当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Tumor necrosis factor-alpha serum levels, weight loss and tissue oxygenation in chronic obstructive pulmonary disease.

Tumor necrosis factor-alpha serum levels, weight loss and tissue oxygenation in chronic obstructive pulmonary disease.

Abstract：

:Weight loss has been recognized as a feature of advanced emphysema and a factor of poor prognosis, but its mechanisms remain obscure. Studies have demonstrated high serum concentrations of TNF-a (cachexin) in chronic obstructive pulmonary disease (COPD) patients with emphysema. Pink puffers (PP) COPD patients have worse tissue oxygenation when compared with blue bloaters (BB) COPD patients. Consequently, PP patients would become cachectic, whereas BB patients with better tissue oxygenation would not. The aim of this study is to test the hypothesis that malnutrition in emphysema is a cytokine-mediated marker of chronic progressive tissue hypoxia. Thirty male COPD patients, without clinical or laboratory evidence of infection and severe air way obstruction (FEV1 < 1.5 l) were allocated: 16 as pink puffers (PP) and 14 as blue bloaters (BB). Lung function measurements included FEV1, FVC, RV, TLC, DLCO and arterial blood gases on room air. TNF-a serum levels were measured by immunoenzymic method (ELISA). Tissue oxygenation was assessed from oxygen delivery (DO2), PvO2 and oxygen extraction ratio (O2ER) obtained after right heart catheterization with Swan Ganz catheter. PP patients demonstrated lower DLCO and higher TLC, FRC and PaO2 from BB. We found that oxygen delivery was better in our BB than in PP patients (CI 2.9 +/- 0.2 vs 2.5 +/- 0.4 l/min/m2--P < 0.01, DO2 16.1 +/- 2.1 vs 13.1 +/- 0.2 ml/min/kg--P < 0.001) and the same was found for tissue oxygenation (PvO2 34.6 +/- 2.9 vs 31.2 +/- 3.8 mmHg--P < 0.01, O2ER 0.27 +/- 0.02 vs 0.34 +/- 0.06%--P < 0.001). The TNF-a values were higher in PP (31.3 +/- 26 pg/ml vs 15.2 +/- 9.9 pg/ml--P < 0.05) and their percent fat-free mass (%FFM) was 49.6 +/- 11.5 vs 42 +/- 8%--P < 0.001. We found that COPD patients with lower DO2 had increased TNF-a levels; but the correlations between TNF-a serum levels and PvO2 or O2ER were not statistically significant. TNF-a levels were elevated in PP patients with tissue hypoxia and may be a factor contributing to the weight loss of these patients.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Pitsiou G,Kyriazis G,Hatzizisi O,Argyropoulou P,Mavrofridis E,Patakas D

doi

10.1053/rmed.2002.1322

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

594-8

issue

8

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(02)91322-3

journal_volume

96

pub_type

杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • An economic analysis of pharmacological treatment of COPD in Spain.

    abstract：BACKGROUND:COPD is a prevalent disease that generates high use of resources. The objective of this study was to quantify the economic consequences of non-adherence to GOLD guidelines for the management of COPD patients. METHOD:An economic model was generated to compare different scenarios of observed vs. expected cost...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.11.019

    authors： Miravitlles M,Brosa M,Velasco M,Crespo C,Gobartt E,Diaz S,González-Rojas N

    更新日期：2009-05-01 00:00:00

  • Three-year follow-up study of allergy in workers in a mushroom factory.

    abstract：:Exposure to mushroom spores may cause many respiratory allergic diseases, however, there has been no serial study in a mushroom factory to address this problem. The aim of this study was to investigate the serial changes in respiratory allergy and the incidence of hypersensitivity pneumonitis (HP) in mushroom workers....

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1187

    authors： Tanaka H,Saikai T,Sugawara H,Tsunematsu K,Takeya I,Koba H,Matsuura A,Imai K,Abe S

    更新日期：2001-12-01 00:00:00

  • Ethnic and racial differences in the presence of idiopathic pulmonary fibrosis at death.

    abstract：BACKGROUND:In studies of idiopathic pulmonary fibrosis (IPF), whites makeup the vast majority of subjects. Whether ethnic/racial differences in idiopathic pulmonary fibrosis occur in the general population is unknown. METHODS:To compare the presence of IPF between ethnic/racial groups of U.S. decedents from 1989 to 20...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.01.002

    authors： Swigris JJ,Olson AL,Huie TJ,Fernandez-Perez ER,Solomon J,Sprunger D,Brown KK

    更新日期：2012-04-01 00:00:00

  • The clinical management in extremely severe COPD.

