Abstract：
:Cyclosporin A (CsA) is an immunomodulator drug that has been used in the treatment of several types of advanced pulmonary interstitial disease. This beneficial effect occurs mainly in circumstances in which alveolitis due to CD4 lymphocytes is absent, suggesting that CsA acts on other types of cells. The present study was undertaken to determine the effect of CsA on inflammatory cytokine secretion by human alveolar macrophages (AMs). Human AMs were collected by bronchoalveolar lavage from four control subjects and 13 patients with interstitial lung disease. Purified human AMs were incubated with different concentrations of CsA (200, 20 and 2 ng ml-1) in the presence or absence of lipopolysaccharide (LPS). Interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha), IL-6 and IL-8 levels were measured in supernatants using specific enzyme-linked immunosorbent assays. It was found that CsA inhibits basal secretion of TNF-alpha and IL-8 at 20 and 200 ng ml-1. However, none of the different concentrations of CsA modified basal secretion of IL-1 beta nor IL-6. By contrast, a lower concentration of CsA (2 ng ml-1) inhibits LPS-stimulated secretion of all inflammatory cytokines. It is concluded that CsA exerts a modest effect on inflammatory cytokine production by human AMs.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Losa García JE,Mateos Rodríguez F,Jiménez López A,García Salgado MJ,Martín de Cabo MR,Pérez Losada J,Pérez Arellano JLdoi
10.1016/s0954-6111(98)90002-6subject
Has Abstractpub_date
1998-05-01 00:00:00pages
722-8issue
5eissn
0954-6111issn
1532-3064pii
S0954-6111(98)90002-6journal_volume
92pub_type
杂志文章abstract：:Nasal mucociliary system is the first line of defense of the upper airways and may be affected acutely by exposure to particulate matter (PM) from biomass burning. Several epidemiologic studies have demonstrated a consistent association between levels of air pollution from biomass burning with increases in hospitaliza...
journal_title：Respiratory medicine
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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更新日期：2008-01-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-01-01 00:00:00
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更新日期：2005-06-01 00:00:00
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更新日期：2003-11-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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更新日期：2001-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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更新日期：2018-12-01 00:00:00
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更新日期：2014-10-01 00:00:00
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更新日期：2019-07-01 00:00:00
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更新日期：2003-08-01 00:00:00
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更新日期：1991-09-01 00:00:00
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更新日期：2017-11-01 00:00:00
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更新日期：2018-12-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-03-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-08-01 00:00:00
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更新日期：2017-05-01 00:00:00
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journal_title：Respiratory medicine
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更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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更新日期：1994-02-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.02.012
更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1053/rmed.2002.1322
更新日期：2002-08-01 00:00:00
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更新日期：2016-05-01 00:00:00
