当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study.

Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study.

Abstract：

OBJECTIVE:We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). METHODS:Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio, waist height ratio and body fat percentage were measured. Lung function was assessed by spirometry using a turbine flowmeter. We analyzed percent predicted for forced expiratory volume in 1 s (FEV1%), forced vital capacity (FVC %) and restrictive respiratory defect (FEV1/FVC ratio > low limits of normal and FVC % <0.80). RESULTS:Of 16186 participants (mean age 61.4 ± 7.2 years; 74.0% women), 116 (0.7%) had only general obesity (BMI ≥28 kg/m2), 4079 (25.2%) had only central obesity (WC: ≥90 cm in men, ≥80 cm in women) and 1591 (9.8%) had both central obesity and general obesity. Comparing to those with neither central nor general obesity, those with only central adiposity and with both central and general obesity had lower pulmonary function (adjusted β range from -2.85 to -6.02 for FEV1% and FVC%, adjusted OR range from 1.14 to 1.70, all P < 0.05). But those with only general obesity had better but non-significant pulmonary function. (Crude β range from 1.46 to 2.92 for FEV1% and FVC%, crude OR range from 0.68 to 0.93, all P > 0.05). Both FEV1% and FVC% decreased per standard deviation increase in obesity indices (adjusted β from -0.46 to -3.17, all P < 0.002). A positive association of central or general obesity with restrictive respiratory defect was observed (adjusted odds ratio (AOR) from 1.50 to 2.04, all P < 0.002). Further adjustment for WC reversed the inverse association between BMI and pulmonary function (adjusted β from 1.93 to 6.22, all P < 0.001) and restrictive respiratory defect (adjusted AOR from 0.72 to 0.80, all P < 0.001). CONCLUSION:Central adiposity and its indices, but not general adiposity and BMI, were independently associated with lower pulmonary function and higher risk of restrictive respiratory defect in older Chinese.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Pan J,Xu L,Lam TH,Jiang CQ,Zhang WS,Jin YL,Zhu F,Zhu T,Thomas GN,Cheng KK,Adab P

doi

10.1016/j.rmed.2017.10.003

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

102-108

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(17)30342-6

journal_volume

132

pub_type

杂志文章

在线工具

Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study.