    abstract：:Chronic obstructive pulmonary disease (COPD) affects 6% of the general population and is the fourth-leading cause of death in the United States with severe and very severe disease accounting for 15% and 3% of physician diagnoses of COPD. Guidelines make few recommendations regarding providing the provision of care for...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.02.011

    authors： Ambrosino N,Simonds A

    更新日期：2007-08-01 00:00:00

  • Mechanism of capsaicin action: recent learnings.

    abstract：:Capsaicin has long been known to act selectively on a subpopulation of neurons to produce initial excitation, followed by a prolonged neuroinhibitory action commonly referred to as 'capsaicin desensitization'. This property has been exploited extensively as a tool with which to investigate the role of these nerves in ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(06)80252-0

    authors： O'Neill TP

    更新日期：1991-01-01 00:00:00

  • The natural history of community-acquired pneumonia in COPD patients: a population database analysis.

    abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease (COPD) are at higher risk of developing Community-Acquired Pneumonia (CAP) than patients in the general population. However, no studies have been performed in general practice assessing longitudinal incidence rates for CAP in COPD patients or risk factors f...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.04.008

    authors： Müllerova H,Chigbo C,Hagan GW,Woodhead MA,Miravitlles M,Davis KJ,Wedzicha JA

    更新日期：2012-08-01 00:00:00

  • Increased serum VDBP as a risk predictor for steroid resistance in asthma patients.

    abstract：BACKGROUND:Asthmatic symptoms usually can be controlled with corticosteroids, but partly asthmatic patients do not respond to corticosteroids, steroid resistance (SR) play a significant role in the poorly responding. However, no approach can accurately predict steroid responsiveness in asthma patients, so prediction of...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.03.011

    authors： Jiang H,Chi X,Zhang X,Wang J

    更新日期：2016-05-01 00:00:00

  • Altered antioxidant status in peripheral skeletal muscle of patients with COPD.

    abstract：:Despite the growing field of interest in the role of pulmonary oxidative stress in chronic obstructive pulmonary disease (COPD), barely any data are available with respect to antioxidant capacity in the peripheral musculature of these patients. The main objective of this study was to assess in detail the antioxidant s...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2004.05.018

    authors： Gosker HR,Bast A,Haenen GR,Fischer MA,van der Vusse GJ,Wouters EF,Schols AM

    更新日期：2005-01-01 00:00:00

  • Oral bacteria--the missing link to ambiguous findings of exhaled nitrogen oxides in cystic fibrosis.

    abstract：BACKGROUND:Nitrite in exhaled breath condensate (EBC) has been shown to be elevated in cystic fibrosis (CF), while exhaled nitric oxide (FENO) is paradoxically low. This has been argued to reflect increased metabolism of NO while its diffusion is obstructed by mucus. However, we wanted to study the possible influence o...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.09.009

    authors： Zetterquist W,Marteus H,Kalm-Stephens P,Näs E,Nordvall L,Johannesson M,Alving K

    更新日期：2009-02-01 00:00:00

  • Non-invasive imaging in a rare case of main pulmonary artery aneurysm.

    abstract：:Report of an incidental chest X-ray finding of a large vessel dilation at the root of the ascending aorta in a 65-year-old female patient while pre-operative routine diagnostic. Due to prior allergic reaction to iodine contrast agent, non-invasive imaging was performed with magnetic resonance imaging (MRI), where the ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.10.023

    authors： Ritter CO,Weininger M,Machann M,Beissert M,Hahn D,Kenn W

    更新日期：2008-05-01 00:00:00

  • Effect of meteorological variables on the incidence of respiratory tract infections.

    abstract：OBJECTIVE:The possible effect of the various meteorological variables on the incidence of upper and lower respiratory tract infections (RTIs) has intrigued the scientific community for decades. METHODS:We performed a retrospective analysis regarding the association between meteorological variables and clinical data fo...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.12.010

    authors： Falagas ME,Theocharis G,Spanos A,Vlara LA,Issaris EA,Panos G,Peppas G

    更新日期：2008-05-01 00:00:00

  • The prevalence of preferential nasal breathing in adults.

    abstract：:The prevalence of preferential nasal breathing was studied in an awake adult population. One hundred and ninety-four people consented to gentle manual compression of the nostrils. They were advised to 'breathe in and out', but no further information regarding breathing was given to avoid influencing the patient. One h...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(93)90026-v

    authors： Ward KA,Nicholls DP,Stanford CF

    更新日期：1993-05-01 00:00:00

  • Pulmonary reflexes after human heart-lung transplantation.

