PAV. Submaximal tests were performed randomly and exercise capacity, cardiovascular and ventilatory response as well as breathlessness subjective perception were evaluated. Lactate plasmatic levels were obtained before and after submaximal exercise. RESULTS:Our data show that patients presented a limited exercise capacity (9.7+/-3.8 mL O(2)/kg/min). Submaximal test was increased in patients with PAV compared with CPAP and without ventilatory support (respectively, 11.1+/-8.8 min, 5.6+/-4.7 and 4.5+/-3.8 min; p<0.05). An improved arterial oxygenation and lower subjective perception to effort was also observed in patients with IPF when exercise was performed with PAV (p<0.05). IPF patients performing submaximal exercise with PAV also presented a lower heart rate during exercise, although systolic and diastolic pressures were not different among submaximal tests. Our results suggest that PAV can increase exercise tolerance and decrease dyspnoea and cardiac effort in patients with idiopathic pulmonary fibrosis.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Moderno EV,Yamaguti WP,Schettino GP,Kairalla RA,Martins MA,Carvalho CR,Carvalho CRdoi
10.1016/j.rmed.2009.08.001subject
Has Abstractpub_date
2010-01-01 00:00:00pages
134-41issue
1eissn
0954-6111issn
1532-3064pii
S0954-6111(09)00254-6journal_volume
104pub_type
杂志文章abstract：AIMS:This study tested inhibitory effects of in vitro Montelukast treatment on nasal airway epithelial cells (AEC) cultured from asthmatic patients treated with Montelukast with and without concomitant allergic rhinitis. We further examined the effect of Montelukast withdrawal in these patients on cytokine release from...
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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更新日期：2003-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2005.12.001
更新日期：2006-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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