    abstract：:Heart-lung transplantation involves denervation of the lungs below the tracheal anastomosis, with associated permanent loss of all pulmonary innervation except post-ganglionic efferent nerves. This is supported by loss of the cough reflex to inhaled USNDW, which also implies that the RARs which mediate this cough mech...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(06)80248-9

    authors： Hathaway T,Higenbottam T,Lowry R,Wallwork J

    更新日期：1991-01-01 00:00:00

  • Infections with mimivirus in patients with chronic obstructive pulmonary disease.

    abstract：INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.08.019

    authors： Vanspauwen MJ,Franssen FM,Raoult D,Wouters EF,Bruggeman CA,Linssen CF

    更新日期：2012-12-01 00:00:00

  • Completion rate of latent tuberculosis infection treatment in patients aged 65 years and older.

    abstract：INTRODUCTION:There are insufficient data on the treatment of latent tuberculosis infection (LTBI) in elderly patients. We investigated the completion rate of treatment in elderly LTBI patients. METHODS:A retrospective multicentre study was conducted at five university hospitals in South Korea. We reviewed the electron...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2019.09.004

    authors： Noh CS,Kim HI,Choi H,Kim Y,Kim CH,Choi JH,Hyun IG,Baek MS

    更新日期：2019-10-01 00:00:00

  • The cost effectiveness of Nucleic Acid Amplification Techniques for the diagnosis of tuberculosis.

    abstract：BACKGROUND:There is wide variation in the techniques deployed to diagnose tuberculosis in the UK, with little agreement on which tools or strategies are cost effective. This analysis therefore comprehensively evaluated the cost effectiveness of currently available diagnostic strategies for routine diagnosis of TB in th...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2011.10.005

    authors： Hughes R,Wonderling D,Li B,Higgins B

    更新日期：2012-02-01 00:00:00

  • Genetic influences on Chronic Obstructive Pulmonary Disease - a twin study.

    abstract：BACKGROUND:Genes that contribute to the risk of developing Chronic Obstructive Pulmonary Disease (COPD) have been identified, but an attempt to accurately quantify the total genetic contribution to COPD has to our knowledge never been conducted. METHODS:Hospital discharge diagnoses data on COPD were analysed in 22,422...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.05.004

    authors： Ingebrigtsen T,Thomsen SF,Vestbo J,van der Sluis S,Kyvik KO,Silverman EK,Svartengren M,Backer V

    更新日期：2010-12-01 00:00:00

  • Prevalence and prognosis of respiratory muscle weakness in heart failure patients with preserved ejection fraction.

    abstract：BACKGROUND:Although respiratory muscle weakness (RMW) is known to predict prognosis in patients with heart failure with reduced ejection fraction (HFrEF), RMW prevalence and its prognosis in those with preserved ejection fraction (HFpEF) remain unknown. We aimed to investigate whether the RMW predicted mortality in HFp...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.105834

    authors： Hamazaki N,Kamiya K,Matsuzawa R,Nozaki K,Ichikawa T,Tanaka S,Nakamura T,Yamashita M,Maekawa E,Noda C,Yamaoka-Tojo M,Matsunaga A,Masuda T,Ako J

    更新日期：2020-01-01 00:00:00

  • Validation of an activity monitor during sleep in patients with chronic respiratory disorders.

    abstract：INTRODUCTION:Objective of this study was to validate an activity monitor (DynaPort MoveMonitor [MM], McRoberts, The Hague, The Netherlands) against night-vision video analysis during sleep. METHODS:Twenty patients (65 ± 11 years old, mean body-mass-index: 27 ± 6 kg/m(2)) with different chronic lung diseases were recru...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.12.017

    authors： Gloeckl R,Damisch T,Prinzen J,van Lummel R,Pengel E,Schoenheit-Kenn U,Kenn K

    更新日期：2015-02-01 00:00:00

  • An overview of nine clinical trials of salmeterol in an asthmatic population.

    abstract：:In an attempt to establish the protection afforded by regular salmeterol use against induced bronchoconstriction in asthmatic patients, a meta-analysis was conducted on nine double-blind clinical trials that fulfilled the inclusion criteria. In each trial, subjects were randomly assigned to receive either salmeterol 5...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析

    doi：10.1016/s0954-6111(98)90012-9

    authors： Verberne AA,Fuller R

    更新日期：1998-05-01 00:00:00

  • Sarcoidosis-associated small fiber neuropathy in a large cohort: Clinical aspects and response to IVIG and anti-TNF alpha treatment.

    abstract：OBJECTIVE:Small fiber neuropathy commonly affects patients with sarcoidosis and is often refractory to standard immunosuppressive therapies used for systemic disease. The clinical features of sarcoidosis-associated small fiber neuropathy (SSFN) and its response to medical therapy have not been described in a large popu...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.03.011

    authors： Tavee JO,Karwa K,Ahmed Z,Thompson N,Parambil J,Culver DA

    更新日期：2017-05-01 00:00:00

  • Stepping down from combination asthma therapy: The predictors of outcome.

    abstract：BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.rmed.2016.06.010

    authors： Koskela HO,Purokivi MK,Kokkarinen J

    更新日期：2016-08-01 00:00:00

  • Increased red cell distribution width: A novel predictor of adverse outcome in patients hospitalized due to acute exacerbation of chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Acute exacerbation of COPD (AECOPD) is one of the leading causes for hospitalization and readmission in developed countries. No laboratory indices were consistently found to be associated with readmission risk. Recent evidence attests that red blood cell distribution width (RDW), conveys important informatio...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.01.011

    authors： Epstein D,Nasser R,Mashiach T,Azzam ZS,Berger G

    更新日期：2018-03-01 00:00:00

  • Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab.

    abstract：BACKGROUND:Omalizumab is a recombinant humanized monoclonal anti-IgE antibody approved in adults and adolescents with moderate-to-severe persistent allergic asthma inadequately controlled with inhaled corticosteroids (ICS). EXCELS is an ongoing prospective observational cohort study of approximately 5000 omalizumab-tre...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.rmed.2012.09.008

    authors： Chen H,Eisner MD,Haselkorn T,Trzaskoma B

    更新日期：2013-01-01 00:00:00

  • A comparison of the expression of lymphocyte activation markers in blood, bronchial biopsies and bronchoalveolar lavage: evidence for an enrichment of activated T lymphocytes in the bronchoalveolar space.

    abstract：:In this study healthy never-smoking subjects (n = 18) were recruited from a population study. Bronchoalveolar lavage (BAL), blood lymphocytes and bronchial biopsies, analysed both in the epithelium and lamina propria, were stained for T and B lymphocytes, natural killer (NK) cells and different subpopulations of T lym...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(99)90156-7

    authors： Ekberg-Jansson A,Arvå E,Nilsson O,Löfdahl CG,Andersson B

    更新日期：1999-08-01 00:00:00

  • Major respiratory adverse events after laparascopic gastric banding surgery for morbid obesity.

    abstract：BACKGROUND:Laparoscopic adjustable gastric banding surgery has become one of the most common restrictive surgical procedures for treatment of morbid obesity worldwide. Although short-term respiratory complications are well known, long-term data is scarce. We investigated the manifestations of major pulmonary complicati...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.05.002

    authors： Avriel A,Warner E,Avinoach E,Avnon LS,Shteinberg M,Shteinberg D,Heimer D,Yona S,Maimon N

    更新日期：2012-08-01 00:00:00

  • Living with chronic obstructive pulmonary disease: a survey of patients' knowledge and attitudes.

    abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a common respiratory condition and the fourth leading cause of death in Canada. However, little is known about the impact of COPD on the lives and attitudes of individuals living with this condition. The purpose of this study was to determine whether Canadian...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.01.018

    authors： Hernandez P,Balter M,Bourbeau J,Hodder R

    更新日期：2009-07-01 00:00:00

  • DQA1*03011 allele: protective or an adverse effect on the development of sarcoidosis; preliminary study.

    abstract：BACKGROUND:Sarcoidosis (SA) is a multisystem granulomatous disorder of unknown etiology. It seems likely that in genetically different predisposed hosts, the same antigen(s) may cause the development of sarcoid Th1 response. The interaction of the T-cell receptor with the human leukocyte antigen-DQA1*03011 peptide-comp...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.06.004

    authors： Dubaniewicz A,Dubaniewicz A,Dubaniewicz A,Moszkowska G

    更新日期：2007-10-01 00:00:00

  • Inhaled corticosteroids for adult asthma: impact of formulation and delivery device on relative pharmacokinetics, efficacy and safety.

    abstract：:Metered dose inhalers (MDIs) are the mainstay of inhaled steroid therapy for asthma. With the phasing out of traditional chlorofluorocarbon (CFC) propellants and their replacement with a new generation of CFC-free products, it is becoming clear that formulation and inhaler characteristics can markedly affect the drug ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(99)90000-8

    authors： Shaw RJ

    更新日期：1999-03-01 00:00:00

  • Evaluation of multidimensional COPD-related subjective fatigue following a pulmonary rehabilitation programme.

    abstract：INTRODUCTION:Subjective fatigue has been recognised as an important, multi-component symptom in COPD. Pulmonary Rehabilitation (PR) improves fatigue component of the Chronic Respiratory Questionnaire, a quality of life (QoL) measure. However, it is not clear if all fatigue dimensions are affected equally. This study ai...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.09.003

    authors： Lewko A,Bidgood PL,Jewell A,Garrod R

    更新日期：2014-01-01 00:00:00